PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31589440-4 2019 The reported nicotinamide-SAM conjugate (named NS1) features an alkyne as a key design element that closely mimics the linear, 180 transition state geometry found in the NNMT-catalyzed SAM NAM methyl transfer reaction. 3-O-methyl-alpha-methyldopamine 196-202 nicotinamide N-methyltransferase Homo sapiens 171-175 31589440-6 2019 An X-ray co-crystal structure and SAR study revealed the ability of an alkynyl linker to span the methyl transfer tunnel of NNMT with ideal shape complementarity. 3-O-methyl-alpha-methyldopamine 98-104 nicotinamide N-methyltransferase Homo sapiens 124-128