PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31547729-2 2020 In mammalian cells, three active DNMTs have been identified: DNMT1 acts as a maintenance methyltransferase to replicate preexisting methylation patterns, whereas DNMT3A and DNMT3B primarily act as de novo methyltransferases that are responsible for establishing DNA methylation patterns by adding a methyl group to cytosine bases. 3-O-methyl-alpha-methyldopamine 89-95 DNA methyltransferase 1 Homo sapiens 61-66