PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9451755-1 1997 Di(2-ethylhexyl) phthalate (DEHP) is a peroxisome proliferator whose administration to rodents induces a pleiotropic response mediated by the peroxisome proliferator-activated receptor-alpha (PPAR alpha). Diethylhexyl Phthalate 0-26 peroxisome proliferator activated receptor alpha Mus musculus 142-190 12151626-2 2002 Using microarray gene expression profiling of mRNA from wild type versus PPARalpha null mice, we detected a 3- to 7-fold downregulation of hepatic lactoferrin (LF) in response to the PP, diethylhexylphthalate (DEHP; 1150 mg/kg). Diethylhexyl Phthalate 187-208 peroxisome proliferator activated receptor alpha Mus musculus 73-82 11693183-4 2001 In order to identify the molecular pathways underlying the adverse effects of PPs in rodent liver, we carried out two-dimensional differential gel electrophoresis to provide quantitative proteomic analyses of diethylhexylphthalate (DEHP)-treated wild-type or PPARalpha-null mouse livers. Diethylhexyl Phthalate 232-236 peroxisome proliferator activated receptor alpha Mus musculus 259-268 9547862-0 1998 Receptor and nonreceptor-mediated organ-specific toxicity of di(2-ethylhexyl)phthalate (DEHP) in peroxisome proliferator-activated receptor alpha-null mice. Diethylhexyl Phthalate 61-86 peroxisome proliferator activated receptor alpha Mus musculus 97-145 9547862-0 1998 Receptor and nonreceptor-mediated organ-specific toxicity of di(2-ethylhexyl)phthalate (DEHP) in peroxisome proliferator-activated receptor alpha-null mice. Diethylhexyl Phthalate 88-92 peroxisome proliferator activated receptor alpha Mus musculus 97-145 9547862-2 1998 To determine if the toxic effects of di(2-ethylhexyl)phthalate (DEHP) are mediated by PPAR alpha, we examined its effect in PPAR alpha-null mice. Diethylhexyl Phthalate 37-62 peroxisome proliferator activated receptor alpha Mus musculus 86-96 9547862-2 1998 To determine if the toxic effects of di(2-ethylhexyl)phthalate (DEHP) are mediated by PPAR alpha, we examined its effect in PPAR alpha-null mice. Diethylhexyl Phthalate 64-68 peroxisome proliferator activated receptor alpha Mus musculus 86-96 9547862-9 1998 These results provide evidence that PPAR alpha mediates the subacute-chronic toxicity of DEHP in liver, kidney, and testis. Diethylhexyl Phthalate 89-93 peroxisome proliferator activated receptor alpha Mus musculus 36-46 9451755-1 1997 Di(2-ethylhexyl) phthalate (DEHP) is a peroxisome proliferator whose administration to rodents induces a pleiotropic response mediated by the peroxisome proliferator-activated receptor-alpha (PPAR alpha). Diethylhexyl Phthalate 0-26 peroxisome proliferator activated receptor alpha Mus musculus 192-202 9451755-1 1997 Di(2-ethylhexyl) phthalate (DEHP) is a peroxisome proliferator whose administration to rodents induces a pleiotropic response mediated by the peroxisome proliferator-activated receptor-alpha (PPAR alpha). Diethylhexyl Phthalate 28-32 peroxisome proliferator activated receptor alpha Mus musculus 142-190 9451755-1 1997 Di(2-ethylhexyl) phthalate (DEHP) is a peroxisome proliferator whose administration to rodents induces a pleiotropic response mediated by the peroxisome proliferator-activated receptor-alpha (PPAR alpha). Diethylhexyl Phthalate 28-32 peroxisome proliferator activated receptor alpha Mus musculus 192-202 25689681-7 2015 In addition to the expected activation of PPARalpha by fibrate drugs, di(2-ethylhexyl) phthalate, and perfluorinated compounds, PPARalpha was activated by benzofuran, galactosamine, and TCDD and suppressed by hepatotoxins acetaminophen, lipopolysaccharide, silicon dioxide nanoparticles, and trovafloxacin. Diethylhexyl Phthalate 70-96 peroxisome proliferator activated receptor alpha Mus musculus 128-137 32642447-3 2020 In this study, we measured liver miRNAs in male B6C3F1 mice exposed to a known chemical activator of the peroxisome proliferator-activated receptor alpha (PPARalpha) pathway, di(2-ethylhexyl) phthalate (DEHP), for 7 and 28 days at concentrations of 0, 750, 1500, 3000, or 6000 ppm in feed. Diethylhexyl Phthalate 175-201 peroxisome proliferator activated receptor alpha Mus musculus 105-153 32642447-3 2020 In this study, we measured liver miRNAs in male B6C3F1 mice exposed to a known chemical activator of the peroxisome proliferator-activated receptor alpha (PPARalpha) pathway, di(2-ethylhexyl) phthalate (DEHP), for 7 and 28 days at concentrations of 0, 750, 1500, 3000, or 6000 ppm in feed. Diethylhexyl Phthalate 203-207 peroxisome proliferator activated receptor alpha Mus musculus 105-153 30660623-9 2019 In conclusion, in utero exposure to DEHP induces neonatal serum glucose malnutrition via PPARalpha. Diethylhexyl Phthalate 36-40 peroxisome proliferator activated receptor alpha Mus musculus 89-98 26519955-7 2016 The 7-day BMDT values for Acot1 as a surrogate measure for PPARalpha activation were 29, 370, and 676 mg/kg/day for DEHP, DNOP, and BBP, respectively, distinguishing DEHP (liver tumor BMD of 35 mg/kg/day) from non-tumorigenic DNOP and BBP. Diethylhexyl Phthalate 116-120 peroxisome proliferator activated receptor alpha Mus musculus 59-68 26519955-7 2016 The 7-day BMDT values for Acot1 as a surrogate measure for PPARalpha activation were 29, 370, and 676 mg/kg/day for DEHP, DNOP, and BBP, respectively, distinguishing DEHP (liver tumor BMD of 35 mg/kg/day) from non-tumorigenic DNOP and BBP. Diethylhexyl Phthalate 166-170 peroxisome proliferator activated receptor alpha Mus musculus 59-68 25351189-12 2015 Exposure to DEHP led to small but statistically significant increases in methylation of specific CpGs within Ppara and Pparg1, which otherwise were generally hypomethylated, but methylation of Glut4 was unaltered. Diethylhexyl Phthalate 12-16 peroxisome proliferator activated receptor alpha Mus musculus 109-114 30660623-8 2019 Exposure to 0.05% DEHP during the in utero and lactational periods also increased food consumption after weaning in both mPPARA and hPPARA mice; this was not observed in Ppara-null offspring. Diethylhexyl Phthalate 18-22 peroxisome proliferator activated receptor alpha Mus musculus 170-175 29669060-12 2018 In vivo DEHP exposure for 6 weeks enhanced the renal dysfunction and renal fibrosis and mortality rate, but decreased the PPARalpha and PPARgamma protein expressions, in a folic acid-induced kidney fibrosis mouse model. Diethylhexyl Phthalate 8-12 peroxisome proliferator activated receptor alpha Mus musculus 122-131 24858501-3 2014 Maternal exposure to di(2-ethylhexyl)phthalate (DEHP), an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha), decreases the number of live fetuses and newborn pups, and their body weights, and it enhances fetal desorption in wild-type mice. Diethylhexyl Phthalate 21-46 peroxisome proliferator activated receptor alpha Mus musculus 119-128 24811840-0 2014 Peroxisome proliferator-activated receptor alpha mediates di-(2-ethylhexyl) phthalate transgenerational repression of ovarian Esr1 expression in female mice. Diethylhexyl Phthalate 58-85 peroxisome proliferator activated receptor alpha Mus musculus 0-48 24811840-1 2014 Di-(2-ethylhexyl)-phthalate (DEHP) is a phthalate ester that binds peroxisome proliferator-activated receptor alpha (PPARalpha) to induce proliferation of peroxisomes and regulate the expression of specific target genes. Diethylhexyl Phthalate 0-27 peroxisome proliferator activated receptor alpha Mus musculus 67-115 24811840-1 2014 Di-(2-ethylhexyl)-phthalate (DEHP) is a phthalate ester that binds peroxisome proliferator-activated receptor alpha (PPARalpha) to induce proliferation of peroxisomes and regulate the expression of specific target genes. Diethylhexyl Phthalate 0-27 peroxisome proliferator activated receptor alpha Mus musculus 117-126 24811840-1 2014 Di-(2-ethylhexyl)-phthalate (DEHP) is a phthalate ester that binds peroxisome proliferator-activated receptor alpha (PPARalpha) to induce proliferation of peroxisomes and regulate the expression of specific target genes. Diethylhexyl Phthalate 29-33 peroxisome proliferator activated receptor alpha Mus musculus 67-115 24811840-1 2014 Di-(2-ethylhexyl)-phthalate (DEHP) is a phthalate ester that binds peroxisome proliferator-activated receptor alpha (PPARalpha) to induce proliferation of peroxisomes and regulate the expression of specific target genes. Diethylhexyl Phthalate 29-33 peroxisome proliferator activated receptor alpha Mus musculus 117-126 24858501-3 2014 Maternal exposure to di(2-ethylhexyl)phthalate (DEHP), an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha), decreases the number of live fetuses and newborn pups, and their body weights, and it enhances fetal desorption in wild-type mice. Diethylhexyl Phthalate 21-46 peroxisome proliferator activated receptor alpha Mus musculus 69-117 24858501-3 2014 Maternal exposure to di(2-ethylhexyl)phthalate (DEHP), an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha), decreases the number of live fetuses and newborn pups, and their body weights, and it enhances fetal desorption in wild-type mice. Diethylhexyl Phthalate 48-52 peroxisome proliferator activated receptor alpha Mus musculus 69-117 24858501-3 2014 Maternal exposure to di(2-ethylhexyl)phthalate (DEHP), an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha), decreases the number of live fetuses and newborn pups, and their body weights, and it enhances fetal desorption in wild-type mice. Diethylhexyl Phthalate 48-52 peroxisome proliferator activated receptor alpha Mus musculus 119-128 24858501-8 2014 Indeed, DEHP itself or metabolite(s) may induce the toxicity, because a difference in the metabolic route is observed between the wild-type and PPARalpha-null mice. Diethylhexyl Phthalate 8-12 peroxisome proliferator activated receptor alpha Mus musculus 144-153 18403868-0 2008 Different mechanisms of DEHP-induced hepatocellular adenoma tumorigenesis in wild-type and Ppar alpha-null mice. Diethylhexyl Phthalate 24-28 peroxisome proliferator activated receptor alpha Mus musculus 91-101 21354252-0 2011 Hepatic peroxisome proliferator-activated receptor alpha may have an important role in the toxic effects of di(2-ethylhexyl)phthalate on offspring of mice. Diethylhexyl Phthalate 108-133 peroxisome proliferator activated receptor alpha Mus musculus 8-56 21354252-1 2011 Maternal exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with adverse effects on offspring, and the metabolites are agonists of peroxisome proliferator-activated receptor (PPAR) alpha, which exhibits species differences in expression and function. Diethylhexyl Phthalate 21-46 peroxisome proliferator activated receptor alpha Mus musculus 139-194 21354252-1 2011 Maternal exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with adverse effects on offspring, and the metabolites are agonists of peroxisome proliferator-activated receptor (PPAR) alpha, which exhibits species differences in expression and function. Diethylhexyl Phthalate 48-52 peroxisome proliferator activated receptor alpha Mus musculus 139-194 20123618-0 2010 The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms. Diethylhexyl Phthalate 14-36 peroxisome proliferator activated receptor alpha Mus musculus 94-103 19850644-0 2010 Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor. Diethylhexyl Phthalate 135-162 peroxisome proliferator activated receptor alpha Mus musculus 20-68 19850644-0 2010 Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor. Diethylhexyl Phthalate 135-162 peroxisome proliferator activated receptor alpha Mus musculus 93-102 19850644-2 2010 Recent studies indicate that the plasticizer di-(2-ethylhexyl) phthalate (DEHP) increased the incidence of liver tumors in PPARalpha-null mice. Diethylhexyl Phthalate 45-72 peroxisome proliferator activated receptor alpha Mus musculus 123-132 19850644-2 2010 Recent studies indicate that the plasticizer di-(2-ethylhexyl) phthalate (DEHP) increased the incidence of liver tumors in PPARalpha-null mice. Diethylhexyl Phthalate 74-78 peroxisome proliferator activated receptor alpha Mus musculus 123-132 19428328-6 2009 Wild-type and PPARalpha-deficient mice were exposed to different doses of DEHP. Diethylhexyl Phthalate 74-78 peroxisome proliferator activated receptor alpha Mus musculus 14-23 18403868-1 2008 Di (2-ethylhexyl) phthalate (DEHP) exposure is thought to lead to hepatocellular hypertrophy and hyperplasia in rodents mediated via peroxisome proliferator-activated receptor alpha (PPAR alpha). Diethylhexyl Phthalate 0-27 peroxisome proliferator activated receptor alpha Mus musculus 133-181 18403868-1 2008 Di (2-ethylhexyl) phthalate (DEHP) exposure is thought to lead to hepatocellular hypertrophy and hyperplasia in rodents mediated via peroxisome proliferator-activated receptor alpha (PPAR alpha). Diethylhexyl Phthalate 0-27 peroxisome proliferator activated receptor alpha Mus musculus 183-193 18403868-1 2008 Di (2-ethylhexyl) phthalate (DEHP) exposure is thought to lead to hepatocellular hypertrophy and hyperplasia in rodents mediated via peroxisome proliferator-activated receptor alpha (PPAR alpha). Diethylhexyl Phthalate 29-33 peroxisome proliferator activated receptor alpha Mus musculus 133-181 18403868-1 2008 Di (2-ethylhexyl) phthalate (DEHP) exposure is thought to lead to hepatocellular hypertrophy and hyperplasia in rodents mediated via peroxisome proliferator-activated receptor alpha (PPAR alpha). Diethylhexyl Phthalate 29-33 peroxisome proliferator activated receptor alpha Mus musculus 183-193 18403868-2 2008 A recent study revealed that long-term exposure to relatively low-dose DEHP (0.05%) caused liver tumors including hepatocellular carcinomas, hepatocellular adenomas, and chologiocellular carcinomas at a higher incidence in Ppar alpha-null mice (25.8%) than in wild-type mice (10.0%). Diethylhexyl Phthalate 71-75 peroxisome proliferator activated receptor alpha Mus musculus 223-233 18403868-5 2008 The gene expressions of apoptotic peptidase activating factor 1 (Apaf1) and DNA-damage-inducible 45 alpha (Gadd45a) were increased in the hepatocellular adenoma tissues of wild-type mice exposed to DEHP, whereas they were unchanged in corresponding tissues of Ppar alpha-null mice. Diethylhexyl Phthalate 198-202 peroxisome proliferator activated receptor alpha Mus musculus 260-270 18403868-7 2008 Taken together, DEHP may induce hepatocellular adenomas, in part, via suppression of G2/M arrest regulated by Gadd45a and caspase 3-dependent apoptosis in Ppar alpha-null mice, but these genes may not be involved in tumorigenesis in the wild-type mice. Diethylhexyl Phthalate 16-20 peroxisome proliferator activated receptor alpha Mus musculus 155-165 17462839-0 2007 The adjuvant effect of di-(2-ethylhexyl) phthalate is mediated through a PPARalpha-independent mechanism. Diethylhexyl Phthalate 23-50 peroxisome proliferator activated receptor alpha Mus musculus 73-82 17462839-3 2007 In vivo formed metabolites of DEHP are peroxisome-proliferator-activated receptor (PPAR) ligands, a group of chemicals that may have immunomodulatory properties. Diethylhexyl Phthalate 30-34 peroxisome proliferator activated receptor alpha Mus musculus 39-81 17462839-3 2007 In vivo formed metabolites of DEHP are peroxisome-proliferator-activated receptor (PPAR) ligands, a group of chemicals that may have immunomodulatory properties. Diethylhexyl Phthalate 30-34 peroxisome proliferator activated receptor alpha Mus musculus 83-87 17575397-0 2007 Di(2-ethylhexyl)phthalate induces hepatic tumorigenesis through a peroxisome proliferator-activated receptor alpha-independent pathway. Diethylhexyl Phthalate 0-25 peroxisome proliferator activated receptor alpha Mus musculus 66-114 17575397-1 2007 Di(2-ethylhexyl)phthalate (DEHP), a commonly used industrial plasticizer, causes liver tumorigenesis presumably via activation of peroxisome proliferator-activated receptor alpha (PPARalpha). Diethylhexyl Phthalate 0-25 peroxisome proliferator activated receptor alpha Mus musculus 130-178 17575397-1 2007 Di(2-ethylhexyl)phthalate (DEHP), a commonly used industrial plasticizer, causes liver tumorigenesis presumably via activation of peroxisome proliferator-activated receptor alpha (PPARalpha). Diethylhexyl Phthalate 0-25 peroxisome proliferator activated receptor alpha Mus musculus 180-189 17575397-1 2007 Di(2-ethylhexyl)phthalate (DEHP), a commonly used industrial plasticizer, causes liver tumorigenesis presumably via activation of peroxisome proliferator-activated receptor alpha (PPARalpha). Diethylhexyl Phthalate 27-31 peroxisome proliferator activated receptor alpha Mus musculus 130-178 17575397-1 2007 Di(2-ethylhexyl)phthalate (DEHP), a commonly used industrial plasticizer, causes liver tumorigenesis presumably via activation of peroxisome proliferator-activated receptor alpha (PPARalpha). Diethylhexyl Phthalate 27-31 peroxisome proliferator activated receptor alpha Mus musculus 180-189 17575397-4 2007 Surprisingly, the incidence of liver tumors was higher in Pparalpha-null mice exposed to 0.05% DEHP (25.8%) than in similarly exposed wild-type mice (10.0%). Diethylhexyl Phthalate 95-99 peroxisome proliferator activated receptor alpha Mus musculus 58-67 17575397-8 2007 The protooncogene c-jun-mRNA was induced, and c-fos-mRNA tended to be induced only in Pparalpha-null mice fed a 0.05% DEHP-containing diet. Diethylhexyl Phthalate 118-122 peroxisome proliferator activated receptor alpha Mus musculus 86-95 17210446-3 2007 Previous in vivo experiments demonstrated that acute administration of the peroxisome proliferator di(2-ethylhexyl) phthalate (DEHP) led to an increase in production of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN) radical adducts in liver, an event that was dependent on Kupffer cell NADPH oxidase, but not peroxisome proliferator-activated receptor (PPAR)alpha. Diethylhexyl Phthalate 99-125 peroxisome proliferator activated receptor alpha Mus musculus 359-363 16937134-0 2007 Induction of peroxisome proliferator-activated receptor alpha (PPARalpha)-related enzymes by di(2-ethylhexyl) phthalate (DEHP) treatment in mice and rats, but not marmosets. Diethylhexyl Phthalate 93-119 peroxisome proliferator activated receptor alpha Mus musculus 13-61 16937134-0 2007 Induction of peroxisome proliferator-activated receptor alpha (PPARalpha)-related enzymes by di(2-ethylhexyl) phthalate (DEHP) treatment in mice and rats, but not marmosets. Diethylhexyl Phthalate 93-119 peroxisome proliferator activated receptor alpha Mus musculus 63-72 16937134-0 2007 Induction of peroxisome proliferator-activated receptor alpha (PPARalpha)-related enzymes by di(2-ethylhexyl) phthalate (DEHP) treatment in mice and rats, but not marmosets. Diethylhexyl Phthalate 121-125 peroxisome proliferator activated receptor alpha Mus musculus 13-61 16937134-0 2007 Induction of peroxisome proliferator-activated receptor alpha (PPARalpha)-related enzymes by di(2-ethylhexyl) phthalate (DEHP) treatment in mice and rats, but not marmosets. Diethylhexyl Phthalate 121-125 peroxisome proliferator activated receptor alpha Mus musculus 63-72 17210446-3 2007 Previous in vivo experiments demonstrated that acute administration of the peroxisome proliferator di(2-ethylhexyl) phthalate (DEHP) led to an increase in production of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN) radical adducts in liver, an event that was dependent on Kupffer cell NADPH oxidase, but not peroxisome proliferator-activated receptor (PPAR)alpha. Diethylhexyl Phthalate 127-131 peroxisome proliferator activated receptor alpha Mus musculus 359-363 17135395-0 2007 Peroxisome proliferator-activated receptor alpha protects against glomerulonephritis induced by long-term exposure to the plasticizer di-(2-ethylhexyl)phthalate. Diethylhexyl Phthalate 134-160 peroxisome proliferator activated receptor alpha Mus musculus 0-48 17135395-2 2007 DEHP toxicity is thought to involve peroxisome proliferator-activated receptor alpha (PPARalpha), but this contention remains controversial. Diethylhexyl Phthalate 0-4 peroxisome proliferator activated receptor alpha Mus musculus 36-84 17135395-2 2007 DEHP toxicity is thought to involve peroxisome proliferator-activated receptor alpha (PPARalpha), but this contention remains controversial. Diethylhexyl Phthalate 0-4 peroxisome proliferator activated receptor alpha Mus musculus 86-95 17135395-6 2007 The results reported here indicate that PPARalpha protects against the nephrotoxic effects of long-term exposure to DEHP. Diethylhexyl Phthalate 116-120 peroxisome proliferator activated receptor alpha Mus musculus 40-49