PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17408424-10 2007 Immunohistochemical analysis confirmed CYP17, HSD3B2, SULT2A1 and CYB5 expression by all cortisol-producing tumours. Hydrocortisone 89-97 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 39-44 15248825-10 2004 Two patients had a mass shown on computed tomography without CYP11B2 but with CYP11B1 and CYP17 expression (indicating cortisol production). Hydrocortisone 119-127 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 90-95 17400813-6 2007 Finally, using RT-PCR, we detected expression of genes encoding four key enzymes participating in steroids synthesis (CYP11A1, CYP11B1, CYP17 and CYP21A2) and showed transformation of progesterone into cortisol-immunoreactivity in cultured ARPE-19 cells. Hydrocortisone 202-210 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 136-141 12924498-7 2003 Immunohistochemical staining showed not only the presence of aldosteronoma, but also the expression of P-450c17, which is involved in the biosynthesis of cortisol, indicating that both cortisol and aldosterone were concurrently synthesized. Hydrocortisone 154-162 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 103-111 15128284-1 2004 The capacity of the adrenal to produce cortisol is controlled in part by 21-hydroxylase (CYP21) and the production of androgens by 17-hydroxylase/17-20-lyase (CYP17), in response to secretagogues including ACTH, angiotensin-II (A-II) and insulin. Hydrocortisone 39-47 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 159-164 12924498-7 2003 Immunohistochemical staining showed not only the presence of aldosteronoma, but also the expression of P-450c17, which is involved in the biosynthesis of cortisol, indicating that both cortisol and aldosterone were concurrently synthesized. Hydrocortisone 185-193 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 103-111 12444089-1 2003 Cytochrome P450c17 catalyzes 17 alpha-hydroxylation needed for cortisol synthesis and 17,20 lyase activity needed to produce sex steroids. Hydrocortisone 63-71 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 12608705-7 2003 The gene CYP11B2 encodes the steroid synthesizing enzymes for aldosterone production, while the genes CYP17 and CYP11B1 are needed for cortisol production. Hydrocortisone 135-143 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 102-107 11196462-3 2000 Cyclic AMP (cAMP) caused human adrenocortical H295R cells to overexpress hCYP17 resulting in hypersecretion of cortisol. Hydrocortisone 111-119 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 73-79 11463853-1 2001 Cytochrome P450c17 catalyzes steroid 17alpha-hydroxylase and 17,20 lyase activities, which are required for the biosynthesis of cortisol and sex steroids. Hydrocortisone 128-136 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 12044959-6 2002 The mechanism of dissociation of cortisol and DHEA synthesis in aging depends on another regulator of 17,20-lyase of cytochrome P450c17 such as cytochrome P450 reductase. Hydrocortisone 33-41 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 117-135 11572038-0 2001 In vitro release of aldosterone and cortisol in human adrenal adenomas correlates to mRNA expression of steroidogenic enzymes for genes CYP11B2 and CYP17. Hydrocortisone 36-44 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 148-153 10824109-2 2000 Most previous studies using reconstituted systems and fast kinetics suggest that the conversion of pregnenolone to dehydroepiandrosterone (DHEA; the precursor of androgen and estrogen biosynthesis) by P450c17 does not require the release of the intermediate 17alpha-OHPreg (a precursor of cortisol biosynthesis). Hydrocortisone 289-297 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 201-208 8732456-5 1996 P450c17, a key enzyme involved in cortisol production, was expressed in the tumor region in all cases in an immunohistochemical study. Hydrocortisone 34-42 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-7 9931027-1 1999 Microsomal 17alpha-hydroxylase/17,20-lyase cytochrome P450 (P450c17) catalyzes both the 17alpha-hydroxylase reaction required to produce cortisol, the major glucocorticoid in many animals, and the 17, 20-lyase activity required for the production of androgens in all animals. Hydrocortisone 137-145 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 60-67 31691616-2 2020 Most defects in CYP17A1 impair both enzymatic activities and cause a combined 17alpha-hydroxylase/17,20-lyase deficiency, which impairs hormone production (cortisol and sex steroids), sexual development, and puberty. Hydrocortisone 156-164 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 16-23 1835446-5 1991 These results suggest that the overproduction of cortisol in adrenocortical adenomas associated with Cushing"s syndrome results from an increased expression of P-450c17 and P-450c21 mRNA. Hydrocortisone 49-57 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 160-168 3077248-1 1988 Congenital adrenal hyperplasia results from a deficiency in any of the five enzymes necessary to synthesize cortisol from cholesterol: cholesterol desmolase (P450scc), 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), 17-hydroxylase (P450c17), 21-hydroxylase (P450c21) and 11-hydroxylase (P450c11). Hydrocortisone 108-116 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 234-241 32203088-3 2020 Pregnenolone is converted to cortisol by the enzymes 3-betaHSD, CYP17A1, CYP21A2, and CYP11B1. Hydrocortisone 29-37 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 64-71 31397841-11 2019 Three days after cell injection, the cortisol-secreting ACC cell area in solvent-treated embryos was significantly higher than that in 1 microM AbiAC-treated embryos, whereas no AbiAc effect was observed in SW13 cells, which lack the Abi target enzyme CYP17A1.Zebrafish embryos xenografted with ACC tumor cells could be a useful, fast, and reproducible experimental model to preclinically test the activity of new drugs in human ACC. Hydrocortisone 37-45 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 252-259 33780934-1 2020 CONTEXT: Steroid 17alpha-hydroxylase/17,20-lyase deficiency (17OHD) is characterized by decreased sex steroids and cortisol, and excessive mineralocorticoid action. Hydrocortisone 115-123 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 9-48 29065432-6 2018 Reverse transcription real time PCR analysis revealed that PIF modulates the expression of two genes in the cortisol synthesis pathway, Steroidogenic Factor 1 (SF1), an activator of steroidogenesis, and the downstream steroidogenic enzyme Cytochrome P450 17A1 (CYP17A1). Hydrocortisone 108-116 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 239-259 31356544-1 2019 BACKGROUND: Cytochrome P450 17A1 (CYP17A1) catalyzes the formation and metabolism of steroid hormones and is required for cortisol and androgens. Hydrocortisone 122-130 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 12-32 31356544-1 2019 BACKGROUND: Cytochrome P450 17A1 (CYP17A1) catalyzes the formation and metabolism of steroid hormones and is required for cortisol and androgens. Hydrocortisone 122-130 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 34-41 29229304-1 2018 Cytochrome P450 17A1 (CYP17A1) is a dual-function enzyme catalyzing reactions necessary for cortisol and androgen biosynthesis. Hydrocortisone 92-100 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-20 29229304-1 2018 Cytochrome P450 17A1 (CYP17A1) is a dual-function enzyme catalyzing reactions necessary for cortisol and androgen biosynthesis. Hydrocortisone 92-100 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 31351131-12 2019 All the key enzymes related to aldosterone and cortisol biosynthesis including CYP11B2, CYP17A1 and CYP11B1 were upregulated by PTH treatment in this model and PTH could serve as a co-stimulator of ANG II to increase CYP11B2 expression. Hydrocortisone 47-55 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 88-95 31351131-15 2019 PTH1R mRNA levels were positively correlated with those of CYP17A1 and CYP11B1, both involved in cortisol production. Hydrocortisone 97-105 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 59-66 29065432-6 2018 Reverse transcription real time PCR analysis revealed that PIF modulates the expression of two genes in the cortisol synthesis pathway, Steroidogenic Factor 1 (SF1), an activator of steroidogenesis, and the downstream steroidogenic enzyme Cytochrome P450 17A1 (CYP17A1). Hydrocortisone 108-116 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 261-268 27702589-3 2017 Cytochrome P450c17 is one of these and is also a multi-functional P450, with two activities, the first 17alpha-hydroxylation of pregnenolone is followed by a subsequent 17,20-lyase transformation to dehydroepiandrosterone (DHEA) as the dominant pathways to cortisol precursors or androgens in humans, respectively. Hydrocortisone 257-265 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-18 28893623-12 2017 A loss of CYP21A2 activity in combination with reduction of CYP17A1 activities by abiraterone could result in lower cortisol levels and may require monitoring for any potential adverse effects. Hydrocortisone 116-124 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 60-67 28487303-3 2017 The enzyme CYP17A1 includes 17alpha-hydroxylase and 17,20-lyase which are required for the synthesis of cortisol and sex steroids, respectively. Hydrocortisone 104-112 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 11-18 26701948-1 2015 The CYP17A1 gene encodes the enzyme P450c17, which mediates both 17alpha-hydroxylase and 17,20-lyase activities and is essential for production of cortisol and sex steroids. Hydrocortisone 147-155 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 4-11 28000554-1 2017 Cytochrome P450 17alpha-hydroxylase, 17,20-lyase (P450c17) is a key enzyme in the synthesis of cortisol in the zona fascicula of the adrenal cortex, and the synthesis of androgen precursors in the adrenal zona reticularis and the gonads. Hydrocortisone 95-103 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 50-57 27789139-6 2016 This could be accomplished through inhibition of enzymes in the cortisol synthetic pathway, 11beta-hydroxylase (Cyp11B1), 17alpha-hydroxylase-C17,20-lyase (Cyp17), and 21-hydroxylase (Cyp21). Hydrocortisone 64-72 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 156-161 26597777-1 2016 INTRODUCTION: Cytochrome P450 11B2 (CYP11B2) plays a pivotal role in aldosterone synthesis, while cytochrome P450 11B1 (CYP11B1) and cytochrome P450 17A1 (CYP17) are involved in cortisol synthesis in normal human adrenal glands. Hydrocortisone 178-186 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 133-153 26514241-3 2016 The biosynthesis of cortisol involves a cascade of cholesterol metabolizing reactions regulated through three major CYP proteins: 17alpha-hydroxylase-C17/20-lyase (CYP17), 21-hydroxylase (CYP21), and 11beta-hydroxylase (CYP11B1). Hydrocortisone 20-28 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 164-169 26514241-5 2016 A series of novel functionalized dioxane analogs have been developed and recently patented as CYP17, CYP21, and CYP11B1 inhibitors, which lead to the modulation of cortisol production as a method for treating, delaying, slowing, and inhibiting the implicated diseases. Hydrocortisone 164-172 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 94-99 25224484-1 2015 A single enzyme, microsomal P450c17, catalyzes the 17alpha-hydroxylase activity needed to make cortisol and the subsequent 17,20 lyase activity needed to produce the 19-carbon precursors of sex steroids. Hydrocortisone 95-103 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 28-35 26161337-1 2015 17alpha-hydroxylase and 17,20-lyase are enzymes encoded by the CYP17A1 gene and are required for the synthesis of sex steroids and cortisol. Hydrocortisone 131-139 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 63-70 26701948-1 2015 The CYP17A1 gene encodes the enzyme P450c17, which mediates both 17alpha-hydroxylase and 17,20-lyase activities and is essential for production of cortisol and sex steroids. Hydrocortisone 147-155 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 36-43 19564722-0 2009 Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors. Hydrocortisone 87-95 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 48-53 22170708-11 2012 CONCLUSION: CYP17A1 inhibition with abiraterone acetate is characterized by significant suppression of androgen and cortisol synthesis. Hydrocortisone 116-124 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 12-19 21094146-4 2011 We show that normal epidermis and cultured PHK express each of the enzymes (CYP11A1, CYP17A1, 3betaHSD1, CYP21 and CYP11B1) that are required for cortisol synthesis. Hydrocortisone 146-154 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 85-92 20160131-2 2010 The ratio of lyase to hydroxylase activity of human P450c17 determines whether steroidogenesis leads to the synthesis of cortisol or sex steroids. Hydrocortisone 121-129 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 52-59 23254310-6 2013 Concomitantly, mitotane resulted in decreased mRNA levels of two cytochromes P450 (CYP11A1 and CYP17A1), mRNAs encoding proteins involved in the synthesis of cortisol and DHEAS. Hydrocortisone 182-190 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 107-114 21848792-10 2011 CONCLUSIONS: In conclusion, CYP11B1 and CYP17 are overexpressed in subclinical CPA and their overexpression accounts for the increased production of cortisol that is characteristic of CPA. Hydrocortisone 149-157 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 40-45 19564722-3 2009 We have previously shown that expression of the gene CYP17, coding for the enzyme in the cortisol pathway, correlates with cortisol release from adrenocortical tumors in vitro. Hydrocortisone 89-97 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 53-58 19564722-3 2009 We have previously shown that expression of the gene CYP17, coding for the enzyme in the cortisol pathway, correlates with cortisol release from adrenocortical tumors in vitro. Hydrocortisone 123-131 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 53-58 19270420-7 2009 In situ hybridization showed that both mRNAs for HSD3B2 and CYP17A1 were strongly expressed in the tumor, suggesting cortisol synthesis. Hydrocortisone 117-125 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 60-67 18422032-1 2008 BACKGROUND: Cytochrome P450c17 (CYP17) has two principal enzyme activities, 17alpha-hydroxylase and 17,20-lyase, which are required for cortisol and androgen biosynthesis, respectively. Hydrocortisone 136-144 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 12-30 18422032-1 2008 BACKGROUND: Cytochrome P450c17 (CYP17) has two principal enzyme activities, 17alpha-hydroxylase and 17,20-lyase, which are required for cortisol and androgen biosynthesis, respectively. Hydrocortisone 136-144 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 32-37