PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26854589-2 2016 CYP11B1 catalyzes the formation of cortisol, while CYP11B2 realizes the biosynthesis of aldosterone. Hydrocortisone 35-43 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 0-7 26597777-1 2016 INTRODUCTION: Cytochrome P450 11B2 (CYP11B2) plays a pivotal role in aldosterone synthesis, while cytochrome P450 11B1 (CYP11B1) and cytochrome P450 17A1 (CYP17) are involved in cortisol synthesis in normal human adrenal glands. Hydrocortisone 178-186 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 98-118 27119751-4 2016 RECENT FINDINGS: Specific antibodies against the CYP11B2 and CYP11B1 enzymes, the last enzyme in aldosterone and cortisol synthesis, respectively, allow for the first time study of the steroidogenic capabilities of cells within the APA and adjacent adrenal. Hydrocortisone 113-121 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 61-68 26597777-1 2016 INTRODUCTION: Cytochrome P450 11B2 (CYP11B2) plays a pivotal role in aldosterone synthesis, while cytochrome P450 11B1 (CYP11B1) and cytochrome P450 17A1 (CYP17) are involved in cortisol synthesis in normal human adrenal glands. Hydrocortisone 178-186 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 120-127 26514241-3 2016 The biosynthesis of cortisol involves a cascade of cholesterol metabolizing reactions regulated through three major CYP proteins: 17alpha-hydroxylase-C17/20-lyase (CYP17), 21-hydroxylase (CYP21), and 11beta-hydroxylase (CYP11B1). Hydrocortisone 20-28 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 220-227 26795197-0 2016 Inhibitors of 11beta-Hydroxylase (CYP11B1) for Treating Diseases Related to Excess Cortisol. Hydrocortisone 83-91 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 34-41 26795197-2 2016 11beta-Hydroxylase (CYP11B1) is considered as an attractive target for treating these diseases, since it is a key enzyme responsible for the last step in cortisol biosynthesis. Hydrocortisone 154-162 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 20-27 26514241-5 2016 A series of novel functionalized dioxane analogs have been developed and recently patented as CYP17, CYP21, and CYP11B1 inhibitors, which lead to the modulation of cortisol production as a method for treating, delaying, slowing, and inhibiting the implicated diseases. Hydrocortisone 164-172 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 112-119 25880059-0 2015 A recombinant CYP11B1 dependent Escherichia coli biocatalyst for selective cortisol production and optimization towards a preparative scale. Hydrocortisone 75-83 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 14-21 26303746-7 2015 Utilizing both CAH and HAH, we have characterized the kinetics of the CYP11B1-mediated conversion of 11-deoxycortisol to cortisol and the CYP11B2-mediated oxidation of corticosterone to aldosterone. Hydrocortisone 109-117 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 70-77 25880059-3 2015 CYP11B1 thus offers a great potential for biotechnological application in large-scale synthesis of cortisol. Hydrocortisone 99-107 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 0-7 25880059-6 2015 For the subsequent optimization of the whole-cell activity 3 different approaches were pursued: Firstly, CYP11B1 expression was enhanced 3.3-fold to 257 nmol*L(-1) by site-directed mutagenesis of position 23 from glycine to arginine, which was accompanied by a 2.6-fold increase in cortisol yield. Hydrocortisone 282-290 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 105-112 25462231-1 2015 Diseases triggered by an abnormally high level of cortisol (hypercortisolism), such as the Cushing"s and metabolic syndromes, could be successfully tackled by inhibitors of CYP11B1, a steroidal cytochrome P450 enzyme that catalyzes the last hydroxylation step of the cortisol biosynthesis. Hydrocortisone 50-58 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 173-180 25584832-1 2015 The mitochondrial cytochrome P450 enzymes inhibitor steroid 11beta-hydroxylase (CYP11B1) can decrease the production of cortisol. Hydrocortisone 120-128 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 52-78 25584832-1 2015 The mitochondrial cytochrome P450 enzymes inhibitor steroid 11beta-hydroxylase (CYP11B1) can decrease the production of cortisol. Hydrocortisone 120-128 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 80-87 24325867-2 2014 The final enzymes in the biosynthesis of aldosterone and cortisol are by the cytochrome P450 CYP11B2 and CYP11B1, respectively. Hydrocortisone 57-65 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 105-112 24810847-3 2014 OBJECTIVE: This study is to investigate the effect of chronic rhinosinusitis (CRS) on expression of 11beta-HSD1, 11beta-HSD2, steroidogenic enzymes (cytochrome P450, family 11, subfamily B, polypeptide 1 [CYP11B1] and cytochrome P450, family 11, subfamily A, polypeptide 1 [CYP11A1]), and endogenous cortisol levels in human sinus mucosa. Hydrocortisone 300-308 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 149-203 24900631-4 2013 Compound 7n was also found to be a potent inhibitor of 11beta-hydroxylase (CYP11B1), which is responsible for cortisol production. Hydrocortisone 110-118 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 75-82 23940125-7 2013 Novel CYP11B1 mutations were functionally analyzed in transiently transfected COS7 cells measuring the conversion of 11-deoxycortisol to cortisol by liquid chromatography-tandem mass spectrometry. Hydrocortisone 125-133 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 6-13 21848792-10 2011 CONCLUSIONS: In conclusion, CYP11B1 and CYP17 are overexpressed in subclinical CPA and their overexpression accounts for the increased production of cortisol that is characteristic of CPA. Hydrocortisone 149-157 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 28-35 23836801-2 2013 We investigated the role of microRNA (miRNA) in their production, with particular emphasis on the CYP11B1 (11beta-hydroxylase) and CYP11B2 (aldosterone synthase) genes, which produce the enzymes responsible for the final stages of cortisol and aldosterone biosynthesis, respectively. Hydrocortisone 231-239 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 98-105 22172629-1 2012 CYP11B1 catalyzes the final step of cortisol biosynthesis. Hydrocortisone 36-44 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 0-7 22172629-4 2012 Nonhydroxylated flavones stimulated CYP11B1-catalyzed cortisol formation at transcriptional level. Hydrocortisone 54-62 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 36-43 23443813-10 2013 The CYP11B2/CYP11B1-equivalent and CYP11B1-dominant APA groups showed significantly higher serum cortisol after 1 mg dexamethasone and larger tumor size than the CYP11B2-dominant APA group. Hydrocortisone 97-105 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 12-19 23443813-10 2013 The CYP11B2/CYP11B1-equivalent and CYP11B1-dominant APA groups showed significantly higher serum cortisol after 1 mg dexamethasone and larger tumor size than the CYP11B2-dominant APA group. Hydrocortisone 97-105 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 35-42 22079243-1 2012 CYP11B1 and CYP11B2 responsible for the final steps of cortisol and aldosterone synthesis, respectively, are believed to be duplicate genes with distinctive promoters. Hydrocortisone 55-63 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 0-7 24900349-0 2011 Optimization of the First Selective Steroid-11beta-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases. Hydrocortisone 105-113 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 36-62 24900349-0 2011 Optimization of the First Selective Steroid-11beta-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases. Hydrocortisone 105-113 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 64-71 24900349-1 2011 CYP11B1 is the key enzyme in cortisol biosynthesis, and its inhibition with selective compounds is a promising strategy for the treatment of diseases associated with elevated cortisol levels, such as Cushing"s syndrome or metabolic disease. Hydrocortisone 29-37 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 0-7 24900349-1 2011 CYP11B1 is the key enzyme in cortisol biosynthesis, and its inhibition with selective compounds is a promising strategy for the treatment of diseases associated with elevated cortisol levels, such as Cushing"s syndrome or metabolic disease. Hydrocortisone 175-183 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 0-7 21239489-6 2011 Additionally, we found induction of CYP11B1 increased production of cortisol and activation of GR pathway during wound healing ex vivo and in vivo using human and porcine wound models, respectively. Hydrocortisone 68-76 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 36-43 21094146-4 2011 We show that normal epidermis and cultured PHK express each of the enzymes (CYP11A1, CYP17A1, 3betaHSD1, CYP21 and CYP11B1) that are required for cortisol synthesis. Hydrocortisone 146-154 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 115-122 20615692-4 2010 Furthermore, this scaffold can achieve high levels of selectivity for CYP11B2 over CYP11B1, a key enzyme in the biosynthesis of cortisol. Hydrocortisone 128-136 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 83-90 21164264-2 2011 Recent evidence suggests that common polymorphisms in the genes mediating the final stages of aldosterone and cortisol production (CYP11B1 and CYP11B2 respectively) are also associated with milder alterations in adrenal corticosteroid biosynthesis. Hydrocortisone 110-118 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 131-138 24900247-1 2011 Outgoing from an etomidate-based design concept, we succeeded in the development of a series of highly active and selective inhibitors of CYP11B1, the key enzyme of cortisol biosynthesis, as potential drugs for the treatment of Cushing"s syndrome and related diseases. Hydrocortisone 165-173 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 138-145 19622340-7 2009 By the same strategy, another stable cell line simultaneously overexpressing human 11beta-hydroxylase (CYP11B1), an enzyme responsible for the final step of cortisol biosynthesis, and the two electron transfer proteins was also established, and an in vitro CYP11B1 assay using 11-deoxycortisol as a substrate was likewise developed to assess the selectivity of CYP11B2 inhibitors. Hydrocortisone 157-165 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 103-110 19342457-1 2009 Aldosterone synthase (CYP11B2) and 11 beta-hydroxylase (CYP11B1) regulate aldosterone and cortisol production, respectively. Hydrocortisone 90-98 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 56-63 19564722-0 2009 Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors. Hydrocortisone 87-95 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 58-65 19342457-14 2009 In conclusion, NRSF/NRSE controls aldosterone and cortisol synthesis by regulating CYP11B2 and CYP11B1 gene transcription mainly through NRSF/NRSE-mediated enhancement of the CACNA1H gene. Hydrocortisone 50-58 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 95-102 18292466-11 2008 Altered 11beta-hydroxylase efficiency (conversion of deoxycortisol to cortisol) as a consequence of variation in the neighboring gene (CYP11B1) may be important in contributing to altered control of aldosterone synthesis, so that the risk of hypertension may reflect a digenic effect, a concept that is discussed further. Hydrocortisone 58-66 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 135-142 19164467-5 2009 Analysis of steroidogenic gene expression indicated that torcetrapib significantly induced the expression of CYP11B2 and CYP11B1, two enzymes in the last step of aldosterone and cortisol biosynthesis pathway, respectively. Hydrocortisone 178-186 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 121-128 17980006-10 2008 RESULTS: Subjects with SNPs associated with reduced 11-hydroxylation efficiency (-344T CYP11B2; TTGG CYP11B1) showed reduced inhibition of ACTH after dexamethasone (P = 0.05) and an altered cortisol-ACTH relationship (decreased cortisol-ACTH ratio, P < 0.02). Hydrocortisone 190-198 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 101-108 17400813-6 2007 Finally, using RT-PCR, we detected expression of genes encoding four key enzymes participating in steroids synthesis (CYP11A1, CYP11B1, CYP17 and CYP21A2) and showed transformation of progesterone into cortisol-immunoreactivity in cultured ARPE-19 cells. Hydrocortisone 202-210 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 127-134 18663314-9 2008 In vitro expression studies performed in HCT116 cells showed a markedly decreased CYP11B1 activity in the L299P mutant (1.6 +/- 0.8%) for the conversion of 11-deoxycortisol to cortisol. Hydrocortisone 164-172 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 82-89 17350062-3 2007 Subsequent examinations revealed that CYP11B1 and CYP11B2 genes, responsible for the respective final steps of the cortisol and aldosterone biosynthetic pathways, exhibited increased responsiveness to PCB126 under high potassium. Hydrocortisone 115-123 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 38-45 15134825-2 2004 Two key players in adrenal steroid hormone biosynthesis are the human mitochondrial cytochrome P450 enzymes CYP11B1 and CYP11B2 that catalyze the final steps in the biosynthesis of cortisol and aldosterone, respectively. Hydrocortisone 181-189 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 108-115 16670167-4 2006 RESULTS: The in vitro expression studies in COS-7 cells revealed an almost complete absence of CYP11B1 activity for the P94L mutant to 0.05% for the conversion of 11-deoxycortisol to cortisol. Hydrocortisone 171-179 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 95-102 15755848-4 2005 In vitro expression studies in COS-7 cells revealed a decreased CYP11B1 activity in the W116C mutant to 2.9 +/- 0.9% (sd) for the conversion of 11-deoxycortisol to cortisol. Hydrocortisone 152-160 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 64-71 15780661-3 2005 In the human adrenal, the mitochondrial cytochrome P450 enzyme CYP11B1 catalyses the conversion of 11-deoxycortisol to cortisol, a key reaction in cortisol biosynthesis that in addition is of fundamental interest for the technical synthesis of glucocorticoids. Hydrocortisone 107-115 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 63-70 15780661-3 2005 In the human adrenal, the mitochondrial cytochrome P450 enzyme CYP11B1 catalyses the conversion of 11-deoxycortisol to cortisol, a key reaction in cortisol biosynthesis that in addition is of fundamental interest for the technical synthesis of glucocorticoids. Hydrocortisone 119-127 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 63-70 12431857-7 2002 The results suggest serotonergic vulnerability that affected mood in FH II subjects and cortisol release in both FH I and FH II subjects. Hydrocortisone 88-96 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 113-127 12608705-7 2003 The gene CYP11B2 encodes the steroid synthesizing enzymes for aldosterone production, while the genes CYP17 and CYP11B1 are needed for cortisol production. Hydrocortisone 135-143 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 112-119 12452430-2 2002 Two key players in these pathways are the human mitochondrial cytochrome P450 enzymes CYP11B1 and CYP11B2, which catalyze the final steps in the biosynthesis of cortisol and aldosterone. Hydrocortisone 161-169 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 86-93 11443188-2 2001 We have studied a patient with congenital adrenal hyperplasia and steroid 11beta-hydroxylase deficiency who was homozygous for a deletion of the CYP11B1 and CYP11B2 genes normally required for cortisol and aldosterone synthesis, respectively. Hydrocortisone 193-201 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 145-152 10411330-4 1999 CYP11B2 catalyzes the final steps in the biosynthesis of aldosterone and is expressed solely in the glomerulosa of the adrenal cortex, while CYP11B1 catalyzes the final steps in the biosynthesis of cortisol and is expressed in the fasciculata/reticularis. Hydrocortisone 198-206 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 141-148 11014212-1 2000 Steroid 11beta-hydroxylase is a mitochondrial enzyme that catalyzes the conversion of deoxycortisol to cortisol. Hydrocortisone 91-99 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 0-26 9814482-0 1998 Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol. Hydrocortisone 80-88 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 12-18 8969896-3 1996 Replacement of 3 amino acids of CYP11B2 by the corresponding residues in CYP11B1 was sufficient to increase cortisol formation from about 5% to 85% of the CYP11B1 wild type level. Hydrocortisone 108-116 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 73-80 9546661-1 1998 Performing residue-swapping experiments between the highly conserved human steroidogenic proteins CYP11B1 and CYP11B2 we recently demonstrated that replacement of specific residues at position 301, 302 and 320 in the aldosterone-producing CYP11B2 protein for such residues that were specific for the highly similar cortisol-producing CYP11B1 protein elevated the 11beta-hydroxylase activity dramatically. Hydrocortisone 315-323 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 98-105 8952579-4 1996 Deficiencies of steroid 11 beta-hydroxylase or 17 alpha-hydroxylase are types of congenital adrenal hyperplasia, the autosomal recessive inability to synthesize cortisol. Hydrocortisone 161-169 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 16-43 8969896-3 1996 Replacement of 3 amino acids of CYP11B2 by the corresponding residues in CYP11B1 was sufficient to increase cortisol formation from about 5% to 85% of the CYP11B1 wild type level. Hydrocortisone 108-116 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 155-162 1518866-4 1992 A related isozyme in the zona fasciculata, CYP11B1, is required for cortisol synthesis; this isozyme, which is normally expressed at much higher levels than CYP11B2, only has 11 beta-hydroxylase activity. Hydrocortisone 68-76 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 43-50 7792811-1 1995 CYP11B1 (11 beta-hydroxylase) and CYP11B2 (aldosterone synthase) are steroidogenic enzymes which mediate the final step (11 beta-hydroxylation) in cortisol synthesis and the final three steps (11 beta-hydroxylation, 18-hydroxylation, and 18-oxidation) in aldosterone synthesis, respectively. Hydrocortisone 147-155 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 0-7 7792811-4 1995 The 11 beta-hydroxylase gene (CYP11B1) is expressed in the zona fasciculata, the zone which also expresses a 17-hydroxylase activity, where it mediates cortisol synthesis under the control of ACTH. Hydrocortisone 152-160 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 30-37 1879383-1 1991 Deficiency of steroid 11 beta-hydroxylase, which is a mitochondrial cytochrome P450 required for cortisol and aldosterone synthesis, causes hypertension as well as virilization. Hydrocortisone 97-105 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 14-41 1775135-1 1991 The steroid 11 beta-hydroxylase (P450c11) enzyme is responsible for the conversion of 11-deoxycortisol to cortisol in the zona fasciculata of the adrenal cortex. Hydrocortisone 94-102 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 4-31 1775135-1 1991 The steroid 11 beta-hydroxylase (P450c11) enzyme is responsible for the conversion of 11-deoxycortisol to cortisol in the zona fasciculata of the adrenal cortex. Hydrocortisone 94-102 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 33-40 2022736-1 1991 Steroid 11 beta-hydroxylase (P450c11) deficiency (failure to convert 11-deoxycortisol to cortisol) causes less than 10% of cases of congenital adrenal hyperplasia in most populations, but it is relatively frequent in Jews of Moroccan origin. Hydrocortisone 77-85 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 0-27 34485929-0 2021 Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis. Hydrocortisone 47-55 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 69-76 34247511-2 2021 CYP11B2 is 93% identical to cortisol-producing CYP11B1, which makes it difficult to design selective drugs. Hydrocortisone 28-36 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 47-54 34485929-1 2021 Human cytochromes P45011beta (CYP11B1) and P450aldo (CYP11B2) are monooxygenases that synthesize cortisol through steroid 11beta-hydroxylation and aldosterone through a three-step process comprising 11beta-hydroxylation and two 18-hydroxylations, respectively. Hydrocortisone 97-105 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 30-37 31613736-6 2020 METHODS AND RESULTS: In the present study, we investigated the effect of adipocyte-derived factors on cortisol synthase gene CYP11B1 mRNA expression in vitro study using adrenocortical carcinoma H295R cells and mouse fibroblast 3T3-L1cells. Hydrocortisone 102-110 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 125-132 34384396-6 2021 Furthermore, in immunostaining for cytochrome P450 (CYP) 11B1, a cortisol-producing enzyme, diffuse staining was observed in tumorous lesion. Hydrocortisone 65-73 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 35-61 3077248-1 1988 Congenital adrenal hyperplasia results from a deficiency in any of the five enzymes necessary to synthesize cortisol from cholesterol: cholesterol desmolase (P450scc), 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), 17-hydroxylase (P450c17), 21-hydroxylase (P450c21) and 11-hydroxylase (P450c11). Hydrocortisone 108-116 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 289-296 33245660-3 2021 Variants in the CYP11B1 gene, which codes for the enzyme responsible for cortisol synthesis, could influence risk of late-life depression, but this hypothesis has not been examined. Hydrocortisone 73-81 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 16-23 32751564-7 2020 CYP11B1 was the steroidogenic enzyme with the most discriminative power to distinguish ACC from ACAc, with a sensitivity of 100%, specificity of 92%, and an expression higher than 4.44%, indicating the presence of a cortisol secreting adenoma. Hydrocortisone 216-224 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 0-7 2592361-1 1989 Steroid 11 beta-hydroxylase (P-450(11) beta) is a mitochondrial cytochrome P-450 enzyme necessary for cortisol biosynthesis. Hydrocortisone 102-110 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 0-27 34015331-8 2021 Comparisons with cholesterol-metabolizing CYP11A1 and cortisol-producing CYP11B1, which also bind adrenodoxin, revealed substantial structural differences in these regions. Hydrocortisone 54-62 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 73-80 32203088-3 2020 Pregnenolone is converted to cortisol by the enzymes 3-betaHSD, CYP17A1, CYP21A2, and CYP11B1. Hydrocortisone 29-37 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 86-93 31613736-8 2020 CONCLUSION: Since CYP11B1 is well known as a limiting enzyme of cortisol synthesis, our study suggests that adipocyte-derived factors may stimulate cortisol secretion, as well as aldosterone secretion. Hydrocortisone 64-72 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 18-25 31613736-8 2020 CONCLUSION: Since CYP11B1 is well known as a limiting enzyme of cortisol synthesis, our study suggests that adipocyte-derived factors may stimulate cortisol secretion, as well as aldosterone secretion. Hydrocortisone 148-156 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 18-25 31351131-12 2019 All the key enzymes related to aldosterone and cortisol biosynthesis including CYP11B2, CYP17A1 and CYP11B1 were upregulated by PTH treatment in this model and PTH could serve as a co-stimulator of ANG II to increase CYP11B2 expression. Hydrocortisone 47-55 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 100-107 31400391-2 2019 The DNA encoding aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1), which catalyzes the final step of cortisol biosynthesis, is less methylated in aldosterone-producing adenomas (APA) and cortisol-producing adenomas (CPA), respectively. Hydrocortisone 116-124 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 72-79 31666955-1 2019 Immunohistochemistry with antibodies targeting enzymes responsible for the final conversion steps of cortisol (CYP11B1) and aldosterone (CYP11B2) is gaining ground as an adjunct tool in the postoperative evaluation of adrenocortical nodules. Hydrocortisone 101-109 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 111-118 31351131-15 2019 PTH1R mRNA levels were positively correlated with those of CYP17A1 and CYP11B1, both involved in cortisol production. Hydrocortisone 97-105 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 71-78 30769265-2 2019 In the last few decades CYP11B1 (11-beta-hydroxylase) and CYP11B2 (aldosterone synthase), key enzymes in the biosynthesis of cortisol and aldosterone, respectively, have been also investigated as targets for the identification of new potent and selective agents for the treatment of Cushing"s syndrome, impaired wound healing and cardiovascular diseases. Hydrocortisone 125-133 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 24-31 31484828-9 2019 In addition, we reveal an inverse correlation between cortisol derivatives and CYP11B1 and the impact of 18-oxocortisol and CYP11B1 on clinical outcome, which provides unprecedented insights into the pathophysiology, clinical features, and steroidogenesis of APAs. Hydrocortisone 54-62 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 79-86 31484828-9 2019 In addition, we reveal an inverse correlation between cortisol derivatives and CYP11B1 and the impact of 18-oxocortisol and CYP11B1 on clinical outcome, which provides unprecedented insights into the pathophysiology, clinical features, and steroidogenesis of APAs. Hydrocortisone 54-62 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 124-131 30965118-3 2019 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) catalyze the formation of cortisol and aldosterone, respectively, in the adrenal cortex. Hydrocortisone 90-98 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 20-27 30425102-2 2019 CYP11B1 is a promising drug target to manage Cushing"s disease, a disorder arising from excessive cortisol production. Hydrocortisone 98-106 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 0-7 30572739-7 2019 Specifically, the authors look at selective inhibitors of CYP11B1 that reduce cortisol production by inhibiting steroid 11beta-hydroxylase and glucocorticoid receptor (GR) antagonists that interrupt cortisol-mediating transcriptional regulation of related genes. Hydrocortisone 78-86 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 58-65 30572739-7 2019 Specifically, the authors look at selective inhibitors of CYP11B1 that reduce cortisol production by inhibiting steroid 11beta-hydroxylase and glucocorticoid receptor (GR) antagonists that interrupt cortisol-mediating transcriptional regulation of related genes. Hydrocortisone 199-207 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 58-65 28747362-10 2018 At birth and day 3, a low cortisol/11-deoxycortisol ratio was found in preterm infants, suggesting an 11-beta-hydroxylase activity (CYP11B1) deficiency. Hydrocortisone 26-34 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 132-139 29878770-1 2018 It is necessary for aldosterone synthase (CYP11B2) inhibitors to have both high potency and high selectivity over 11beta-hydroxylase (CYP11B1), a critical enzyme for cortisol synthesis. Hydrocortisone 166-174 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 134-141 28894201-0 2017 Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia. Hydrocortisone 0-8 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 56-63 29312923-1 2017 Cortisol synthase (CYP11B1) is the main enzyme for the endogenous synthesis of cortisol and its inhibition is a potential way for the treatment of diseases associated with increased cortisol levels, such as Cushing"s syndrome, metabolic diseases, and delayed wound healing. Hydrocortisone 79-87 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 19-26 29312923-1 2017 Cortisol synthase (CYP11B1) is the main enzyme for the endogenous synthesis of cortisol and its inhibition is a potential way for the treatment of diseases associated with increased cortisol levels, such as Cushing"s syndrome, metabolic diseases, and delayed wound healing. Hydrocortisone 182-190 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 19-26 28894201-3 2017 However, in hypercortisolemia, the role of DNA methylation of 11beta-hydroxylase (CYP11B1), which catalyzes cortisol biosynthesis and is highly homologous to CYP11B2, is unclear. Hydrocortisone 17-25 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 82-89 28894201-8 2017 Our study results suggest that DNA methylation at the CYP11B1 promoter plays a role in the regulation of CYP11B1 expression and cortisol production in CPA, and that somatic mutations associated with CPA reduce DNA methylation at the CYP11B1 promoter. Hydrocortisone 128-136 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 54-61 28514642-4 2017 In vitro expression studies, immunofluorescence demonstrated that wild type and mutant (L410R and G411C) proteins of CYP11B1 were correctly expressed on the mitochondria, and enzyme activity assay revealed the mutant reduced the 11-hydroxylase activity to 10% (P<0.001) for the conversion of 11beta-deoxycortisol to cortisol. Hydrocortisone 307-315 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 117-124