PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2548411-3 1989 The ACTH response to induced hypoglycemia was measured after no prior corticosteroid feedback signal or after a corticosteroid feedback signal produced by infusion, two bolus injections, or three bolus injections of cortisol and corticosterone. Hydrocortisone 216-224 proopiomelanocortin Canis lupus familiaris 4-8 2542006-14 1989 The results show that small hemorrhage elicits changes in B-ACTH that are dissociated in time and magnitude from changes in IR-ACTH, are coincident with changes in cortisol secretion, and are greater in dogs that fail to maintain arterial pressure. Hydrocortisone 164-172 proopiomelanocortin Canis lupus familiaris 60-64 6318936-0 1983 Feedback suppression of ACTH secretion by cortisol in dogs: lags after large signals equal those following very small signals. Hydrocortisone 42-50 proopiomelanocortin Canis lupus familiaris 24-28 2847563-5 1988 The infusion of a vasopressin V1-receptor agonist, but not of either a vasopressin V2-receptor agonist or oxytocin, also caused a significant enhancement of ACTH-stimulated cortisol secretion. Hydrocortisone 173-181 proopiomelanocortin Canis lupus familiaris 157-161 6098199-2 1984 Absolute concentration of cortisol was less in resting, dexamethasone-suppressed, and ACTH-stimulated plasma samples, when measured by HPLC relative to cortisol concentrations determined by radioimmunoassay. Hydrocortisone 26-34 proopiomelanocortin Canis lupus familiaris 86-90 6314462-5 1983 Plasma cortisol levels were significantly reduced after ACTH injection in dogs previously given prednisone demonstrating that a single intramuscular prednisone dose causes detectable adrenocortical suppression one week after administration. Hydrocortisone 7-15 proopiomelanocortin Canis lupus familiaris 56-60 6318936-1 1983 Previously, low stepwise infusions of cortisol in resting adrenalectomized dogs (plateaux less than or equal to 6 micrograms/dL) were shown to reduce ACTH secretion only after 20 min. Hydrocortisone 38-46 proopiomelanocortin Canis lupus familiaris 150-154 6262051-1 1981 Adrenocortical sensitivity to ACTH, defined as the slope of the log dose-response curve, was determined in awake dogs by measuring cortisol secretory rates after graded doses of ACTH. Hydrocortisone 131-139 proopiomelanocortin Canis lupus familiaris 30-34 7293796-7 1981 We therefore speculate that apomorphine activates central dopaminergic receptors which cause a release of ACTH from the pituitary into the circulation, which in turn stimulates the release of cortisol from the adrenals. Hydrocortisone 192-200 proopiomelanocortin Canis lupus familiaris 106-110 15436579-0 1950 The effect of ACTH upon the level of 17-hydroxycorticosterone in the adrenal vein blood of dogs. Hydrocortisone 37-61 proopiomelanocortin Canis lupus familiaris 14-18 4356264-12 1973 Concentrations of cortisol were significantly higher in fetal adrenal effluent (pre-ACTH) than in fetal peripheral plasma in normal pregnancies, which demonstrates secretion of cortisol by the fetus and shows that corticosteroid of maternal origin does not lead to complete suppression of fetal pituitary-adrenal function. Hydrocortisone 18-26 proopiomelanocortin Canis lupus familiaris 84-88 30735671-4 2019 We also gave repeated injections of ACTH to adult females to assess whether this would result in an increase of hair cortisol concentrations, compared with control individuals repeatedly injected with saline. Hydrocortisone 117-125 proopiomelanocortin Canis lupus familiaris 36-40 33755348-4 2021 In abdominal sonography, enlargement of the caudal pole of the left adrenal gland was found, but the cortisol level of post-ACTH stimulation test was below the cut-off value, and LDDST was negative. Hydrocortisone 101-109 proopiomelanocortin Canis lupus familiaris 124-128 30735671-6 2019 Despite the significant elevation of plasma cortisol in the treatment groups following ACTH injection, the elevation of FGM levels in the treatment groups were not significantly different from those in the control group over the following 12 h. Repeated injection of a high dose of ACTH failed to increase hair cortisol concentration in treatment animals. Hydrocortisone 44-52 proopiomelanocortin Canis lupus familiaris 282-286 30230611-9 2018 For dogs suspected of having hypoadrenocorticism, the ACTH-stimulated cortisol concentrations in response to both doses of ACTH were equivalent (90% confidence interval [CI], 80.5-97.2%; P = .04). Hydrocortisone 70-78 proopiomelanocortin Canis lupus familiaris 54-58 30230611-9 2018 For dogs suspected of having hypoadrenocorticism, the ACTH-stimulated cortisol concentrations in response to both doses of ACTH were equivalent (90% confidence interval [CI], 80.5-97.2%; P = .04). Hydrocortisone 70-78 proopiomelanocortin Canis lupus familiaris 123-127 27003023-7 2016 Excessive suppression of cortisol production was defined as an ACTH-stimulated cortisol concentration < 2.0 mug/dL. Hydrocortisone 25-33 proopiomelanocortin Canis lupus familiaris 63-67 27824928-14 2016 The findings suggest that CBX inhibits ACTH secretion from canine pituitary tumors, resulting in lower cortisol concentrations. Hydrocortisone 103-111 proopiomelanocortin Canis lupus familiaris 39-43 30334283-0 2018 The interpretive contribution of the baseline serum cortisol concentration of the ACTH stimulation test in the diagnosis of pituitary dependent hyperadrenocorticism in dogs. Hydrocortisone 52-60 proopiomelanocortin Canis lupus familiaris 82-86 28870207-7 2017 However, dogs with low post-ACTH cortisol concentrations during trilostane therapy had less increased epinephrine, norepinephrine and normetanephrine:creatinine ratios compared to healthy dogs. Hydrocortisone 33-41 proopiomelanocortin Canis lupus familiaris 28-32 27003023-10 2016 A baseline cortisol concentration > 3.2 mug/dL predicted that ACTH-stimulated cortisol concentration would be >= 2.0 mug/dL with 100% certainty; however, 14 of 64 tests with a baseline cortisol concentration > 3.2 mug/dL had an ACTH-stimulated cortisol concentration <= 3.2 mug/dL, which was suggestive of inadequate adrenocortical cortisol reserves. Hydrocortisone 11-19 proopiomelanocortin Canis lupus familiaris 65-69 27003023-10 2016 A baseline cortisol concentration > 3.2 mug/dL predicted that ACTH-stimulated cortisol concentration would be >= 2.0 mug/dL with 100% certainty; however, 14 of 64 tests with a baseline cortisol concentration > 3.2 mug/dL had an ACTH-stimulated cortisol concentration <= 3.2 mug/dL, which was suggestive of inadequate adrenocortical cortisol reserves. Hydrocortisone 11-19 proopiomelanocortin Canis lupus familiaris 237-241 27003023-10 2016 A baseline cortisol concentration > 3.2 mug/dL predicted that ACTH-stimulated cortisol concentration would be >= 2.0 mug/dL with 100% certainty; however, 14 of 64 tests with a baseline cortisol concentration > 3.2 mug/dL had an ACTH-stimulated cortisol concentration <= 3.2 mug/dL, which was suggestive of inadequate adrenocortical cortisol reserves. Hydrocortisone 81-89 proopiomelanocortin Canis lupus familiaris 65-69 27003023-10 2016 A baseline cortisol concentration > 3.2 mug/dL predicted that ACTH-stimulated cortisol concentration would be >= 2.0 mug/dL with 100% certainty; however, 14 of 64 tests with a baseline cortisol concentration > 3.2 mug/dL had an ACTH-stimulated cortisol concentration <= 3.2 mug/dL, which was suggestive of inadequate adrenocortical cortisol reserves. Hydrocortisone 81-89 proopiomelanocortin Canis lupus familiaris 65-69 27003023-10 2016 A baseline cortisol concentration > 3.2 mug/dL predicted that ACTH-stimulated cortisol concentration would be >= 2.0 mug/dL with 100% certainty; however, 14 of 64 tests with a baseline cortisol concentration > 3.2 mug/dL had an ACTH-stimulated cortisol concentration <= 3.2 mug/dL, which was suggestive of inadequate adrenocortical cortisol reserves. Hydrocortisone 81-89 proopiomelanocortin Canis lupus familiaris 65-69 27003023-10 2016 A baseline cortisol concentration > 3.2 mug/dL predicted that ACTH-stimulated cortisol concentration would be >= 2.0 mug/dL with 100% certainty; however, 14 of 64 tests with a baseline cortisol concentration > 3.2 mug/dL had an ACTH-stimulated cortisol concentration <= 3.2 mug/dL, which was suggestive of inadequate adrenocortical cortisol reserves. Hydrocortisone 81-89 proopiomelanocortin Canis lupus familiaris 65-69 24112376-4 2013 OBJECTIVES: To investigate whether ACTH-independent hypersecretion of cortisol may be associated with aberrant activation of the melanocortin 2 receptor (MC2R)-cyclic AMP (cAMP)-protein kinase A (PKA) pathway. Hydrocortisone 70-78 proopiomelanocortin Canis lupus familiaris 35-39 24274887-13 2013 The only detectable endocrine effect in treated dogs was a reduction in cortisol concentration in response to ACTH stimulation in 2 of 4 dogs at 12 weeks after the first inoculation. Hydrocortisone 72-80 proopiomelanocortin Canis lupus familiaris 110-114 16342524-8 2005 Of the 127 dogs with suspected hyperadrenocorticism, 59 (46.5%) had high ACTH-stimulated cortisol concentrations; of those, 42 of 59 (71.2%) and 32 of 53 (60.4%) had high serum 17OHP and corticosterone concentrations, respectively. Hydrocortisone 89-97 proopiomelanocortin Canis lupus familiaris 73-77 22708651-11 2012 Sensitivity and specificity, respectively, for diagnosing HAC for post-ACTH cortisol were 84 and 59%, progesterone 88 and 55%, and 17-hydroxyprogesterone 91 and 59%, and for post-ACTH cortisol, progesterone and 17-hydroxyprogesterone combined were 88 and 55%. Hydrocortisone 76-84 proopiomelanocortin Canis lupus familiaris 71-75 22280384-6 2012 RESULTS: Serum cortisol concentrations were significantly higher than the preadministration (baseline) concentrations for all treatments 60 minutes after administration of ACTH. Hydrocortisone 15-23 proopiomelanocortin Canis lupus familiaris 172-176 16342524-9 2005 Of dogs with serum cortisol concentration within reference range after ACTH administration, 9 of 68 (13.2%) and 7 of 67 (10.4%) had high serum 17OHP and corticosterone concentrations, respectively. Hydrocortisone 19-27 proopiomelanocortin Canis lupus familiaris 71-75 16342524-12 2005 Changes in serum 17OHP or corticosterone concentrations after administration of ACTH are proportionate with changes in cortisol concentration. Hydrocortisone 119-127 proopiomelanocortin Canis lupus familiaris 80-84 8805097-5 1996 In all dogs, results of adrenocorticotrophic hormone (ACTH) stimulation testing revealed a low to low-normal serum baseline cortisol concentration that failed to increase after ACTH administration. Hydrocortisone 124-132 proopiomelanocortin Canis lupus familiaris 54-58 12418519-9 2002 Low basal ACTH-stimulated cortisol concentrations were predictive of higher subsequent values. Hydrocortisone 26-34 proopiomelanocortin Canis lupus familiaris 10-14 11432429-15 2001 ACTH injections resulted in an increase above baseline values of 355%, (median) in 11,17-DOA concentrations in cats and of 702% in the concentrations of cortisol equivalents in dogs by about 25 h and 22 h (median) after injection, respectively. Hydrocortisone 153-161 proopiomelanocortin Canis lupus familiaris 0-4 8389997-9 1993 Although daily cortisol concentrations were below assay sensitivity, the mean peak post-CRH cortisol concentration was 6.7 +/- 1.8 micrograms/dl, indicating that the immunoreactive ACTH was biologically active. Hydrocortisone 15-23 proopiomelanocortin Canis lupus familiaris 181-185 8682712-13 1996 In all dogs, ACTH stimulation testing revealed a low to low-normal baseline serum cortisol concentration with little to no rise after ACTH administration. Hydrocortisone 82-90 proopiomelanocortin Canis lupus familiaris 13-17 8533298-0 1995 Effect of bursal anti-steroidogenic peptide (BASP) on cortisol biosynthesis in ACTH-stimulated canine adrenocortical carcinoma cells in vitro. Hydrocortisone 54-62 proopiomelanocortin Canis lupus familiaris 79-83 7928549-3 1994 After 2 weeks, the ACTH-stimulated serum cortisol concentration had decreased to within or below the reference range for baseline cortisol concentration in 18 (56.3%) of the 32 dogs; the remaining 14 (43.7%) still responded to ACTH administration with serum cortisol concentrations above the reference range. Hydrocortisone 41-49 proopiomelanocortin Canis lupus familiaris 19-23 7928549-3 1994 After 2 weeks, the ACTH-stimulated serum cortisol concentration had decreased to within or below the reference range for baseline cortisol concentration in 18 (56.3%) of the 32 dogs; the remaining 14 (43.7%) still responded to ACTH administration with serum cortisol concentrations above the reference range. Hydrocortisone 130-138 proopiomelanocortin Canis lupus familiaris 19-23 8389997-9 1993 Although daily cortisol concentrations were below assay sensitivity, the mean peak post-CRH cortisol concentration was 6.7 +/- 1.8 micrograms/dl, indicating that the immunoreactive ACTH was biologically active. Hydrocortisone 92-100 proopiomelanocortin Canis lupus familiaris 181-185 2156673-4 1990 The ACTH responses to hypoglycemia were inhibited by cortisol infusions of 9 or 18 micrograms/kg.min beginning at 0 min [mean ACTH from 30-90 min: after vehicle, 557 +/- 57 (+/- SEM); after cortisol, 221 +/- 20 and 201 +/- 48 pg/ml, respectively], but the overall responses were not significantly reduced by infusions beginning 20, 30, or 60 min after the injection of insulin. Hydrocortisone 53-61 proopiomelanocortin Canis lupus familiaris 4-8 2156673-4 1990 The ACTH responses to hypoglycemia were inhibited by cortisol infusions of 9 or 18 micrograms/kg.min beginning at 0 min [mean ACTH from 30-90 min: after vehicle, 557 +/- 57 (+/- SEM); after cortisol, 221 +/- 20 and 201 +/- 48 pg/ml, respectively], but the overall responses were not significantly reduced by infusions beginning 20, 30, or 60 min after the injection of insulin. Hydrocortisone 53-61 proopiomelanocortin Canis lupus familiaris 126-130 2156673-6 1990 The infusion of cortisol also significantly reduced basal ACTH; however, this inhibition was not significant until 40 min. Hydrocortisone 16-24 proopiomelanocortin Canis lupus familiaris 58-62 2156673-7 1990 In further experiments the ACTH response to insulin-induced hypoglycemia was measured after infusing 45 micrograms/kg cortisol over 2, 5, or 15 min at rates of 22.5, 9, or 3 micrograms/kg.min. Hydrocortisone 118-126 proopiomelanocortin Canis lupus familiaris 27-31 34904763-6 2022 MATERIALS AND METHODS: Cortisol was measured pre- and post-adrenocorticotropic (ACTH) stimulation on D0. Hydrocortisone 23-31 proopiomelanocortin Canis lupus familiaris 80-84 34904763-9 2022 RESULTS: The median pre- and post-ACTH cortisol concentrations on D28 were 2.5 microg/dL (range 2.0-5.0 microg/dL) and 14.3 microg/dL (range 11.5-23.1 microg/dL), respectively. Hydrocortisone 39-47 proopiomelanocortin Canis lupus familiaris 34-38 34147706-1 2021 Hyperadrenocorticism (HAC) is one of the most common endocrine diseases in dogs characterized by excessive cortisol production caused by an adrenocorticotropic hormone (ACTH)-secreting tumor, namely pituitary-dependent HAC (PDH) or cortisol-secreting adrenal tumor. Hydrocortisone 107-115 proopiomelanocortin Canis lupus familiaris 140-167 34147706-1 2021 Hyperadrenocorticism (HAC) is one of the most common endocrine diseases in dogs characterized by excessive cortisol production caused by an adrenocorticotropic hormone (ACTH)-secreting tumor, namely pituitary-dependent HAC (PDH) or cortisol-secreting adrenal tumor. Hydrocortisone 107-115 proopiomelanocortin Canis lupus familiaris 169-173