PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32510471-3 2020 Here, we show that 17-hydroxyprogesterone (17-OHP), an intermediate steroid in the biosynthetic pathway that converts cholesterol to cortisol, binds to and stimulates the transcriptional activity of GR. Hydrocortisone 133-141 nuclear receptor subfamily 3, group C, member 1 Mus musculus 199-201 3660400-7 1987 Glucocorticoid receptor contents were higher in lymph-node metastatic tumor (100 fmole/mg cytoplasmic protein, mean) than in s.c. transplanted tumors (74.5 fmole/mg, mean) respectively treated with 12.5 mg of hydrocortisone. Hydrocortisone 209-223 nuclear receptor subfamily 3, group C, member 1 Mus musculus 0-23 33454208-0 2021 Regulation of p38 MAPK and glucocorticoid receptor activation by hydrocortisone in mono-and co-cultured pancreatic acinar and stellate cells. Hydrocortisone 65-79 nuclear receptor subfamily 3, group C, member 1 Mus musculus 27-50 33454208-8 2021 RESULTS: Hydrocortisone inhibited pp38 MAPK up-regulation evoked by co-culture in PACs and PSCs and increased nuclear translocation of GR in PAC monocultures and in co-cultured PACs and PSCs. Hydrocortisone 9-23 nuclear receptor subfamily 3, group C, member 1 Mus musculus 135-137 33454208-10 2021 In the former no change in nuclear GR but a significant decrease in total GR as analyzed by Western blot was caused by hydrocortisone. Hydrocortisone 119-133 nuclear receptor subfamily 3, group C, member 1 Mus musculus 74-76 33371687-0 2021 Self-Assembling Derivative of Hydrocortisone as Glucocorticoid Receptor-Targeted Nanotherapeutics for Synergistic, Combination Therapy against Colorectal Tumor. Hydrocortisone 30-44 nuclear receptor subfamily 3, group C, member 1 Mus musculus 48-71 33371687-1 2021 Hydrocortisone, a natural glucocorticoid secreted by adrenal and extra-adrenal tissues, locally governs the transcription of genes involved in inflammation, immune response, metabolism, and energy homeostasis via binding to its cognate glucocorticoid receptor (GR). Hydrocortisone 0-14 nuclear receptor subfamily 3, group C, member 1 Mus musculus 236-259 33371687-1 2021 Hydrocortisone, a natural glucocorticoid secreted by adrenal and extra-adrenal tissues, locally governs the transcription of genes involved in inflammation, immune response, metabolism, and energy homeostasis via binding to its cognate glucocorticoid receptor (GR). Hydrocortisone 0-14 nuclear receptor subfamily 3, group C, member 1 Mus musculus 261-263 32226647-11 2020 NR3C1, activated by cortisol under stress, could act as a transcription factor to upregulate the expression of GKN2. Hydrocortisone 20-28 nuclear receptor subfamily 3, group C, member 1 Mus musculus 0-5 21872610-2 2011 The purpose of this study was to determine whether the adrenal cortical hormones, hydrocortisone (cortisol), modulate PTHrP expression and glucocorticoid receptor (GR)beta in mice kidney. Hydrocortisone 82-96 nuclear receptor subfamily 3, group C, member 1 Mus musculus 139-162 32348866-4 2020 Through targeted next-generation sequencing of a panel of cortisol and dopamine pathway genes, we observed hypermethylation of the glucocorticoid receptor gene, Nr3c1, in the midbrain of C57/BL6N males in response to dual deltamethrin and corticosterone exposures during development. Hydrocortisone 58-66 nuclear receptor subfamily 3, group C, member 1 Mus musculus 131-154 32348866-4 2020 Through targeted next-generation sequencing of a panel of cortisol and dopamine pathway genes, we observed hypermethylation of the glucocorticoid receptor gene, Nr3c1, in the midbrain of C57/BL6N males in response to dual deltamethrin and corticosterone exposures during development. Hydrocortisone 58-66 nuclear receptor subfamily 3, group C, member 1 Mus musculus 161-166 30734664-10 2019 We also demonstrated pharmacological actions as follows: dexamethasone and hydrocortisone, steroidal medications binding to GR, inhibited the Mmp9 promoter but did not inhibit tumorigenesis. Hydrocortisone 75-89 nuclear receptor subfamily 3, group C, member 1 Mus musculus 124-126 28340615-10 2017 Inhibition of glucocorticoid receptor-associated Src kinase also produced a decrease in cortisol-induced RNS. Hydrocortisone 88-96 nuclear receptor subfamily 3, group C, member 1 Mus musculus 14-37 22021181-5 2011 We therefore studied the FBR to polyvinylidenfluoride (PVDF) mesh material that was coated with four different substances: hydrocortisone (COR) or mifepristone (MIF), which respectively stimulate and block the glucocorticoid receptor, and aldosterone (ALD) or spironolactone (SPI), which respectively stimulate and block the mineralocorticoid receptor. Hydrocortisone 123-137 nuclear receptor subfamily 3, group C, member 1 Mus musculus 210-233 21872610-2 2011 The purpose of this study was to determine whether the adrenal cortical hormones, hydrocortisone (cortisol), modulate PTHrP expression and glucocorticoid receptor (GR)beta in mice kidney. Hydrocortisone 98-106 nuclear receptor subfamily 3, group C, member 1 Mus musculus 139-162 18029262-8 2008 The results suggest that inhibition of 11betaHSD1 activity reduces the availability of cortisol to activate the glucocorticoid receptor, down regulates gluconeogenesis and thus reduces plasma glucose levels in cortisone-induced diabetic KK mice. Hydrocortisone 87-95 nuclear receptor subfamily 3, group C, member 1 Mus musculus 112-135 11704655-7 2001 Twenty-four hours coincubation of cells with desipramine, clomipramine or paroxetine, also enhanced GR function in the presence of cortisol, but not of corticosterone. Hydrocortisone 131-139 nuclear receptor subfamily 3, group C, member 1 Mus musculus 100-102 15790664-7 2005 At the molecular level, hydrocortisone induces increase of occludin at protein and mRNA levels by activation of the glucocorticoid receptor (GR) and its binding to putative glucocorticoid responsive elements in the occludin promoter. Hydrocortisone 24-38 nuclear receptor subfamily 3, group C, member 1 Mus musculus 116-139 15790664-7 2005 At the molecular level, hydrocortisone induces increase of occludin at protein and mRNA levels by activation of the glucocorticoid receptor (GR) and its binding to putative glucocorticoid responsive elements in the occludin promoter. Hydrocortisone 24-38 nuclear receptor subfamily 3, group C, member 1 Mus musculus 141-143 7522859-25 1994 This local inhibition (~50%), also seen with hydrocortisone (30 microg), was prevented by the concomitant administration of the steroid antagonist RU38486 (10 microg) indicating the involvement of glucocorticoid receptor in the response.7. Hydrocortisone 45-59 nuclear receptor subfamily 3, group C, member 1 Mus musculus 197-220 11579225-0 2001 Homology modelling of the ligand-binding domain of glucocorticoid receptor: binding site interactions with cortisol and corticosterone. Hydrocortisone 107-115 nuclear receptor subfamily 3, group C, member 1 Mus musculus 51-74 8571373-10 1995 The Ah receptor (AhR) binds TCDD and the glucocorticoid receptor (GR) binds HC. Hydrocortisone 76-78 nuclear receptor subfamily 3, group C, member 1 Mus musculus 41-64 8571373-10 1995 The Ah receptor (AhR) binds TCDD and the glucocorticoid receptor (GR) binds HC. Hydrocortisone 76-78 nuclear receptor subfamily 3, group C, member 1 Mus musculus 66-68 8079364-11 1994 The present results suggest that glucocorticoids, including hydrocortisone and DEX, in hepatocyte culture media can affect DMN-induced immunosuppression in the hepatocyte/splenocyte co-culture system via a pathway which does not appear to be related to the glucocorticoid receptor. Hydrocortisone 60-74 nuclear receptor subfamily 3, group C, member 1 Mus musculus 257-280 7914432-6 1994 Studies of the hormone signal transduction pathway showed that serum cortisol and plasma glucagon levels of jvs mice were 2 and 3 times higher, respectively, than those of normal mice, and that the hormone binding activity of glucocorticoid receptor (GR) in the cytosol of jvs liver was 50% of normal mice, which reflected the amount of receptor protein in the cytosol. Hydrocortisone 69-77 nuclear receptor subfamily 3, group C, member 1 Mus musculus 226-249