PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18215451-0 2008 Different modes of inhibition of mouse Cyp2a5 and rat CYP2A3 by the food-derived 8-methoxypsoralen. Methoxsalen 81-98 cytochrome P450, family 2, subfamily a, polypeptide 3 Rattus norvegicus 54-60 18215451-5 2008 There is no published data on the inhibition of CYP2A3 by 8-MOP. Methoxsalen 58-63 cytochrome P450, family 2, subfamily a, polypeptide 3 Rattus norvegicus 48-54 18215451-8 2008 By contrast, 8-MOP was able to inhibit CYP2A3-mediated coumarin 7-hydroxylase only in a non-competitive way (K(iu)=0.22 microM). Methoxsalen 13-18 cytochrome P450, family 2, subfamily a, polypeptide 3 Rattus norvegicus 39-45 18215451-8 2008 By contrast, 8-MOP was able to inhibit CYP2A3-mediated coumarin 7-hydroxylase only in a non-competitive way (K(iu)=0.22 microM). Methoxsalen 13-18 cytochrome P450, family 2, subfamily a, polypeptide 3 Rattus norvegicus 55-77 18215451-9 2008 In conclusion, we showed that 8-MOP inhibits Cyp2a5 and CYP2A3 through different mechanisms. Methoxsalen 30-35 cytochrome P450, family 2, subfamily a, polypeptide 3 Rattus norvegicus 56-62 12679052-4 2003 Coumarin 7-hydroxylase was inhibited by 8-methoxypsoralen. Methoxsalen 40-57 cytochrome P450, family 2, subfamily a, polypeptide 3 Rattus norvegicus 0-22 8863822-9 1996 Consistent with CYP2A3 being a major catalyst in microsomal metabolism of DCBN, the activities of both CYP2A3 and rat olfactory microsomes in DCBN metabolism were inhibited strongly by metyrapone and methoxsalen (ID50 < 1 microM, with DCBN at 30 microM), but only marginally by 4-methylpyrazole, an inhibitor of CYP2E1. Methoxsalen 200-211 cytochrome P450, family 2, subfamily a, polypeptide 3 Rattus norvegicus 16-22 8863822-9 1996 Consistent with CYP2A3 being a major catalyst in microsomal metabolism of DCBN, the activities of both CYP2A3 and rat olfactory microsomes in DCBN metabolism were inhibited strongly by metyrapone and methoxsalen (ID50 < 1 microM, with DCBN at 30 microM), but only marginally by 4-methylpyrazole, an inhibitor of CYP2E1. Methoxsalen 200-211 cytochrome P450, family 2, subfamily a, polypeptide 3 Rattus norvegicus 103-109