PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2730678-0 1989 Activation of 8-methoxypsoralen by cytochrome P-450. Methoxsalen 14-31 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 35-51 1497908-5 1992 The activity of cytochrome P-450IIB1, the major pulmonary cytochrome P-450 isozyme in rats, was clearly inhibited by 8-methoxypsoralen. Methoxsalen 117-134 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 16-32 2117068-5 1990 Monoclonal antibody 2-66-3, which recognizes the major isozymes of rat cytochrome P-450 induced by phenobarbital and unknown isozymes in the mouse, enhanced the covalent binding of 8-MOP metabolites in microsomes of mice pretreated with vehicle (+74%), phenobarbital (+44%) or BNF (+31%) without affecting the disappearance of 8-MOP. Methoxsalen 181-186 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 71-87 2117068-5 1990 Monoclonal antibody 2-66-3, which recognizes the major isozymes of rat cytochrome P-450 induced by phenobarbital and unknown isozymes in the mouse, enhanced the covalent binding of 8-MOP metabolites in microsomes of mice pretreated with vehicle (+74%), phenobarbital (+44%) or BNF (+31%) without affecting the disappearance of 8-MOP. Methoxsalen 327-332 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 71-87 2506333-0 1989 Suicide inactivation of cytochrome P-450 by methoxsalen. Methoxsalen 44-55 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 24-40 2506333-8 1989 Whereas methoxsalen itself did not produce any binding spectrum, in contrast either in vivo administration of methoxsalen or incubation in vitro with methoxsalen and NADPH resulted in a low-to-high spin conversion of cytochrome P-450 as suggested by the appearance of a spectrum analogous to a type I binding spectrum. Methoxsalen 110-121 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 217-233 2506333-8 1989 Whereas methoxsalen itself did not produce any binding spectrum, in contrast either in vivo administration of methoxsalen or incubation in vitro with methoxsalen and NADPH resulted in a low-to-high spin conversion of cytochrome P-450 as suggested by the appearance of a spectrum analogous to a type I binding spectrum. Methoxsalen 110-121 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 217-233 2506333-10 1989 We conclude that suicide inactivation of cytochrome P-450 by methoxsalen is related to the covalent binding of a methoxsalen intermediate to the protein moiety of several cytochrome P-450 isoenzymes (including UT-A, PB-B/D, PCN-E as well as ISF-G and/or beta NF-B). Methoxsalen 61-72 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 41-57 2506333-10 1989 We conclude that suicide inactivation of cytochrome P-450 by methoxsalen is related to the covalent binding of a methoxsalen intermediate to the protein moiety of several cytochrome P-450 isoenzymes (including UT-A, PB-B/D, PCN-E as well as ISF-G and/or beta NF-B). Methoxsalen 61-72 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 171-187 2506333-10 1989 We conclude that suicide inactivation of cytochrome P-450 by methoxsalen is related to the covalent binding of a methoxsalen intermediate to the protein moiety of several cytochrome P-450 isoenzymes (including UT-A, PB-B/D, PCN-E as well as ISF-G and/or beta NF-B). Methoxsalen 113-124 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 41-57 2506333-10 1989 We conclude that suicide inactivation of cytochrome P-450 by methoxsalen is related to the covalent binding of a methoxsalen intermediate to the protein moiety of several cytochrome P-450 isoenzymes (including UT-A, PB-B/D, PCN-E as well as ISF-G and/or beta NF-B). Methoxsalen 113-124 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 171-187 2025880-3 1991 The role of cytochrome P-450 in the activation of 2-NP is indicated by the increase of liver DNA damage in rats pretreated with phenobarbital or beta-naphtoflavone, and by its reduction produced by methoxsalen. Methoxsalen 198-209 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 12-28 2730678-12 1989 Collectively, these results indicate that 8-MOP is biotransformed by two or more isozymes of cytochrome P-450 to reactive electrophiles capable of binding to tissue macromolecules. Methoxsalen 42-47 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 93-109 3735138-3 1986 CO-binding cytochrome P-450 decreased when hepatic microsomes were incubated for 10 min with an NADPH-generating system and 8-methoxypsoralen, 5-methoxypsoralen or psoralen (400 microM), but remained unchanged with trioxsalen (400 microM). Methoxsalen 124-141 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 11-27 3941395-9 1986 We conclude that methoxsalen is activated into a metabolite which destroys cytochrome P-450. Methoxsalen 17-28 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 75-91 7108267-8 1982 8-MOP administered daily for 6 days to rats caused a greater than 4-fold enhancement of AHH and greater than 2-fold enhancement of ethylmorphine N-demethylase and cytochrome P-450. Methoxsalen 0-5 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 163-179 3941395-0 1986 Inactivation of cytochrome P-450 by the drug methoxsalen. Methoxsalen 45-56 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 16-32 3941395-4 1986 Methoxsalen (25-1000 microM) decreased cytochrome P-450 in vitro, in the presence of EDTA; this effect required NADPH and oxygen, was decreased by piperonyl butoxide and was increased by phenobarbital pretreatment. Methoxsalen 0-11 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 39-55