PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17003103-0	2007	Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome P450 3A4 and carboxylesterase HCE2: evidence on an involvement of the pregnane X receptor.	Methoxsalen	28-45	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	54-73	
17003103-3	2007	In this study, we report that 8-MOP is a potent inducer of cytochrome P450 3A4 (CYP3A4) and carboxylesterase 2 (HCE2), two major human enzymes that catalyze oxidative and hydrolytic reactions, respectively.	Methoxsalen	30-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-78	
17003103-3	2007	In this study, we report that 8-MOP is a potent inducer of cytochrome P450 3A4 (CYP3A4) and carboxylesterase 2 (HCE2), two major human enzymes that catalyze oxidative and hydrolytic reactions, respectively.	Methoxsalen	30-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	80-86	
17003103-4	2007	In human primary hepatocytes, 8-MOP markedly induced the expression of CYP3A4 (approximately sixfold) and HCE2 (approximately threefold) and the induction occurred in a concentration-dependent manner (0-50 microM).	Methoxsalen	30-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	71-77	
17003103-6	2007	In a reporter assay, 8-MOP stimulated both CYP3A4 and HCE2 promoters, and the stimulation was enhanced by cotransfection of PXR.	Methoxsalen	21-26	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	43-49