PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26316083-0 2015 8-Methoxypsoralen Induces Intrinsic Apoptosis in HepG2 Cells: Involvement of Reactive Oxygen Species Generation and ERK1/2 Pathway Inhibition. Methoxsalen 0-17 mitogen-activated protein kinase 3 Homo sapiens 116-122 28550731-9 2017 Finally, xanthotoxin suppressed the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 and p38 mitogen-activated protein kinase (MAPK). Methoxsalen 9-20 mitogen-activated protein kinase 3 Homo sapiens 67-114 28550731-9 2017 Finally, xanthotoxin suppressed the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 and p38 mitogen-activated protein kinase (MAPK). Methoxsalen 9-20 mitogen-activated protein kinase 3 Homo sapiens 157-161 26316083-8 2015 In addition, the activation of ERK1/2 was drastically decreased by 8-MOP as ERK inhibitor PD98059, indicating a role of ERK1/2 signaling pathway in 8-MOP-induced cell apoptosis. Methoxsalen 67-72 mitogen-activated protein kinase 3 Homo sapiens 31-37 26316083-8 2015 In addition, the activation of ERK1/2 was drastically decreased by 8-MOP as ERK inhibitor PD98059, indicating a role of ERK1/2 signaling pathway in 8-MOP-induced cell apoptosis. Methoxsalen 67-72 mitogen-activated protein kinase 3 Homo sapiens 120-126 26316083-8 2015 In addition, the activation of ERK1/2 was drastically decreased by 8-MOP as ERK inhibitor PD98059, indicating a role of ERK1/2 signaling pathway in 8-MOP-induced cell apoptosis. Methoxsalen 148-153 mitogen-activated protein kinase 3 Homo sapiens 31-37 26316083-8 2015 In addition, the activation of ERK1/2 was drastically decreased by 8-MOP as ERK inhibitor PD98059, indicating a role of ERK1/2 signaling pathway in 8-MOP-induced cell apoptosis. Methoxsalen 148-153 mitogen-activated protein kinase 3 Homo sapiens 120-126 26316083-9 2015 CONCLUSION: 8-MOP induces intrinsic apoptosis by increasing ROS generation and inhibiting ERK1/2 pathway in HepG2 cells. Methoxsalen 12-17 mitogen-activated protein kinase 3 Homo sapiens 90-96