PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10990075-10	2000	Cyclophosphamide treatment decreased IL-12, IL-1beta, IL-2, IFN-gamma and TNF-alpha gene expressions in mononuclear spleen cells but IL-4 gene expression increased.	Cyclophosphamide	0-16	interleukin 1 beta	Rattus norvegicus	44-52	
1761361-2	1991	Intact or cyclophosphamide-treated mice received human rIL-1 beta according to different regimens, and their sera were assayed for CSA at 4, 24 or 48 h. The results indicated that (1) cyclophosphamide alone significantly increased the level of circulating CSA, (2) administration of IL-1 to intact or neutropenic mice resulted in a biphasic pattern of CSA response, an early burst at 4 h being followed at 24-48 h by a significant decrease.	Cyclophosphamide	10-26	interleukin 1 beta	Rattus norvegicus	55-65	
7630433-1	1995	Effects of indomethacin, N omega-nitro-L-arginine (NNA) and naloxone, and of pretreatment with cyclophosphamide (CY), on the interleukin (IL)-1 beta induced inhibition of exocytotic noradrenaline release were investigated in the isolated, vascularly perfused spleen of the rat.	Cyclophosphamide	95-111	interleukin 1 beta	Rattus norvegicus	125-148	
7630433-1	1995	Effects of indomethacin, N omega-nitro-L-arginine (NNA) and naloxone, and of pretreatment with cyclophosphamide (CY), on the interleukin (IL)-1 beta induced inhibition of exocytotic noradrenaline release were investigated in the isolated, vascularly perfused spleen of the rat.	Cyclophosphamide	113-115	interleukin 1 beta	Rattus norvegicus	125-148	
2111738-2	1990	Cyclophosphamide-treated mice received human rIL-1 beta at 7.0, 0.7, or 00.7 micrograms/kg, according to different regimens, to be challenged with a lethal ip inoculum of pseudomonas cells 5 days after myelosuppression.	Cyclophosphamide	0-16	interleukin 1 beta	Rattus norvegicus	45-55	
35156781-16	2022	RESULTS: Thiamine pyrophosphate significantly decreased the cyclophosphamide-induced increase in the levels of the oxidant parameter malondialdehyde (MDA), proinflammatory nuclear factor kappa B (NF-kappaB), tumor necrosis factor alpha (TNF-alpha), and interleukin 1 beta (IL-1beta).	Cyclophosphamide	60-76	interleukin 1 beta	Rattus norvegicus	253-271	
33333050-6	2021	In addition, CYP induced marked increases in the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and nitric oxide (NO) confirmed by histological alterations.	Cyclophosphamide	13-16	interleukin 1 beta	Rattus norvegicus	100-117	
27852964-11	2016	Furthermore, we found that spinal IL-1beta was dramatically increased in cyclophosphamide-induced cystitis, and activated astrocytes were the only source of IL-1beta release, which contributed to allodynia in cystitis rats.	Cyclophosphamide	73-89	interleukin 1 beta	Rattus norvegicus	34-42	
31356540-10	2019	Eliminating ROS with N-acetylcysteine or preinject CY into rat jugular vein reduces the expression of IL-6, TNF-a, and, especially, IL-1b in an in vivo I/R model.	Cyclophosphamide	51-53	interleukin 1 beta	Rattus norvegicus	132-137	
24262494-10	2014	Up-regulated myeloperoxidase, IL-1beta, IL-6 and TNF-alpha expression in cyclophosphamide treated rats was also suppressed in rebamipide treated rats.	Cyclophosphamide	73-89	interleukin 1 beta	Rattus norvegicus	30-38	
27051922-9	2015	In case of immunodeficiency caused by cyclophosphamide, there was a significant decrease in IL-1beta, IL-4 and IL-6, but the introduction of phenotropil largely restored their levels.	Cyclophosphamide	38-54	interleukin 1 beta	Rattus norvegicus	92-100	
19303104-2	2009	Evidence suggests that tumor necrosis factor-alpha (R&D Systems), interleukin-1beta and cyclooxygenase-2 are directly involved in the pathogenesis of cyclophosphamide induced cystitis and these molecules depend on transcription factor NF-kappaB for maximal secretion.	Cyclophosphamide	154-170	interleukin 1 beta	Rattus norvegicus	70-87	
18206168-11	2008	The elevated expression of inducible nitric oxide synthase and interleukin-1beta in cyclophosphamide induced cystitis was significantly down-regulated by exogenously applied bilirubin.	Cyclophosphamide	84-100	interleukin 1 beta	Rattus norvegicus	63-80