PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15261554-6	2004	In our studies of cyclophosphamide, we have found that although it is a general immunosuppressant that affects both T cell and B cell functions, cyclophosphamide has selective immune effects in MS by suppressing IL-12- and Th1-type responses and enhancing Th2/Th3 responses (IL-4, IL-10, TGF-beta; eosinophils in peripheral blood).	Cyclophosphamide	145-161	interleukin 4	Homo sapiens	275-279	
14698862-9	2004	We report here that in patients with secondary progressive MS, cyclophosphamide induces a marked increase in the percentage of CCR4(+) T cells that produce high levels of IL-4 and reverses the increase in the percentages of IFN-gamma-producing CCR5(+) and CXCR3(+) CD8(+) T cells.	Cyclophosphamide	63-79	interleukin 4	Homo sapiens	171-175	
14698862-10	2004	Furthermore, therapy with cyclophosphamide increases IL-4-producing CD4(+) T cells and reverses the increase in IFN-gamma-producing CD8(+) T cells.	Cyclophosphamide	26-42	interleukin 4	Homo sapiens	53-57	
11990872-4	2002	Although a general immunosuppressant that affects both T- and B-cell function, cyclophosphamide has selective immune effects in MS by suppressing IL-12 and Th1-type responses and enhancing Th2/Th3 responses (IL-4, IL-10, TGF-beta; eosinophils in peripheral blood).	Cyclophosphamide	79-95	interleukin 4	Homo sapiens	208-212	
9683547-0	1998	Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4-secreting T cells in multiple sclerosis patients.	Cyclophosphamide	6-22	interleukin 4	Homo sapiens	79-83	
9683547-2	1998	Thus therapies which decrease T cells secreting IFN-gamma production or increase IL-4 production would be expected to have an ameliorating effect on MS. We have previously reported increased anti-CD3-induced IL-4 secretion by T cells in progressive MS patients treated with cyclophosphamide plus methylprednisolone (CY/MP) which was associated with eosinophilia.	Cyclophosphamide	274-290	interleukin 4	Homo sapiens	208-212	
9307252-0	1997	Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia.	Cyclophosphamide	33-49	interleukin 4	Homo sapiens	112-125	
32953676-7	2020	Conclusion: The combination of cyclophosphamide, prednisolone, and Qing Shen Fang improves conditions of patients with LN and significantly reduces their IFN-gamma and IL-4 levels in serum.	Cyclophosphamide	31-47	interleukin 4	Homo sapiens	168-172