PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14997269-6 2004 METHODS: We perfused mCPP, 5-HT(1B/2C) agonist, at multiple doses via a microdialysis probe into the three local brain areas and observed food intake. 1-(3-chlorophenyl)piperazine 21-25 5-hydroxytryptamine receptor 1B Rattus norvegicus 27-34 18190518-3 2008 Subcutaneous injection of mCPP (3 mg/kg) completely blocked fast-induced refeeding in freely behaving, non-anaesthetized male rats, an effect that was not modified by the 5-HT(1B) receptor antagonist but was partially reversed by the 5-HT(2C) receptor antagonist. 1-(3-chlorophenyl)piperazine 26-30 5-hydroxytryptamine receptor 1B Rattus norvegicus 171-178 14997269-11 2004 The results also suggested that mCPP acts not only as a 5-HT(1B/2C) agonist, but also as a 5-HT releaser or as a re-uptake inhibitor. 1-(3-chlorophenyl)piperazine 32-36 5-hydroxytryptamine receptor 1B Rattus norvegicus 56-63 8332610-5 1993 In contrast, 1-3-(chlorophenyl)piperazine (mCPP) and 1-(3-(trifluoromethyl)phenyl)piperazine (TFMPP) (5-HT1B/1C agonists) reduced intake of 1.8 and 0.9% saline in the two tests. 1-(3-chlorophenyl)piperazine 13-41 5-hydroxytryptamine receptor 1B Rattus norvegicus 102-108 10065922-15 1998 This suggests that 5-HT1B and 5-HT2C receptors are required for the generalization of mCPP to the EtOH cue. 1-(3-chlorophenyl)piperazine 86-90 5-hydroxytryptamine receptor 1B Rattus norvegicus 19-25 9683007-9 1998 These results show that the discriminative stimulus effects of mCPP are predominantly mediated by 5-HT2C receptors, and to some extent by 5-HT1B receptors. 1-(3-chlorophenyl)piperazine 63-67 5-hydroxytryptamine receptor 1B Rattus norvegicus 138-144 9342779-7 1997 Likewise, the 5-HT1B/2C agonist mCPP (0.56-1.7 mg/kg; IP) completely substituted only in the 1.0 g/kg ethanol training group. 1-(3-chlorophenyl)piperazine 32-36 5-hydroxytryptamine receptor 1B Rattus norvegicus 14-20 7862847-5 1994 The 5-HT1B/5-HT1C agonists, TFMPP (at a dose of 1.0 mg/kg) and mCPP (at a dose of 3.0 mg/kg), appeared to produce satiety as their effects on the satiety sequence were similar to those induced by a food pre-load. 1-(3-chlorophenyl)piperazine 63-67 5-hydroxytryptamine receptor 1B Rattus norvegicus 4-10 9053586-4 1995 The effects of the 5-HT1B/5-HT1C receptor agonist with promigraine action, m-chlorophenylpiperazine (m-CPP), indicated anxiogenic action, which was increased to a certain extent when it was combined with FLU. 1-(3-chlorophenyl)piperazine 75-99 5-hydroxytryptamine receptor 1B Rattus norvegicus 19-25 9053586-4 1995 The effects of the 5-HT1B/5-HT1C receptor agonist with promigraine action, m-chlorophenylpiperazine (m-CPP), indicated anxiogenic action, which was increased to a certain extent when it was combined with FLU. 1-(3-chlorophenyl)piperazine 101-106 5-hydroxytryptamine receptor 1B Rattus norvegicus 19-25 1348421-3 1992 The anticonflict effect of m-CPP (0.25 mg/kg) was antagonized by the non-selective 5-HT antagonist metergoline (1-4 mg/kg) and by the beta-adrenoceptor blocker SDZ 21009 (2 and 4 mg/kg) with affinity for 5-HT1A and 5-HT1B receptors. 1-(3-chlorophenyl)piperazine 27-32 5-hydroxytryptamine receptor 1B Rattus norvegicus 215-221 2311675-2 1990 m-Chlorophenylpiperazine (m-CPP) is a 5-HT1B and 5-HT1C agonist, weak 5-HT2 antagonist, and trazodone metabolite. 1-(3-chlorophenyl)piperazine 0-24 5-hydroxytryptamine receptor 1B Rattus norvegicus 38-44 1648746-2 1991 Consistent with the serotonergic properties of THBC, administration of the 5HT1B agonists TFMPP and mCPP to THBC-trained rats resulted in THBC-appropriate responding. 1-(3-chlorophenyl)piperazine 100-104 5-hydroxytryptamine receptor 1B Rattus norvegicus 75-80 2356002-6 1990 The 5-HT1B selective agonists mCPP and TFMPP significantly decreased the receptive field are of the ventroflexion reflex (log ED50 values: mCPP, 3.79 nmol/kg; TFMPP, 3.61 nmol/kg) with no significant effect on the dorsiflexion or lateral flexion reflexes. 1-(3-chlorophenyl)piperazine 30-34 5-hydroxytryptamine receptor 1B Rattus norvegicus 4-10 2356002-6 1990 The 5-HT1B selective agonists mCPP and TFMPP significantly decreased the receptive field are of the ventroflexion reflex (log ED50 values: mCPP, 3.79 nmol/kg; TFMPP, 3.61 nmol/kg) with no significant effect on the dorsiflexion or lateral flexion reflexes. 1-(3-chlorophenyl)piperazine 139-143 5-hydroxytryptamine receptor 1B Rattus norvegicus 4-10 2524392-1 1989 8-OH-DPAT, a selective 5-HT1A agonist, and mCPP, which has preferential affinity for 5-HT1B and 5-HT1C receptors, were studied for their effects on aversive brain stimulation in rats. 1-(3-chlorophenyl)piperazine 43-47 5-hydroxytryptamine receptor 1B Rattus norvegicus 85-91 2530591-6 1989 1-(m-Chlorophenyl) piperazine (mCPP, 1-5 mg/kg), a 5-HT1B agonist, had no effect on ASR amplitude on PND 13 or 17 and then produced a dose-related decrease in the response on PND 21. 1-(3-chlorophenyl)piperazine 0-29 5-hydroxytryptamine receptor 1B Rattus norvegicus 51-57 2530591-6 1989 1-(m-Chlorophenyl) piperazine (mCPP, 1-5 mg/kg), a 5-HT1B agonist, had no effect on ASR amplitude on PND 13 or 17 and then produced a dose-related decrease in the response on PND 21. 1-(3-chlorophenyl)piperazine 31-35 5-hydroxytryptamine receptor 1B Rattus norvegicus 51-57 2524392-5 1989 The proaversive effect of 8-OH-DPAT and the antiaversive effect of mCPP suggest that 5-HT1A and non-5-HT1a (5-HT1B or 5-HT1C) receptors play distinct roles in mechanisms of aversion, perhaps at different locations in the CNS. 1-(3-chlorophenyl)piperazine 67-71 5-hydroxytryptamine receptor 1B Rattus norvegicus 108-114 2906446-0 1988 Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors. 1-(3-chlorophenyl)piperazine 36-40 5-hydroxytryptamine receptor 1B Rattus norvegicus 71-77 2901357-1 1988 Intravenous administration of the 5-HT1B agonist, m-chlorophenylpiperazine (m-CPP) to rats produced increases in plasma prolactin (peak effect at 15 min), corticosterone (peak effect at 30 min) and a decrease in plasma growth hormone (peak effect at 15 min) concentrations. 1-(3-chlorophenyl)piperazine 50-74 5-hydroxytryptamine receptor 1B Rattus norvegicus 34-40 2901357-1 1988 Intravenous administration of the 5-HT1B agonist, m-chlorophenylpiperazine (m-CPP) to rats produced increases in plasma prolactin (peak effect at 15 min), corticosterone (peak effect at 30 min) and a decrease in plasma growth hormone (peak effect at 15 min) concentrations. 1-(3-chlorophenyl)piperazine 76-81 5-hydroxytryptamine receptor 1B Rattus norvegicus 34-40 2855237-6 1988 In contrast, the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin, the 5-HT1B agonists 1-(m-trifluoromethylphenyl)piperazine and 1-(m-chlorophenyl)-piperazine and the 5-HT3 agonist 2-methyl-5-HT were inactive. 1-(3-chlorophenyl)piperazine 134-163 5-hydroxytryptamine receptor 1B Rattus norvegicus 76-82 2970973-3 1988 Conversely, the 5-HT2 agonist DOI and the 5-HT1B agonist mCPP increased mouthing and decreased probing. 1-(3-chlorophenyl)piperazine 57-61 5-hydroxytryptamine receptor 1B Rattus norvegicus 42-48 3666036-1 1987 Ru 24969 and two other putative 5-HT1B agonists 1-(3-chlorophenyl)piperazine (mCPP) and 1-[3-(trifluoromethyl) phenyl]piperazine (TFMPP) and RU 24969 dose-dependently decreased food intake over 4 h (and in the case of RU 24969 also over 24 h) in free-feeding male Sprague-Dawley rats. 1-(3-chlorophenyl)piperazine 48-76 5-hydroxytryptamine receptor 1B Rattus norvegicus 32-38 3666036-1 1987 Ru 24969 and two other putative 5-HT1B agonists 1-(3-chlorophenyl)piperazine (mCPP) and 1-[3-(trifluoromethyl) phenyl]piperazine (TFMPP) and RU 24969 dose-dependently decreased food intake over 4 h (and in the case of RU 24969 also over 24 h) in free-feeding male Sprague-Dawley rats. 1-(3-chlorophenyl)piperazine 78-82 5-hydroxytryptamine receptor 1B Rattus norvegicus 32-38 3664076-1 1987 1 Administration of the 5-HT1B receptor agonist m-chlorophenylpiperazine (m-CPP) to rats produces dose-dependent decreases in locomotor activity and food intake. 1-(3-chlorophenyl)piperazine 48-72 5-hydroxytryptamine receptor 1B Rattus norvegicus 24-30 3664076-1 1987 1 Administration of the 5-HT1B receptor agonist m-chlorophenylpiperazine (m-CPP) to rats produces dose-dependent decreases in locomotor activity and food intake. 1-(3-chlorophenyl)piperazine 74-79 5-hydroxytryptamine receptor 1B Rattus norvegicus 24-30 3505364-4 1987 In contrast, dorsal raphe neurons were only weakly responsive to microiontophoretic application of mCPP and TFMPP; dose-response relationships for the 5-HT1B compounds were significantly displaced from that of 5-HT. 1-(3-chlorophenyl)piperazine 99-103 5-hydroxytryptamine receptor 1B Rattus norvegicus 151-157 3941588-5 1986 The affinity for serotonin receptors in the rat fundus was similar for all three phenylpiperazines in spite of the reported selectivity of MCPP and TFMPP for 5HT1B and of LY165163 for 5HT1A receptors. 1-(3-chlorophenyl)piperazine 139-143 5-hydroxytryptamine receptor 1B Rattus norvegicus 158-163