PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21605661-3 2011 Soy isoflavones could be an effective complementary treatment given that they inhibit the survival signaling pathways of various cancer cells through altered activation of APE1/Ref-1, NF-kappaB, and HIF-1alpha, which are genes essential for tumor cell survival, tumor growth, and angiogenesis, thus making such cells more sensitive to radiotherapy. Isoflavones 4-15 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 172-176 21605661-3 2011 Soy isoflavones could be an effective complementary treatment given that they inhibit the survival signaling pathways of various cancer cells through altered activation of APE1/Ref-1, NF-kappaB, and HIF-1alpha, which are genes essential for tumor cell survival, tumor growth, and angiogenesis, thus making such cells more sensitive to radiotherapy. Isoflavones 4-15 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 177-182 19101986-1 2009 We previously showed that treatment of prostate cancer cells with soy isoflavones and radiation resulted in greater cell killing in vitro, and caused downregulation of NF-kappaB and APE1/Ref-1. Isoflavones 70-81 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 182-186 19101986-1 2009 We previously showed that treatment of prostate cancer cells with soy isoflavones and radiation resulted in greater cell killing in vitro, and caused downregulation of NF-kappaB and APE1/Ref-1. Isoflavones 70-81 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 187-192 30322962-0 2018 Retraction: Down-regulation of Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 Expression by Soy Isoflavones Enhances Prostate Cancer Radiotherapy In vitro and In vivo. Isoflavones 101-112 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 31-67 30322962-0 2018 Retraction: Down-regulation of Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 Expression by Soy Isoflavones Enhances Prostate Cancer Radiotherapy In vitro and In vivo. Isoflavones 101-112 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 68-82 21325978-0 2011 Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer. Isoflavones 4-15 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 55-59 21325978-0 2011 Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer. Isoflavones 4-15 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 60-65 21325978-11 2011 Soy isoflavones inhibited the radiation-induced activity of the DNA repair/redox enzyme APE1/Ref-1 and the transcription factors NF-kappaB and HIF-1alpha. Isoflavones 4-15 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 88-92 21325978-11 2011 Soy isoflavones inhibited the radiation-induced activity of the DNA repair/redox enzyme APE1/Ref-1 and the transcription factors NF-kappaB and HIF-1alpha. Isoflavones 4-15 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 93-98 19101986-11 2009 Transfection experiments indicate that APE1/Ref-1 inhibition by isoflavones impairs the radiation-induced transcription activity of NF-kappaB and HIF-1alpha. Isoflavones 64-75 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 39-43 19101986-11 2009 Transfection experiments indicate that APE1/Ref-1 inhibition by isoflavones impairs the radiation-induced transcription activity of NF-kappaB and HIF-1alpha. Isoflavones 64-75 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 44-49 19101986-13 2009 Our novel findings suggest that the increased responsiveness to radiation mediated by soy isoflavones could be due to pleiotropic effects of isoflavones blocking cell survival pathways induced by radiation including Src/STAT3/HIF-1alpha, APE1/Ref-1 and NF-kappaB. Isoflavones 90-101 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 238-242 19101986-13 2009 Our novel findings suggest that the increased responsiveness to radiation mediated by soy isoflavones could be due to pleiotropic effects of isoflavones blocking cell survival pathways induced by radiation including Src/STAT3/HIF-1alpha, APE1/Ref-1 and NF-kappaB. Isoflavones 90-101 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 243-248 19101986-13 2009 Our novel findings suggest that the increased responsiveness to radiation mediated by soy isoflavones could be due to pleiotropic effects of isoflavones blocking cell survival pathways induced by radiation including Src/STAT3/HIF-1alpha, APE1/Ref-1 and NF-kappaB. Isoflavones 141-152 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 238-242 19101986-13 2009 Our novel findings suggest that the increased responsiveness to radiation mediated by soy isoflavones could be due to pleiotropic effects of isoflavones blocking cell survival pathways induced by radiation including Src/STAT3/HIF-1alpha, APE1/Ref-1 and NF-kappaB. Isoflavones 141-152 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 243-248 17332344-6 2007 Soy isoflavones decreased APE1/Ref-1 expression in vitro, whereas radiation up-regulated it. Isoflavones 4-15 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 26-30 17332344-6 2007 Soy isoflavones decreased APE1/Ref-1 expression in vitro, whereas radiation up-regulated it. Isoflavones 4-15 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 31-36 17332344-7 2007 Pretreatment with soy isoflavones followed by radiation inhibited APE1/Ref-1 expression. Isoflavones 22-33 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 66-70 17332344-7 2007 Pretreatment with soy isoflavones followed by radiation inhibited APE1/Ref-1 expression. Isoflavones 22-33 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 71-76 17332344-8 2007 APE1/Ref-1 decrease correlated with decreased DNA-binding activity of NF-kappaB mediated by soy isoflavones and radiation, thus promoting cell killing. Isoflavones 96-107 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 0-4 17332344-8 2007 APE1/Ref-1 decrease correlated with decreased DNA-binding activity of NF-kappaB mediated by soy isoflavones and radiation, thus promoting cell killing. Isoflavones 96-107 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 5-10 17332344-9 2007 In vivo treatment of prostate tumors with soy isoflavones and radiation down-regulated APE1/Ref-1 protein expression and NF-kappaB activity, confirming the molecular alterations observed in vitro. Isoflavones 46-57 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 87-91 17332344-9 2007 In vivo treatment of prostate tumors with soy isoflavones and radiation down-regulated APE1/Ref-1 protein expression and NF-kappaB activity, confirming the molecular alterations observed in vitro. Isoflavones 46-57 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 92-97 17332344-10 2007 The down-regulation of APE1/Ref-1 and NF-kappaB by isoflavones, in vitro and in vivo, supports our hypothesis that these markers represent biological targets of isoflavones. Isoflavones 51-62 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 23-27 17332344-10 2007 The down-regulation of APE1/Ref-1 and NF-kappaB by isoflavones, in vitro and in vivo, supports our hypothesis that these markers represent biological targets of isoflavones. Isoflavones 51-62 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 28-33 17332344-10 2007 The down-regulation of APE1/Ref-1 and NF-kappaB by isoflavones, in vitro and in vivo, supports our hypothesis that these markers represent biological targets of isoflavones. Isoflavones 161-172 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 23-27 17332344-10 2007 The down-regulation of APE1/Ref-1 and NF-kappaB by isoflavones, in vitro and in vivo, supports our hypothesis that these markers represent biological targets of isoflavones. Isoflavones 161-172 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 28-33 17332344-11 2007 Indeed, a 2-fold increase in APE1/Ref-1 expression, obtained by cDNA transfection, resulted in a 2-fold increase in NF-kappaB DNA-binding activity, and both of which were down-regulated by soy isoflavones, confirming the cross-talk between these molecules and, in turn, causing radiosensitization. Isoflavones 193-204 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 29-33 17332344-11 2007 Indeed, a 2-fold increase in APE1/Ref-1 expression, obtained by cDNA transfection, resulted in a 2-fold increase in NF-kappaB DNA-binding activity, and both of which were down-regulated by soy isoflavones, confirming the cross-talk between these molecules and, in turn, causing radiosensitization. Isoflavones 193-204 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 34-39