PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20577121-2 2010 This systematic review and meta-analysis was performed to clarify the effects of soy isoflavone extract supplements on systolic and diastolic blood pressure (SBP and DBP) in adult humans. Isoflavones 85-95 selenium binding protein 1 Homo sapiens 158-161 20577121-7 2010 Daily ingestion of 25-375 mg soy isoflavones (aglycone equivalents) for 2-24 weeks significantly decreased SBP by 1.92 mmHg (95% confidence interval -3.45 to -0.39; P = 0.01) compared with placebo (heterogeneity P = 0.39, fixed effect model) in adults with normal blood pressure and prehypertension. Isoflavones 33-44 selenium binding protein 1 Homo sapiens 107-110 20577121-11 2010 CONCLUSION: Soy isoflavone extracts significantly decreased SBP but not DBP in adult humans, and no dose-response relationship was observed. Isoflavones 16-26 selenium binding protein 1 Homo sapiens 60-63 20577121-12 2010 Further studies are needed to address factors related to the observed effects of soy isoflavones on SBP and to verify the effect in hypertensive patients. Isoflavones 85-96 selenium binding protein 1 Homo sapiens 100-103 23203140-6 2013 However, a subgroup analysis among 130 pre and hypertensive women suggested that soy protein and isoflavones significantly reduced SBP [-4.25%, 95% confidence interval (CI) -7.9 to -0.6%, P = 0.02] and the level of soluble intercellular adhesion molecule (sICAM)-1 (-22.6%, 95% CI -42.8 to -2.3%, P = 0.02) relative to milk protein after 6-month intervention. Isoflavones 97-108 selenium binding protein 1 Homo sapiens 131-134