PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35373399-9	2022	Moreover, SI treatment significantly suppressed nuclear factor kappa B p65, nitric oxide synthase, and cyclooxygenase 2 activation, as well as the pro-inflammatory cytokines (Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta)) release in the hippocampus of CSD-treated mice.	Isoflavones	10-12	tumor necrosis factor	Mus musculus	175-202	
35373399-9	2022	Moreover, SI treatment significantly suppressed nuclear factor kappa B p65, nitric oxide synthase, and cyclooxygenase 2 activation, as well as the pro-inflammatory cytokines (Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta)) release in the hippocampus of CSD-treated mice.	Isoflavones	10-12	tumor necrosis factor	Mus musculus	204-213	
31470503-9	2019	Furthermore, the gene-expressions of TNF-alpha and CXCL2 (MIP-2) in the isoflavone + smoking group were significantly less than those in the smoking group.	Isoflavones	72-82	tumor necrosis factor	Mus musculus	37-46	
16271352-5	2005	Moreover, E2 and isoflavone enhanced the production of tumor necrosis factor-alpha that is one of the important cytokines regarding NO production.	Isoflavones	17-27	tumor necrosis factor	Mus musculus	55-82	
21946955-4	2012	A total amount of 10 micromol/l of biochanin A or genistein significantly suppressed the secretion of tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL-6) in LPS-induced RAW264.7 cells, whereas another two isoflavones, formononectin and daidzein, only significantly suppressed the secretion of IL-6.	Isoflavones	217-228	tumor necrosis factor	Mus musculus	102-129	
17825101-2	2007	This project examined whether supplementation with soy isoflavones (IF), shown to have anti-inflammatory properties, could prevent tissue expression of TNF-alpha and the development of skeletal pathology in an animal model of chronic inflammation.	Isoflavones	51-66	tumor necrosis factor	Mus musculus	152-161	
27465724-2	2016	We have previously demonstrated that isoflavones, such as genistein and daidzein, prevent TNF-alpha-induced muscle atrophy in C2C12 myotubes.	Isoflavones	37-48	tumor necrosis factor	Mus musculus	90-99	
21658942-0	2011	The soy isoflavone genistein blunts nuclear factor kappa-B, MAPKs and TNF-alpha activation and ameliorates muscle function and morphology in mdx mice.	Isoflavones	8-18	tumor necrosis factor	Mus musculus	70-79	
17849275-3	2007	Therefore, we examined the effects of individual isoflavones (daidzein, daidzin, genistein, and genistin) on the LPS-induced production of TNF-alpha.	Isoflavones	49-60	tumor necrosis factor	Mus musculus	139-148