PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20444693-1	2010	Numerous in vitro and in vivo studies have shown that isoflavones exhibit anti-proliferative activity against epidermal growth factor (EGF) receptor-positive malignancies of the breast, colon, skin, and prostate.	Isoflavones	54-65	epidermal growth factor receptor	Homo sapiens	110-148	
20124483-6	2010	Treatment of pancreatic cancer cells with the natural products 3,3"-diinodolylmethane (DIM) or isoflavone, which increased miR-146a expression, caused a downregulation of EGFR, MTA-2, IRAK-1, and NF-kappaB, resulting in an inhibition of pancreatic cancer cell invasion.	Isoflavones	95-105	epidermal growth factor receptor	Homo sapiens	171-175	
10454197-9	1999	Further successful application of this pharmacophore model led to the identification and optimization of phenylamino-pyrazolo[4,3-d]pyrimidines and substituted isoflavones and quinolones, other classes of potent, selective, and ATP competitive EGFR kinase inhibitors with IC50 values in the low nanomolar range.	Isoflavones	160-171	epidermal growth factor receptor	Homo sapiens	244-248	
10090785-0	1999	Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: isoflavones and 3-phenyl-4(1H)-quinolones.	Isoflavones	80-91	epidermal growth factor receptor	Homo sapiens	47-51	
10090785-1	1999	Using a pharmacophore model for ATP-competitive inhibitors interacting with the active site of the EGFR protein tyrosine kinase together with published X-ray crystal data of quercetin (2) in complex with the Hck tyrosine kinase and of deschloroflavopiridol (3b) in complex with CDK2, a putative binding mode of the isoflavone genistein (1) was proposed.	Isoflavones	315-325	epidermal growth factor receptor	Homo sapiens	99-103	
27793905-0	2016	Isoflavone Extracts Enhance the Effect of Epidermal Growth Factor Receptor Inhibitors in NSCLC Cell Lines.	Isoflavones	0-10	epidermal growth factor receptor	Homo sapiens	42-74	
18424208-0	2008	Developmental changes and the impact of isoflavones on mRNA expression of IGF-I receptor, EGF receptor and related growth factors in porcine skeletal muscle cell cultures.	Isoflavones	40-51	epidermal growth factor receptor	Homo sapiens	90-102	
33771918-3	2021	In men with BPH, finasteride treatment induced EGFR nuclear expression, but, when finasteride was combined with isoflavones, EGFR remained on the cell membrane.	Isoflavones	112-123	epidermal growth factor receptor	Homo sapiens	125-129	
24585454-2	2014	Here, we address the question whether these metabolites differ in their biological activity from the parent isoflavone, exemplified for the epidermal growth factor receptor and topoisomerase II, potentially resulting in an enhanced toxic profile.	Isoflavones	108-118	epidermal growth factor receptor	Homo sapiens	140-172