PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34873494-0	2021	Erratum: A preclinical report of a cobimetinib-inspired novel anticancer small-molecule scaffold of isoflavones, NSC777213, for targeting PI3K/AKT/mTOR/MEK in multiple cancers.	Isoflavones	100-111	AKT serine/threonine kinase 1	Homo sapiens	143-146	
23272911-0	2013	Deregulation of PI3K/Akt/mTOR signaling pathways by isoflavones and its implication in cancer treatment.	Isoflavones	52-63	AKT serine/threonine kinase 1	Homo sapiens	21-24	
34249417-0	2021	A preclinical report of a cobimetinib-inspired novel anticancer small-molecule scaffold of isoflavones, NSC777213, for targeting PI3K/AKT/mTOR/MEK in multiple cancers.	Isoflavones	91-102	AKT serine/threonine kinase 1	Homo sapiens	134-137	
29496164-0	2018	Dietary isoflavone daidzein synergizes centchroman action via induction of apoptosis and inhibition of PI3K/Akt pathway in MCF-7/MDA MB-231 human breast cancer cells.	Isoflavones	8-18	AKT serine/threonine kinase 1	Homo sapiens	108-111	
29761845-0	2018	The O-methylated isoflavone, formononetin, inhibits human ovarian cancer cell proliferation by sub G0/G1 cell phase arrest through PI3K/AKT and ERK1/2 inactivation.	Isoflavones	17-27	AKT serine/threonine kinase 1	Homo sapiens	136-139	
23272911-7	2013	In this review article, we discuss our current understanding of the regulation of PI3K/Akt/mTOR signaling pathways by isoflavones, which could be responsible for their observed in vitro and in vivo activity against human cancers.	Isoflavones	118-129	AKT serine/threonine kinase 1	Homo sapiens	87-90	
22412975-6	2012	By pathway and network analysis, we also observed the regulatory effects of isoflavone and BR-DIM on multiple signaling pathways such as AR/PSA, NKX3-1/Akt/p27, MITF, etc.	Isoflavones	76-86	AKT serine/threonine kinase 1	Homo sapiens	152-155	
21161820-2	2011	Soy isoflavones decreased the expression of proliferating cell nuclear antigen (PCNA), extracellular signal-regulated kinase (ERK)-1/2, AKT, and nuclear factor (NF)-kappaB.	Isoflavones	4-15	AKT serine/threonine kinase 1	Homo sapiens	136-139	
20107864-2	2011	An isoflavone, genistein, inactivates Akt and NF-kappaB and enhances the anti-tumor activity of erlotinib and gemcitabine in experimental systems of pancreas cancer.	Isoflavones	3-13	AKT serine/threonine kinase 1	Homo sapiens	38-41	
22200028-2	2011	Emerging experimental evidence shows that isoflavones could induce cancer cell death by regulating multiple cellular signaling pathways including Akt, NF-kappaB, MAPK, Wnt, androgen receptor (AR), p53 and Notch signaling, all of which have been found to be deregulated in cancer cells.	Isoflavones	42-53	AKT serine/threonine kinase 1	Homo sapiens	146-149	
20177775-6	2010	In this study we investigated the effect of combination treatment of rapamycin with isoflavones such as genistein and biochanin A on mTOR pathway and activation of Akt and eIF4E in human glioblastoma (U87) cells.	Isoflavones	84-95	AKT serine/threonine kinase 1	Homo sapiens	164-167	
18687691-0	2008	Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells.	Isoflavones	59-69	AKT serine/threonine kinase 1	Homo sapiens	14-17	
20177775-7	2010	Our results show that combination treatment of rapamycin with isoflavones, especially biochanin A at 50 muM, decreased the phosphorylation of Akt and eIF4E proteins and rendered U87 cells more sensitive to rapamycin treatment when compared to cells treated with rapamycin alone.	Isoflavones	62-73	AKT serine/threonine kinase 1	Homo sapiens	142-145	
19472400-0	2009	NV-128, a novel isoflavone derivative, induces caspase-independent cell death through the Akt/mammalian target of rapamycin pathway.	Isoflavones	16-26	AKT serine/threonine kinase 1	Homo sapiens	90-93	
18687691-6	2008	We found that isoflavone inhibited the phosphorylation of Akt and FOXO3a, regulated the phosphorylation of Src, and increased the expression of GSK-3beta, leading to the down-regulation of AR and its target gene PSA.	Isoflavones	14-24	AKT serine/threonine kinase 1	Homo sapiens	58-61	
18687691-9	2008	These results suggest that isoflavone-induced inhibition of cell proliferation and induction of apoptosis are partly mediated through the regulation of the Akt/FOXO3a/GSK-3beta/AR signaling network.	Isoflavones	27-37	AKT serine/threonine kinase 1	Homo sapiens	156-159	
16840783-0	2006	The isoflavone Equol mediates rapid vascular relaxation: Ca2+-independent activation of endothelial nitric-oxide synthase/Hsp90 involving ERK1/2 and Akt phosphorylation in human endothelial cells.	Isoflavones	4-14	AKT serine/threonine kinase 1	Homo sapiens	149-152	
16840783-6	2006	Our findings provide the first evidence that nutritionally relevant plasma concentrations of equol (and other soy protein isoflavones) rapidly stimulate phosphorylation of ERK1/2 and phosphatidylinositol 3-kinase/Akt, leading to the activation of NOS and increased NO production at resting cytosolic Ca2+ levels.	Isoflavones	122-133	AKT serine/threonine kinase 1	Homo sapiens	213-216