PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10761703-0	2000	p53-independent induction of p21 (WAF1/CIP1), reduction of cyclin B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells.	Isoflavones	92-102	tumor protein p53	Homo sapiens	0-3	
15833870-0	2005	Phenoxodiol, a novel isoflavone, induces G1 arrest by specific loss in cyclin-dependent kinase 2 activity by p53-independent induction of p21WAF1/CIP1.	Isoflavones	21-31	tumor protein p53	Homo sapiens	109-112	
21833626-8	2011	Our findings support experimental data implicating combined effects of MDM2 protein and the p53-mediated pathway in breast carcinogenesis, and suggest that soy isoflavones may exert protective effect via down-regulation of the MDM2 protein.	Isoflavones	160-171	tumor protein p53	Homo sapiens	92-95	
22200028-2	2011	Emerging experimental evidence shows that isoflavones could induce cancer cell death by regulating multiple cellular signaling pathways including Akt, NF-kappaB, MAPK, Wnt, androgen receptor (AR), p53 and Notch signaling, all of which have been found to be deregulated in cancer cells.	Isoflavones	42-53	tumor protein p53	Homo sapiens	197-200	
21134073-6	2011	Combined treatment of isoflavones and curcumin additively suppressed cellular proliferation and induced phosphorylation of ATM, histone H2AX, Chk2 and p53.	Isoflavones	22-33	tumor protein p53	Homo sapiens	151-154	
12199376-4	2002	The levels of a cell cycle regulatory protein, P53, in response to the treatment of isoflavones, were also determined.	Isoflavones	84-95	tumor protein p53	Homo sapiens	47-50	
33939887-10	2021	Breast tissue-occurring metabolites" antiproliferation was mainly exerted in p53-wild-type MCF-7 cells by curcuminoids through cell cycle arrest, senescence, and apoptosis induction via p53/p21 induction, while isoflavone-derived metabolites exerted estrogenic-like activity.	Isoflavones	211-221	tumor protein p53	Homo sapiens	77-80	
33939887-10	2021	Breast tissue-occurring metabolites" antiproliferation was mainly exerted in p53-wild-type MCF-7 cells by curcuminoids through cell cycle arrest, senescence, and apoptosis induction via p53/p21 induction, while isoflavone-derived metabolites exerted estrogenic-like activity.	Isoflavones	211-221	tumor protein p53	Homo sapiens	186-189