PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22440466-4 2011 In addition, the serum concentrations of IGF-I and interleukin-6 were increased by high levels of soy isoflavones (P < 0.05). Isoflavones 102-113 insulin like growth factor 1 Homo sapiens 41-46 32292572-11 2020 In AAM, a reduction in serum IGF-1 concentrations and IGF1: IGFBP-3 ratios were observed with isoflavone supplementation. Isoflavones 94-104 insulin like growth factor 1 Homo sapiens 29-34 32292572-11 2020 In AAM, a reduction in serum IGF-1 concentrations and IGF1: IGFBP-3 ratios were observed with isoflavone supplementation. Isoflavones 94-104 insulin like growth factor 1 Homo sapiens 54-58 25285521-6 2014 We subsequently assessed the combined influence of genetics and diet (daily intake of protein, fat and soy isoflavones) on IGF-1 and IGFBP-3 levels. Isoflavones 107-118 insulin like growth factor 1 Homo sapiens 123-128 25285521-7 2014 RESULTS: Among women aged less than 50 years, circulating IGF-1 serum levels were significantly lower for those with CC genotype for IGF-1 rs1520220 than levels for those with the GC or GG genotypes (in recessive model: P = 0.007).In gene-diet analyses among these women, we found carrying CC genotype for IGF-1 rs1520220 and high soy isoflavone intake tend to be associated with lower circulating IGF-1 levels synthetically (P = 0.002). Isoflavones 335-345 insulin like growth factor 1 Homo sapiens 58-63 25285521-7 2014 RESULTS: Among women aged less than 50 years, circulating IGF-1 serum levels were significantly lower for those with CC genotype for IGF-1 rs1520220 than levels for those with the GC or GG genotypes (in recessive model: P = 0.007).In gene-diet analyses among these women, we found carrying CC genotype for IGF-1 rs1520220 and high soy isoflavone intake tend to be associated with lower circulating IGF-1 levels synthetically (P = 0.002). Isoflavones 335-345 insulin like growth factor 1 Homo sapiens 133-138 25285521-7 2014 RESULTS: Among women aged less than 50 years, circulating IGF-1 serum levels were significantly lower for those with CC genotype for IGF-1 rs1520220 than levels for those with the GC or GG genotypes (in recessive model: P = 0.007).In gene-diet analyses among these women, we found carrying CC genotype for IGF-1 rs1520220 and high soy isoflavone intake tend to be associated with lower circulating IGF-1 levels synthetically (P = 0.002). Isoflavones 335-345 insulin like growth factor 1 Homo sapiens 133-138 25285521-7 2014 RESULTS: Among women aged less than 50 years, circulating IGF-1 serum levels were significantly lower for those with CC genotype for IGF-1 rs1520220 than levels for those with the GC or GG genotypes (in recessive model: P = 0.007).In gene-diet analyses among these women, we found carrying CC genotype for IGF-1 rs1520220 and high soy isoflavone intake tend to be associated with lower circulating IGF-1 levels synthetically (P = 0.002). Isoflavones 335-345 insulin like growth factor 1 Homo sapiens 133-138 25285521-8 2014 Women with GG or GC genotypes for IGF-1 rs1520220 and with low intake of soy isoflavones had the highest levels of circulating IGF-1 (geometric mean [95% CI]: 195 [37, 1021] microg/L). Isoflavones 77-88 insulin like growth factor 1 Homo sapiens 127-132 25285521-11 2014 High soy isoflavone intake may interact with carrying CC genotype for IGF-1-rs1520220 to lower women"s serum IGF-1 levels more. Isoflavones 9-19 insulin like growth factor 1 Homo sapiens 70-75 25285521-11 2014 High soy isoflavone intake may interact with carrying CC genotype for IGF-1-rs1520220 to lower women"s serum IGF-1 levels more. Isoflavones 9-19 insulin like growth factor 1 Homo sapiens 109-114 23075937-5 2012 Recent studies on mechanisms of action of soy in breast cancer provide insights into epigenetic effects and the interaction of isoflavones with IGF-1 and with a number of polymorphisms of genes associated with breast cancer risk such as MDM2 and CYP1B1. Isoflavones 127-138 insulin like growth factor 1 Homo sapiens 144-149 22440466-5 2011 Furthermore, a diet containing soy isoflavones enhanced IGF-I mRNA expression levels in longissimus muscle, but decreased these levels in perirenal fat. Isoflavones 35-46 insulin like growth factor 1 Homo sapiens 56-61 22440466-7 2011 The data indicated that soy isoflavones regulated the BW gain and fat percentage of Chinese Guangxi minipigs, which also showed changes in IGF-I system and PPARgamma. Isoflavones 28-39 insulin like growth factor 1 Homo sapiens 139-144 19502719-0 2009 Effects of capsaicin and isoflavone on blood pressure and serum levels of insulin-like growth factor-I in normotensive and hypertensive volunteers with alopecia. Isoflavones 25-35 insulin like growth factor 1 Homo sapiens 74-102 19502719-2 2009 Since administration of capsaicin and isoflavone increases serum levels of IGF-I by sensory neuron stimulation in subjects with alopecia, it is possible that administration of capsaicin and isoflavone reduces arterial blood pressure in patients with hypertension. Isoflavones 38-48 insulin like growth factor 1 Homo sapiens 75-80 19502719-2 2009 Since administration of capsaicin and isoflavone increases serum levels of IGF-I by sensory neuron stimulation in subjects with alopecia, it is possible that administration of capsaicin and isoflavone reduces arterial blood pressure in patients with hypertension. Isoflavones 190-200 insulin like growth factor 1 Homo sapiens 75-80 17237315-8 2007 Interestingly, the change in serum IGF-I concentrations after isoflavone supplementation was negatively associated with serum equol concentrations (r=-0.49, P=0.002). Isoflavones 62-72 insulin like growth factor 1 Homo sapiens 35-40 19502719-6 2009 Serum levels of IGF-I significantly increased in both normotensive and hypertensive volunteers after administration of capsaicin and isoflavone. Isoflavones 133-143 insulin like growth factor 1 Homo sapiens 16-21 19502719-7 2009 These observations suggest that administration of capsaicin and isoflavone might reduce BP in hypertensive, but not in normotensive subjects, probably by increasing serum levels of IGF-I. Isoflavones 64-74 insulin like growth factor 1 Homo sapiens 181-186 17237315-3 2007 We conducted a randomized, placebo-controlled, double-blind crossover study to investigate the effect of an 8-wk isolated isoflavone supplementation (84 mg/d) on serum concentrations of total IGF-I, free IGF-I, total IGF-II, IGF binding protein (BP)-1, IGFBP-2, and IGFBP-3. Isoflavones 122-132 insulin like growth factor 1 Homo sapiens 192-197 17237315-10 2007 However, to our knowledge, this is the first study that suggests isoflavones might have an IGF-I lowering effect in equol producers only. Isoflavones 65-76 insulin like growth factor 1 Homo sapiens 91-96 17474858-2 2006 Due to their estrogen-like structure, soy isoflavones may affect IGF-I levels in a similar way as exogenous estrogens. Isoflavones 42-53 insulin like growth factor 1 Homo sapiens 65-70 17571965-0 2007 Relationship of dietary protein and soy isoflavones to serum IGF-1 and IGF binding proteins in the Prostate Cancer Lifestyle Trial. Isoflavones 40-51 insulin like growth factor 1 Homo sapiens 61-66 12730416-2 2003 To test the hypothesis that long-term soy isoflavone supplementation decreases circulating IGF-I concentrations, we conducted a controlled, parallel-arm, double-blind intervention study with 150 participants (85% men), 50-80 y old. Isoflavones 42-52 insulin like growth factor 1 Homo sapiens 91-96 16176606-10 2005 However, urinary isoflavone excretion during the study period was positively associated with IGF-1 (P=0.04) and the IGF-1:IGFBP-3 ratio (P=0.06). Isoflavones 17-27 insulin like growth factor 1 Homo sapiens 93-98 16176606-10 2005 However, urinary isoflavone excretion during the study period was positively associated with IGF-1 (P=0.04) and the IGF-1:IGFBP-3 ratio (P=0.06). Isoflavones 17-27 insulin like growth factor 1 Homo sapiens 116-121 14969347-6 2004 In the present study, we investigated whether isoflavones (Isocal) extracted from Sophorae fructus affect the growth factors IGF-I and TGF-beta that have been known to be related with bone formation. Isoflavones 46-57 insulin like growth factor 1 Homo sapiens 125-130 14969347-9 2004 In conclusion, the products which contain enriched glucosidic isoflavone and nutrient supplements such as shark cartilage and calcium can be used for osteoporosis therapy by enhancing the production of IGF-I and TGF-beta. Isoflavones 62-72 insulin like growth factor 1 Homo sapiens 202-207