PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31601026-3	2019	In a recent study, we exploited the high versatility of the natural isoflavone scaffold for targeting the Hh signaling pathway at multiple levels showing that the simultaneous targeting of Smo and Gli1 provided synergistic Hh pathway inhibition stronger than single administration.	Isoflavones	68-78	GLI family zinc finger 1	Homo sapiens	197-201	
26666870-5	2016	As a result, an isoflavone derivative that showed ability to inhibit both Smo and Gli1 has been identified; namely, Glabrescione B.	Isoflavones	16-26	GLI family zinc finger 1	Homo sapiens	82-86	
30025349-0	2018	Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold.	Isoflavones	101-111	GLI family zinc finger 1	Homo sapiens	73-76	
30025349-4	2018	The introduction of specific substitutions on the isoflavone"s ring B allowed the identification of molecules targeting preferentially Smo or Gli1.	Isoflavones	50-60	GLI family zinc finger 1	Homo sapiens	142-146	
30025349-6	2018	The combined administration of two different isoflavones behaving as Smo and Gli antagonists, respectively, in primary medulloblastoma (MB) cells highlighted the synergistic effects of these agents, thus paving the way to further and innovative strategies for the pharmacological inhibition of Hh signaling.	Isoflavones	45-56	GLI family zinc finger 1	Homo sapiens	77-80