PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32786866-6	2020	Other flavones such as wogonin selectively inhibited CYP1A1-catalyzed (omega-n)-hydroxylation with an IC50 value of 0.10-0.22 muM, while the isoflavone genistein was a selective omega-hydroxylase inhibitor (IC50: 5.5-46 muM).	Isoflavones	141-151	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-59	
21438753-3	2011	A case-control study was conducted to assess the associations between soy isoflavone intake and the CYP1A1 Ile462Val, CYP1B1 Val432Leu, and COMT Val158Met polymorphisms and breast cancer, as well as their combined effects on breast cancer.	Isoflavones	74-84	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	100-106	
16814747-0	2006	Metabolism of the soyabean isoflavone daidzein by CYP1A2 and the extra-hepatic CYPs 1A1 and 1B1 affects biological activity.	Isoflavones	27-37	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	79-95	
10597900-0	1999	Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.	Isoflavones	79-90	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-20	
10597900-2	1999	We found that the isoflavones genistin and daidzin, and their respective aglucone forms daidzein and genistein, block 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin)-induced CYP1A1 enzyme activity.	Isoflavones	18-29	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	177-183	
10597900-3	1999	This inhibition is correlated with the capacity of the isoflavones to prevent CYP1A1-mediated covalent binding of benzo[a]pyrene (BaP) metabolites to DNA.	Isoflavones	55-66	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	78-84	
10597900-6	1999	We therefore evaluated the isoflavones for direct effects on the CYP1A1 enzyme.	Isoflavones	27-38	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	65-71	
10597900-8	1999	The extent of CYP1A1 inhibition increases with time of preincubation at 37 degrees C, but not at 4 degrees C, in the presence of isoflavone plus NADPH; after 60 min preincubation the inhibition remains non-competitive, with apparent Ki values of 55 microM and 50 microM, respectively.	Isoflavones	129-139	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-20	
10597900-11	1999	The dependency on NADPH, temperature and time for inhibition of CYP1A1 suggests that metabolism of either isoflavone or molecular oxygen to reactive species is required.	Isoflavones	106-116	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	64-70	
10597900-12	1999	Isoflavone-mediated inhibition of CYP1A1 activity may contribute to the mechanism by which these soybean isoflavones protect against carcinogenesis.	Isoflavones	0-10	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	34-40	
10597900-12	1999	Isoflavone-mediated inhibition of CYP1A1 activity may contribute to the mechanism by which these soybean isoflavones protect against carcinogenesis.	Isoflavones	105-116	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	34-40	
15479032-0	2004	Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover).	Isoflavones	79-90	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	33-61	
15479032-7	2004	CYP1A1 catalyzed isoflavone 4"-O-demethylation and hydroxylations with similar efficiency, whereas CYP1B1 favored 4"-O-demethylation over hydroxylations.	Isoflavones	17-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6	
12844379-2	2003	The soyabean isoflavone genistein was demonstrated earlier in our laboratory to be an effective inhibitor of dimethylbenz[a]anthracene (DMBA)-induced DNA damage in MCF-7 cells by curbing cytochrome P450 (CYP) 1 enzymes.	Isoflavones	13-23	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	187-210	
31621310-2	2019	Therefore, we examined the structure-activity relationships of isoflavones and isomeric flavone and flavanones as AhR ligands on the basis of their induction of CYP1A1, CYP1B1, and UGT1A1 gene expression in colon cancer Caco2 cells and young adult mouse colonocyte (YAMC) cells.	Isoflavones	63-74	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	161-167