PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15226466-6	2004	In the isoflavone and placebo groups, changes in triglycerides were -0.2 +/- 0.6 and 0.4 +/- 0.6 mmol/L, P = 0.02, and changes in PAI-1 were -3.06 +/- 5.88 and 4.95 +/- 6.25 IU/L, P = 0.004, respectively.	Isoflavones	7-17	serpin family E member 1	Homo sapiens	130-135	
8945961-7	1996	We found that the isoflavone compound genistein (25 micrograms/ml) prevented the TNF-alpha-induced expression of PAI-1 and TF while also slightly counteracting the decrease in t-PA synthesis.	Isoflavones	18-28	serpin family E member 1	Homo sapiens	113-118	
7949170-2	1994	Here we report that the isoflavone compound genistein prevents the increase in synthesis of PAI-1 induced by these inflammatory mediators in human endothelial cells in vitro, and partially reduces the basal PAI-1 production by these cells.	Isoflavones	24-34	serpin family E member 1	Homo sapiens	92-97	
7949170-2	1994	Here we report that the isoflavone compound genistein prevents the increase in synthesis of PAI-1 induced by these inflammatory mediators in human endothelial cells in vitro, and partially reduces the basal PAI-1 production by these cells.	Isoflavones	24-34	serpin family E member 1	Homo sapiens	207-212	
30707970-0	2019	Soy isoflavones reduce asthma exacerbation in asthmatic patients with high PAI-1-producing genotypes.	Isoflavones	0-15	serpin family E member 1	Homo sapiens	75-80	
30707970-2	2019	Previous studies suggest that soy isoflavones can reduce PAI-1 levels.	Isoflavones	34-45	serpin family E member 1	Homo sapiens	57-62	
30707970-3	2019	OBJECTIVE: We sought to investigate PAI-1 genotype-specific differences of the soy isoflavone response in asthma outcomes.	Isoflavones	83-93	serpin family E member 1	Homo sapiens	36-41	
30707970-4	2019	METHODS: A PAI-1 functional polymorphism (rs1799768, 4G5G) was characterized in subjects with poorly controlled asthma enrolled in a randomized clinical trial of soy isoflavones (n = 265).	Isoflavones	162-177	serpin family E member 1	Homo sapiens	11-16	
30707970-10	2019	Soy isoflavones reduced plasma PAI-1 levels compared with placebo.	Isoflavones	0-15	serpin family E member 1	Homo sapiens	31-36	
30707970-12	2019	CONCLUSIONS: This study demonstrates that soy isoflavone treatment provides a significant benefit in reducing the number of severe asthma exacerbations in asthmatic patients with the high PAI-1-producing genotype.	Isoflavones	46-56	serpin family E member 1	Homo sapiens	188-193	
30707970-13	2019	PAI-1 polymorphisms can be used as a genetic biomarker for soy isoflavone-responsive patients with asthma.	Isoflavones	63-73	serpin family E member 1	Homo sapiens	0-5