PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33923487-8 2021 Flavones, flavonols, flavanones, and isoflavones are the main subclasses of flavonoids reported as AhR modulators. Isoflavones 37-48 aryl hydrocarbon receptor Homo sapiens 99-102 18060767-0 2008 Red clover isoflavones biochanin A and formononetin are potent ligands of the human aryl hydrocarbon receptor. Isoflavones 11-22 aryl hydrocarbon receptor Homo sapiens 84-109 31621310-0 2019 Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure-Activity Relationships. Isoflavones 0-11 aryl hydrocarbon receptor Homo sapiens 15-26 31621310-2 2019 Therefore, we examined the structure-activity relationships of isoflavones and isomeric flavone and flavanones as AhR ligands on the basis of their induction of CYP1A1, CYP1B1, and UGT1A1 gene expression in colon cancer Caco2 cells and young adult mouse colonocyte (YAMC) cells. Isoflavones 63-74 aryl hydrocarbon receptor Homo sapiens 114-117 31621310-4 2019 The structure-activity relationships for the flavonoids were complex and both response and cell context specific; however, there was significant variability in the AhR activities of the isomeric substituted isoflavones and flavones. Isoflavones 207-218 aryl hydrocarbon receptor Homo sapiens 164-167 31621310-6 2019 In contrast, both 5,7-dihydroxy-4-methoxy substituted isoflavone (biochanin A) and flavone (acacetin) induced all three AhR-responsive genes; 4",5,7-trimethoxyisoflavone was a potent AhR agonist, and the isomeric flavone was AhR-inactive. Isoflavones 54-64 aryl hydrocarbon receptor Homo sapiens 120-123 31621310-6 2019 In contrast, both 5,7-dihydroxy-4-methoxy substituted isoflavone (biochanin A) and flavone (acacetin) induced all three AhR-responsive genes; 4",5,7-trimethoxyisoflavone was a potent AhR agonist, and the isomeric flavone was AhR-inactive. Isoflavones 54-64 aryl hydrocarbon receptor Homo sapiens 183-186 31621310-6 2019 In contrast, both 5,7-dihydroxy-4-methoxy substituted isoflavone (biochanin A) and flavone (acacetin) induced all three AhR-responsive genes; 4",5,7-trimethoxyisoflavone was a potent AhR agonist, and the isomeric flavone was AhR-inactive. Isoflavones 54-64 aryl hydrocarbon receptor Homo sapiens 183-186 25926549-0 2015 Agonistic effect of selected isoflavones on arylhydrocarbon receptor in a novel AZ-AhR transgenic gene reporter human cell line. Isoflavones 29-40 aryl hydrocarbon receptor Homo sapiens 83-86 25926549-3 2015 Well characterised family of natural AhR ligands are isoflavones, which are compounds found predominantly in soy beans or red clover. Isoflavones 53-64 aryl hydrocarbon receptor Homo sapiens 37-40 25926549-4 2015 In this study we have examined agonistic effect of selected isoflavones (genistein, daidzein, biochanin A, formononetin and equol) on AhR in the novel transgenic gene reporter human cell line AZ-AhR, a stably transfected AhR-responsive cell line allowing rapid and sensitive assessment of AhR transcriptional activity. Isoflavones 60-71 aryl hydrocarbon receptor Homo sapiens 134-137 22507882-3 2012 Isoflavones are part of a family which include some well characterised endogenous AhR ligands. Isoflavones 0-11 aryl hydrocarbon receptor Homo sapiens 82-85 17869316-3 2008 Among the compounds tested, marked AhR activation was exhibited by isoflavones such as daidzein, resveratrol (a stilbene) structure, some flavanones such as naringenin, and flavones such as baicalein. Isoflavones 67-78 aryl hydrocarbon receptor Homo sapiens 35-38 31621310-7 2019 These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists. Isoflavones 197-208 aryl hydrocarbon receptor Homo sapiens 88-91 31621310-7 2019 These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists. Isoflavones 197-208 aryl hydrocarbon receptor Homo sapiens 313-316 31621310-7 2019 These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists. Isoflavones 285-296 aryl hydrocarbon receptor Homo sapiens 88-91 28985473-10 2017 Experiments with the isoflavones showed that the AhR agonists (BA, FN) preferentially induced CYP1B1 expression as well as 4-MeOE1. Isoflavones 21-32 aryl hydrocarbon receptor Homo sapiens 49-52 22254019-0 2010 Potential health-modulating effects of isoflavones and metabolites via activation of PPAR and AhR. Isoflavones 39-50 aryl hydrocarbon receptor Homo sapiens 94-97 22254019-5 2010 Some isoflavones are potent aryl hydrocarbon receptor (AhR) agonists and induce cell cycle arrest, chemoprevention and modulate xenobiotic metabolism. Isoflavones 5-16 aryl hydrocarbon receptor Homo sapiens 28-53 22254019-5 2010 Some isoflavones are potent aryl hydrocarbon receptor (AhR) agonists and induce cell cycle arrest, chemoprevention and modulate xenobiotic metabolism. Isoflavones 5-16 aryl hydrocarbon receptor Homo sapiens 55-58 17950758-7 2007 Thus, FLA inhibited the estrogen action without binding to the ER by acting as a competitive agonist for AhR, which meaning that there can be anti-estrogenic flavonoids such as FLA as well as estrogenic ones such as isoflavones. Isoflavones 216-227 aryl hydrocarbon receptor Homo sapiens 105-108 12673038-4 2003 Among them, isoflavones such as daidzein, resveratrol having a stilbene structure, and some flavonoids such as naringenin, hesperetin, and baicalein showed AhR activation. Isoflavones 12-23 aryl hydrocarbon receptor Homo sapiens 156-159