PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33749495-8 2021 Long-chain omega-3 fatty acids, the soy isoflavone genistein, the AMPK activator berberine, glucosamine, and ketone bodies can down-regulate NF-kappaB activation. Isoflavones 40-50 nuclear factor kappa B subunit 1 Homo sapiens 141-150 34619497-6 2021 Despite the limited scope covering their molecular mechanisms, isoflavones substantially contributed to protecting from ALI via inhibiting toll-like receptor 4 (TLR4)/Myd88/NF-kappaB pathway and subsequent cytokines, chemokines, and adherent proteins. Isoflavones 63-74 nuclear factor kappa B subunit 1 Homo sapiens 173-182 21803611-10 2013 The isoflavone sensitized the TRAIL-resistant LNCaP cells through the inhibition of transcription factor NF-kappaB(p65) activity, increased the expression of the death receptor TRAIL-R2 (DR5), and disrupted mitochondrial membrane potential (DeltaPsim). Isoflavones 4-14 nuclear factor kappa B subunit 1 Homo sapiens 105-114 28108024-0 2017 Isolation of isoflavones from Iris kashmiriana Baker as potential anti proliferative agents targeting NF-kappaB. Isoflavones 13-24 nuclear factor kappa B subunit 1 Homo sapiens 102-111 28108024-7 2017 NF-kappaB (transcription factor that facilitates angiogenesis, inflammation, invasion and metastasis) was selected as a target to evaluate the anticancer and antioxidant activity of isoflavones and its analogues. Isoflavones 182-193 nuclear factor kappa B subunit 1 Homo sapiens 0-9 28108024-8 2017 Designed library of isoflavones and analogues were docked into the active site of NF-kappa B and the most active 15 analogues were selected for synthesis. Isoflavones 20-31 nuclear factor kappa B subunit 1 Homo sapiens 82-92 28168165-12 2017 The increase in Arg-1 expression mediated by soy isoflavones could be associated with the inhibition of radiation-induced activation of NF-kappaB and the control of pro-inflammatory cytokine production demonstrated in this study. Isoflavones 49-60 nuclear factor kappa B subunit 1 Homo sapiens 136-145 23391445-6 2013 Among them, isoflavone, indole-3-carbinol (I3C), and its in vivo dimeric compound 3,3"-diindolylmethane (DIM) have shown their promising effects on the inhibition of NF-kappaB with corresponding reduction of oxidative stress. Isoflavones 12-22 nuclear factor kappa B subunit 1 Homo sapiens 166-175 21907578-1 2011 It has been previously shown that some flavonoids inhibit NF-kappaB; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFalpha induced NF-kappaB inhibitory effects on HCT116 human colon cancer cells have not yet been reported. Isoflavones 157-167 nuclear factor kappa B subunit 1 Homo sapiens 58-67 21907578-1 2011 It has been previously shown that some flavonoids inhibit NF-kappaB; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFalpha induced NF-kappaB inhibitory effects on HCT116 human colon cancer cells have not yet been reported. Isoflavones 157-167 nuclear factor kappa B subunit 1 Homo sapiens 207-216 22200028-2 2011 Emerging experimental evidence shows that isoflavones could induce cancer cell death by regulating multiple cellular signaling pathways including Akt, NF-kappaB, MAPK, Wnt, androgen receptor (AR), p53 and Notch signaling, all of which have been found to be deregulated in cancer cells. Isoflavones 42-53 nuclear factor kappa B subunit 1 Homo sapiens 151-160 21161820-2 2011 Soy isoflavones decreased the expression of proliferating cell nuclear antigen (PCNA), extracellular signal-regulated kinase (ERK)-1/2, AKT, and nuclear factor (NF)-kappaB. Isoflavones 4-15 nuclear factor kappa B subunit 1 Homo sapiens 145-171 20107864-2 2011 An isoflavone, genistein, inactivates Akt and NF-kappaB and enhances the anti-tumor activity of erlotinib and gemcitabine in experimental systems of pancreas cancer. Isoflavones 3-13 nuclear factor kappa B subunit 1 Homo sapiens 46-55 21605661-3 2011 Soy isoflavones could be an effective complementary treatment given that they inhibit the survival signaling pathways of various cancer cells through altered activation of APE1/Ref-1, NF-kappaB, and HIF-1alpha, which are genes essential for tumor cell survival, tumor growth, and angiogenesis, thus making such cells more sensitive to radiotherapy. Isoflavones 4-15 nuclear factor kappa B subunit 1 Homo sapiens 184-193 21161820-6 2011 ERK-1/2 and AKT expressions were unaltered and NF-kappaB was modestly upregulated by soy isoflavones after transient knockdown of ER-beta expression. Isoflavones 89-100 nuclear factor kappa B subunit 1 Homo sapiens 47-56 25961211-9 2010 Soy isoflavones are structurally similar to both hormones, and elicit strong anticancer effects and antiangiogenesis via inhibition of NF-kappaB, even in hormone receptor independent breast cancers seen in epidemiologic studies. Isoflavones 4-15 nuclear factor kappa B subunit 1 Homo sapiens 135-144 20124483-6 2010 Treatment of pancreatic cancer cells with the natural products 3,3"-diinodolylmethane (DIM) or isoflavone, which increased miR-146a expression, caused a downregulation of EGFR, MTA-2, IRAK-1, and NF-kappaB, resulting in an inhibition of pancreatic cancer cell invasion. Isoflavones 95-105 nuclear factor kappa B subunit 1 Homo sapiens 196-205 20829041-0 2010 Isoflavone derivatives inhibit NF-kappaB-dependent transcriptional activity. Isoflavones 0-10 nuclear factor kappa B subunit 1 Homo sapiens 31-40 20829041-2 2010 Isoflavones are known to have anti-inflammatory and anti-tumor activities, due, in part, to inhibition of NF-kappaB activity. Isoflavones 0-11 nuclear factor kappa B subunit 1 Homo sapiens 106-115 20829041-3 2010 However, the structural moiety of isoflavones responsible for the inhibition of NF-kappaB is not clearly understood. Isoflavones 34-45 nuclear factor kappa B subunit 1 Homo sapiens 80-89 20829041-4 2010 In this work, structure-activity relationships of isoflavone derivatives were examined with regard to NF-kappaB inhibition, using CoMFA and CoMSIA. Isoflavones 50-60 nuclear factor kappa B subunit 1 Homo sapiens 102-111 16475211-2 2006 The authors previously showed that the soy isoflavone genistein down-regulates the activation of NF-kappaB in many carcinoma cell lines in vitro. Isoflavones 43-53 nuclear factor kappa B subunit 1 Homo sapiens 97-106 17349919-5 2007 We have critically evaluated the literature that estrogenic compounds modulate vascular reactivity in vitro and in vivo, and conclude that isoflavones may protect against cardiovascular disease by virtue of their ability to activate intracellular signaling pathways, leading to increased NO bioavailability and an upregulation of antioxidant gene expression via the key transcription factors NFkappaB and Nrf2. Isoflavones 139-150 nuclear factor kappa B subunit 1 Homo sapiens 392-400 17332344-8 2007 APE1/Ref-1 decrease correlated with decreased DNA-binding activity of NF-kappaB mediated by soy isoflavones and radiation, thus promoting cell killing. Isoflavones 96-107 nuclear factor kappa B subunit 1 Homo sapiens 70-79 17332344-9 2007 In vivo treatment of prostate tumors with soy isoflavones and radiation down-regulated APE1/Ref-1 protein expression and NF-kappaB activity, confirming the molecular alterations observed in vitro. Isoflavones 46-57 nuclear factor kappa B subunit 1 Homo sapiens 121-130 17332344-10 2007 The down-regulation of APE1/Ref-1 and NF-kappaB by isoflavones, in vitro and in vivo, supports our hypothesis that these markers represent biological targets of isoflavones. Isoflavones 51-62 nuclear factor kappa B subunit 1 Homo sapiens 38-47 17332344-10 2007 The down-regulation of APE1/Ref-1 and NF-kappaB by isoflavones, in vitro and in vivo, supports our hypothesis that these markers represent biological targets of isoflavones. Isoflavones 161-172 nuclear factor kappa B subunit 1 Homo sapiens 38-47 17332344-11 2007 Indeed, a 2-fold increase in APE1/Ref-1 expression, obtained by cDNA transfection, resulted in a 2-fold increase in NF-kappaB DNA-binding activity, and both of which were down-regulated by soy isoflavones, confirming the cross-talk between these molecules and, in turn, causing radiosensitization. Isoflavones 193-204 nuclear factor kappa B subunit 1 Homo sapiens 116-125 14707277-4 2003 Soy isoflavone genistein promotes apoptosis by decreasing NF-kappaB activity. Isoflavones 0-14 nuclear factor kappa B subunit 1 Homo sapiens 58-67 11368927-0 2001 Soy isoflavone supplementation in healthy men prevents NF-kappa B activation by TNF-alpha in blood lymphocytes. Isoflavones 4-14 nuclear factor kappa B subunit 1 Homo sapiens 55-65 11368927-4 2001 We have previously demonstrated that the soy isoflavone, genistein, inhibits the activation of the redox-sensitive transcription factor, NF-kappa B, in prostate cancer cells in vitro. Isoflavones 45-55 nuclear factor kappa B subunit 1 Homo sapiens 137-147 11368927-6 2001 Additionally, we investigated the in vivo effect of soy isoflavone supplementation on NF-kappa B activation induced by TNF-alpha in vitro in peripheral blood lymphocytes of six healthy men. Isoflavones 56-66 nuclear factor kappa B subunit 1 Homo sapiens 86-96 11368927-7 2001 We show that healthy male subjects receiving 50 mg isoflavone mixture (Novasoy) twice daily for 3 weeks are protected from TNF-alpha induced NF-kappa B activation. Isoflavones 51-61 nuclear factor kappa B subunit 1 Homo sapiens 141-151 11368927-10 2001 This preliminary study demonstrates that soy isoflavone supplementation may protect cells from oxidative stress-inducing agents by inhibiting NF-kappa B activation and decreasing DNA adduct levels. Isoflavones 45-55 nuclear factor kappa B subunit 1 Homo sapiens 142-152