PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11836071-12	2002	One week of treatment with the same isoflavone diet produced an effect opposite to that of estradiol in the PVN, increasing ERbeta mRNA expression above control levels.	Isoflavones	36-46	estrogen receptor 2	Rattus norvegicus	124-130	
12021182-2	2002	In a previous study, we found that an isoflavone supplement, containing a mixture of soy phytoestrogens, inhibited estrogen-dependent female sexual behavior and was antiestrogenic for both ER alpha- and ER beta-dependent gene expression in the hypothalamus.	Isoflavones	38-48	estrogen receptor 2	Rattus norvegicus	203-210	
19141699-5	2009	Expression of estrogen receptor (ER)-beta was assessed in rat colon tumors and in DLD-1 human colon adenocarcinoma cells exposed to soy isoflavones.	Isoflavones	136-147	estrogen receptor 2	Rattus norvegicus	14-41	
19141699-8	2009	Expression of ERbeta increased in colon tumors of soy isoflavone-treated groups compared with the control.	Isoflavones	54-64	estrogen receptor 2	Rattus norvegicus	14-20	
19141699-11	2009	The overexpression of ERbeta in both rat colon tumors and DLD-1 cells caused by soy isoflavones suggests that ERbeta is a critical mediator in mitigating its cancer-preventive effects.	Isoflavones	84-95	estrogen receptor 2	Rattus norvegicus	22-28	
17266774-0	2007	AVPV neurons containing estrogen receptor-beta in adult male rats are influenced by soy isoflavones.	Isoflavones	88-99	estrogen receptor 2	Rattus norvegicus	24-46	
17266774-10	2007	When estrogen receptor (ER) alpha and beta were examined by immunohistochemistry, we observed a 22% reduction of ERbeta-positive cell numbers in AVPV with consumption of soy isoflavones, whereas no significant change in ERalpha-positive cell numbers was detected.	Isoflavones	174-185	estrogen receptor 2	Rattus norvegicus	113-119	
17266774-13	2007	CONCLUSION: In summary, these findings provide direct evidence that consumption of soy isoflavones, but not the exposure to equol, influences the loss of ERbeta-containing neurons in male AVPV.	Isoflavones	87-98	estrogen receptor 2	Rattus norvegicus	154-160	
14643853-5	2003	ERbeta function was therefore manipulated by feeding rat diets differing in soya isoflavone content.	Isoflavones	81-91	estrogen receptor 2	Rattus norvegicus	0-6	
10359841-4	1999	Treatment of ovariectomized female rats with the isoflavone phytoestrogen genistein, which shows 20-fold higher binding affinity to ERbeta than to ERalpha, or with 17beta-estradiol, which does not differentiate between the two receptors, provides similar dose-dependent vasculoprotective effect in rat carotid injury model.	Isoflavones	49-59	estrogen receptor 2	Rattus norvegicus	132-138	
11416015-1	2001	Epidemiological evidence suggests that isoflavone phytoestrogens may reduce the risk of cancer, osteoporosis, and heart disease, effects at least partially mediated by estrogen receptors alpha and beta (ERalpha and ERbeta).	Isoflavones	39-49	estrogen receptor 2	Rattus norvegicus	215-221	
11416015-9	2001	These results suggest that isoflavone phytoestrogens are antiestrogenic on both ERalpha- and ERbeta-dependent gene expression in the brain and estrogen-dependent behavior.	Isoflavones	27-37	estrogen receptor 2	Rattus norvegicus	93-99	
29374955-2	2018	Genistein isa soy-derived isoflavone that exerts antioxidant effects by binding to estrogen receptors (ERs), ERalphaand ERbeta.	Isoflavones	26-36	estrogen receptor 2	Rattus norvegicus	120-126	
24426188-5	2014	The mRNA and protein expression of estrogen receptor beta were significantly higher in isoflavone treatment groups than those in control group group.	Isoflavones	87-97	estrogen receptor 2	Rattus norvegicus	35-57	
28077306-3	2017	Most isoflavones have a higher affinity for ERbeta, which is involved in sexually dimorphic behavioral regulation.	Isoflavones	5-16	estrogen receptor 2	Rattus norvegicus	44-50	
23297501-1	2012	OBJECTIVE: To investigate the effects of pre- and post-natal exposure to soy isoflavones (SIF) on the related indicators of the reproductive system development and ER-beta expression in male rat offspring.	Isoflavones	77-88	estrogen receptor 2	Rattus norvegicus	164-171	
22449546-1	2012	S-equol is a selective estrogen receptor beta (ERbeta) agonist which is produced in certain individuals after ingestion of its precursor daidzein, an isoflavone present in soy.	Isoflavones	150-160	estrogen receptor 2	Rattus norvegicus	23-45	
22449546-1	2012	S-equol is a selective estrogen receptor beta (ERbeta) agonist which is produced in certain individuals after ingestion of its precursor daidzein, an isoflavone present in soy.	Isoflavones	150-160	estrogen receptor 2	Rattus norvegicus	47-53	
22249396-0	2012	Soy isoflavones administered pre- and postnatally may affect the ERalpha and ERbeta expression and elements" content in bones of mature male rats.	Isoflavones	0-15	estrogen receptor 2	Rattus norvegicus	77-83	
22249396-1	2012	The aim of this study was to assess the influence of soy isoflavones, administered pre- and later postnatally, on the estrogen receptor alpha (ERalpha) and beta (ERbeta) expression in bones and to examine the mineral metabolism of the skeletal system in male rats.	Isoflavones	57-68	estrogen receptor 2	Rattus norvegicus	162-168