PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24062607-10 2013 Isoflavone led to a stronger descent of the concentration of ALP and a decrease of IL-6 and TNF-alpha level than placebo. Isoflavones 0-10 interleukin 6 Homo sapiens 83-87 32979840-8 2020 Subgroup analysis showed that soy supplementation had a significant impact on decreasing IL-6 and TNF-alpha levels when studies had a long-term intervention (>=12 weeks) and used low dose isoflavone (<100 mg/day). Isoflavones 188-198 interleukin 6 Homo sapiens 89-93 24267042-0 2013 Soy proteins and isoflavones reduce interleukin-6 but not serum lipids in older women: a randomized controlled trial. Isoflavones 17-28 interleukin 6 Homo sapiens 36-49 24062607-11 2013 For climacteric women, soy isoflavone in the dose of 90 mg/day could improve some menopausal syndromes and was effective on increasing limb bone density, which maybe had the relationship with the levels of IL-6, TNF-alpha and ALP in serum. Isoflavones 27-37 interleukin 6 Homo sapiens 206-210 22440466-4 2011 In addition, the serum concentrations of IGF-I and interleukin-6 were increased by high levels of soy isoflavones (P < 0.05). Isoflavones 102-113 interleukin 6 Homo sapiens 51-64 12150965-0 2002 Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway. Isoflavones 0-11 interleukin 6 Homo sapiens 21-34 12150965-1 2002 The hypothesis tested in this in vitro study was that the expression and production of dietary isoflavone-mediated osteoclastogenesis-regulatory cytokines, such as interleukin-6 (IL-6) and osteoprotegerin (OPG), are related to the different levels of estrogen receptors expressed in two hFOB osteoblastic cell lines. Isoflavones 95-105 interleukin 6 Homo sapiens 164-177 12150965-1 2002 The hypothesis tested in this in vitro study was that the expression and production of dietary isoflavone-mediated osteoclastogenesis-regulatory cytokines, such as interleukin-6 (IL-6) and osteoprotegerin (OPG), are related to the different levels of estrogen receptors expressed in two hFOB osteoblastic cell lines. Isoflavones 95-105 interleukin 6 Homo sapiens 179-183 12150965-4 2002 The increased expression of OPG and decreased IL-6 production by isoflavones were dose-dependent. Isoflavones 65-76 interleukin 6 Homo sapiens 46-50 12150965-6 2002 After adding the ER binding blocker, ICI-182,780, the effects of isoflavones on OPG and IL-6 production disappeared. Isoflavones 65-76 interleukin 6 Homo sapiens 88-92 12150965-7 2002 In summary, the inhibition by dietary isoflavones of IL-6 production and the stimulation of OPG appear to be mediated, at least in part, via a genomic pathway operating through estrogen receptors and gene expression mechanisms. Isoflavones 38-49 interleukin 6 Homo sapiens 53-57 34630655-7 2021 The present study revealed that among the isoflavone derivatives examined (daidzein, genistein and glycitein), daidzein inhibited the production of IL-6, but not IL-8, by IL-1beta-stimulated synovial MH7A cells via the suppression of NF-kappaB p65 and ERK1/2 activation. Isoflavones 42-52 interleukin 6 Homo sapiens 148-152 16651441-1 2006 We have analyzed in molecular detail how soy isoflavones (genistein, daidzein, and biochanin A) suppress nuclear factor-kappaB (NF-kappaB)-driven interleukin-6 (IL6) expression. Isoflavones 45-56 interleukin 6 Homo sapiens 146-159 16651441-1 2006 We have analyzed in molecular detail how soy isoflavones (genistein, daidzein, and biochanin A) suppress nuclear factor-kappaB (NF-kappaB)-driven interleukin-6 (IL6) expression. Isoflavones 45-56 interleukin 6 Homo sapiens 161-164 16651441-3 2006 Our results in estrogen-unresponsive fibroblasts, mitogen- and stress-activated protein kinase (MSK) knockout cells, and estrogen receptor (ER)-deficient breast tumor cells show that phytoestrogenic isoflavones can selectively block nuclear NF-kappaB transactivation of specific target genes (in particular IL6), independently of their estrogenic activity. Isoflavones 199-210 interleukin 6 Homo sapiens 307-310 15313415-0 2004 Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Isoflavones 0-14 interleukin 6 Homo sapiens 40-53 14723336-0 2003 Inhibition of IL-1beta and IL-6 in osteoblast-like cell by isoflavones extracted from Sophorae fructus. Isoflavones 59-70 interleukin 6 Homo sapiens 27-31 12077742-7 2002 Assessing the results of men and women separately, women showed significantly higher interleukin-6 (IL-6) values after the high-isoflavone soy diet (P =.013) compared to control values. Isoflavones 128-138 interleukin 6 Homo sapiens 85-98 12077742-7 2002 Assessing the results of men and women separately, women showed significantly higher interleukin-6 (IL-6) values after the high-isoflavone soy diet (P =.013) compared to control values. Isoflavones 128-138 interleukin 6 Homo sapiens 100-104 12077742-8 2002 For women, the difference between the high- and low-isoflavone IL-6 values was significant using the unadjusted data (P =.048) but not after adjustment. Isoflavones 52-62 interleukin 6 Homo sapiens 63-67 12077742-10 2002 Thus, high levels of isoflavone intake appear to increase serum concentrations of IL-6 in women. Isoflavones 21-31 interleukin 6 Homo sapiens 82-86 34455600-0 2022 The efficacy of soy isoflavones combined with soy protein on serum concentration of interleukin-6 and tumor necrosis factor-alpha among postmenopausal women? Isoflavones 20-31 interleukin 6 Homo sapiens 84-97 34455600-3 2022 The present study aimed to summarize the effect of soy isoflavones and soy protein on circulating interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in postmenopausal women. Isoflavones 55-66 interleukin 6 Homo sapiens 98-111 34455600-3 2022 The present study aimed to summarize the effect of soy isoflavones and soy protein on circulating interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in postmenopausal women. Isoflavones 55-66 interleukin 6 Homo sapiens 113-117 34455600-9 2022 In subgroup analysis, soy isoflavones plus soy protein could increase the serum concentration of IL-6 in studies with soy isoflavones dose <=87 mg/d, cross-over design, weak quality, and studies on participants who had health risk factors or diseases. Isoflavones 26-37 interleukin 6 Homo sapiens 97-101 34455600-9 2022 In subgroup analysis, soy isoflavones plus soy protein could increase the serum concentration of IL-6 in studies with soy isoflavones dose <=87 mg/d, cross-over design, weak quality, and studies on participants who had health risk factors or diseases. Isoflavones 122-133 interleukin 6 Homo sapiens 97-101