PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21161820-2 2011 Soy isoflavones decreased the expression of proliferating cell nuclear antigen (PCNA), extracellular signal-regulated kinase (ERK)-1/2, AKT, and nuclear factor (NF)-kappaB. Isoflavones 4-15 mitogen-activated protein kinase 3 Homo sapiens 87-134 17156992-4 2007 All four isoflavones (10 micromol/L) significantly increased ERK1/2 activity in RWPE-1 cells, as determined by immunoblotting. Isoflavones 9-20 mitogen-activated protein kinase 3 Homo sapiens 61-67 17156992-5 2007 Isoflavone-induced ERK1/2 activation was rapid and sustained for approximately 2 h posttreatment. Isoflavones 0-10 mitogen-activated protein kinase 3 Homo sapiens 19-25 17156992-10 2007 The ability of isoflavones to modulate ERK1/2 signaling cascade via VEGFR signaling in the prostate may be responsible, in part, for the anticancer activity of soy. Isoflavones 15-26 mitogen-activated protein kinase 3 Homo sapiens 39-45 16840783-0 2006 The isoflavone Equol mediates rapid vascular relaxation: Ca2+-independent activation of endothelial nitric-oxide synthase/Hsp90 involving ERK1/2 and Akt phosphorylation in human endothelial cells. Isoflavones 4-14 mitogen-activated protein kinase 3 Homo sapiens 138-144 16840783-6 2006 Our findings provide the first evidence that nutritionally relevant plasma concentrations of equol (and other soy protein isoflavones) rapidly stimulate phosphorylation of ERK1/2 and phosphatidylinositol 3-kinase/Akt, leading to the activation of NOS and increased NO production at resting cytosolic Ca2+ levels. Isoflavones 122-133 mitogen-activated protein kinase 3 Homo sapiens 172-178 29761845-0 2018 The O-methylated isoflavone, formononetin, inhibits human ovarian cancer cell proliferation by sub G0/G1 cell phase arrest through PI3K/AKT and ERK1/2 inactivation. Isoflavones 17-27 mitogen-activated protein kinase 3 Homo sapiens 144-150 19679176-7 2009 RESULTS: Our in vitro studies showed that UVB-induced HaCaT cell death and the phosphorylation of p38, JNK, and ERK1/2 decreased in the presence of isoflavone extract. Isoflavones 148-158 mitogen-activated protein kinase 3 Homo sapiens 112-118 17404070-10 2007 The COX-2 stimulatory effect of soy-isoflavones appeared to be modulated by ERK-1 and -2 and p38. Isoflavones 32-47 mitogen-activated protein kinase 3 Homo sapiens 76-88 15071348-0 2004 The isoflavone metabolite cis-tetrahydrodaidzein inhibits ERK-1 activation and proliferation in human vascular smooth muscle cells. Isoflavones 4-14 mitogen-activated protein kinase 3 Homo sapiens 58-63 15071348-7 2004 Thus, the isoflavone metabolite cis-THD inhibits PDGF-induced ERK-1 activation and cell proliferation in human VSMC, suggesting a potential beneficial effect in cardiovascular protection. Isoflavones 10-20 mitogen-activated protein kinase 3 Homo sapiens 62-67 34630655-7 2021 The present study revealed that among the isoflavone derivatives examined (daidzein, genistein and glycitein), daidzein inhibited the production of IL-6, but not IL-8, by IL-1beta-stimulated synovial MH7A cells via the suppression of NF-kappaB p65 and ERK1/2 activation. Isoflavones 42-52 mitogen-activated protein kinase 3 Homo sapiens 252-258