PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31928160-10 2021 For example, genistein which is a widely studied isoflavone has known AR antagonist property. Isoflavones 49-59 androgen receptor Homo sapiens 70-72 22200028-2 2011 Emerging experimental evidence shows that isoflavones could induce cancer cell death by regulating multiple cellular signaling pathways including Akt, NF-kappaB, MAPK, Wnt, androgen receptor (AR), p53 and Notch signaling, all of which have been found to be deregulated in cancer cells. Isoflavones 42-53 androgen receptor Homo sapiens 173-190 22200028-2 2011 Emerging experimental evidence shows that isoflavones could induce cancer cell death by regulating multiple cellular signaling pathways including Akt, NF-kappaB, MAPK, Wnt, androgen receptor (AR), p53 and Notch signaling, all of which have been found to be deregulated in cancer cells. Isoflavones 42-53 androgen receptor Homo sapiens 192-194 18687691-0 2008 Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells. Isoflavones 59-69 androgen receptor Homo sapiens 35-37 18687691-5 2008 Therefore, we investigated the molecular effects of isoflavone on the Akt/FOXO3a/GSK-3beta/AR signaling network in hormone-sensitive LNCaP and hormone-insensitive C4-2B PCa cells. Isoflavones 52-62 androgen receptor Homo sapiens 91-93 18687691-6 2008 We found that isoflavone inhibited the phosphorylation of Akt and FOXO3a, regulated the phosphorylation of Src, and increased the expression of GSK-3beta, leading to the down-regulation of AR and its target gene PSA. Isoflavones 14-24 androgen receptor Homo sapiens 189-191 18687691-7 2008 We also found that isoflavone inhibited AR nuclear translocation and promoted FOXO3a translocation to the nucleus. Isoflavones 19-29 androgen receptor Homo sapiens 40-42 18687691-8 2008 By electrophoretic mobility shift assay and chromatin immunoprecipitation assay, we found that isoflavone inhibited FOXO3a binding to the promoter of AR and increased FOXO3a binding to the p27(KIP1) promoter, resulting in the alteration of AR and p27(KIP1) expression, the inhibition of cell proliferation, and the induction of apoptosis in both androgen-sensitive and -insensitive PCa cells. Isoflavones 95-105 androgen receptor Homo sapiens 150-152 18687691-8 2008 By electrophoretic mobility shift assay and chromatin immunoprecipitation assay, we found that isoflavone inhibited FOXO3a binding to the promoter of AR and increased FOXO3a binding to the p27(KIP1) promoter, resulting in the alteration of AR and p27(KIP1) expression, the inhibition of cell proliferation, and the induction of apoptosis in both androgen-sensitive and -insensitive PCa cells. Isoflavones 95-105 androgen receptor Homo sapiens 240-242 18687691-9 2008 These results suggest that isoflavone-induced inhibition of cell proliferation and induction of apoptosis are partly mediated through the regulation of the Akt/FOXO3a/GSK-3beta/AR signaling network. Isoflavones 27-37 androgen receptor Homo sapiens 177-179 18852123-2 2008 The soy isoflavone genistein has been shown previously to down-regulate AR in androgen-dependent prostate cancer cell lines such as LNCaP. Isoflavones 8-18 androgen receptor Homo sapiens 72-74 17585029-0 2007 Isoflavone-rich soy protein isolate suppresses androgen receptor expression without altering estrogen receptor-beta expression or serum hormonal profiles in men at high risk of prostate cancer. Isoflavones 0-10 androgen receptor Homo sapiens 47-64 30680195-6 2019 An important strategy for the prevention and/or treatment of prostate cancer might thus be the action of soy isoflavones on the AR signaling pathway. Isoflavones 109-120 androgen receptor Homo sapiens 128-130 30680195-7 2019 The current review article provides a detailed overview of the anticancer potential of soy isoflavones (genistein, daidzein and glycitein), as mediated by their effect on AR. Isoflavones 91-102 androgen receptor Homo sapiens 171-173 27088761-8 2016 Taken together, soy isoflavones, especially equol, appear to be promising as chemopreventive and therapeutic agents for prostate cancer based on the fact that equol augments Skp2-mediated androgen receptor degradation. Isoflavones 20-31 androgen receptor Homo sapiens 188-205 23872207-6 2014 Phytoestrogens such as isoflavones can have a marked impact on the most essential therapy target of CRPC i.e. the androgen receptor. Isoflavones 23-34 androgen receptor Homo sapiens 114-131 22422102-6 2012 Based on our previous observations, we hypothesize that the effects of isoflavones on prostate carcinogenesis are mainly mediated through the down regulation of androgen receptor (AR) and AR activity in AA men is higher due to its shorter length of Glutamine repeats in its N-terminus. Isoflavones 71-82 androgen receptor Homo sapiens 161-178 22422102-6 2012 Based on our previous observations, we hypothesize that the effects of isoflavones on prostate carcinogenesis are mainly mediated through the down regulation of androgen receptor (AR) and AR activity in AA men is higher due to its shorter length of Glutamine repeats in its N-terminus. Isoflavones 71-82 androgen receptor Homo sapiens 180-182 22422102-6 2012 Based on our previous observations, we hypothesize that the effects of isoflavones on prostate carcinogenesis are mainly mediated through the down regulation of androgen receptor (AR) and AR activity in AA men is higher due to its shorter length of Glutamine repeats in its N-terminus. Isoflavones 71-82 androgen receptor Homo sapiens 188-190