PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15355849-8 2005 Disruption of c-myc expression using specific c-myc antisense oligomers not only inhibited normal cell growth (without DFMO) but also prevented the restoration of cell proliferation by spermidine in polyamine-deficient cells. Spermidine 185-195 MYC proto-oncogene, bHLH transcription factor Homo sapiens 14-19 15355849-8 2005 Disruption of c-myc expression using specific c-myc antisense oligomers not only inhibited normal cell growth (without DFMO) but also prevented the restoration of cell proliferation by spermidine in polyamine-deficient cells. Spermidine 185-195 MYC proto-oncogene, bHLH transcription factor Homo sapiens 46-51 35100927-2 2022 Polyamines (putrescine, spermidine, spermine) are critical for mammalian cell proliferation and MYC coordinately regulates polyamine metabolism through ornithine decarboxylase (ODC). Spermidine 24-34 MYC proto-oncogene, bHLH transcription factor Homo sapiens 96-99 35100927-4 2022 Spermidine is required for the hypusine-dependent activation of eukaryotic translation initiation factors 5A1 (eIF5A1) and 5A2 (eIF5A2) and connects the MYC/ODC-induced deregulation of spermidine to eIF5A1/2 protein translation, which is increased during cancer cell proliferation. Spermidine 0-10 MYC proto-oncogene, bHLH transcription factor Homo sapiens 153-156 35100927-4 2022 Spermidine is required for the hypusine-dependent activation of eukaryotic translation initiation factors 5A1 (eIF5A1) and 5A2 (eIF5A2) and connects the MYC/ODC-induced deregulation of spermidine to eIF5A1/2 protein translation, which is increased during cancer cell proliferation. Spermidine 185-195 MYC proto-oncogene, bHLH transcription factor Homo sapiens 153-156 2511847-4 1989 Our data demonstrate that depletion of spermidine results in a 60-90% decrease in c-myc mRNA steady state levels. Spermidine 39-49 MYC proto-oncogene, bHLH transcription factor Homo sapiens 82-87