PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8550737-3 1996 Spermidine depletion induced by the ornithine decarboxylase inhibitor, alpha-difluoromethylornithine (DFMO), resulted in complete cytostasis and loss of mitogenic response to either E2 or insulin (or IGF-I). Spermidine 0-10 insulin like growth factor 1 Homo sapiens 200-205 8550737-6 1996 E2 and either IGF-I or insulin induced early increases in putrescine and spermidine, but not spermine, contents in both MCF-7 and ZR-75-1 cells. Spermidine 73-83 insulin like growth factor 1 Homo sapiens 14-19 8550737-7 1996 Moreover, spermidine depletion and decarboxylated S-adenosylmethionine accumulation induced by DFMO required prior mitogenic stimulation by E2 and/or IGF-I. Spermidine 10-20 insulin like growth factor 1 Homo sapiens 150-155