PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21831529-0	2011	Spermidine may decrease ER stress in pancreatic beta cells and may reduce apoptosis via activating AMPK dependent autophagy pathway.	Spermidine	0-10	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	99-103	
21831529-10	2011	Hence either inhibition of mTOR or activation of AMPK by spermidine will play two crucial roles, first being the activation of autophagy and secondly the reduction of endoplasmic reticulum stress which will reduce beta cell death by apoptosis and thus can be a novel therapeutic candidate in the treatment of insulin resistance in type 2 diabetes and preserving pancreatic beta cell mass.	Spermidine	57-67	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	49-53