PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26973410-9 2016 Considering its unique property of using simple nutrients such as calcium, polyamines, and certain amino acids/oligopeptides as activators, it is possible that through targeting of CaSR with a combination of specific nutrients, novel oral rehydrating solutions that are inexpensive and practical to use in all countries may be developed. Polyamines 75-85 calcium sensing receptor Homo sapiens 181-185 27458380-11 2016 Considering the essential roles CaSR plays in gastrointestinal physiology and immunology, research may lead to a translational opportunity for the development of novel therapies that are based on CaSR"s unique property of using simple nutrients such as calcium, polyamines, and certain amino acids/oligopeptides as activators. Polyamines 262-272 calcium sensing receptor Homo sapiens 32-36 27458380-11 2016 Considering the essential roles CaSR plays in gastrointestinal physiology and immunology, research may lead to a translational opportunity for the development of novel therapies that are based on CaSR"s unique property of using simple nutrients such as calcium, polyamines, and certain amino acids/oligopeptides as activators. Polyamines 262-272 calcium sensing receptor Homo sapiens 196-200 23267858-2 2013 While extracellular calcium (Ca(2+)o) is considered the primary physiological ligand, the CaSR is activated physiologically by a plethora of molecules including polyamines and l-amino acids. Polyamines 161-171 calcium sensing receptor Homo sapiens 90-94 27692178-1 2016 The extracellular calcium-sensing receptor (CaSR) is a unique G protein-coupled receptor (GPCR) activated by extracellular Ca2+ and by other physiological cations including Mg2+, amino acids, and polyamines. Polyamines 196-206 calcium sensing receptor Homo sapiens 18-42 27692178-1 2016 The extracellular calcium-sensing receptor (CaSR) is a unique G protein-coupled receptor (GPCR) activated by extracellular Ca2+ and by other physiological cations including Mg2+, amino acids, and polyamines. Polyamines 196-206 calcium sensing receptor Homo sapiens 44-48 26144376-10 2015 Polyamines act to prevent cAMP-mediated Cl(-) hypersecretion in the colon, acting through CaSR to inhibit PKC-mediated [Ca(2+)]i release from intracellular stores. Polyamines 0-10 calcium sensing receptor Homo sapiens 90-94 16938272-1 2006 The Calcium-Sensing Receptor (CaSR) is a G-protein-coupled receptor that regulates calcium homeostasis by altering parathyroid hormone release, and which binds divalent and trivalent cations, amino acids, polyamines, and polycationic ligands. Polyamines 205-215 calcium sensing receptor Homo sapiens 4-28 21170870-2 2010 An important member of these "sensors" is the calcium-sensing receptor (CaSR), which is constantly monitoring the extracellular environment for changes in salinity, pH, calcium, amino acids and polyamines. Polyamines 194-204 calcium sensing receptor Homo sapiens 72-76 19779033-4 2009 Numerous agonists and modulators of the CaR are now known in addition to Ca2+(o), including various divalent and trivalent cations, aromatic l-amino acids, polyamines, and aminoglycoside antibiotics. Polyamines 156-166 calcium sensing receptor Homo sapiens 40-43 20336672-7 2010 In normal physiology as well as in pathologic conditions, CaSR is activated by signals arising from mineral ions, amino acids, polyamines, glutathione, and amyloid-beta in conjunction with Ca(2+) and other divalent cationic ligands. Polyamines 127-137 calcium sensing receptor Homo sapiens 58-62 16938272-1 2006 The Calcium-Sensing Receptor (CaSR) is a G-protein-coupled receptor that regulates calcium homeostasis by altering parathyroid hormone release, and which binds divalent and trivalent cations, amino acids, polyamines, and polycationic ligands. Polyamines 205-215 calcium sensing receptor Homo sapiens 30-34 16782456-3 2006 In many cells and tissues, CaR also acts as a coincidence detector, sensing both changes in extracellular Ca(2+) plus the presence of various allosteric activators including amino acids, polyamines, and/or peptides. Polyamines 187-197 calcium sensing receptor Homo sapiens 27-30 9357776-0 1997 The Ca2+-sensing receptor: a target for polyamines. Polyamines 40-50 calcium sensing receptor Homo sapiens 4-25 15667336-4 2005 While calcium is the physiological agonist of the receptor, several other polyvalent cations and polycations can also modulate CaR function as do certain L-aromatic amino acids, polyamines, salinity and pH. Polyamines 178-188 calcium sensing receptor Homo sapiens 127-130 9357776-2 1997 Polyamines are endogenous polyvalent cations that can act as agonists for the CaR, as shown by our current studies of human embryonic kidney (HEK-293) cells transfected with the human CaR. Polyamines 0-10 calcium sensing receptor Homo sapiens 78-81 9357776-2 1997 Polyamines are endogenous polyvalent cations that can act as agonists for the CaR, as shown by our current studies of human embryonic kidney (HEK-293) cells transfected with the human CaR. Polyamines 0-10 calcium sensing receptor Homo sapiens 184-187 9357776-9 1997 These data suggest that polyamines could be effective agonists for the CaR, and several tissues, including the brain, may use the CaR as a target for the actions of spermine and other endogenous polycationic agonists. Polyamines 24-34 calcium sensing receptor Homo sapiens 71-74 31717830-3 2019 The calcium sensing receptor (CaSR) is a unique G protein-coupled receptor (GPCR) activated by extracellular Ca2+ and by other physiological cations, aminoacids, and polyamines. Polyamines 166-176 calcium sensing receptor Homo sapiens 4-28 32467152-3 2020 The calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor that responds to multiple endogenous agonists and allosteric modulators, including divalent and trivalent cations, L-amino acids, gamma-glutamyl peptides, polyamines, polycationic peptides, and protons. Polyamines 231-241 calcium sensing receptor Homo sapiens 4-28 32467152-3 2020 The calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor that responds to multiple endogenous agonists and allosteric modulators, including divalent and trivalent cations, L-amino acids, gamma-glutamyl peptides, polyamines, polycationic peptides, and protons. Polyamines 231-241 calcium sensing receptor Homo sapiens 30-34 31717830-3 2019 The calcium sensing receptor (CaSR) is a unique G protein-coupled receptor (GPCR) activated by extracellular Ca2+ and by other physiological cations, aminoacids, and polyamines. Polyamines 166-176 calcium sensing receptor Homo sapiens 30-34 30626206-2 2019 Approach and Results- Metabonomic screen of eEVs from cigarette-smoking human subjects reveals prominent elevation of spermine-a polyamine metabolite with potent agonist activity for the extracellular CaSR (calcium-sensing receptor). Polyamines 129-138 calcium sensing receptor Homo sapiens 201-205 30626206-2 2019 Approach and Results- Metabonomic screen of eEVs from cigarette-smoking human subjects reveals prominent elevation of spermine-a polyamine metabolite with potent agonist activity for the extracellular CaSR (calcium-sensing receptor). Polyamines 129-138 calcium sensing receptor Homo sapiens 207-231