PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26835380-6 2015 However, polyamines are also critical for mammalian cell proliferation and the finding that MYC coordinately regulates all aspects of polyamine metabolism suggests polyamines may be required to support cancer promotion by MYC. Polyamines 164-174 MYC proto-oncogene, bHLH transcription factor Homo sapiens 92-95 26178413-4 2015 Increased mRNA expressions of c-myc protooncogene and ornithine decarboxylase (ODC), biosynthetic enzyme of polyamines, were detected in Bag-1L+ cells, and western blots against the protein product of c-Myc and ODC confirmed these findings. Polyamines 108-118 MYC proto-oncogene, bHLH transcription factor Homo sapiens 30-35 26178413-5 2015 Once ODC, a c-Myc target, gets activated, polyamine biosynthesis increases. Polyamines 42-51 MYC proto-oncogene, bHLH transcription factor Homo sapiens 12-17 26178413-10 2015 In this line, our results suggested that Bag-1 indirectly affects cell survival through c-Myc activated signalling that causes elevation of ODC levels, leading to an increase of the polyamine content. Polyamines 182-191 MYC proto-oncogene, bHLH transcription factor Homo sapiens 88-93 26835380-6 2015 However, polyamines are also critical for mammalian cell proliferation and the finding that MYC coordinately regulates all aspects of polyamine metabolism suggests polyamines may be required to support cancer promotion by MYC. Polyamines 164-174 MYC proto-oncogene, bHLH transcription factor Homo sapiens 222-225 25808495-8 2015 Depletion of cellular polyamines also increased CELF1 and enhanced CELF1 association with Myc mRNA, thus suppressing MYC translation. Polyamines 22-32 MYC proto-oncogene, bHLH transcription factor Homo sapiens 90-93 25808495-8 2015 Depletion of cellular polyamines also increased CELF1 and enhanced CELF1 association with Myc mRNA, thus suppressing MYC translation. Polyamines 22-32 MYC proto-oncogene, bHLH transcription factor Homo sapiens 117-120 23144800-7 2012 Moreover, a decrease in intracellular polyamine concentrations stimulated by methylglyoxal-bis(guanylhydrazone) (MGBG) enhanced the ACTD-induced inhibition of c-myc transcription and DNA replication in several cancer cell lines. Polyamines 38-47 MYC proto-oncogene, bHLH transcription factor Homo sapiens 159-164 21693166-2 2011 The effect of the natural polyamines on telomeric and some oncogenic G-quadruplexes including bcl-2, c-kit, and c-myc G-quadruplexes has been studied by using absorption, fluorescence, CD, and NMR methods. Polyamines 26-36 MYC proto-oncogene, bHLH transcription factor Homo sapiens 112-117 22195744-4 2011 Metabolic tracer analysis revealed a Myc-dependent metabolic pathway linking glutaminolysis to the biosynthesis of polyamines. Polyamines 115-125 MYC proto-oncogene, bHLH transcription factor Homo sapiens 37-40 19812253-5 2009 In cells with high content of cellular polyamines, HuR silencing or Chk2 silencing reduced c-Myc translation and c-Myc expression levels. Polyamines 39-49 MYC proto-oncogene, bHLH transcription factor Homo sapiens 91-96 19812253-0 2009 Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation. Polyamines 0-10 MYC proto-oncogene, bHLH transcription factor Homo sapiens 20-25 19812253-4 2009 Depletion of cellular polyamines inhibited Chk2 and reduced the affinity of HuR for c-Myc mRNA; these effects were completely reversed by addition of the polyamine putrescine or by Chk2 overexpression. Polyamines 22-32 MYC proto-oncogene, bHLH transcription factor Homo sapiens 84-89 19812253-4 2009 Depletion of cellular polyamines inhibited Chk2 and reduced the affinity of HuR for c-Myc mRNA; these effects were completely reversed by addition of the polyamine putrescine or by Chk2 overexpression. Polyamines 22-31 MYC proto-oncogene, bHLH transcription factor Homo sapiens 84-89 20103728-3 2010 report new evidence (beginning on p. 140 in this issue of the journal) indicating that spermidine synthase, a fellow enzyme of ornithine decarboxylase in polyamine metabolism, is transactivated in part by the MYC gene and is a potential target for chemoprevention of B-cell lymphomas. Polyamines 154-163 MYC proto-oncogene, bHLH transcription factor Homo sapiens 209-212 19812253-5 2009 In cells with high content of cellular polyamines, HuR silencing or Chk2 silencing reduced c-Myc translation and c-Myc expression levels. Polyamines 39-49 MYC proto-oncogene, bHLH transcription factor Homo sapiens 113-118 19812253-6 2009 Our findings demonstrate that polyamines regulate c-Myc translation in IECs through HuR phosphorylation by Chk2 and provide new insight into the molecular functions of cellular polyamines. Polyamines 30-40 MYC proto-oncogene, bHLH transcription factor Homo sapiens 50-55 19176757-0 2009 Polyamines regulate E-cadherin transcription through c-Myc modulating intestinal epithelial barrier function. Polyamines 0-10 MYC proto-oncogene, bHLH transcription factor Homo sapiens 53-58 19789308-5 2009 The rate-limiting enzyme in polyamine biosynthesis, ODC, is a bona fide MYC target, as are other regulatory enzymes in this pathway. Polyamines 28-37 MYC proto-oncogene, bHLH transcription factor Homo sapiens 72-75 19789308-7 2009 Studies with transgenic cancer models also support the finding that the effect of MYC on tumor initiation and progression can be attenuated through the repression of polyamine production. Polyamines 166-175 MYC proto-oncogene, bHLH transcription factor Homo sapiens 82-85 19789308-8 2009 High-risk neuroblastomas (an often lethal embryonal tumor in which MYC activation is paramount) deregulate numerous polyamine enzymes to promote the expansion of intracellular polyamine pools. Polyamines 116-125 MYC proto-oncogene, bHLH transcription factor Homo sapiens 67-70 19789308-8 2009 High-risk neuroblastomas (an often lethal embryonal tumor in which MYC activation is paramount) deregulate numerous polyamine enzymes to promote the expansion of intracellular polyamine pools. Polyamines 176-185 MYC proto-oncogene, bHLH transcription factor Homo sapiens 67-70 19789308-10 2009 Here, we review the potential clinical application of these and additional polyamine depletion agents to neuroblastoma and other advanced cancers in which MYC is operative. Polyamines 75-84 MYC proto-oncogene, bHLH transcription factor Homo sapiens 155-158 19324889-0 2009 Elevated polyamines induce c-MYC overexpression by perturbing quadruplex-WC duplex equilibrium. Polyamines 9-19 MYC proto-oncogene, bHLH transcription factor Homo sapiens 27-32 19324889-3 2009 Herein, using c-MYC quadruplex model, we have attempted to understand quadruplex-polyamine interaction and its role in transcriptional regulation. Polyamines 81-90 MYC proto-oncogene, bHLH transcription factor Homo sapiens 14-19 19324889-5 2009 Our study demonstrates that polyamines affect the c-MYC quadruplex conformation, perturb its recognition properties and delays duplex formation. Polyamines 28-38 MYC proto-oncogene, bHLH transcription factor Homo sapiens 50-55 19324889-6 2009 The relative free energy difference (DeltaDeltaG degrees) between the duplex and quadruplex structure indicate that polyamines stabilize and favor c-MYC quadruplex over duplex. Polyamines 116-126 MYC proto-oncogene, bHLH transcription factor Homo sapiens 147-152 19324889-7 2009 Further, we investigated the influence of polyamine mediated perturbation of this equilibrium on c-MYC expression. Polyamines 42-51 MYC proto-oncogene, bHLH transcription factor Homo sapiens 97-102 19324889-8 2009 Our results suggest that polyamines induce structural transition of c-MYC quadruplex to a transcriptionally active motif with distinctive molecular recognition property, which drives c-MYC expression. Polyamines 25-35 MYC proto-oncogene, bHLH transcription factor Homo sapiens 68-73 19324889-8 2009 Our results suggest that polyamines induce structural transition of c-MYC quadruplex to a transcriptionally active motif with distinctive molecular recognition property, which drives c-MYC expression. Polyamines 25-35 MYC proto-oncogene, bHLH transcription factor Homo sapiens 183-188 19176757-5 2009 Decreasing cellular polyamines reduced c-Myc and repressed E-cadherin transcription as indicated by a decrease in levels of E-cadherin promoter activity and its mRNA. Polyamines 20-30 MYC proto-oncogene, bHLH transcription factor Homo sapiens 39-44 19176757-6 2009 Forced expression of the c-myc gene by infection with adenoviral vector containing c-Myc cDNA stimulated E-cadherin promoter activity and increased E-cadherin mRNA and protein levels in polyamine-deficient cells. Polyamines 186-195 MYC proto-oncogene, bHLH transcription factor Homo sapiens 25-30 19176757-6 2009 Forced expression of the c-myc gene by infection with adenoviral vector containing c-Myc cDNA stimulated E-cadherin promoter activity and increased E-cadherin mRNA and protein levels in polyamine-deficient cells. Polyamines 186-195 MYC proto-oncogene, bHLH transcription factor Homo sapiens 83-88 19176757-10 2009 These results indicate that polyamines enhance E-cadherin transcription by activating c-Myc, thus promoting function of the epithelial barrier. Polyamines 28-38 MYC proto-oncogene, bHLH transcription factor Homo sapiens 86-91 19147568-3 2009 A key downstream target of Myc oncoproteins in tumorigenesis is ornithine decarboxylase (Odc), the rate-limiting enzyme of polyamine biosynthesis. Polyamines 123-132 MYC proto-oncogene, bHLH transcription factor Homo sapiens 27-30 17680562-6 2007 Upregulation of genes involved in polyamine synthesis, methionine salvage and downregulation of polyamine negative regulator OAZ1, was highest in c-Myc/Tgf-alpha HCCs and HCCP. Polyamines 34-43 MYC proto-oncogene, bHLH transcription factor Homo sapiens 146-151 17680562-6 2007 Upregulation of genes involved in polyamine synthesis, methionine salvage and downregulation of polyamine negative regulator OAZ1, was highest in c-Myc/Tgf-alpha HCCs and HCCP. Polyamines 96-105 MYC proto-oncogene, bHLH transcription factor Homo sapiens 146-151 9462700-4 1998 Specificity of the downregulation of MYC expression by BESpm treatment was demonstrated by comparison to effects on the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase (SSAT) and the polyamine biosynthetic enzyme ornithine decarboxylase (ODC). Polyamines 203-212 MYC proto-oncogene, bHLH transcription factor Homo sapiens 37-40 16706751-0 2006 Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region. Polyamines 0-9 MYC proto-oncogene, bHLH transcription factor Homo sapiens 20-25 16706751-2 2006 Our previous studies have shown that polyamines are essential for expression of the c-myc gene and that polyamine-induced c-Myc plays a critical role in stimulation of normal IEC (intestinal epithelial cell) proliferation, but the exact downstream targets of induced c-Myc are still unclear. Polyamines 37-47 MYC proto-oncogene, bHLH transcription factor Homo sapiens 84-89 16706751-2 2006 Our previous studies have shown that polyamines are essential for expression of the c-myc gene and that polyamine-induced c-Myc plays a critical role in stimulation of normal IEC (intestinal epithelial cell) proliferation, but the exact downstream targets of induced c-Myc are still unclear. Polyamines 37-46 MYC proto-oncogene, bHLH transcription factor Homo sapiens 84-89 16706751-4 2006 The current study was designed to determine whether induced c-Myc stimulates normal IEC proliferation by repressing p21Cip1 transcription following up-regulation of polyamines. Polyamines 165-175 MYC proto-oncogene, bHLH transcription factor Homo sapiens 60-65 16706751-6 2006 In contrast, depletion of cellular polyamines by inhibiting ODC enzyme activity with alpha-difluoromethylornithine decreased c-Myc, but increased p21Cip1 transcription. Polyamines 35-45 MYC proto-oncogene, bHLH transcription factor Homo sapiens 125-130 16706751-7 2006 Ectopic expression of wild-type c-myc not only inhibited basal levels of p21Cip1 transcription in control cells, but also prevented increased p21Cip1 in polyamine-deficient cells. Polyamines 153-162 MYC proto-oncogene, bHLH transcription factor Homo sapiens 32-37 16706751-9 2006 These findings confirm that p21Cip1 is one of the direct mediators of induced c-Myc following increased polyamines and that p21Cip1 repression by c-Myc is implicated in stimulation of normal IEC proliferation. Polyamines 104-114 MYC proto-oncogene, bHLH transcription factor Homo sapiens 78-83 15857080-13 2005 CONCLUSIONS: Our data show that as the polyamine content decreases, TGF-beta1, c-myc, MMP-1 and -2, and COL-I mRNA levels increase, therefore a negative regulatory role of the polyamines on the mRNA expression could be suggested. Polyamines 39-48 MYC proto-oncogene, bHLH transcription factor Homo sapiens 79-84 15355849-0 2005 Polyamine-modulated expression of c-myc plays a critical role in stimulation of normal intestinal epithelial cell proliferation. Polyamines 0-9 MYC proto-oncogene, bHLH transcription factor Homo sapiens 34-39 15355849-2 2005 Our previous studies indicated that cellular polyamines are absolutely required for cell proliferation in crypts of small intestinal mucosa and that polyamines have the ability to stimulate expression of the c-myc gene. Polyamines 149-159 MYC proto-oncogene, bHLH transcription factor Homo sapiens 208-213 15355849-3 2005 The current study went further to determine whether induced nuclear c-Myc plays a role in stimulation of cell proliferation by polyamines in intestinal crypt cells (IEC-6 line). Polyamines 127-137 MYC proto-oncogene, bHLH transcription factor Homo sapiens 68-73 15355849-6 2005 Depletion of cellular polyamines by pretreatment with alpha-difluoromethylornithine (DFMO) prevented increases in c-myc expression and DNA synthesis induced by 5% dFBS. Polyamines 22-32 MYC proto-oncogene, bHLH transcription factor Homo sapiens 114-119 15355849-7 2005 c-Myc gene transcription and cell proliferation decreased in polyamine-deficient cells, whereas the natural polyamine spermidine given together with DFMO maintained c-myc gene expression and cell growth at normal levels. Polyamines 61-70 MYC proto-oncogene, bHLH transcription factor Homo sapiens 0-5 15355849-8 2005 Disruption of c-myc expression using specific c-myc antisense oligomers not only inhibited normal cell growth (without DFMO) but also prevented the restoration of cell proliferation by spermidine in polyamine-deficient cells. Polyamines 199-208 MYC proto-oncogene, bHLH transcription factor Homo sapiens 14-19 15355849-8 2005 Disruption of c-myc expression using specific c-myc antisense oligomers not only inhibited normal cell growth (without DFMO) but also prevented the restoration of cell proliferation by spermidine in polyamine-deficient cells. Polyamines 199-208 MYC proto-oncogene, bHLH transcription factor Homo sapiens 46-51 15355849-10 2005 These results indicate that polyamine-induced nuclear c-Myc interacts with Max, binds to the specific DNA sequence, and plays an important role in stimulation of normal intestinal epithelial cell proliferation. Polyamines 28-37 MYC proto-oncogene, bHLH transcription factor Homo sapiens 54-59 12810952-3 2003 Ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, is a transcriptional target of c-myc and a modifier of APC-dependent tumorigenesis. Polyamines 51-60 MYC proto-oncogene, bHLH transcription factor Homo sapiens 103-108 11598794-0 2001 Down-modulation of c-myc expression by phorbol ester protects CEM T leukaemia cells from starvation-induced apoptosis: role of ornithine decarboxylase and polyamines. Polyamines 155-165 MYC proto-oncogene, bHLH transcription factor Homo sapiens 19-24 11443226-3 2001 Different polyamines, preferentially activated protein kinases (tyrosine kinases and MAP kinases), stimulated the expression of nuclear protooncogenes (myc, jun, and fos). Polyamines 10-20 MYC proto-oncogene, bHLH transcription factor Homo sapiens 152-155 10581008-0 1999 Polyamine depletion up-regulates c-Myc expression, yet induces G(1) arrest and terminal differentiation of F9 teratocarcinoma stem cells. Polyamines 0-9 MYC proto-oncogene, bHLH transcription factor Homo sapiens 33-38 10581008-5 1999 In transfection experiments, using ODC promoter-reporter gene fusion constructs, the accumulation of c-Myc protein, resulting from polyamine depletion, led to increased reporter gene expression. Polyamines 131-140 MYC proto-oncogene, bHLH transcription factor Homo sapiens 101-106 10581008-6 1999 This finding is consistent with the view that depletion of polyamines relieves the suppression that they exert on c-myc mRNA translation, causing an accumulation of c-Myc protein, which in turn transactivates its target gene, the bona fide ODC gene. Polyamines 59-69 MYC proto-oncogene, bHLH transcription factor Homo sapiens 114-119 10581008-6 1999 This finding is consistent with the view that depletion of polyamines relieves the suppression that they exert on c-myc mRNA translation, causing an accumulation of c-Myc protein, which in turn transactivates its target gene, the bona fide ODC gene. Polyamines 59-69 MYC proto-oncogene, bHLH transcription factor Homo sapiens 165-170 10581008-8 1999 These results suggest a new role for polyamines-as negative regulators of c-Myc expression. Polyamines 37-47 MYC proto-oncogene, bHLH transcription factor Homo sapiens 74-79 10535358-0 1999 The c-myc gene regulates the polyamine pathway in DMSO-induced apoptosis. Polyamines 29-38 MYC proto-oncogene, bHLH transcription factor Homo sapiens 4-9 10535358-5 1999 Ornithine decarboxylase (ODC), a key enzyme involved in polyamine biosynthesis, is regulated by c-myc, which is a transcriptional activator implicated not only in the control of cell proliferation and differentiation but also in programmed cell death. Polyamines 56-65 MYC proto-oncogene, bHLH transcription factor Homo sapiens 96-101 16439861-7 2006 c-Myc induces expression of the ornithine decarboxylase (ODC) gene, which synthesizes polyamines that are necessary for cell growth. Polyamines 86-96 MYC proto-oncogene, bHLH transcription factor Homo sapiens 0-5 16382048-5 2005 Loss of APC function leads to alterations in c-Myc-regulated genes including ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis. Polyamines 128-137 MYC proto-oncogene, bHLH transcription factor Homo sapiens 45-50 15768429-3 2005 The polyamines (PA) are compounds playing a relevant role in both protein synthesis processes and cell differentiation through c-myc and c-fos gene activation. Polyamines 4-14 MYC proto-oncogene, bHLH transcription factor Homo sapiens 127-132 15768429-3 2005 The polyamines (PA) are compounds playing a relevant role in both protein synthesis processes and cell differentiation through c-myc and c-fos gene activation. Polyamines 16-18 MYC proto-oncogene, bHLH transcription factor Homo sapiens 127-132 10423165-3 1999 In our current study, we showed that the Km values for purified CKII were similar for casein and Myc oncoprotein under a variety of assay conditions, and that specific natural and synthetic polyamines stimulated CKII phosphorylation of Myc oncoprotein 2- to 20-fold via increases in Vmax. Polyamines 190-200 MYC proto-oncogene, bHLH transcription factor Homo sapiens 236-239 10423165-5 1999 Because the Myc oncoprotein transactivates several genes for key proteins involved in the regulation of cellular proliferation, including the omithine decarboxylase gene (rate-limiting enzyme of polyamine synthesis), we suggest that there may be linkages between polyamines, CKII, and Myc in the control of cellular proliferation. Polyamines 195-204 MYC proto-oncogene, bHLH transcription factor Homo sapiens 12-15 10423165-5 1999 Because the Myc oncoprotein transactivates several genes for key proteins involved in the regulation of cellular proliferation, including the omithine decarboxylase gene (rate-limiting enzyme of polyamine synthesis), we suggest that there may be linkages between polyamines, CKII, and Myc in the control of cellular proliferation. Polyamines 195-204 MYC proto-oncogene, bHLH transcription factor Homo sapiens 285-288 10423165-5 1999 Because the Myc oncoprotein transactivates several genes for key proteins involved in the regulation of cellular proliferation, including the omithine decarboxylase gene (rate-limiting enzyme of polyamine synthesis), we suggest that there may be linkages between polyamines, CKII, and Myc in the control of cellular proliferation. Polyamines 263-273 MYC proto-oncogene, bHLH transcription factor Homo sapiens 12-15 10423165-5 1999 Because the Myc oncoprotein transactivates several genes for key proteins involved in the regulation of cellular proliferation, including the omithine decarboxylase gene (rate-limiting enzyme of polyamine synthesis), we suggest that there may be linkages between polyamines, CKII, and Myc in the control of cellular proliferation. Polyamines 263-273 MYC proto-oncogene, bHLH transcription factor Homo sapiens 285-288 9462700-0 1998 Inhibition of cell growth in CaCO2 cells by the polyamine analogue N1,N12-bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levels. Polyamines 48-57 MYC proto-oncogene, bHLH transcription factor Homo sapiens 123-126 8929217-6 1996 In addition, reporter gene expression was induced approximately 3 fold in stable transformants containing an integrated c-myc or ODC promoter-reporter gene construct suggesting that elevated levels of polyamines, such as those found in transformed cells, have a stimulatory effect on gene expression. Polyamines 201-211 MYC proto-oncogene, bHLH transcription factor Homo sapiens 120-125 35100927-2 2022 Polyamines (putrescine, spermidine, spermine) are critical for mammalian cell proliferation and MYC coordinately regulates polyamine metabolism through ornithine decarboxylase (ODC). Polyamines 0-10 MYC proto-oncogene, bHLH transcription factor Homo sapiens 96-99 7567474-0 1995 Suppression of c-myc oncogene expression by a polyamine-complexed triplex forming oligonucleotide in MCF-7 breast cancer cells. Polyamines 46-55 MYC proto-oncogene, bHLH transcription factor Homo sapiens 15-20 8695842-1 1996 Ornithine decarboxylase (ODC), a rate-limiting enzyme of polyamine biosynthesis, has been shown to be required for entry into and progression through the cell cycle and to be a transcriptional target of the proto-oncogene, c-myc. Polyamines 57-66 MYC proto-oncogene, bHLH transcription factor Homo sapiens 207-228 1378845-2 1992 Our previous studies have determined that depletion of intracellular polyamines by alpha-difluoromethylornithine results in a marked decrease in the transcription of the human c-myc gene. Polyamines 69-79 MYC proto-oncogene, bHLH transcription factor Homo sapiens 176-181 1378845-4 1992 These studies demonstrate that polyamine depletion of the human colon cancer cell line COLO 320 results in induction of an endogenous RNA transcript with high homology to the antisense strand of the second intervening sequence (PvuII-RsaI) of the c-myc gene. Polyamines 31-40 MYC proto-oncogene, bHLH transcription factor Homo sapiens 247-252 35100927-3 2022 ODC is a MYC target gene and rate-limiting enzyme of polyamine biosynthesis and the FDA-approved anti-protozoan drug alpha-difluoromethylornithine (DFMO) inhibits ODC activity and induces polyamine depletion that leads to tumor growth arrest. Polyamines 188-197 MYC proto-oncogene, bHLH transcription factor Homo sapiens 9-12 35100927-2 2022 Polyamines (putrescine, spermidine, spermine) are critical for mammalian cell proliferation and MYC coordinately regulates polyamine metabolism through ornithine decarboxylase (ODC). Polyamines 123-132 MYC proto-oncogene, bHLH transcription factor Homo sapiens 96-99 35100927-3 2022 ODC is a MYC target gene and rate-limiting enzyme of polyamine biosynthesis and the FDA-approved anti-protozoan drug alpha-difluoromethylornithine (DFMO) inhibits ODC activity and induces polyamine depletion that leads to tumor growth arrest. Polyamines 53-62 MYC proto-oncogene, bHLH transcription factor Homo sapiens 9-12 3325885-1 1987 The mRNA expression of c-myc and N-myc in the human neuroblastoma cell line SH-SY5Y was found not to change appreciably during the cell cycle and was also unaffected by proliferative inhibition induced by serum starvation or polyamine depletion. Polyamines 225-234 MYC proto-oncogene, bHLH transcription factor Homo sapiens 23-28 3128541-0 1988 Effect of polyamine depletion on c-myc expression in human colon carcinoma cells. Polyamines 10-19 MYC proto-oncogene, bHLH transcription factor Homo sapiens 33-38 3128541-3 1988 In the present study, we demonstrate that polyamine depletion induced by 2-difluoromethylornithine in COLO 320 human colon carcinoma cells results in a greater than 90% decrease in expression of a key gene in the maintenance of cell growth, the c-myc protooncogene. Polyamines 42-51 MYC proto-oncogene, bHLH transcription factor Homo sapiens 245-250 3128541-4 1988 The decrease in c-myc expression accompanying polyamine depletion appears to occur at the transcriptional level. Polyamines 46-55 MYC proto-oncogene, bHLH transcription factor Homo sapiens 16-21 3128541-8 1988 These studies demonstrate that polyamines may be critical to the expression of c-myc and suggest one mechanism by which they modulate cell growth. Polyamines 31-41 MYC proto-oncogene, bHLH transcription factor Homo sapiens 79-84 2511847-2 1989 Our previous studies have shown that generalized polyamine depletion of the human colon cancer cell line COLO 320 by 2-difluoromethylornithine is associated with decreased transcription of the c-myc, c-fos, and ornithine decarboxylase (ODC) genes. Polyamines 49-58 MYC proto-oncogene, bHLH transcription factor Homo sapiens 193-198 32380424-1 2020 Myc has emerged as a pivotal transcription factor for four metabolic pathways: aerobic glycolysis, glutaminolysis, polyamine synthesis, and HIF-1alpha/mTOR. Polyamines 115-124 MYC proto-oncogene, bHLH transcription factor Homo sapiens 0-3 32786875-3 2020 Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the biosynthesis of polyamines, which are oncometabolites that contribute to cell proliferation in NB and other c-MYC/MYCN-driven cancers. Polyamines 79-89 MYC proto-oncogene, bHLH transcription factor Homo sapiens 171-176 31164374-7 2019 MYC-driven SCLC preferentially depends on arginine-regulated pathways including polyamine biosynthesis and mTOR pathway activation. Polyamines 80-89 MYC proto-oncogene, bHLH transcription factor Homo sapiens 0-3 30404920-0 2018 Polyamine synthesis as a target of MYC oncogenes. Polyamines 0-9 MYC proto-oncogene, bHLH transcription factor Homo sapiens 35-38 30404920-5 2018 ODC and polyamine levels are often up-regulated and contribute to tumor hyperproliferation, especially of MYC-driven cancers. Polyamines 8-17 MYC proto-oncogene, bHLH transcription factor Homo sapiens 106-109 30404920-7 2018 We discuss the regulation of ODC and polyamines, which besides their well-known interactions with DNA and tRNA/rRNA, are involved in regulating RNA transcription and translation, ribosome function, proteasomal degradation, the circadian clock, and immunity, events that are also controlled by MYC proteins. Polyamines 37-47 MYC proto-oncogene, bHLH transcription factor Homo sapiens 293-296 31064849-4 2019 Mechanistically, PGC1alpha inhibits the expression of c-MYC and ornithine decarboxylase 1 (ODC1), the rate-limiting enzyme for polyamine synthesis. Polyamines 127-136 MYC proto-oncogene, bHLH transcription factor Homo sapiens 54-59 31064849-5 2019 Analysis of in vivo metastases and clinical data from patients with prostate cancer support the proposition that the PGC1alpha/c-MYC/ODC1 axis regulates polyamine biosynthesis and prostate cancer aggressiveness. Polyamines 153-162 MYC proto-oncogene, bHLH transcription factor Homo sapiens 127-132 29799508-5 2018 Polyamine metabolism is coordinately regulated by MYC to increase polyamines in proliferative tissues, and this is further augmented in the many cancer cells harboring hyperactivated MYC. Polyamines 0-9 MYC proto-oncogene, bHLH transcription factor Homo sapiens 50-53 29799508-5 2018 Polyamine metabolism is coordinately regulated by MYC to increase polyamines in proliferative tissues, and this is further augmented in the many cancer cells harboring hyperactivated MYC. Polyamines 0-9 MYC proto-oncogene, bHLH transcription factor Homo sapiens 183-186 29799508-5 2018 Polyamine metabolism is coordinately regulated by MYC to increase polyamines in proliferative tissues, and this is further augmented in the many cancer cells harboring hyperactivated MYC. Polyamines 66-76 MYC proto-oncogene, bHLH transcription factor Homo sapiens 50-53 29799508-6 2018 In this review, we discuss MYC-driven regulation of polyamines and protein synthetic capacity as a key function of its oncogenic output, and how this dependency may be perturbed through direct pharmacologic targeting of components of the protein synthetic machinery, such as the polyamines themselves, the eukaryotic translation initiation factor 4F (eIF4F) complex, and the eukaryotic translation initiation factor 5A (eIF5A). Polyamines 52-62 MYC proto-oncogene, bHLH transcription factor Homo sapiens 27-30 29799508-6 2018 In this review, we discuss MYC-driven regulation of polyamines and protein synthetic capacity as a key function of its oncogenic output, and how this dependency may be perturbed through direct pharmacologic targeting of components of the protein synthetic machinery, such as the polyamines themselves, the eukaryotic translation initiation factor 4F (eIF4F) complex, and the eukaryotic translation initiation factor 5A (eIF5A). Polyamines 279-289 MYC proto-oncogene, bHLH transcription factor Homo sapiens 27-30 29445227-4 2018 Polyamines, the inducer of AZ2, also destabilize c-Myc in an AZ2-dependent manner. Polyamines 0-10 MYC proto-oncogene, bHLH transcription factor Homo sapiens 49-54