PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12426106-1 2002 Ornithine decarboxylase antizyme 1 and 2 (OAZ1 and OAZ2) are expressed ubiquitously, and control the intracellular concentration of polyamines. Polyamines 132-142 ornithine decarboxylase antizyme 1 Mus musculus 0-40 18369191-1 2008 Antizyme inhibitor (AzI) regulates cellular polyamine homeostasis by binding to the polyamine-induced protein, Antizyme (Az), with greater affinity than ornithine decarboxylase (ODC). Polyamines 44-53 ornithine decarboxylase antizyme 1 Mus musculus 0-8 18369191-1 2008 Antizyme inhibitor (AzI) regulates cellular polyamine homeostasis by binding to the polyamine-induced protein, Antizyme (Az), with greater affinity than ornithine decarboxylase (ODC). Polyamines 44-53 ornithine decarboxylase antizyme 1 Mus musculus 111-119 18369191-1 2008 Antizyme inhibitor (AzI) regulates cellular polyamine homeostasis by binding to the polyamine-induced protein, Antizyme (Az), with greater affinity than ornithine decarboxylase (ODC). Polyamines 84-93 ornithine decarboxylase antizyme 1 Mus musculus 0-8 18369191-1 2008 Antizyme inhibitor (AzI) regulates cellular polyamine homeostasis by binding to the polyamine-induced protein, Antizyme (Az), with greater affinity than ornithine decarboxylase (ODC). Polyamines 84-93 ornithine decarboxylase antizyme 1 Mus musculus 111-119 16568078-2 2006 Antizyme inhibitor retains no enzymatic activity, but exhibits high affinity to antizyme (Az), a negative regulator of polyamine homeostasis. Polyamines 119-128 ornithine decarboxylase antizyme 1 Mus musculus 80-88 16568078-2 2006 Antizyme inhibitor retains no enzymatic activity, but exhibits high affinity to antizyme (Az), a negative regulator of polyamine homeostasis. Polyamines 119-128 ornithine decarboxylase antizyme 1 Mus musculus 90-92 16568078-7 2006 These effects of AzI are a result of its ability to neutralize Az, as overexpression of an AzI mutant with reduced Az binding failed to alter cellular polyamine metabolism and growth properties. Polyamines 151-160 ornithine decarboxylase antizyme 1 Mus musculus 17-19 22562773-6 2012 The genes involved in the regulation of polyamine synthesis (AZ1, AZ2 and AZIN1) were expressed in all the renal zones, predominantly in the cortex, while AZIN2 gene was more abundant in the OS. Polyamines 40-49 ornithine decarboxylase antizyme 1 Mus musculus 61-64 19997757-1 2010 Ornithine decarboxylase (ODC), antizyme (AZ), and antizyme inhibitor (AIn) play a key role in regulation of intracellular polyamine levels by forming a regulatory circuit through their interactions. Polyamines 122-131 ornithine decarboxylase antizyme 1 Mus musculus 31-39 19997757-1 2010 Ornithine decarboxylase (ODC), antizyme (AZ), and antizyme inhibitor (AIn) play a key role in regulation of intracellular polyamine levels by forming a regulatory circuit through their interactions. Polyamines 122-131 ornithine decarboxylase antizyme 1 Mus musculus 50-58 12941943-1 2003 Antizyme-1 (AZ1) is a protein that negatively regulates polyamine synthesis by inhibiting the key synthetic enzyme ornithine decarboxylase and targeting it for degradation by the 26 S proteasome. Polyamines 56-65 ornithine decarboxylase antizyme 1 Mus musculus 0-10 12941943-1 2003 Antizyme-1 (AZ1) is a protein that negatively regulates polyamine synthesis by inhibiting the key synthetic enzyme ornithine decarboxylase and targeting it for degradation by the 26 S proteasome. Polyamines 56-65 ornithine decarboxylase antizyme 1 Mus musculus 12-15 12873989-1 2003 Antizyme (AZ) is known to be a regulator of polyamine metabolism that inhibits ornithine decarboxylase activity and polyamine transport, thus restricting polyamine levels. Polyamines 44-53 ornithine decarboxylase antizyme 1 Mus musculus 0-8 12873989-1 2003 Antizyme (AZ) is known to be a regulator of polyamine metabolism that inhibits ornithine decarboxylase activity and polyamine transport, thus restricting polyamine levels. Polyamines 44-53 ornithine decarboxylase antizyme 1 Mus musculus 10-12 12873989-1 2003 Antizyme (AZ) is known to be a regulator of polyamine metabolism that inhibits ornithine decarboxylase activity and polyamine transport, thus restricting polyamine levels. Polyamines 116-125 ornithine decarboxylase antizyme 1 Mus musculus 0-8 12873989-1 2003 Antizyme (AZ) is known to be a regulator of polyamine metabolism that inhibits ornithine decarboxylase activity and polyamine transport, thus restricting polyamine levels. Polyamines 116-125 ornithine decarboxylase antizyme 1 Mus musculus 10-12 12873989-1 2003 Antizyme (AZ) is known to be a regulator of polyamine metabolism that inhibits ornithine decarboxylase activity and polyamine transport, thus restricting polyamine levels. Polyamines 116-125 ornithine decarboxylase antizyme 1 Mus musculus 0-8 12873989-1 2003 Antizyme (AZ) is known to be a regulator of polyamine metabolism that inhibits ornithine decarboxylase activity and polyamine transport, thus restricting polyamine levels. Polyamines 116-125 ornithine decarboxylase antizyme 1 Mus musculus 10-12 12426106-1 2002 Ornithine decarboxylase antizyme 1 and 2 (OAZ1 and OAZ2) are expressed ubiquitously, and control the intracellular concentration of polyamines. Polyamines 132-142 ornithine decarboxylase antizyme 1 Mus musculus 42-46 11507056-2 2001 AZ is a multifunctional regulator of polyamine metabolism that inhibits ODC activity, stimulates ODC degradation, and suppresses polyamine uptake. Polyamines 37-46 ornithine decarboxylase antizyme 1 Mus musculus 0-2 11856366-1 2002 Antizyme is a polyamine-induced cellular protein that binds to ornithine decarboxylase (ODC), and targets it to rapid ubiquitin-independent degradation by the 26S proteasome. Polyamines 14-23 ornithine decarboxylase antizyme 1 Mus musculus 0-8 11507056-2 2001 AZ is a multifunctional regulator of polyamine metabolism that inhibits ODC activity, stimulates ODC degradation, and suppresses polyamine uptake. Polyamines 129-138 ornithine decarboxylase antizyme 1 Mus musculus 0-2 10970775-3 2000 Antizyme-1 is thought to be a major factor in regulating cellular polyamine content, acting both to inhibit ornithine decarboxylase (ODC) activity and to target it for degradation, as well as preventing polyamine uptake. Polyamines 66-75 ornithine decarboxylase antizyme 1 Mus musculus 0-10 11241834-3 2001 Inactivation of ODC is mainly exerted by antizyme (AZ), a 20--25 kDa polyamine-induced protein that binds to ODC, inactivates it, and targets it for degradation by the 26S proteasome without ubiquitination. Polyamines 69-78 ornithine decarboxylase antizyme 1 Mus musculus 41-49 11241834-3 2001 Inactivation of ODC is mainly exerted by antizyme (AZ), a 20--25 kDa polyamine-induced protein that binds to ODC, inactivates it, and targets it for degradation by the 26S proteasome without ubiquitination. Polyamines 69-78 ornithine decarboxylase antizyme 1 Mus musculus 51-53 11241834-5 2001 The expression patterns for ODC and AZ were found to be developmentally regulated, suggesting important functions for the polyamines in early embryogenesis, axonogenesis, epithelial-mesenchymal interaction, and in apoptosis. Polyamines 122-132 ornithine decarboxylase antizyme 1 Mus musculus 36-38 11241834-9 2001 The presence of AZ in the nucleus may suggest that nuclear ODC activity is under tight control, and that polyamine production can be rapidly interrupted when those developmental events, which depend on access to nuclear polyamines, have been completed. Polyamines 220-230 ornithine decarboxylase antizyme 1 Mus musculus 16-18 10970775-3 2000 Antizyme-1 is thought to be a major factor in regulating cellular polyamine content, acting both to inhibit ornithine decarboxylase (ODC) activity and to target it for degradation, as well as preventing polyamine uptake. Polyamines 203-212 ornithine decarboxylase antizyme 1 Mus musculus 0-10 10698696-5 2000 By causing ribosomal frameshifting, polyamines induce the synthesis of antizyme, a 23-kDa protein, which binds to ODC, inhibits its activity and promotes its degradation by the 26 S proteasome. Polyamines 36-46 ornithine decarboxylase antizyme 1 Mus musculus 71-79 10698696-11 2000 Our results indicate that induction of AZI synthesis may represent a means of rescuing ODC molecules that have been inactivated and tagged for degradation by antizyme, when culture conditions improve and polyamine production is needed for cell growth and proliferation. Polyamines 204-213 ornithine decarboxylase antizyme 1 Mus musculus 158-166 8090747-3 1994 Since antizyme is the only protein thus far recognized that can interact with ODC, depletion of free antizyme was regarded as the reason for the abnormal accumulation of polyamines. Polyamines 170-180 ornithine decarboxylase antizyme 1 Mus musculus 6-14 8090747-0 1994 Antizyme protects against abnormal accumulation and toxicity of polyamines in ornithine decarboxylase-overproducing cells. Polyamines 64-74 ornithine decarboxylase antizyme 1 Mus musculus 0-8 9210404-1 1997 Ornithine decarboxylase antizyme is a protein that participates in the regulation of cellular polyamine levels. Polyamines 94-103 ornithine decarboxylase antizyme 1 Mus musculus 24-32 8090747-3 1994 Since antizyme is the only protein thus far recognized that can interact with ODC, depletion of free antizyme was regarded as the reason for the abnormal accumulation of polyamines. Polyamines 170-180 ornithine decarboxylase antizyme 1 Mus musculus 101-109 8090747-6 1994 The results indicate that antizyme can regulate not only the amount of ODC but also the activity of polyamine transport. Polyamines 100-109 ornithine decarboxylase antizyme 1 Mus musculus 26-34 35563006-0 2022 Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions. Polyamines 8-17 ornithine decarboxylase antizyme 1 Mus musculus 42-50 35563006-7 2022 Thus, the (OAZ1)2-Polyamine complex may be needed to inhibit polyamine uptake. Polyamines 61-70 ornithine decarboxylase antizyme 1 Mus musculus 11-15 35563006-8 2022 The efficiency of polyamine-induced ribosomal +1 frameshifting of OAZ1 mRNA could also be differentially modulated by MeSpds-2-MeSpd was a poor inducer of OAZ1 biosynthesis and hence a poor downregulator of ODC activity unlike the other MeSpds. Polyamines 18-27 ornithine decarboxylase antizyme 1 Mus musculus 66-70 35563006-8 2022 The efficiency of polyamine-induced ribosomal +1 frameshifting of OAZ1 mRNA could also be differentially modulated by MeSpds-2-MeSpd was a poor inducer of OAZ1 biosynthesis and hence a poor downregulator of ODC activity unlike the other MeSpds. Polyamines 18-27 ornithine decarboxylase antizyme 1 Mus musculus 155-159 35563006-9 2022 These findings offer new insight into the OAZ1-mediated regulation of polyamine homeostasis and provide the chemical tools to study it. Polyamines 70-79 ornithine decarboxylase antizyme 1 Mus musculus 42-46 8074711-0 1994 Antizyme delays the restoration by spermine of growth of polyamine-deficient cells through its negative regulation of polyamine transport. Polyamines 57-66 ornithine decarboxylase antizyme 1 Mus musculus 0-8 8074711-0 1994 Antizyme delays the restoration by spermine of growth of polyamine-deficient cells through its negative regulation of polyamine transport. Polyamines 118-127 ornithine decarboxylase antizyme 1 Mus musculus 0-8 8074711-2 1994 Treatments of the transfected cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), and dexamethasone, an inducer of antizyme, both caused a decrease in ODC activity and polyamine contents and inhibition of cell growth. Polyamines 212-221 ornithine decarboxylase antizyme 1 Mus musculus 159-167 8074711-6 1994 These results clearly indicate that antizyme has dual functions: one for ODC degradation and the other for negative regulation of polyamine transport. Polyamines 130-139 ornithine decarboxylase antizyme 1 Mus musculus 36-44 35563006-2 2022 Their homeostasis is strictly controlled, and a key downregulator of the polyamine pool is the polyamine-inducible protein, antizyme 1 (OAZ1). Polyamines 73-82 ornithine decarboxylase antizyme 1 Mus musculus 95-134 35563006-2 2022 Their homeostasis is strictly controlled, and a key downregulator of the polyamine pool is the polyamine-inducible protein, antizyme 1 (OAZ1). Polyamines 73-82 ornithine decarboxylase antizyme 1 Mus musculus 136-140 35563006-3 2022 OAZ1 inhibits polyamine uptake and targets ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis, for proteasomal degradation. Polyamines 14-23 ornithine decarboxylase antizyme 1 Mus musculus 0-4 35563006-3 2022 OAZ1 inhibits polyamine uptake and targets ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis, for proteasomal degradation. Polyamines 102-111 ornithine decarboxylase antizyme 1 Mus musculus 0-4 35563006-4 2022 Here we report, for the first time, that polyamines induce dimerization of mouse recombinant full-length OAZ1, forming an (OAZ1)2-Polyamine complex. Polyamines 41-51 ornithine decarboxylase antizyme 1 Mus musculus 105-109 35563006-4 2022 Here we report, for the first time, that polyamines induce dimerization of mouse recombinant full-length OAZ1, forming an (OAZ1)2-Polyamine complex. Polyamines 41-51 ornithine decarboxylase antizyme 1 Mus musculus 123-127 35563006-6 2022 Importantly, the ability of compounds to inhibit polyamine uptake correlated with the efficiency of the (OAZ1)2-Polyamine complex formation. Polyamines 49-58 ornithine decarboxylase antizyme 1 Mus musculus 105-109 6432061-3 1984 The calcium chelator EGTA (pCa 6.4) inhibited basal and polyamine-stimulated antizyme activity, and this inhibition was prevented by concurrent incubation with calcium, but not with magnesium. Polyamines 56-65 ornithine decarboxylase antizyme 1 Mus musculus 77-85 24174210-7 2014 However, antizyme 1 overexpression caused only minor changes in tissue polyamine levels demonstrating the challenges in using the "antizyme approach" to deplete polyamines in a living animal. Polyamines 71-80 ornithine decarboxylase antizyme 1 Mus musculus 9-19 24174210-7 2014 However, antizyme 1 overexpression caused only minor changes in tissue polyamine levels demonstrating the challenges in using the "antizyme approach" to deplete polyamines in a living animal. Polyamines 161-171 ornithine decarboxylase antizyme 1 Mus musculus 9-19 28467636-3 2018 Due to their structural similarity to ODC, both AZIN1 and AZIN2 counteract the inhibitory action of 3 known antizymes (AZ1-3) on the ODC synthesis of polyamines, thus increasing intracytoplasmic levels of polyamines. Polyamines 150-160 ornithine decarboxylase antizyme 1 Mus musculus 119-124 28467636-3 2018 Due to their structural similarity to ODC, both AZIN1 and AZIN2 counteract the inhibitory action of 3 known antizymes (AZ1-3) on the ODC synthesis of polyamines, thus increasing intracytoplasmic levels of polyamines. Polyamines 205-215 ornithine decarboxylase antizyme 1 Mus musculus 119-124