PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27512953-4 2016 Inhibition of myeloperoxidase, which is essential for NET formation and can generate reactive chlorinated polyamines through hypochlorous acid, decreased polyamine incorporation. Polyamines 106-116 myeloperoxidase Homo sapiens 14-29 27512953-4 2016 Inhibition of myeloperoxidase, which is essential for NET formation and can generate reactive chlorinated polyamines through hypochlorous acid, decreased polyamine incorporation. Polyamines 106-115 myeloperoxidase Homo sapiens 14-29 34085520-0 2021 Polyamine-Conjugated Nitroxides Are Efficacious Inhibitors of Oxidative Reactions Catalyzed by Endothelial-Localized Myeloperoxidase. Polyamines 0-9 myeloperoxidase Homo sapiens 117-132 34085520-5 2021 Here we studied a series of piperidine nitroxides conjugated to polyamine moieties as novel endothelial-targeted MPO inhibitors. Polyamines 64-73 myeloperoxidase Homo sapiens 113-116 34085520-7 2021 Nitroxides effectively inhibited the consumption of MPO"s substrate hydrogen peroxide (H2O2) and formation of HOCl catalyzed by endothelial-localized MPO, with their efficacy dependent on both nitroxide and conjugated-polyamine structure. Polyamines 218-227 myeloperoxidase Homo sapiens 52-55 34085520-7 2021 Nitroxides effectively inhibited the consumption of MPO"s substrate hydrogen peroxide (H2O2) and formation of HOCl catalyzed by endothelial-localized MPO, with their efficacy dependent on both nitroxide and conjugated-polyamine structure. Polyamines 218-227 myeloperoxidase Homo sapiens 150-153 34085520-11 2021 Novel polyamine-conjugated nitroxides, ethylenediamine-TEMPO and putrescine-TEMPO, emerged as efficacious nitroxides uniquely exhibiting high endothelial cell uptake and efficient inhibition of MPO-catalyzed HOCl production, protein nitration, and NO oxidation. Polyamines 6-15 myeloperoxidase Homo sapiens 194-197 34085520-12 2021 Polyamine-conjugated nitroxides represent a versatile class of antioxidant drugs capable of targeting endothelial-localized MPO during vascular inflammation. Polyamines 0-9 myeloperoxidase Homo sapiens 124-127