PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25849284-4	2015	Apoptosis in the polyamine-depleted cells occurs by the mitochondrial intrinsic pathway, as evidenced by loss of mitochondrial membrane potential, increase in pro-apoptotic Bax, decrease in anti-apoptotic Bcl-xl, Bcl2 and Mcl-1 and release of cytochrome c from mitochondria, upon transduction with AdSAT1.	Polyamines	17-26	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	222-227	
16048438-0	2005	STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells.	Polyamines	78-87	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	39-44	
19250631-6	2009	Moreover, siRNA-mediated down-regulation of MCL-1 was found to counter-act the protective effect of polyamine inhibition.	Polyamines	100-109	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	44-49	
19250631-7	2009	We conclude that the polyamines regulate hypoxia-induced apoptosis in ECs through PI3K/AKT and MCL-1 dependent pathways.	Polyamines	21-31	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	95-100	
16048438-8	2005	Polyamine depletion increased mRNA and protein levels for Bcl-2, Mcl-1 (myeloid cell leukaemia-1) and c-IAP2 (inhibitor of apoptosis protein-2).	Polyamines	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	65-70	
19250631-0	2009	The polyamines regulate endothelial cell survival during hypoxic stress through PI3K/AKT and MCL-1.	Polyamines	4-14	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	93-98	
19250631-4	2009	Inhibition of the polyamines resulted in a significant induction of PI3K/AKT and its down-stream target MCL-1, i.e. an anti-apoptotic member of the BCL-2 family.	Polyamines	18-28	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	104-109	
19250631-5	2009	Specific inhibitors of PI3K reversed the decrease of hypoxia-induced apoptosis as well as the induction of MCL-1 in polyamine-deprived cells.	Polyamines	116-125	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	107-112