PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19473115-1 2009 SSAT (Spermidine/spermine N1-acetyltransferase, also known as SAT1), the key enzyme in the catabolism of polyamines, is turned over rapidly and there is only a low amount present in the cell. Polyamines 105-115 spermidine/spermine N1-acetyl transferase 1 Mus musculus 0-4 20012117-3 2010 SSAT induction results in an enhanced polyamine catabolism manifested as a depletion of spermidine and spermine and an overaccumulation of putrescine in all tissues. Polyamines 38-47 spermidine/spermine N1-acetyl transferase 1 Mus musculus 0-4 19473115-0 2009 Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts. Polyamines 129-138 spermidine/spermine N1-acetyl transferase 1 Mus musculus 42-82 19473115-1 2009 SSAT (Spermidine/spermine N1-acetyltransferase, also known as SAT1), the key enzyme in the catabolism of polyamines, is turned over rapidly and there is only a low amount present in the cell. Polyamines 105-115 spermidine/spermine N1-acetyl transferase 1 Mus musculus 6-46 19473115-1 2009 SSAT (Spermidine/spermine N1-acetyltransferase, also known as SAT1), the key enzyme in the catabolism of polyamines, is turned over rapidly and there is only a low amount present in the cell. Polyamines 105-115 spermidine/spermine N1-acetyl transferase 1 Mus musculus 62-66 19164485-1 2009 Expression of spermine/spermidine-N1-acetyltransferase (SSAT), the rate-limiting enzyme of polyamine backconversion cascade, increases after ischemia-reperfusion injuries (IRI). Polyamines 91-100 spermidine/spermine N1-acetyl transferase 1 Mus musculus 14-54 19164485-1 2009 Expression of spermine/spermidine-N1-acetyltransferase (SSAT), the rate-limiting enzyme of polyamine backconversion cascade, increases after ischemia-reperfusion injuries (IRI). Polyamines 91-100 spermidine/spermine N1-acetyl transferase 1 Mus musculus 56-60 17485446-2 2007 Here we demonstrate that transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N(1)-acetyltransferase (SSAT) had reduced white adipose tissue (WAT) mass, high basal metabolic rate, improved glucose tolerance, high insulin sensitivity, and enhanced expression of the OXPHOS genes, coordinated by increased levels of PGC-1 alpha and 5"-AMP-activated protein kinase (AMPK) in WAT. Polyamines 56-65 spermidine/spermine N1-acetyl transferase 1 Mus musculus 102-144 17675337-4 2007 This result suggests that toxic products such as reactive oxygen species and aldehydes liberated by the action of polyamine oxidase on the acetylated polyamines formed by SSAT may enhance tumor development. Polyamines 150-160 spermidine/spermine N1-acetyl transferase 1 Mus musculus 171-175 17485446-2 2007 Here we demonstrate that transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N(1)-acetyltransferase (SSAT) had reduced white adipose tissue (WAT) mass, high basal metabolic rate, improved glucose tolerance, high insulin sensitivity, and enhanced expression of the OXPHOS genes, coordinated by increased levels of PGC-1 alpha and 5"-AMP-activated protein kinase (AMPK) in WAT. Polyamines 56-65 spermidine/spermine N1-acetyl transferase 1 Mus musculus 146-150 17485446-3 2007 As accelerated polyamine flux caused by SSAT overexpression depleted the ATP pool in adipocytes of SSAT mice and N(1),N(11)-diethylnorspermine-treated wild-type fetal fibroblasts, we propose that low ATP levels lead to the induction of AMPK, which in turn activates PGC-1 alpha in WAT of SSAT mice. Polyamines 15-24 spermidine/spermine N1-acetyl transferase 1 Mus musculus 40-44 17485446-3 2007 As accelerated polyamine flux caused by SSAT overexpression depleted the ATP pool in adipocytes of SSAT mice and N(1),N(11)-diethylnorspermine-treated wild-type fetal fibroblasts, we propose that low ATP levels lead to the induction of AMPK, which in turn activates PGC-1 alpha in WAT of SSAT mice. Polyamines 15-24 spermidine/spermine N1-acetyl transferase 1 Mus musculus 99-103 17485446-3 2007 As accelerated polyamine flux caused by SSAT overexpression depleted the ATP pool in adipocytes of SSAT mice and N(1),N(11)-diethylnorspermine-treated wild-type fetal fibroblasts, we propose that low ATP levels lead to the induction of AMPK, which in turn activates PGC-1 alpha in WAT of SSAT mice. Polyamines 15-24 spermidine/spermine N1-acetyl transferase 1 Mus musculus 99-103 17485446-4 2007 Our hypothesis is supported by the finding that the phenotype of SSAT mice was reversed when the accelerated polyamine flux was reduced by the inhibition of polyamine biosynthesis in WAT. Polyamines 109-118 spermidine/spermine N1-acetyl transferase 1 Mus musculus 65-69 17485446-4 2007 Our hypothesis is supported by the finding that the phenotype of SSAT mice was reversed when the accelerated polyamine flux was reduced by the inhibition of polyamine biosynthesis in WAT. Polyamines 157-166 spermidine/spermine N1-acetyl transferase 1 Mus musculus 65-69 17125596-1 2006 The N(1)-acetylation of spermidine or spermine by spermidine/spermine N(1)-acetyltransferase (SSAT) is the ratecontrolling enzymatic step in the polyamine catabolism. Polyamines 145-154 spermidine/spermine N1-acetyl transferase 1 Mus musculus 50-92 17371273-2 2007 In particular, the polyamine catabolic enzyme SSAT (spermidine/spermine N(1)-acetyltransferase) seems to have different roles in tumorigenesis, depending upon the particular system being analysed. Polyamines 19-28 spermidine/spermine N1-acetyl transferase 1 Mus musculus 46-50 17371273-2 2007 In particular, the polyamine catabolic enzyme SSAT (spermidine/spermine N(1)-acetyltransferase) seems to have different roles in tumorigenesis, depending upon the particular system being analysed. Polyamines 19-28 spermidine/spermine N1-acetyl transferase 1 Mus musculus 52-94 17371283-3 2007 The enzymes ODC (ornithine decarboxylase), AdoMetDC (S-adenosylmethionine decarboxylase) and SSAT (spermidine/spermine N(1)-acetyltransferase) are critical for polyamine pool maintenance. Polyamines 160-169 spermidine/spermine N1-acetyl transferase 1 Mus musculus 99-141 17125596-1 2006 The N(1)-acetylation of spermidine or spermine by spermidine/spermine N(1)-acetyltransferase (SSAT) is the ratecontrolling enzymatic step in the polyamine catabolism. Polyamines 145-154 spermidine/spermine N1-acetyl transferase 1 Mus musculus 94-98 17125596-3 2006 Contrary to SSAT deficient ES cells, polyamine pools in SSAT-KO mice remained almost unchanged in response to N(1),N(11)-diethylnorspermine (DENSPM) treatment compared to a significant reduction of the polyamine pools in the wild-type animals and ES cells. Polyamines 37-46 spermidine/spermine N1-acetyl transferase 1 Mus musculus 56-60 17125596-5 2006 The latter finding indicates that inducible SSAT plays an essential role in vivo in DENSPM treatmentevoked polyamine depletion, but a controversial role in toxicity of DENSPM. Polyamines 107-116 spermidine/spermine N1-acetyl transferase 1 Mus musculus 44-48 17125596-7 2006 Further characterization of SSAT knockout mice revealed insulin resistance at old age which supported the role of polyamine catabolism in glucose metabolism detected earlier with our SSAT overexpressing mice displaying enhanced basal metabolic rate, high insulin sensitivity and improved glucose tolerance. Polyamines 114-123 spermidine/spermine N1-acetyl transferase 1 Mus musculus 28-32 17125596-7 2006 Further characterization of SSAT knockout mice revealed insulin resistance at old age which supported the role of polyamine catabolism in glucose metabolism detected earlier with our SSAT overexpressing mice displaying enhanced basal metabolic rate, high insulin sensitivity and improved glucose tolerance. Polyamines 114-123 spermidine/spermine N1-acetyl transferase 1 Mus musculus 183-187 16647090-1 2006 Nuclear factor erythroid 2-related factor 2 (Nrf-2) binds to a specific polyamine responsive element (PRE) in the promoter region of the spermidine-spermine acetyltransferase (SSAT) gene, a key component of the polyamine catabolic pathway. Polyamines 72-81 spermidine/spermine N1-acetyl transferase 1 Mus musculus 137-174 16647090-1 2006 Nuclear factor erythroid 2-related factor 2 (Nrf-2) binds to a specific polyamine responsive element (PRE) in the promoter region of the spermidine-spermine acetyltransferase (SSAT) gene, a key component of the polyamine catabolic pathway. Polyamines 72-81 spermidine/spermine N1-acetyl transferase 1 Mus musculus 176-180 16647090-1 2006 Nuclear factor erythroid 2-related factor 2 (Nrf-2) binds to a specific polyamine responsive element (PRE) in the promoter region of the spermidine-spermine acetyltransferase (SSAT) gene, a key component of the polyamine catabolic pathway. Polyamines 211-220 spermidine/spermine N1-acetyl transferase 1 Mus musculus 137-174 16647090-1 2006 Nuclear factor erythroid 2-related factor 2 (Nrf-2) binds to a specific polyamine responsive element (PRE) in the promoter region of the spermidine-spermine acetyltransferase (SSAT) gene, a key component of the polyamine catabolic pathway. Polyamines 211-220 spermidine/spermine N1-acetyl transferase 1 Mus musculus 176-180 15888550-5 2005 The expression of SSAT, the rate-limiting enzyme in the polyamine catabolic pathway, had increased fivefold 6 h after IRI and correlated with increased putrescine levels in the liver, consistent with increased SSAT enzymatic activity in IRI. Polyamines 56-65 spermidine/spermine N1-acetyl transferase 1 Mus musculus 18-22 16392825-4 2006 The efficient substitution of natural polyamines by their derivatives was confirmed in vivo with the rats harboring the same MT-SSAT transgene and in vitro with the immortalized fibroblasts derived from these animals. Polyamines 38-48 spermidine/spermine N1-acetyl transferase 1 Mus musculus 128-132 15888550-7 2005 The interaction of the polyamine pathway with the p53-p21 pathway was shown in vitro, where activation of SSAT with polyamine analog or the addition of putrescine to cultured hepatocytes induced the expression of p53 and p21 and decreased cell viability. Polyamines 23-32 spermidine/spermine N1-acetyl transferase 1 Mus musculus 106-110 15888550-7 2005 The interaction of the polyamine pathway with the p53-p21 pathway was shown in vitro, where activation of SSAT with polyamine analog or the addition of putrescine to cultured hepatocytes induced the expression of p53 and p21 and decreased cell viability. Polyamines 116-125 spermidine/spermine N1-acetyl transferase 1 Mus musculus 106-110 15958588-2 2005 Although most polyamine-based anticancer strategies target biosynthesis, we recently showed that activation of polyamine catabolism at the level of spermidine/spermine N(1)-acetyltransferase-1 (SSAT) suppresses tumor outgrowth in a mouse prostate cancer model. Polyamines 14-23 spermidine/spermine N1-acetyl transferase 1 Mus musculus 148-192 15958588-2 2005 Although most polyamine-based anticancer strategies target biosynthesis, we recently showed that activation of polyamine catabolism at the level of spermidine/spermine N(1)-acetyltransferase-1 (SSAT) suppresses tumor outgrowth in a mouse prostate cancer model. Polyamines 14-23 spermidine/spermine N1-acetyl transferase 1 Mus musculus 194-198 15958588-2 2005 Although most polyamine-based anticancer strategies target biosynthesis, we recently showed that activation of polyamine catabolism at the level of spermidine/spermine N(1)-acetyltransferase-1 (SSAT) suppresses tumor outgrowth in a mouse prostate cancer model. Polyamines 111-120 spermidine/spermine N1-acetyl transferase 1 Mus musculus 148-192 15958588-2 2005 Although most polyamine-based anticancer strategies target biosynthesis, we recently showed that activation of polyamine catabolism at the level of spermidine/spermine N(1)-acetyltransferase-1 (SSAT) suppresses tumor outgrowth in a mouse prostate cancer model. Polyamines 111-120 spermidine/spermine N1-acetyl transferase 1 Mus musculus 194-198 15958588-9 2005 Based on these data, we propose a model in which SSAT expression alters flux through the polyamine pathway giving rise to metabolic events that promote tumorigenesis. Polyamines 89-98 spermidine/spermine N1-acetyl transferase 1 Mus musculus 49-53 15276653-2 2004 We show that cisplatin significantly induces the expression of two enzymes critical to proper homeostasis of cellular polyamines, ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SSAT). Polyamines 118-128 spermidine/spermine N1-acetyl transferase 1 Mus musculus 164-204 15252047-1 2004 The enzyme spermidine/spermine N(1)-acetyltransferase (SSAT) regulates the catabolism and export of intracellular polyamines. Polyamines 114-124 spermidine/spermine N1-acetyl transferase 1 Mus musculus 11-53 15252047-1 2004 The enzyme spermidine/spermine N(1)-acetyltransferase (SSAT) regulates the catabolism and export of intracellular polyamines. Polyamines 114-124 spermidine/spermine N1-acetyl transferase 1 Mus musculus 55-59 15737201-1 2005 Overexpression of the rate-limiting enzyme in polyamine catabolism spermidine/spermine N1-acetyltransferase (SSAT) in transgenic (Tg) mouse leads to accumulation of putrescine in the skin and permanent hair loss at the age of 3 wk. Polyamines 46-55 spermidine/spermine N1-acetyl transferase 1 Mus musculus 67-107 15737201-1 2005 Overexpression of the rate-limiting enzyme in polyamine catabolism spermidine/spermine N1-acetyltransferase (SSAT) in transgenic (Tg) mouse leads to accumulation of putrescine in the skin and permanent hair loss at the age of 3 wk. Polyamines 46-55 spermidine/spermine N1-acetyl transferase 1 Mus musculus 109-113 15276653-2 2004 We show that cisplatin significantly induces the expression of two enzymes critical to proper homeostasis of cellular polyamines, ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SSAT). Polyamines 118-128 spermidine/spermine N1-acetyl transferase 1 Mus musculus 206-210 12000764-4 2002 The SSAT-deficient cells proliferated normally and appeared to maintain otherwise similar polyamine pools as did the wild-type cells, with the possible exception of constantly elevated (about 30%) cellular spermidine. Polyamines 90-99 spermidine/spermine N1-acetyl transferase 1 Mus musculus 4-8 14552906-1 2003 Activation of polyamine catabolism in transgenic mice through an overexpression of spermidine/spermine N(1)-acetyltransferase (SSAT) results in a massive overaccumulation of the diamine putrescine in most tissues including brain. Polyamines 14-23 spermidine/spermine N1-acetyl transferase 1 Mus musculus 83-125 14552906-1 2003 Activation of polyamine catabolism in transgenic mice through an overexpression of spermidine/spermine N(1)-acetyltransferase (SSAT) results in a massive overaccumulation of the diamine putrescine in most tissues including brain. Polyamines 14-23 spermidine/spermine N1-acetyl transferase 1 Mus musculus 127-131 15159132-1 2004 The present work addresses the role of polyamines in learning and general behavior by subjecting transgenic mice overexpressing polyamine catabolic enzyme, spermidine/spermine N(1)-acetyltransferase (SSAT) and their syngenic littermates to neurobehavioral profiling assessment (SHIRPA) and to radial eight-arm maze. Polyamines 39-49 spermidine/spermine N1-acetyl transferase 1 Mus musculus 200-204 11709547-1 2002 Overexpression of SSAT (polyamine catabolic enzyme) in female mice results in impaired ovarian folliculogenesis and uterine hypoplasia. Polyamines 24-33 spermidine/spermine N1-acetyl transferase 1 Mus musculus 18-22 12545203-1 2002 A differential expression pattern of spermidine/spermine N(1)-acetyltransferase (SSAT), the enzyme critical to proper homeostasis of cellular polyamines, is reported in mouse kidney undergoing hyperplasia and hypertrophy. Polyamines 142-152 spermidine/spermine N1-acetyl transferase 1 Mus musculus 37-79 12545203-1 2002 A differential expression pattern of spermidine/spermine N(1)-acetyltransferase (SSAT), the enzyme critical to proper homeostasis of cellular polyamines, is reported in mouse kidney undergoing hyperplasia and hypertrophy. Polyamines 142-152 spermidine/spermine N1-acetyl transferase 1 Mus musculus 81-85 11513732-0 2001 Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N(1)-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice. Polyamines 146-156 spermidine/spermine N1-acetyl transferase 1 Mus musculus 57-99 11114236-4 2000 When a sub-G(1)peak appeared at 4 h after dexamethasone treatment, the activity of the polyamine catabolic enzyme spermidine/spermine N(1)-acetyltransferase (SSAT) was significantly increased and the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (AdoMetDC) was significantly decreased compared to the activities found in the thymi of control mice. Polyamines 87-96 spermidine/spermine N1-acetyl transferase 1 Mus musculus 114-156 10712633-1 2000 We recently generated a transgenic mouse line with activated polyamine catabolism through overexpression of spermidine/spermine N1-acetyltransferase (SSAT). Polyamines 61-70 spermidine/spermine N1-acetyl transferase 1 Mus musculus 108-148 10712633-1 2000 We recently generated a transgenic mouse line with activated polyamine catabolism through overexpression of spermidine/spermine N1-acetyltransferase (SSAT). Polyamines 61-70 spermidine/spermine N1-acetyl transferase 1 Mus musculus 150-154 11302933-3 2001 We hypothesized that the inducible polyamine-catabolizing enzyme, SSAT, was an alternate pathway for acetylating amantadine. Polyamines 35-44 spermidine/spermine N1-acetyl transferase 1 Mus musculus 66-70 11114236-4 2000 When a sub-G(1)peak appeared at 4 h after dexamethasone treatment, the activity of the polyamine catabolic enzyme spermidine/spermine N(1)-acetyltransferase (SSAT) was significantly increased and the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (AdoMetDC) was significantly decreased compared to the activities found in the thymi of control mice. Polyamines 87-96 spermidine/spermine N1-acetyl transferase 1 Mus musculus 158-162 11114236-4 2000 When a sub-G(1)peak appeared at 4 h after dexamethasone treatment, the activity of the polyamine catabolic enzyme spermidine/spermine N(1)-acetyltransferase (SSAT) was significantly increased and the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (AdoMetDC) was significantly decreased compared to the activities found in the thymi of control mice. Polyamines 216-225 spermidine/spermine N1-acetyl transferase 1 Mus musculus 158-162 10101027-0 1999 Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase show enhanced sensitivity to the polyamine analog, N1, N11-diethylnorspermine. Polyamines 31-40 spermidine/spermine N1-acetyl transferase 1 Mus musculus 77-117 10101027-0 1999 Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase show enhanced sensitivity to the polyamine analog, N1, N11-diethylnorspermine. Polyamines 151-160 spermidine/spermine N1-acetyl transferase 1 Mus musculus 77-117 10101027-1 1999 We have recently generated transgenic mice in which polyamine catabolism has been activated by overexpressing the rate-limiting enzyme of polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT). Polyamines 52-61 spermidine/spermine N1-acetyl transferase 1 Mus musculus 160-200 10101027-1 1999 We have recently generated transgenic mice in which polyamine catabolism has been activated by overexpressing the rate-limiting enzyme of polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT). Polyamines 52-61 spermidine/spermine N1-acetyl transferase 1 Mus musculus 202-206 10101027-1 1999 We have recently generated transgenic mice in which polyamine catabolism has been activated by overexpressing the rate-limiting enzyme of polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT). Polyamines 138-147 spermidine/spermine N1-acetyl transferase 1 Mus musculus 160-200 10101027-1 1999 We have recently generated transgenic mice in which polyamine catabolism has been activated by overexpressing the rate-limiting enzyme of polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT). Polyamines 138-147 spermidine/spermine N1-acetyl transferase 1 Mus musculus 202-206 10101027-14 1999 The findings indicate a contributing role for SSAT in whole animal toxicity by SSAT-inducing polyamine analogs. Polyamines 93-102 spermidine/spermine N1-acetyl transferase 1 Mus musculus 46-50 10101027-14 1999 The findings indicate a contributing role for SSAT in whole animal toxicity by SSAT-inducing polyamine analogs. Polyamines 93-102 spermidine/spermine N1-acetyl transferase 1 Mus musculus 79-83 25231394-1 2015 Spermidine/spermine N (1)-acetyltransferase (SSAT) is a catabolic regulator of polyamines, ubiquitous molecules essential for cell proliferation and differentiation. Polyamines 79-89 spermidine/spermine N1-acetyl transferase 1 Mus musculus 45-49 8241266-0 1993 Cloning and sequence analysis of the gene and cDNA encoding mouse spermidine/spermine N1-acetyltransferase--a gene uniquely regulated by polyamines and their analogs. Polyamines 137-147 spermidine/spermine N1-acetyl transferase 1 Mus musculus 66-106 8241266-1 1993 The polyamine catabolizing enzyme, spermidine/spermine N1-acetyltransferase (SSAT), has been implicated as a critical determinant of polyamine pool maintenance. Polyamines 4-13 spermidine/spermine N1-acetyl transferase 1 Mus musculus 35-75 8241266-1 1993 The polyamine catabolizing enzyme, spermidine/spermine N1-acetyltransferase (SSAT), has been implicated as a critical determinant of polyamine pool maintenance. Polyamines 4-13 spermidine/spermine N1-acetyl transferase 1 Mus musculus 77-81 8241266-1 1993 The polyamine catabolizing enzyme, spermidine/spermine N1-acetyltransferase (SSAT), has been implicated as a critical determinant of polyamine pool maintenance. Polyamines 133-142 spermidine/spermine N1-acetyl transferase 1 Mus musculus 35-75 8241266-1 1993 The polyamine catabolizing enzyme, spermidine/spermine N1-acetyltransferase (SSAT), has been implicated as a critical determinant of polyamine pool maintenance. Polyamines 133-142 spermidine/spermine N1-acetyl transferase 1 Mus musculus 77-81 8241266-14 1993 Further elucidation of the structural features of the SSAT gene may reveal how it is positively regulated by polyamines and their analogs. Polyamines 109-119 spermidine/spermine N1-acetyl transferase 1 Mus musculus 54-58 1581359-1 1992 The effect of stress on the activity and level of mRNA of spermidine/spermine N1-acetyltransferase (SAT), a polyamine degradation rate-limiting enzyme, was studied in Ehrlich ascites tumor cells. Polyamines 108-117 spermidine/spermine N1-acetyl transferase 1 Mus musculus 58-98 1581359-1 1992 The effect of stress on the activity and level of mRNA of spermidine/spermine N1-acetyltransferase (SAT), a polyamine degradation rate-limiting enzyme, was studied in Ehrlich ascites tumor cells. Polyamines 108-117 spermidine/spermine N1-acetyl transferase 1 Mus musculus 100-103 2497746-0 1989 Structure-function correlations of polyamine analog-induced increases in spermidine/spermine acetyltransferase activity. Polyamines 35-44 spermidine/spermine N1-acetyl transferase 1 Mus musculus 73-110 2497746-1 1989 The cytosolic enzyme, spermidine/spermine acetyltransferase (SSAT), is distinguished by its role in polyamine interconversion and by its high inducibility in response to a variety of physiological and pharmacological stimuli. Polyamines 100-109 spermidine/spermine N1-acetyl transferase 1 Mus musculus 22-59 2497746-1 1989 The cytosolic enzyme, spermidine/spermine acetyltransferase (SSAT), is distinguished by its role in polyamine interconversion and by its high inducibility in response to a variety of physiological and pharmacological stimuli. Polyamines 100-109 spermidine/spermine N1-acetyl transferase 1 Mus musculus 61-65 2497746-2 1989 Among a series of fifteen polyamines and polyamine analogs, the most potent inducers of SSAT activity in cultured L1210 cells were found to be N1,N8-bis(ethyl)spermidine (BES) and N1,N12-bis(ethyl)spermine (BESm). Polyamines 26-36 spermidine/spermine N1-acetyl transferase 1 Mus musculus 88-92 2497746-2 1989 Among a series of fifteen polyamines and polyamine analogs, the most potent inducers of SSAT activity in cultured L1210 cells were found to be N1,N8-bis(ethyl)spermidine (BES) and N1,N12-bis(ethyl)spermine (BESm). Polyamines 26-35 spermidine/spermine N1-acetyl transferase 1 Mus musculus 88-92 29729200-10 2018 Similarly, while pharmacological induction of SAT1 and SMOX using the polyamine analogue bis(ethyl)norspermine (BENSPM) alleviated asthmatic features with reduced TSLP levels and BEC apoptosis, pharmacological inhibition of these enzymes using BERENIL or MDL72527, respectively, worsened them. Polyamines 70-79 spermidine/spermine N1-acetyl transferase 1 Mus musculus 46-50 29715464-5 2018 In this study, we aim to investigate the roles of the rate-limiting polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase (SAT1) in regulating beige adipocyte biogenesis and inflammation. Polyamines 68-77 spermidine/spermine N1-acetyl transferase 1 Mus musculus 137-141 10024505-0 1999 Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue. Polyamines 218-227 spermidine/spermine N1-acetyl transferase 1 Mus musculus 18-58 10024505-9 1999 Treatment of the transgenic animals with the polyamine analogue N1,N11-diethylnorspermine (DENSPM) resulted in an immense induction, more than 40000-fold, of enzyme activity in the liver of transgenic animals, and minor changes in the SSAT mRNA level. Polyamines 45-54 spermidine/spermine N1-acetyl transferase 1 Mus musculus 235-239 10024505-12 1999 These results indicated that, even without its own promoter, SSAT is powerfully induced by the polyamine analogue through a mechanism that appears to involve a direct translational and/or heterogenous nuclear RNA processing control. Polyamines 95-104 spermidine/spermine N1-acetyl transferase 1 Mus musculus 61-65 10024505-13 1999 It is likewise significant that overexpression of SSAT renders the animals extremely sensitive to polyamine analogues. Polyamines 98-107 spermidine/spermine N1-acetyl transferase 1 Mus musculus 50-54 9442032-1 1998 A recently generated transgenic mouse line having activated polyamine catabolism due to systemic overexpression of spermidine/spermine N1-acetyltransferase (SSAT) was used to isolate primary fetal fibroblasts as a means to further elucidate the cellular consequences of activated polyamine catabolism. Polyamines 60-69 spermidine/spermine N1-acetyl transferase 1 Mus musculus 115-155 9442032-1 1998 A recently generated transgenic mouse line having activated polyamine catabolism due to systemic overexpression of spermidine/spermine N1-acetyltransferase (SSAT) was used to isolate primary fetal fibroblasts as a means to further elucidate the cellular consequences of activated polyamine catabolism. Polyamines 60-69 spermidine/spermine N1-acetyl transferase 1 Mus musculus 157-161 9442032-1 1998 A recently generated transgenic mouse line having activated polyamine catabolism due to systemic overexpression of spermidine/spermine N1-acetyltransferase (SSAT) was used to isolate primary fetal fibroblasts as a means to further elucidate the cellular consequences of activated polyamine catabolism. Polyamines 280-289 spermidine/spermine N1-acetyl transferase 1 Mus musculus 157-161 9442032-4 1998 Treatment with the polyamine analogue N1,N11-diethylnorspermine (DENSPM) increased SSAT activity in the transgenic fibroblasts approximately 380-fold, whereas mRNA increased only approximately 3-fold, indicating post-mRNA regulation. Polyamines 19-28 spermidine/spermine N1-acetyl transferase 1 Mus musculus 83-87 7803498-5 1994 The activity of spermidine/spermine N1-acetyltransferase (SAT), a rate-limiting enzyme of polyamine biodegradation, was enhanced with the addition of SS in a time- and dose-dependent manner. Polyamines 90-99 spermidine/spermine N1-acetyl transferase 1 Mus musculus 16-56 7803498-5 1994 The activity of spermidine/spermine N1-acetyltransferase (SAT), a rate-limiting enzyme of polyamine biodegradation, was enhanced with the addition of SS in a time- and dose-dependent manner. Polyamines 90-99 spermidine/spermine N1-acetyl transferase 1 Mus musculus 58-61 27228136-1 2016 Spermidine/spermine N1-acetyltransferase (SSAT) is a catabolic regulator of polyamines, ubiquitous molecules essential for cell proliferation and differentiation. Polyamines 76-86 spermidine/spermine N1-acetyl transferase 1 Mus musculus 0-40 27228136-1 2016 Spermidine/spermine N1-acetyltransferase (SSAT) is a catabolic regulator of polyamines, ubiquitous molecules essential for cell proliferation and differentiation. Polyamines 76-86 spermidine/spermine N1-acetyl transferase 1 Mus musculus 42-46 25231394-8 2015 The polyamine pattern in osteoblasts of SSAT mice was distorted in comparison with wild-type mice. Polyamines 4-13 spermidine/spermine N1-acetyl transferase 1 Mus musculus 40-44 25231394-9 2015 However, treatment of osteoblasts with a SSAT-inducing functional polyamine analogue suggested that defective osteoblastogenesis resulted rather from other consequences of enhanced SSAT activity than lowered levels of the higher polyamines. Polyamines 66-75 spermidine/spermine N1-acetyl transferase 1 Mus musculus 41-45 25231394-9 2015 However, treatment of osteoblasts with a SSAT-inducing functional polyamine analogue suggested that defective osteoblastogenesis resulted rather from other consequences of enhanced SSAT activity than lowered levels of the higher polyamines. Polyamines 66-75 spermidine/spermine N1-acetyl transferase 1 Mus musculus 181-185 25231394-9 2015 However, treatment of osteoblasts with a SSAT-inducing functional polyamine analogue suggested that defective osteoblastogenesis resulted rather from other consequences of enhanced SSAT activity than lowered levels of the higher polyamines. Polyamines 229-239 spermidine/spermine N1-acetyl transferase 1 Mus musculus 41-45 21946432-1 2012 The alpha9beta1 integrin accelerates cell migration through binding of the alpha9 cytoplasmic domain to SSAT, which catalyzes the catabolism of higher order polyamines, spermidine and spermine, to the lower order polyamine, putrescine. Polyamines 157-167 spermidine/spermine N1-acetyl transferase 1 Mus musculus 104-108 24607957-2 2014 Spermidine/spermine N(1)-acetyltransferase (SSAT), which regulates intracellular levels of polyamines by catabolizing spermidine and spermine, has a controversial role in the development of cancers. Polyamines 91-101 spermidine/spermine N1-acetyl transferase 1 Mus musculus 0-42 24607957-2 2014 Spermidine/spermine N(1)-acetyltransferase (SSAT), which regulates intracellular levels of polyamines by catabolizing spermidine and spermine, has a controversial role in the development of cancers. Polyamines 91-101 spermidine/spermine N1-acetyl transferase 1 Mus musculus 44-48 23836421-1 2014 Spermidine/spermine N(1)-acetyltransferase (SSAT) regulates intracellular polyamine levels by catabolizing spermidine and spermine which are essential for cell proliferation and differentiation. Polyamines 74-83 spermidine/spermine N1-acetyl transferase 1 Mus musculus 0-42 23836421-1 2014 Spermidine/spermine N(1)-acetyltransferase (SSAT) regulates intracellular polyamine levels by catabolizing spermidine and spermine which are essential for cell proliferation and differentiation. Polyamines 74-83 spermidine/spermine N1-acetyl transferase 1 Mus musculus 44-48 23836421-7 2014 The data suggest that SSAT overexpression and the concomitantly accelerated polyamine metabolism in hematopoietic cells and bone marrow microenvironment affect lineage commitment and lead to the development of a mouse myeloproliferative disease in SSAT mice. Polyamines 76-85 spermidine/spermine N1-acetyl transferase 1 Mus musculus 248-252 22772469-2 2012 Here, we showed that integrin alpha9beta1 on airway smooth muscle localizes the polyamine catabolizing enzyme spermidine/spermine N1-acetyltransferase (SSAT) in close proximity to the lipid kinase PIP5K1gamma. Polyamines 80-89 spermidine/spermine N1-acetyl transferase 1 Mus musculus 110-150 22772469-2 2012 Here, we showed that integrin alpha9beta1 on airway smooth muscle localizes the polyamine catabolizing enzyme spermidine/spermine N1-acetyltransferase (SSAT) in close proximity to the lipid kinase PIP5K1gamma. Polyamines 80-89 spermidine/spermine N1-acetyl transferase 1 Mus musculus 152-156 22772469-7 2012 Therefore, integrin alpha9beta1 appears to serve as a brake on airway smooth muscle contraction by recruiting SSAT, which facilitates local catabolism of polyamines and thereby inhibits PIP5K1gamma. Polyamines 154-164 spermidine/spermine N1-acetyl transferase 1 Mus musculus 110-114 22180015-2 2012 We have analyzed the endocrine pancreas functionality in four months-old male mice overexpressing the rate limiting enzyme in the polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT). Polyamines 130-139 spermidine/spermine N1-acetyl transferase 1 Mus musculus 152-192 21809076-6 2012 The polyamine-acetylating enzyme, spermidine/spermine N(1)-acetyltransferase (SSAT) activity was increased within a few hours after stimulus for differentiation, and was found to be elevated by APCHA. Polyamines 4-13 spermidine/spermine N1-acetyl transferase 1 Mus musculus 34-76 21809076-6 2012 The polyamine-acetylating enzyme, spermidine/spermine N(1)-acetyltransferase (SSAT) activity was increased within a few hours after stimulus for differentiation, and was found to be elevated by APCHA. Polyamines 4-13 spermidine/spermine N1-acetyl transferase 1 Mus musculus 78-82 21814792-6 2012 In survival studies, the enhanced polyamine catabolism and concomitantly altered cellular polyamine pools in SSAT mice did not affect the LPS-induced mortality of these animals. Polyamines 90-99 spermidine/spermine N1-acetyl transferase 1 Mus musculus 109-113 24717514-7 2014 Polyamine flux including synthesis, catabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1) and by polyamine oxidase (PAO), and has a major role in energy metabolism. Polyamines 0-9 spermidine/spermine N1-acetyl transferase 1 Mus musculus 139-181 24717514-7 2014 Polyamine flux including synthesis, catabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1) and by polyamine oxidase (PAO), and has a major role in energy metabolism. Polyamines 0-9 spermidine/spermine N1-acetyl transferase 1 Mus musculus 183-187 24717514-7 2014 Polyamine flux including synthesis, catabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1) and by polyamine oxidase (PAO), and has a major role in energy metabolism. Polyamines 0-9 spermidine/spermine N1-acetyl transferase 1 Mus musculus 200-204 23881108-2 2014 Our data, in conjunction with other studies, suggest an unexpected role for the polyamine catabolic enzyme spermidine/spermine-N1-acetyltransferase (SSAT) in fat homeostasis. Polyamines 80-89 spermidine/spermine N1-acetyl transferase 1 Mus musculus 149-153 23881108-7 2014 Adipose-specific SSAT knockout mice and global SSAT knockout mice on a high-fat diet exhibited similar growth curves and proteomic patterns in their WAT, confirming that attenuated consumption of acetyl-CoA in acetylation of polyamines in adipose tissue drives the obese phenotype of these mice. Polyamines 225-235 spermidine/spermine N1-acetyl transferase 1 Mus musculus 17-21 21946432-1 2012 The alpha9beta1 integrin accelerates cell migration through binding of the alpha9 cytoplasmic domain to SSAT, which catalyzes the catabolism of higher order polyamines, spermidine and spermine, to the lower order polyamine, putrescine. Polyamines 157-166 spermidine/spermine N1-acetyl transferase 1 Mus musculus 104-108 20577801-2 2011 We studied a transgenic mouse line overexpressing the rate limiting enzyme in the polyamine catabolism, spermidine/spermine N (1)-acetyltransferase (SSAT) that is characterized by increased putrescine and decreased spermidine and spermine pools. Polyamines 82-91 spermidine/spermine N1-acetyl transferase 1 Mus musculus 149-153 21878558-2 2011 We have recently shown that spermidine/spermine-N(1)-acetyltransferase (SSAT1), the key polyamine catabolic enzyme, acetylates TETA in vitro. Polyamines 88-97 spermidine/spermine N1-acetyl transferase 1 Mus musculus 72-77