PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2498524-2 1989 It is reasoned that perturbation of a second regulatory element in polyamine biosynthesis, i.e., the generation of propylamine groups from S-adenosylmethionine (AdoMet), would potentiate the effectiveness of DFMO. Polyamines 67-76 methionine adenosyltransferase 1A Rattus norvegicus 161-167 8920979-2 1996 As a result, S-adenosylmethionine synthetase activity increased 2.3-fold, an effect that was accompanied by increased S-adenosylmethionine, a depletion of ATP and NAD levels, elevation of the S-adenosylmethionine/S-adenosylhomocysteine ratio (the methylation ratio), increased DNA methylation and polyamine levels (spermidine and spermine), and normal GSH levels. Polyamines 297-306 methionine adenosyltransferase 1A Rattus norvegicus 13-44 10809741-1 2000 We previously reported that S-adenosylmethionine (AdoMet), a key molecule in methylation reactions and polyamine biosynthesis, enhances axenic culture of the AIDS-associated opportunistic fungal pathogen Pneumocystis carinii. Polyamines 103-112 methionine adenosyltransferase 1A Rattus norvegicus 50-56