PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29853605-1 2018 Ornithine decarboxylase (ODC) is the rate-limiting enzyme for polyamine biosynthesis and restricts M1 macrophage activation in gastrointestinal (GI) infections. Polyamines 62-71 ornithine decarboxylase, structural 1 Mus musculus 0-23 30927735-1 2019 OBJECTIVES: The chemopreventive drug alpha-difluoromethylornithine (DFMO) has been shown to have an antinociceptive effect on mechanical allodynia in inflammatory arthritis by directly inhibiting ornithine decarboxylase (ODC) and decreasing polyamine production in inflammatory sites. Polyamines 241-250 ornithine decarboxylase, structural 1 Mus musculus 196-219 30700572-2 2019 Polyamines are highly regulated essential cations that are frequently elevated in cancer cells, and the rate-limiting enzyme in polyamine synthesis, ornithine decarboxylase 1 (ODC1), is a direct transcriptional target of MYCN. Polyamines 0-10 ornithine decarboxylase, structural 1 Mus musculus 149-174 30700572-2 2019 Polyamines are highly regulated essential cations that are frequently elevated in cancer cells, and the rate-limiting enzyme in polyamine synthesis, ornithine decarboxylase 1 (ODC1), is a direct transcriptional target of MYCN. Polyamines 0-10 ornithine decarboxylase, structural 1 Mus musculus 176-180 30700572-2 2019 Polyamines are highly regulated essential cations that are frequently elevated in cancer cells, and the rate-limiting enzyme in polyamine synthesis, ornithine decarboxylase 1 (ODC1), is a direct transcriptional target of MYCN. Polyamines 128-137 ornithine decarboxylase, structural 1 Mus musculus 149-174 30700572-2 2019 Polyamines are highly regulated essential cations that are frequently elevated in cancer cells, and the rate-limiting enzyme in polyamine synthesis, ornithine decarboxylase 1 (ODC1), is a direct transcriptional target of MYCN. Polyamines 128-137 ornithine decarboxylase, structural 1 Mus musculus 176-180 30700572-3 2019 Treatment of neuroblastoma cells with the ODC1 inhibitor difluoromethylornithine (DFMO), although a promising therapeutic strategy, is only partially effective at impeding neuroblastoma cell growth due to activation of compensatory mechanisms resulting in increased polyamine uptake from the surrounding microenvironment. Polyamines 266-275 ornithine decarboxylase, structural 1 Mus musculus 42-46 30566531-0 2018 New insights of polyamine metabolism in testicular physiology: A role of ornithine decarboxylase antizyme inhibitor 2 (AZIN2) in the modulation of testosterone levels and sperm motility. Polyamines 16-25 ornithine decarboxylase, structural 1 Mus musculus 73-96 30566531-2 2018 Antizymes (OAZs) and antizyme inhibitors (AZINs) are modulators of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis and polyamine uptake. Polyamines 114-123 ornithine decarboxylase, structural 1 Mus musculus 67-90 30566531-2 2018 Antizymes (OAZs) and antizyme inhibitors (AZINs) are modulators of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis and polyamine uptake. Polyamines 114-123 ornithine decarboxylase, structural 1 Mus musculus 92-95 30566531-2 2018 Antizymes (OAZs) and antizyme inhibitors (AZINs) are modulators of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis and polyamine uptake. Polyamines 141-150 ornithine decarboxylase, structural 1 Mus musculus 67-90 30566531-2 2018 Antizymes (OAZs) and antizyme inhibitors (AZINs) are modulators of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis and polyamine uptake. Polyamines 141-150 ornithine decarboxylase, structural 1 Mus musculus 92-95 28467636-3 2018 Due to their structural similarity to ODC, both AZIN1 and AZIN2 counteract the inhibitory action of 3 known antizymes (AZ1-3) on the ODC synthesis of polyamines, thus increasing intracytoplasmic levels of polyamines. Polyamines 150-160 ornithine decarboxylase, structural 1 Mus musculus 38-41 28467636-3 2018 Due to their structural similarity to ODC, both AZIN1 and AZIN2 counteract the inhibitory action of 3 known antizymes (AZ1-3) on the ODC synthesis of polyamines, thus increasing intracytoplasmic levels of polyamines. Polyamines 150-160 ornithine decarboxylase, structural 1 Mus musculus 133-136 28467636-3 2018 Due to their structural similarity to ODC, both AZIN1 and AZIN2 counteract the inhibitory action of 3 known antizymes (AZ1-3) on the ODC synthesis of polyamines, thus increasing intracytoplasmic levels of polyamines. Polyamines 205-215 ornithine decarboxylase, structural 1 Mus musculus 38-41 28467636-3 2018 Due to their structural similarity to ODC, both AZIN1 and AZIN2 counteract the inhibitory action of 3 known antizymes (AZ1-3) on the ODC synthesis of polyamines, thus increasing intracytoplasmic levels of polyamines. Polyamines 205-215 ornithine decarboxylase, structural 1 Mus musculus 133-136 30198908-3 2018 Our study revealed that AHR also positively regulates intracellular polyamine production via direct transcriptional activation of 2 genes, ODC1 and AZIN1, which are involved in polyamine biosynthesis and control, respectively. Polyamines 68-77 ornithine decarboxylase, structural 1 Mus musculus 139-143 30198908-3 2018 Our study revealed that AHR also positively regulates intracellular polyamine production via direct transcriptional activation of 2 genes, ODC1 and AZIN1, which are involved in polyamine biosynthesis and control, respectively. Polyamines 177-186 ornithine decarboxylase, structural 1 Mus musculus 139-143 29853605-1 2018 Ornithine decarboxylase (ODC) is the rate-limiting enzyme for polyamine biosynthesis and restricts M1 macrophage activation in gastrointestinal (GI) infections. Polyamines 62-71 ornithine decarboxylase, structural 1 Mus musculus 25-28 29635516-9 2018 We also found increased levels of the polyamine putrescine due to increased activity of ornithine decarboxylase, the rate-determining enzyme in polyamine synthesis. Polyamines 38-47 ornithine decarboxylase, structural 1 Mus musculus 88-111 29240775-1 2017 Ornithine Decarboxylase (ODC) a key enzyme in polyamine biosynthesis is often overexpressed in cancers and contributes to polyamine-induced cell proliferation. Polyamines 46-55 ornithine decarboxylase, structural 1 Mus musculus 0-23 29080175-1 2018 Ornithine decarboxylase (ODC) is the first rate-limiting enzyme in the polyamine biosynthetic pathway. Polyamines 71-80 ornithine decarboxylase, structural 1 Mus musculus 0-23 29080175-1 2018 Ornithine decarboxylase (ODC) is the first rate-limiting enzyme in the polyamine biosynthetic pathway. Polyamines 71-80 ornithine decarboxylase, structural 1 Mus musculus 25-28 29240775-1 2017 Ornithine Decarboxylase (ODC) a key enzyme in polyamine biosynthesis is often overexpressed in cancers and contributes to polyamine-induced cell proliferation. Polyamines 46-55 ornithine decarboxylase, structural 1 Mus musculus 25-28 29240775-1 2017 Ornithine Decarboxylase (ODC) a key enzyme in polyamine biosynthesis is often overexpressed in cancers and contributes to polyamine-induced cell proliferation. Polyamines 122-131 ornithine decarboxylase, structural 1 Mus musculus 0-23 29240775-1 2017 Ornithine Decarboxylase (ODC) a key enzyme in polyamine biosynthesis is often overexpressed in cancers and contributes to polyamine-induced cell proliferation. Polyamines 122-131 ornithine decarboxylase, structural 1 Mus musculus 25-28 29240775-7 2017 ODC-regulated polyamines (putrescine [Put] and/or spermidine [Spd]) known activators of cell proliferation were strongly decreased in response to DFMO, in both tumor tissue ([Put] (p = 0.0006), [Spd] (p<0.0001)) and blood plasma ([Put] (p<0.0001), [Spd] (p = 0.0049)) of treated mice. Polyamines 14-24 ornithine decarboxylase, structural 1 Mus musculus 0-3 28637295-4 2017 In the mouse, inhibiting the rate-limiting enzyme of polyamine synthesis, ornithine decarboxylase (ODC1) during early pregnancy largely prevents implantation, but the fate of the nonimplanted embryos is unknown. Polyamines 53-62 ornithine decarboxylase, structural 1 Mus musculus 74-97 28637295-4 2017 In the mouse, inhibiting the rate-limiting enzyme of polyamine synthesis, ornithine decarboxylase (ODC1) during early pregnancy largely prevents implantation, but the fate of the nonimplanted embryos is unknown. Polyamines 53-62 ornithine decarboxylase, structural 1 Mus musculus 99-103 28637295-10 2017 Examination of the polyamine pathway enzymes and a number of implantation factors indicated inhibition of ODC1 resulted in a uterine phenotype that resembled diapause, with some compensatory increases in crucial genes. Polyamines 19-28 ornithine decarboxylase, structural 1 Mus musculus 106-110 27084713-1 2016 Antizymes and antizyme inhibitors are key regulatory proteins of polyamine levels by affecting ornithine decarboxylase and polyamine uptake. Polyamines 65-74 ornithine decarboxylase, structural 1 Mus musculus 95-118 27473037-6 2016 Capsaicin induced an increase in expression of ornithine decarboxylase protein, which is the key enzyme in polyamine biosynthesis in cardiomyocytes. Polyamines 107-116 ornithine decarboxylase, structural 1 Mus musculus 47-70 26426536-4 2015 The rate-limiting enzyme in polyamine biosynthesis is ornithine decarboxylase, which is encoded by the gene Odc1. Polyamines 28-37 ornithine decarboxylase, structural 1 Mus musculus 54-77 26529275-2 2016 Inhibition of polyamine synthesis by alpha-difluoro-methylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, attenuates VSMC proliferation with high sensitivity and specificity. Polyamines 14-23 ornithine decarboxylase, structural 1 Mus musculus 105-128 26676750-1 2016 Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis that is associated with cell growth and tumor formation. Polyamines 77-86 ornithine decarboxylase, structural 1 Mus musculus 0-23 26676750-1 2016 Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis that is associated with cell growth and tumor formation. Polyamines 77-86 ornithine decarboxylase, structural 1 Mus musculus 25-28 26426536-4 2015 The rate-limiting enzyme in polyamine biosynthesis is ornithine decarboxylase, which is encoded by the gene Odc1. Polyamines 28-37 ornithine decarboxylase, structural 1 Mus musculus 108-112 24305501-7 2014 Among pathways that were differentially responsive to testosterone in prostate, we identified ornithine decarboxylase (Odc1), an enzyme in polyamine biosynthesis, as a testosterone-responsive gene that is unresponsive to rFst. Polyamines 139-148 ornithine decarboxylase, structural 1 Mus musculus 94-117 25807386-4 2015 Increased arginase can also provide ornithine for synthesis of polyamines via ornithine decarboxylase (ODC) and proline/collagen via ornithine aminotransferase (OAT), leading to vascular cell proliferation and collagen formation, respectively. Polyamines 63-73 ornithine decarboxylase, structural 1 Mus musculus 78-101 25807386-4 2015 Increased arginase can also provide ornithine for synthesis of polyamines via ornithine decarboxylase (ODC) and proline/collagen via ornithine aminotransferase (OAT), leading to vascular cell proliferation and collagen formation, respectively. Polyamines 63-73 ornithine decarboxylase, structural 1 Mus musculus 103-106 25248858-1 2014 Ornithine decarboxylase (ODC) is the key rate-limiting enzyme in the polyamine synthesis pathway and it is overexpressed in a variety of cancers. Polyamines 69-78 ornithine decarboxylase, structural 1 Mus musculus 0-23 25248858-1 2014 Ornithine decarboxylase (ODC) is the key rate-limiting enzyme in the polyamine synthesis pathway and it is overexpressed in a variety of cancers. Polyamines 69-78 ornithine decarboxylase, structural 1 Mus musculus 25-28 25248858-2 2014 We found that polyamine synthesis and modulation of ODC signaling occurs at early stages of pancreatic precursor lesions and increases as the tumor progresses in Kras-activated p48(Cre/+)-LSL-Kras(G12D/+) mice. Polyamines 14-23 ornithine decarboxylase, structural 1 Mus musculus 52-55 24717514-7 2014 Polyamine flux including synthesis, catabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1) and by polyamine oxidase (PAO), and has a major role in energy metabolism. Polyamines 0-9 ornithine decarboxylase, structural 1 Mus musculus 105-128 24717514-7 2014 Polyamine flux including synthesis, catabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1) and by polyamine oxidase (PAO), and has a major role in energy metabolism. Polyamines 0-9 ornithine decarboxylase, structural 1 Mus musculus 130-133 26112945-1 2015 AIM: To study the influence of polyamine metabolism inhibitors on the growth, metastasis and ornithine decarboxylase (ODC) activity of Lewis lung carcinoma. Polyamines 31-40 ornithine decarboxylase, structural 1 Mus musculus 93-116 26112945-1 2015 AIM: To study the influence of polyamine metabolism inhibitors on the growth, metastasis and ornithine decarboxylase (ODC) activity of Lewis lung carcinoma. Polyamines 31-40 ornithine decarboxylase, structural 1 Mus musculus 118-121 26112945-6 2015 Determination of ODC - the key enzyme of the polyamine synthesis - in the samples of experimental tumors was performed by method of Luqman S. RESULTS: Administration of DFMO or it"s combination with nor-NOHA resulted in the decrease of tumor growth rate, number and volume of lung metastases and was accompanied with reduced ODC activity in tumor tissue. Polyamines 45-54 ornithine decarboxylase, structural 1 Mus musculus 17-20 25516968-5 2015 Expression of Odc1, the rate-limiting enzyme in the conversion of ornithine into putrescine in the synthesis of polyamines, is reduced in Mga mutant cells, and the survival of mutant ICM cells as well as ESCs is rescued in culture by the addition of exogenous putrescine. Polyamines 112-122 ornithine decarboxylase, structural 1 Mus musculus 14-18 24305501-7 2014 Among pathways that were differentially responsive to testosterone in prostate, we identified ornithine decarboxylase (Odc1), an enzyme in polyamine biosynthesis, as a testosterone-responsive gene that is unresponsive to rFst. Polyamines 139-148 ornithine decarboxylase, structural 1 Mus musculus 119-123 23874910-3 2013 Antizymes and antizyme inhibitors are key regulatory proteins of polyamine levels by affecting ornithine decarboxylase, the rate-limiting biosynthetic enzyme, and polyamine uptake. Polyamines 65-74 ornithine decarboxylase, structural 1 Mus musculus 95-118 23884694-1 2014 Elevated expression of ornithine decarboxylase (ODC), the regulatory enzyme in polyamine biosynthesis, targeted to the epidermis is sufficient to promote skin tumor development following a single subthreshold dose of dimethylbenz(a)anthracene (DMBA). Polyamines 79-88 ornithine decarboxylase, structural 1 Mus musculus 23-46 23884694-1 2014 Elevated expression of ornithine decarboxylase (ODC), the regulatory enzyme in polyamine biosynthesis, targeted to the epidermis is sufficient to promote skin tumor development following a single subthreshold dose of dimethylbenz(a)anthracene (DMBA). Polyamines 79-88 ornithine decarboxylase, structural 1 Mus musculus 48-51 23884694-4 2014 Because increased ODC activity not only stimulates proliferation but also increases reactive oxygen species (ROS) generation via subsequent induction of polyamine catabolic oxidases, we used an inhibitor of polyamine catabolic oxidase activity, MDL72527, to investigate whether ROS generation by polyamine catabolic oxidases contributes to skin tumorigenesis in DMBA-initiated ODC-ER transgenic skin. Polyamines 153-162 ornithine decarboxylase, structural 1 Mus musculus 18-21 24778323-3 2014 A polyamine-blocking therapy (PBT) that combines the well-characterized ornithine decarboxylase (ODC) inhibitor difluoromethylornithine (DFMO) with AMXT 1501, a novel inhibitor of the polyamine transport system, blocked tumor growth in immunocompetent mice but not in athymic nude mice lacking T cells. Polyamines 2-11 ornithine decarboxylase, structural 1 Mus musculus 72-95 23519605-1 2013 The role that the induction of cardiac ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, by beta-adrenergic agents may have in heart hypertrophy is a controversial issue. Polyamines 86-95 ornithine decarboxylase, structural 1 Mus musculus 39-62 23519605-1 2013 The role that the induction of cardiac ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, by beta-adrenergic agents may have in heart hypertrophy is a controversial issue. Polyamines 86-95 ornithine decarboxylase, structural 1 Mus musculus 64-67 23470627-2 2013 The product of arginase activity, L-ornithine, can be metabolized into polyamines by ornithine decarboxylase. Polyamines 71-81 ornithine decarboxylase, structural 1 Mus musculus 85-108 23470627-7 2013 Chronic inhibition of polyamine synthesis using an ornithine decarboxylase inhibitor significantly reduced polyamine levels, restored nitrite/nitrate levels to normal, and abrogated the AHR to methacholine in the acute model of allergic airways inflammation. Polyamines 22-31 ornithine decarboxylase, structural 1 Mus musculus 51-74 23470627-7 2013 Chronic inhibition of polyamine synthesis using an ornithine decarboxylase inhibitor significantly reduced polyamine levels, restored nitrite/nitrate levels to normal, and abrogated the AHR to methacholine in the acute model of allergic airways inflammation. Polyamines 107-116 ornithine decarboxylase, structural 1 Mus musculus 51-74 23300995-7 2013 Furthermore, JAK2 (V617F) induced the expression of a target gene of c-Myc, ornithine decarboxylase (ODC), known as the rate-limiting enzyme in polyamine biosynthesis. Polyamines 144-153 ornithine decarboxylase, structural 1 Mus musculus 76-99 23574701-1 2013 We overexpressed a mouse ornithine decarboxylase gene under the control of a constitutive and an estradiol-inducible promoter in Arabidopsis thaliana to increase our understanding of the regulation of polyamine metabolism. Polyamines 201-210 ornithine decarboxylase, structural 1 Mus musculus 25-48 23300995-7 2013 Furthermore, JAK2 (V617F) induced the expression of a target gene of c-Myc, ornithine decarboxylase (ODC), known as the rate-limiting enzyme in polyamine biosynthesis. Polyamines 144-153 ornithine decarboxylase, structural 1 Mus musculus 101-104 22610166-2 2012 Tumor promoter treatment induces the rate-limiting enzymes in polyamine biosynthesis, ornithine decarboxylase (ODC), and S-adenosylmethionine decarboxylase (AdoMetDC), and targeted ODC overexpression is sufficient for tumor promotion in initiated mouse skin. Polyamines 62-71 ornithine decarboxylase, structural 1 Mus musculus 181-184 23181218-4 2012 ODC1, an oncogenic MYCN target, is rate-limiting for polyamine synthesis, and is overexpressed in many cancers including neuroblastoma. Polyamines 53-62 ornithine decarboxylase, structural 1 Mus musculus 0-4 21809076-2 2012 Alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC) a limiting enzyme of polyamine biosynthesis, depleted the cellular polyamines and prevented triglyceride accumulation and differentiation in 3T3-L1 cells. Polyamines 105-114 ornithine decarboxylase, structural 1 Mus musculus 54-77 22361732-5 2012 The latter is followed by generation of polyamines by ornithine decarboxylase (ODC) and L-proline (L-Pro) by ornithine aminotransferase (OAT). Polyamines 40-50 ornithine decarboxylase, structural 1 Mus musculus 54-77 22361732-5 2012 The latter is followed by generation of polyamines by ornithine decarboxylase (ODC) and L-proline (L-Pro) by ornithine aminotransferase (OAT). Polyamines 40-50 ornithine decarboxylase, structural 1 Mus musculus 79-82 21814794-1 2012 Ornithine decarboxylase (ODC), the first enzyme of polyamine metabolism, is rapidly upregulated in response to agents that induce a pathological cardiac hypertrophy. Polyamines 51-60 ornithine decarboxylase, structural 1 Mus musculus 0-23 21814794-1 2012 Ornithine decarboxylase (ODC), the first enzyme of polyamine metabolism, is rapidly upregulated in response to agents that induce a pathological cardiac hypertrophy. Polyamines 51-60 ornithine decarboxylase, structural 1 Mus musculus 25-28 21814794-4 2012 The current work studies the cooperation between the cardiac polyamines and L-arginine (L-Arg) availability in MHC-ODC mice. Polyamines 61-71 ornithine decarboxylase, structural 1 Mus musculus 115-118 21809076-2 2012 Alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC) a limiting enzyme of polyamine biosynthesis, depleted the cellular polyamines and prevented triglyceride accumulation and differentiation in 3T3-L1 cells. Polyamines 105-114 ornithine decarboxylase, structural 1 Mus musculus 79-82 21809076-2 2012 Alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC) a limiting enzyme of polyamine biosynthesis, depleted the cellular polyamines and prevented triglyceride accumulation and differentiation in 3T3-L1 cells. Polyamines 151-161 ornithine decarboxylase, structural 1 Mus musculus 54-77 21809076-2 2012 Alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC) a limiting enzyme of polyamine biosynthesis, depleted the cellular polyamines and prevented triglyceride accumulation and differentiation in 3T3-L1 cells. Polyamines 151-161 ornithine decarboxylase, structural 1 Mus musculus 79-82 21730362-1 2011 Induction of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, in ODC transgenic skin stimulates epidermal proliferation but not hyperplasia, activates underlying stromal cells and promotes skin tumorigenesis following a single subthreshold dose of a carcinogen. Polyamines 60-69 ornithine decarboxylase, structural 1 Mus musculus 13-36 21730362-1 2011 Induction of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, in ODC transgenic skin stimulates epidermal proliferation but not hyperplasia, activates underlying stromal cells and promotes skin tumorigenesis following a single subthreshold dose of a carcinogen. Polyamines 60-69 ornithine decarboxylase, structural 1 Mus musculus 38-41 21730362-1 2011 Induction of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, in ODC transgenic skin stimulates epidermal proliferation but not hyperplasia, activates underlying stromal cells and promotes skin tumorigenesis following a single subthreshold dose of a carcinogen. Polyamines 60-69 ornithine decarboxylase, structural 1 Mus musculus 87-90 21505150-1 2011 The aim of this study is to determine if the Odc1 gene, which encodes ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, is directly regulated by the androgen receptor (AR) in skeletal muscle myoblasts and if Odc1 regulates myoblast proliferation and differentiation. Polyamines 129-138 ornithine decarboxylase, structural 1 Mus musculus 45-49 21505150-1 2011 The aim of this study is to determine if the Odc1 gene, which encodes ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, is directly regulated by the androgen receptor (AR) in skeletal muscle myoblasts and if Odc1 regulates myoblast proliferation and differentiation. Polyamines 129-138 ornithine decarboxylase, structural 1 Mus musculus 70-93 21505150-1 2011 The aim of this study is to determine if the Odc1 gene, which encodes ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, is directly regulated by the androgen receptor (AR) in skeletal muscle myoblasts and if Odc1 regulates myoblast proliferation and differentiation. Polyamines 129-138 ornithine decarboxylase, structural 1 Mus musculus 95-98 21505150-1 2011 The aim of this study is to determine if the Odc1 gene, which encodes ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, is directly regulated by the androgen receptor (AR) in skeletal muscle myoblasts and if Odc1 regulates myoblast proliferation and differentiation. Polyamines 129-138 ornithine decarboxylase, structural 1 Mus musculus 241-245 21237263-2 2011 Ornithine decarboxylase (ODC) is the rate-limiting enzyme in endogenous polyamine production. Polyamines 72-81 ornithine decarboxylase, structural 1 Mus musculus 0-23 21536795-2 2011 Recently, we have demonstrated that a Deltaodc L. donovani null mutant lacking ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, was profoundly compromised in its ability to infect mice, indicating that ODC is essential for the infectious mammalian stage of the parasite and further validating the enzyme as a possible drug target. Polyamines 138-147 ornithine decarboxylase, structural 1 Mus musculus 104-107 21237263-2 2011 Ornithine decarboxylase (ODC) is the rate-limiting enzyme in endogenous polyamine production. Polyamines 72-81 ornithine decarboxylase, structural 1 Mus musculus 25-28 20685649-1 2010 Ornithine decarboxylase (ODC) is the first and usually rate-limiting enzyme in the polyamine biosynthetic pathway. Polyamines 83-92 ornithine decarboxylase, structural 1 Mus musculus 0-23 20844550-2 2011 We hypothesized that increased activity of epidermal ornithine decarboxylase (ODC), a key regulatory enzyme in polyamine biosynthesis, may suppress the cutaneous immune response in addition to stimulating proliferation. Polyamines 111-120 ornithine decarboxylase, structural 1 Mus musculus 53-76 20844550-2 2011 We hypothesized that increased activity of epidermal ornithine decarboxylase (ODC), a key regulatory enzyme in polyamine biosynthesis, may suppress the cutaneous immune response in addition to stimulating proliferation. Polyamines 111-120 ornithine decarboxylase, structural 1 Mus musculus 78-81 20685649-1 2010 Ornithine decarboxylase (ODC) is the first and usually rate-limiting enzyme in the polyamine biosynthetic pathway. Polyamines 83-92 ornithine decarboxylase, structural 1 Mus musculus 25-28 20103729-3 2010 Inhibition of ornithine decarboxylase, an enzyme of the polyamine biosynthetic pathway and a Myc target, has been shown to be chemopreventive. Polyamines 56-65 ornithine decarboxylase, structural 1 Mus musculus 14-37 20410304-4 2010 We have reported that H. pylori induces apoptosis of macrophages by generation of polyamines from ornithine decarboxylase (ODC), which is dependent on c-Myc as a transcriptional enhancer. Polyamines 82-92 ornithine decarboxylase, structural 1 Mus musculus 123-126 19956999-4 2010 We bring together an analysis of certain metabolic changes, particularly in amino acids, to infer the responsive regulation brought about by increased diamine or polyamine levels in actively growing poplar cell cultures (transformed with mouse ornithine decarboxylase gene to accumulate high Put levels) and ripening tomato pericarp (transformed with yeast S-adenosylmethionine decarboxylase gene to accumulate high Spd and Spm levels at the cost of Put). Polyamines 162-171 ornithine decarboxylase, structural 1 Mus musculus 244-267 19997757-1 2010 Ornithine decarboxylase (ODC), antizyme (AZ), and antizyme inhibitor (AIn) play a key role in regulation of intracellular polyamine levels by forming a regulatory circuit through their interactions. Polyamines 122-131 ornithine decarboxylase, structural 1 Mus musculus 0-23 19997757-1 2010 Ornithine decarboxylase (ODC), antizyme (AZ), and antizyme inhibitor (AIn) play a key role in regulation of intracellular polyamine levels by forming a regulatory circuit through their interactions. Polyamines 122-131 ornithine decarboxylase, structural 1 Mus musculus 25-28 19427401-3 2009 Polyamine deficiency was induced by adding an inhibitor of ornithine decarboxylase, alpha-difluoromethylornithine, to the medium. Polyamines 0-9 ornithine decarboxylase, structural 1 Mus musculus 59-82 20095973-3 2009 Preclinical studies have demonstrated that DFMO (difluoromethylornithine), an irreversible inhibitor of ODC (ornithine decarboxylase) which is the first enzyme in polyamine biosynthesis, combined with NSAIDs (non-steroidal anti-inflammatory drugs) suppresses colorectal carcinogenesis in murine models. Polyamines 163-172 ornithine decarboxylase, structural 1 Mus musculus 104-107 20095973-3 2009 Preclinical studies have demonstrated that DFMO (difluoromethylornithine), an irreversible inhibitor of ODC (ornithine decarboxylase) which is the first enzyme in polyamine biosynthesis, combined with NSAIDs (non-steroidal anti-inflammatory drugs) suppresses colorectal carcinogenesis in murine models. Polyamines 163-172 ornithine decarboxylase, structural 1 Mus musculus 109-132 20095974-2 2009 Our first transgenic mice overexpressing ODC (ornithine decarboxylase) were generated in 1991 and, thereafter, most genes involved in polyamine metabolism have been used for overproduction of the respective proteins, either ubiquitously or in a tissue-specific fashion in transgenic animals. Polyamines 134-143 ornithine decarboxylase, structural 1 Mus musculus 41-44 20095974-2 2009 Our first transgenic mice overexpressing ODC (ornithine decarboxylase) were generated in 1991 and, thereafter, most genes involved in polyamine metabolism have been used for overproduction of the respective proteins, either ubiquitously or in a tissue-specific fashion in transgenic animals. Polyamines 134-143 ornithine decarboxylase, structural 1 Mus musculus 46-69 19281226-5 2009 The resulting novel two-drug combination therapy targeting cellular polyamine metabolism has shown exceptional efficacy against cutaneous squamous cell carcinomas (SCC) in a transgenic ornithine decarboxylase (ODC) mouse model of skin cancer. Polyamines 68-77 ornithine decarboxylase, structural 1 Mus musculus 185-208 19893612-3 2009 Ornithine decarboxylase antizymes (OAZs) control the intracellular concentration of polyamines in a feedback manner. Polyamines 84-94 ornithine decarboxylase, structural 1 Mus musculus 0-23 19281226-5 2009 The resulting novel two-drug combination therapy targeting cellular polyamine metabolism has shown exceptional efficacy against cutaneous squamous cell carcinomas (SCC) in a transgenic ornithine decarboxylase (ODC) mouse model of skin cancer. Polyamines 68-77 ornithine decarboxylase, structural 1 Mus musculus 210-213 18390925-6 2008 Real-time PCR confirms that expression of genes encoding polyamine biosynthetic enzymes, ornithine decarboxylase (Odc1), and S-adenosylmethionine decarboxylase (Amd1), is reduced in ARKO muscle, suggesting androgens act through regulation of polyamine biosynthesis. Polyamines 242-251 ornithine decarboxylase, structural 1 Mus musculus 114-118 18583422-1 2008 Polyamines play an essential role in murine development, as demonstrated by both gene ablation in ornithine decarboxylase (ODC)-deficient embryos and pharmacological treatments of pregnant mice. Polyamines 0-10 ornithine decarboxylase, structural 1 Mus musculus 98-121 18583422-1 2008 Polyamines play an essential role in murine development, as demonstrated by both gene ablation in ornithine decarboxylase (ODC)-deficient embryos and pharmacological treatments of pregnant mice. Polyamines 0-10 ornithine decarboxylase, structural 1 Mus musculus 123-126 19047152-4 2008 High-risk tumors without MYCN amplification also overexpress ODC1, the rate-limiting enzyme in polyamine biosynthesis, when compared with lower-risk tumors, suggesting that this pathway may be pivotal. Polyamines 95-104 ornithine decarboxylase, structural 1 Mus musculus 61-65 18202119-6 2008 The expression of Odc antizyme 1 and spermidine/spermine N1-acetyltransferase was also highly shown at implantation sites and regulated by Odc or polyamine level in uterine cells. Polyamines 146-155 ornithine decarboxylase, structural 1 Mus musculus 18-21 17570504-1 2007 Overexpression of ornithine decarboxylase (ODC), resulting in increased polyamine metabolism, is a common feature of epithelial tumors. Polyamines 72-81 ornithine decarboxylase, structural 1 Mus musculus 18-41 18381427-6 2008 Ker/ODC also displays increased generation of H(2)O(2), acrolein-lysine conjugates, and protein oxidation products as well as polyamine-dependent DNA damage, as measured by the comet assay and the expression of the phosphorylated form of the histone variant gamma H2AX. Polyamines 126-135 ornithine decarboxylase, structural 1 Mus musculus 4-7 18381427-7 2008 Both reactive oxygen species generation and apoptotic cell death of Ker/ODC may, at least in part, be due to induction of a polyamine catabolic pathway that generates both H(2)O(2) and cytotoxic aldehydes, because spermine oxidase (SMO) levels are induced in Ker/ODC. Polyamines 124-133 ornithine decarboxylase, structural 1 Mus musculus 72-75 18381427-7 2008 Both reactive oxygen species generation and apoptotic cell death of Ker/ODC may, at least in part, be due to induction of a polyamine catabolic pathway that generates both H(2)O(2) and cytotoxic aldehydes, because spermine oxidase (SMO) levels are induced in Ker/ODC. Polyamines 124-133 ornithine decarboxylase, structural 1 Mus musculus 263-266 17234230-3 2007 A key enzyme in polyamine biosynthesis, ornithine decarboxylase (ODC) is upregulated in skin tumors compared to normal skin. Polyamines 16-25 ornithine decarboxylase, structural 1 Mus musculus 40-63 17234230-3 2007 A key enzyme in polyamine biosynthesis, ornithine decarboxylase (ODC) is upregulated in skin tumors compared to normal skin. Polyamines 16-25 ornithine decarboxylase, structural 1 Mus musculus 65-68 17234230-5 2007 The formation of skin tumors in these transgenic mice is dependent upon polyamine biosynthesis, especially putrescine, since treatment with inhibitors of ODC activity blocks the formation of skin tumors and causes the rapid regression of existing tumors. Polyamines 72-81 ornithine decarboxylase, structural 1 Mus musculus 154-157 17686999-1 2007 The role of ornithine decarboxylase (ODC) in polyamine metabolism has long been established, but the exact source of ornithine has always been unclear. Polyamines 45-54 ornithine decarboxylase, structural 1 Mus musculus 12-35 17686999-1 2007 The role of ornithine decarboxylase (ODC) in polyamine metabolism has long been established, but the exact source of ornithine has always been unclear. Polyamines 45-54 ornithine decarboxylase, structural 1 Mus musculus 37-40 18381427-1 2008 We examined the effect of increased expression of ornithine decarboxylase (ODC), a key rate-limiting enzyme in polyamine biosynthesis, on cell survival in primary cultures of keratinocytes isolated from the skin of K6/ODC transgenic mice (Ker/ODC) and their normal littermates (Ker/Norm). Polyamines 111-120 ornithine decarboxylase, structural 1 Mus musculus 50-73 18381427-1 2008 We examined the effect of increased expression of ornithine decarboxylase (ODC), a key rate-limiting enzyme in polyamine biosynthesis, on cell survival in primary cultures of keratinocytes isolated from the skin of K6/ODC transgenic mice (Ker/ODC) and their normal littermates (Ker/Norm). Polyamines 111-120 ornithine decarboxylase, structural 1 Mus musculus 75-78 18381427-5 2008 ATM activation is polyamine dependent because alpha-difluoromethylornithine, a specific inhibitor of ODC activity, blocks its phosphorylation. Polyamines 18-27 ornithine decarboxylase, structural 1 Mus musculus 101-104 17675337-9 2007 They support the use of strategies to modulate polyamine levels through the inhibition of ODC activity or polyamine uptake, but not via increased SSAT expression, for cancer chemoprevention in individuals at high risk for skin tumor development. Polyamines 47-56 ornithine decarboxylase, structural 1 Mus musculus 90-93 17570504-1 2007 Overexpression of ornithine decarboxylase (ODC), resulting in increased polyamine metabolism, is a common feature of epithelial tumors. Polyamines 72-81 ornithine decarboxylase, structural 1 Mus musculus 43-46 17570504-7 2007 Altered association of Tip60 with E2F1 and a subset of newly identified Tip60-interacting transcription factors was detected in ODC mouse skin and tumors, implying novel polyamine modulation of Tip60-regulated gene expression. Polyamines 170-179 ornithine decarboxylase, structural 1 Mus musculus 128-131 17148758-7 2007 Combination treatment of mice with alpha-difluoromethylornithine (a suicide inhibitor of ODC) and a polyamine-deficient diet produced a marked decrease in adrenal polyamine and catecholamine levels and a significant reduction in plasma corticosterone and aldosterone concentrations that were not associated with a decrease in the mRNA levels of steroidogenic proteins. Polyamines 163-172 ornithine decarboxylase, structural 1 Mus musculus 89-92 17371283-3 2007 The enzymes ODC (ornithine decarboxylase), AdoMetDC (S-adenosylmethionine decarboxylase) and SSAT (spermidine/spermine N(1)-acetyltransferase) are critical for polyamine pool maintenance. Polyamines 160-169 ornithine decarboxylase, structural 1 Mus musculus 17-40 17371283-8 2007 We found that this cross-talk modulated the expression of ODC and AdoMetDC, enzymes limiting polyamine biosynthesis, but not SSAT. Polyamines 93-102 ornithine decarboxylase, structural 1 Mus musculus 58-61 17219416-2 2007 Antizyme (AZ) is a negative regulator of polyamine metabolism that inhibits ODC activity, stimulates ODC degradation, and suppresses polyamine uptake. Polyamines 41-50 ornithine decarboxylase, structural 1 Mus musculus 76-79 16568078-1 2006 Antizyme inhibitor (AzI) is a homolog of ornithine decarboxylase (ODC), a key enzyme of polyamine synthesis. Polyamines 88-97 ornithine decarboxylase, structural 1 Mus musculus 41-64 16916800-1 2006 Ornithine decarboxylase (ODC), a key enzyme in the biosynthesis of polyamines, is a labile protein that is regulated by interacting with antizymes (AZs), a family of polyamine-induced proteins. Polyamines 67-77 ornithine decarboxylase, structural 1 Mus musculus 0-23 16916800-1 2006 Ornithine decarboxylase (ODC), a key enzyme in the biosynthesis of polyamines, is a labile protein that is regulated by interacting with antizymes (AZs), a family of polyamine-induced proteins. Polyamines 67-77 ornithine decarboxylase, structural 1 Mus musculus 25-28 16916800-1 2006 Ornithine decarboxylase (ODC), a key enzyme in the biosynthesis of polyamines, is a labile protein that is regulated by interacting with antizymes (AZs), a family of polyamine-induced proteins. Polyamines 67-76 ornithine decarboxylase, structural 1 Mus musculus 0-23 16916800-1 2006 Ornithine decarboxylase (ODC), a key enzyme in the biosynthesis of polyamines, is a labile protein that is regulated by interacting with antizymes (AZs), a family of polyamine-induced proteins. Polyamines 67-76 ornithine decarboxylase, structural 1 Mus musculus 25-28 16953303-2 2006 Ornithine decarboxylase (ODC), an important enzyme in polyamine biosynthesis, is increased in cancer cells. Polyamines 54-63 ornithine decarboxylase, structural 1 Mus musculus 0-23 16953303-2 2006 Ornithine decarboxylase (ODC), an important enzyme in polyamine biosynthesis, is increased in cancer cells. Polyamines 54-63 ornithine decarboxylase, structural 1 Mus musculus 25-28 16568078-1 2006 Antizyme inhibitor (AzI) is a homolog of ornithine decarboxylase (ODC), a key enzyme of polyamine synthesis. Polyamines 88-97 ornithine decarboxylase, structural 1 Mus musculus 66-69 16445292-2 2006 The overexpression of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, also elevates CK2 kinase activity in primary keratinocytes and tissues of K6/ODC transgenic mice. Polyamines 81-90 ornithine decarboxylase, structural 1 Mus musculus 22-45 16459331-1 2006 Ornithine decarboxylase (ODC) initiates the polyamine biosynthetic pathway. Polyamines 44-53 ornithine decarboxylase, structural 1 Mus musculus 0-23 16459331-1 2006 Ornithine decarboxylase (ODC) initiates the polyamine biosynthetic pathway. Polyamines 44-53 ornithine decarboxylase, structural 1 Mus musculus 25-28 16459331-2 2006 The amount of ODC is altered in response to many growth factors, oncogenes, and tumor promoters and to changes in polyamine levels. Polyamines 114-123 ornithine decarboxylase, structural 1 Mus musculus 14-17 16678846-6 2006 The activity of ornithine decarboxylase, the rate limiting enzyme of polyamine biosynthesis that synthesizes putrescine, is rapidly and transiently induced in ischemic cells, reaching a maximum after 3 h, and leading to increased polyamine levels. Polyamines 69-78 ornithine decarboxylase, structural 1 Mus musculus 16-39 16678846-6 2006 The activity of ornithine decarboxylase, the rate limiting enzyme of polyamine biosynthesis that synthesizes putrescine, is rapidly and transiently induced in ischemic cells, reaching a maximum after 3 h, and leading to increased polyamine levels. Polyamines 230-239 ornithine decarboxylase, structural 1 Mus musculus 16-39 16678846-7 2006 Pharmacological inhibition of ornithine decarboxylase by alpha-difluoromethylornithine (DFMO) depletes H9c2 cardiomyoblasts of polyamines and protects the cells against ischemia-induced apoptosis. Polyamines 127-137 ornithine decarboxylase, structural 1 Mus musculus 30-53 16678846-10 2006 In cardiomyocytes obtained from transgenic mice overexpressing ornithine decarboxylase in the heart, caspase activation is dramatically increased following induction of apoptosis, with respect to cardiomyocytes from control mice, confirming a proapoptotic effect of polyamines. Polyamines 266-276 ornithine decarboxylase, structural 1 Mus musculus 63-86 16445292-2 2006 The overexpression of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, also elevates CK2 kinase activity in primary keratinocytes and tissues of K6/ODC transgenic mice. Polyamines 81-90 ornithine decarboxylase, structural 1 Mus musculus 47-50 15375010-0 2005 Elevated polyamines lead to selective induction of apoptosis and inhibition of tumorigenesis by (-)-epigallocatechin-3-gallate (EGCG) in ODC/Ras transgenic mice. Polyamines 9-19 ornithine decarboxylase, structural 1 Mus musculus 137-140 15734996-4 2005 Compared with Odc(+/+) mice, Odc(+/-) mice exhibit reduced epidermal ODC enzyme activity and polyamine accumulation following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Polyamines 93-102 ornithine decarboxylase, structural 1 Mus musculus 29-32 15734996-7 2005 These results support the concept that differences in tissue polyamine levels, resulting from either overexpression or reductions in ODC, are important modifiers of tumor susceptibility. Polyamines 61-70 ornithine decarboxylase, structural 1 Mus musculus 133-136 15514084-2 2005 Although ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, is a target of LH in the ovary, the functional significance of ODC induction has remained elusive. Polyamines 56-65 ornithine decarboxylase, structural 1 Mus musculus 9-32 15514084-2 2005 Although ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, is a target of LH in the ovary, the functional significance of ODC induction has remained elusive. Polyamines 56-65 ornithine decarboxylase, structural 1 Mus musculus 34-37 15539552-0 2005 Testosterone down-regulates ornithine aminotransferase gene and up-regulates arginase II and ornithine decarboxylase genes for polyamines synthesis in the murine kidney. Polyamines 127-137 ornithine decarboxylase, structural 1 Mus musculus 93-116 15611981-1 2005 Elevated polyamine levels as a consequence of targeted overexpression of ornithine decarboxylase (ODC) to murine skin enhance susceptibility to tumorigenesis in this tissue. Polyamines 9-18 ornithine decarboxylase, structural 1 Mus musculus 73-96 15611981-1 2005 Elevated polyamine levels as a consequence of targeted overexpression of ornithine decarboxylase (ODC) to murine skin enhance susceptibility to tumorigenesis in this tissue. Polyamines 9-18 ornithine decarboxylase, structural 1 Mus musculus 98-101 15265947-2 2004 Importantly, arginase synthesizes ornithine, which is metabolized by the enzyme ornithine decarboxylase (ODC) to produce polyamines. Polyamines 121-131 ornithine decarboxylase, structural 1 Mus musculus 80-103 15276653-2 2004 We show that cisplatin significantly induces the expression of two enzymes critical to proper homeostasis of cellular polyamines, ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SSAT). Polyamines 118-128 ornithine decarboxylase, structural 1 Mus musculus 130-153 15276653-2 2004 We show that cisplatin significantly induces the expression of two enzymes critical to proper homeostasis of cellular polyamines, ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SSAT). Polyamines 118-128 ornithine decarboxylase, structural 1 Mus musculus 155-158 15265947-2 2004 Importantly, arginase synthesizes ornithine, which is metabolized by the enzyme ornithine decarboxylase (ODC) to produce polyamines. Polyamines 121-131 ornithine decarboxylase, structural 1 Mus musculus 105-108 15067319-1 2004 Solar ultraviolet B (UVB) radiation induces cutaneous ornithine decarboxylase (ODC), the first enzyme in the polyamine-biosynthesis pathway, which drives continued proliferation and clonal expansion of initiated (mutated) cells, leading to tumorigenesis. Polyamines 109-118 ornithine decarboxylase, structural 1 Mus musculus 54-77 15175104-8 2004 The enzymatic activity of ODC, the target of DFMO, was substantially reduced after treatment with 1% DFMO and the high SCC polyamine levels, especially putrescine, were also significantly lowered. Polyamines 123-132 ornithine decarboxylase, structural 1 Mus musculus 26-29 15067319-1 2004 Solar ultraviolet B (UVB) radiation induces cutaneous ornithine decarboxylase (ODC), the first enzyme in the polyamine-biosynthesis pathway, which drives continued proliferation and clonal expansion of initiated (mutated) cells, leading to tumorigenesis. Polyamines 109-118 ornithine decarboxylase, structural 1 Mus musculus 79-82 12220664-4 2002 Both ERK and caspase activation were blocked in cells depleted of polyamines by the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO). Polyamines 66-76 ornithine decarboxylase, structural 1 Mus musculus 84-107 12873989-1 2003 Antizyme (AZ) is known to be a regulator of polyamine metabolism that inhibits ornithine decarboxylase activity and polyamine transport, thus restricting polyamine levels. Polyamines 44-53 ornithine decarboxylase, structural 1 Mus musculus 79-102 12653638-3 2003 Mice with large increases in ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase or antizyme, a protein regulating polyamine synthesis by reducing polyamine transport and ODC in the heart, have been produced using constructs in which the protein is expressed from the alpha -myosin heavy-chain promoter. Polyamines 129-138 ornithine decarboxylase, structural 1 Mus musculus 29-52 12653638-3 2003 Mice with large increases in ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase or antizyme, a protein regulating polyamine synthesis by reducing polyamine transport and ODC in the heart, have been produced using constructs in which the protein is expressed from the alpha -myosin heavy-chain promoter. Polyamines 129-138 ornithine decarboxylase, structural 1 Mus musculus 54-57 12653638-3 2003 Mice with large increases in ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase or antizyme, a protein regulating polyamine synthesis by reducing polyamine transport and ODC in the heart, have been produced using constructs in which the protein is expressed from the alpha -myosin heavy-chain promoter. Polyamines 129-138 ornithine decarboxylase, structural 1 Mus musculus 185-188 12653638-3 2003 Mice with large increases in ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase or antizyme, a protein regulating polyamine synthesis by reducing polyamine transport and ODC in the heart, have been produced using constructs in which the protein is expressed from the alpha -myosin heavy-chain promoter. Polyamines 161-170 ornithine decarboxylase, structural 1 Mus musculus 29-52 12653638-3 2003 Mice with large increases in ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase or antizyme, a protein regulating polyamine synthesis by reducing polyamine transport and ODC in the heart, have been produced using constructs in which the protein is expressed from the alpha -myosin heavy-chain promoter. Polyamines 161-170 ornithine decarboxylase, structural 1 Mus musculus 54-57 15228220-1 2004 Increased levels or overexpression of ornithine decarboxylase (ODC), a rate-limiting enzyme in polyamine biosynthesis pathway, is characteristic of tumor cells. Polyamines 95-104 ornithine decarboxylase, structural 1 Mus musculus 38-61 15228220-1 2004 Increased levels or overexpression of ornithine decarboxylase (ODC), a rate-limiting enzyme in polyamine biosynthesis pathway, is characteristic of tumor cells. Polyamines 95-104 ornithine decarboxylase, structural 1 Mus musculus 63-66 14640556-5 2003 The conjugate is also at least 230 times more active in suppressing the growth of L1210 murine leukemia cells than is the parent ligand, decreases the activities of the polyamine biosynthetic enzymes ornithine decarboxylase and S-adenosylmethionine decarboxylase, and upregulates spermidine-spermine N (1)-acetyltransferase. Polyamines 169-178 ornithine decarboxylase, structural 1 Mus musculus 200-223 14568000-2 2003 Capitalizing on the relative inefficiency of a moderate ionic strength extraction buffer to dissociate histones, we obtained evidence of altered chromatin in transgenic mice that overexpress ornithine decarboxylase (ODC), which catalyzes polyamine synthesis. Polyamines 238-247 ornithine decarboxylase, structural 1 Mus musculus 191-214 14568000-2 2003 Capitalizing on the relative inefficiency of a moderate ionic strength extraction buffer to dissociate histones, we obtained evidence of altered chromatin in transgenic mice that overexpress ornithine decarboxylase (ODC), which catalyzes polyamine synthesis. Polyamines 238-247 ornithine decarboxylase, structural 1 Mus musculus 216-219 14568000-4 2003 This could reflect tighter tethering of nucleosomes to DNA or a more compacted chromatin structure due to elevated intracellular concentrations of polyamines since this effect is reversible upon treatment with alpha-difluoromethylornithine (DFMO), a specific inhibitor of ODC enzymatic activity. Polyamines 147-157 ornithine decarboxylase, structural 1 Mus musculus 272-275 12709396-2 2003 In murine kidney, testosterone enhances gene expression of ornithine decarboxylase (ODC), the first enzyme in polyamine biosynthesis. Polyamines 110-119 ornithine decarboxylase, structural 1 Mus musculus 59-82 12709396-2 2003 In murine kidney, testosterone enhances gene expression of ornithine decarboxylase (ODC), the first enzyme in polyamine biosynthesis. Polyamines 110-119 ornithine decarboxylase, structural 1 Mus musculus 84-87 12709396-3 2003 In this study, we document the time course effect of testosterone on 1) gene expression of ODC, antizyme 1 (AZ1), and spermidine/spermine-N1-acetyltransferase (N1-SSAT); 2) ODC activity in proximal convoluted tubules (PCT) and cortical proximal straight tubules (CPST); and 3) renal polyamine levels. Polyamines 283-292 ornithine decarboxylase, structural 1 Mus musculus 91-94 12856719-1 2003 We have recently shown that administration of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in polyamine (PA) biosynthesis reduces pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice. Polyamines 182-191 ornithine decarboxylase, structural 1 Mus musculus 113-136 12856719-1 2003 We have recently shown that administration of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in polyamine (PA) biosynthesis reduces pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice. Polyamines 182-191 ornithine decarboxylase, structural 1 Mus musculus 138-141 12856719-1 2003 We have recently shown that administration of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in polyamine (PA) biosynthesis reduces pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice. Polyamines 193-195 ornithine decarboxylase, structural 1 Mus musculus 113-136 12856719-1 2003 We have recently shown that administration of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in polyamine (PA) biosynthesis reduces pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice. Polyamines 193-195 ornithine decarboxylase, structural 1 Mus musculus 138-141 12220664-7 2002 Ornithine decarboxylase activity decreased after etoposide, indicating that DFMO exerts its effect by depleting cellular polyamines before induction of apoptosis. Polyamines 121-131 ornithine decarboxylase, structural 1 Mus musculus 0-23 12054570-2 2002 Our results show that blockade of the preovulatory rise of ovarian ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, by treatment with the specific inhibitor alpha-difluoromethylornithine (DFMO) leads to a significant decrease in the ovarian progesterone content and a dramatic fall in the plasma levels of this hormone during the following diestrus. Polyamines 114-123 ornithine decarboxylase, structural 1 Mus musculus 67-90 11978014-4 2002 A combination of inhibitors of ornithine decarboxylase, S-adenosylmethionine decarboxylase, or spermidine synthase decreased intracellular polyamine levels and induced cell death in a WEHI231 murine B cell line. Polyamines 139-148 ornithine decarboxylase, structural 1 Mus musculus 31-54 12054570-2 2002 Our results show that blockade of the preovulatory rise of ovarian ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, by treatment with the specific inhibitor alpha-difluoromethylornithine (DFMO) leads to a significant decrease in the ovarian progesterone content and a dramatic fall in the plasma levels of this hormone during the following diestrus. Polyamines 114-123 ornithine decarboxylase, structural 1 Mus musculus 92-95 12054575-1 2002 Ornithine decarboxylase (ODC), the first rate-limiting enzyme in the polyamine biosynthesis is one of the most rapidly degraded proteins in eukaryotic cells. Polyamines 69-78 ornithine decarboxylase, structural 1 Mus musculus 25-28 11853879-11 2002 Rather, increased intracellular concentrations of polyamines following ODC induction might constitute a feedback mechanism to limit melanogenesis activation by alphaMSH. Polyamines 50-60 ornithine decarboxylase, structural 1 Mus musculus 71-74 11853879-1 2002 Ornithine decarboxylase (ODC) is the rate-limiting enzyme in the biosynthesis of polyamines, a family of cationic compounds required for optimal cell proliferation and differentiation. Polyamines 81-91 ornithine decarboxylase, structural 1 Mus musculus 0-23 11853879-1 2002 Ornithine decarboxylase (ODC) is the rate-limiting enzyme in the biosynthesis of polyamines, a family of cationic compounds required for optimal cell proliferation and differentiation. Polyamines 81-91 ornithine decarboxylase, structural 1 Mus musculus 25-28 11507056-2 2001 AZ is a multifunctional regulator of polyamine metabolism that inhibits ODC activity, stimulates ODC degradation, and suppresses polyamine uptake. Polyamines 37-46 ornithine decarboxylase, structural 1 Mus musculus 72-75 11782361-2 2002 We used transgenic mice to examine the effects of constitutive expression of ornithine decarboxylase (ODC), a key rate-limiting enzyme in polyamine biosynthesis, on histone acetylation in epithelial cells in skin. Polyamines 138-147 ornithine decarboxylase, structural 1 Mus musculus 77-100 11782361-2 2002 We used transgenic mice to examine the effects of constitutive expression of ornithine decarboxylase (ODC), a key rate-limiting enzyme in polyamine biosynthesis, on histone acetylation in epithelial cells in skin. Polyamines 138-147 ornithine decarboxylase, structural 1 Mus musculus 102-105 11782361-6 2002 Treatment with the ODC enzyme inhibitor alpha-difluoromethylornithine, which results in regression of ODC/Ras tumors, reverses the effects on HAT and deacetylase enzyme function, implicating polyamine biosynthesis in the regulation of histone acetylation. Polyamines 191-200 ornithine decarboxylase, structural 1 Mus musculus 19-22 11513732-0 2001 Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N(1)-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice. Polyamines 146-156 ornithine decarboxylase, structural 1 Mus musculus 29-52 11513732-3 2001 Interestingly, the profound depletion of the higher polyamines in the hybrid animals occurred in the presence of strikingly high ODC activity and tremendous putrescine accumulation. Polyamines 52-62 ornithine decarboxylase, structural 1 Mus musculus 129-132 11507056-2 2001 AZ is a multifunctional regulator of polyamine metabolism that inhibits ODC activity, stimulates ODC degradation, and suppresses polyamine uptake. Polyamines 37-46 ornithine decarboxylase, structural 1 Mus musculus 97-100 11241834-2 2001 Cells acquire polyamines by energy-dependent transport and by synthesis where the highly regulated ornithine decarboxylase (ODC) catalyzes the first and rate-controlling step. Polyamines 14-24 ornithine decarboxylase, structural 1 Mus musculus 99-122 11241834-3 2001 Inactivation of ODC is mainly exerted by antizyme (AZ), a 20--25 kDa polyamine-induced protein that binds to ODC, inactivates it, and targets it for degradation by the 26S proteasome without ubiquitination. Polyamines 69-78 ornithine decarboxylase, structural 1 Mus musculus 109-112 11241834-5 2001 The expression patterns for ODC and AZ were found to be developmentally regulated, suggesting important functions for the polyamines in early embryogenesis, axonogenesis, epithelial-mesenchymal interaction, and in apoptosis. Polyamines 122-132 ornithine decarboxylase, structural 1 Mus musculus 28-31 11241834-2 2001 Cells acquire polyamines by energy-dependent transport and by synthesis where the highly regulated ornithine decarboxylase (ODC) catalyzes the first and rate-controlling step. Polyamines 14-24 ornithine decarboxylase, structural 1 Mus musculus 124-127 11241834-3 2001 Inactivation of ODC is mainly exerted by antizyme (AZ), a 20--25 kDa polyamine-induced protein that binds to ODC, inactivates it, and targets it for degradation by the 26S proteasome without ubiquitination. Polyamines 69-78 ornithine decarboxylase, structural 1 Mus musculus 16-19 11235918-3 2001 The present study demonstrates a novel link between alterations in phorbol ester tumour promoter mediated regulation during malignant conversion and the expression of ornithine decarboxylase and S-adenosylmethionine decarboxylase, key rate-limiting and regulatory activities in the biosynthesis of polyamines. Polyamines 298-308 ornithine decarboxylase, structural 1 Mus musculus 167-190 11244502-5 2001 Ectopic expression of ODC-Az gene in hamster malignant oral keratinocytes led to reduce ODC activity and the subsequent demethylation of 5-methyl cytosines, presumably via the ODC/ polyamines/ decarboxylated S-adenosylmethionine (dc-AdoMet) pathways. Polyamines 181-191 ornithine decarboxylase, structural 1 Mus musculus 22-25 11244502-6 2001 Our data suggest that ODC-Az shared the same pathway of polyamines/ dc-AdoMet/DNA methyltransferase (DNA MTase). Polyamines 56-66 ornithine decarboxylase, structural 1 Mus musculus 22-25 11235918-10 2001 The status of the cellular polyamine levels was also an important determinant of the PMA-mediated alterations that occurred in ODC and in SAMDC expression in these H-ras transformed cells. Polyamines 27-36 ornithine decarboxylase, structural 1 Mus musculus 127-130 10781085-1 2000 Previous studies with mice overproducing ornithine decarboxylase have demonstrated the importance of polyamine homeostasis for normal mammalian spermatogenesis. Polyamines 101-110 ornithine decarboxylase, structural 1 Mus musculus 41-64 10970775-3 2000 Antizyme-1 is thought to be a major factor in regulating cellular polyamine content, acting both to inhibit ornithine decarboxylase (ODC) activity and to target it for degradation, as well as preventing polyamine uptake. Polyamines 66-75 ornithine decarboxylase, structural 1 Mus musculus 108-131 10970775-3 2000 Antizyme-1 is thought to be a major factor in regulating cellular polyamine content, acting both to inhibit ornithine decarboxylase (ODC) activity and to target it for degradation, as well as preventing polyamine uptake. Polyamines 66-75 ornithine decarboxylase, structural 1 Mus musculus 133-136 11180396-2 2001 The present study demonstrates a novel link between alterations in TGF-beta(1) regulation during cellular transformation and malignant conversion and the expression of ornithine decarboxylase (ODC) which is a key rate limiting activity in the biosynthesis of polyamines and which is an enzyme that plays an important role in cell growth and differentiation. Polyamines 259-269 ornithine decarboxylase, structural 1 Mus musculus 168-191 11180396-2 2001 The present study demonstrates a novel link between alterations in TGF-beta(1) regulation during cellular transformation and malignant conversion and the expression of ornithine decarboxylase (ODC) which is a key rate limiting activity in the biosynthesis of polyamines and which is an enzyme that plays an important role in cell growth and differentiation. Polyamines 259-269 ornithine decarboxylase, structural 1 Mus musculus 193-196 11180396-8 2001 Evidence is also presented to suggest a possible role for cellular polyamines in the TGF-beta(1)-mediated alterations in ODC expression in H-ras transformed cells. Polyamines 67-77 ornithine decarboxylase, structural 1 Mus musculus 121-124 10903418-1 2000 Ornithine decarboxylase is the rate-limiting enzyme in the biosynthesis of polyamines, which are believed to play an essential role in diverse biological processes including cell proliferation and differentiation. Polyamines 75-85 ornithine decarboxylase, structural 1 Mus musculus 0-23 10727431-1 2000 The regulation of polyamine transport by antizyme, a protein that is involved in the rapid degradation of ornithine decarboxylase (ODC), was studied in FM3A mouse cells overproducing ODC. Polyamines 18-27 ornithine decarboxylase, structural 1 Mus musculus 106-129 10727431-1 2000 The regulation of polyamine transport by antizyme, a protein that is involved in the rapid degradation of ornithine decarboxylase (ODC), was studied in FM3A mouse cells overproducing ODC. Polyamines 18-27 ornithine decarboxylase, structural 1 Mus musculus 131-134 10727431-1 2000 The regulation of polyamine transport by antizyme, a protein that is involved in the rapid degradation of ornithine decarboxylase (ODC), was studied in FM3A mouse cells overproducing ODC. Polyamines 18-27 ornithine decarboxylase, structural 1 Mus musculus 183-186 10772389-2 2000 The growth phase, known as anagen, is associated with rapid rates of cell turnover, and variations in the rate of DNA synthesis in mouse skin throughout the hair cycle are accompanied by changes in the activity of ornithine decarboxylase (ODC), a key enzyme in the synthesis of polyamines, which are actively involved in regulation of normal cell division, differentiation, and growth. Polyamines 278-288 ornithine decarboxylase, structural 1 Mus musculus 214-237 10772389-2 2000 The growth phase, known as anagen, is associated with rapid rates of cell turnover, and variations in the rate of DNA synthesis in mouse skin throughout the hair cycle are accompanied by changes in the activity of ornithine decarboxylase (ODC), a key enzyme in the synthesis of polyamines, which are actively involved in regulation of normal cell division, differentiation, and growth. Polyamines 278-288 ornithine decarboxylase, structural 1 Mus musculus 239-242 10698696-1 2000 Ornithine decarboxylase (ODC) catalyses the first step in the synthesis of the polyamines putrescine, spermidine and spermine. Polyamines 79-89 ornithine decarboxylase, structural 1 Mus musculus 0-23 10698696-1 2000 Ornithine decarboxylase (ODC) catalyses the first step in the synthesis of the polyamines putrescine, spermidine and spermine. Polyamines 79-89 ornithine decarboxylase, structural 1 Mus musculus 25-28 10698696-5 2000 By causing ribosomal frameshifting, polyamines induce the synthesis of antizyme, a 23-kDa protein, which binds to ODC, inhibits its activity and promotes its degradation by the 26 S proteasome. Polyamines 36-46 ornithine decarboxylase, structural 1 Mus musculus 114-117 9585063-2 1998 Feeding high doses of vitamin E suppressed the NNK-induced elevation of the activity of ornithine decarboxylase, a key enzyme of polyamine biosynthesis, in the lungs of mice at 4 weeks after injection. Polyamines 129-138 ornithine decarboxylase, structural 1 Mus musculus 88-111 10593650-6 1999 Thus, ODC/polyamine-induced activation of cyclin E/Cdk2 and cyclin A/Cdk2-associated kinase activity may cooperate with the ras induction of cyclin D/Cdk4/6-associated retinoblastoma protein phosphorylation to not only stimulate proliferation but ultimately contribute to tumor development. Polyamines 10-19 ornithine decarboxylase, structural 1 Mus musculus 6-9 10446971-5 1999 ODC activity and tissue polyamine contents were differentially elevated in ear and chest skin during carcinogenesis, such that there was a marked elevation of both parameters of polyamine metabolism as early as 4 weeks of age in the ear, whereas in the chest, polyamine metabolism was increased significantly only in the late stages of neoplastic progression and in epidermal cancers. Polyamines 178-187 ornithine decarboxylase, structural 1 Mus musculus 0-3 10446971-5 1999 ODC activity and tissue polyamine contents were differentially elevated in ear and chest skin during carcinogenesis, such that there was a marked elevation of both parameters of polyamine metabolism as early as 4 weeks of age in the ear, whereas in the chest, polyamine metabolism was increased significantly only in the late stages of neoplastic progression and in epidermal cancers. Polyamines 178-187 ornithine decarboxylase, structural 1 Mus musculus 0-3 10430664-6 1999 We also show, through analysis of an interspecific backcross, that Amd-2 is located on Chr 12, tightly linked to the gene (Odc) that encodes ornithine decarboxylase, another key enzyme in polyamine synthesis. Polyamines 188-197 ornithine decarboxylase, structural 1 Mus musculus 123-126 10430664-6 1999 We also show, through analysis of an interspecific backcross, that Amd-2 is located on Chr 12, tightly linked to the gene (Odc) that encodes ornithine decarboxylase, another key enzyme in polyamine synthesis. Polyamines 188-197 ornithine decarboxylase, structural 1 Mus musculus 141-164 9926931-1 1999 Anti-tumor activity of antizyme which targets the ornithine decarboxylase (ODC) required for cell growth and transformation Cell proliferation and transformation induced by growth factor stimulation or by carcinogens, viruses, or oncogenes are characterized by an associated increase in polyamine levels, which is mediated by increased polyamine biosynthesis and enhanced uptake of polyamines. Polyamines 287-296 ornithine decarboxylase, structural 1 Mus musculus 50-73 9926931-1 1999 Anti-tumor activity of antizyme which targets the ornithine decarboxylase (ODC) required for cell growth and transformation Cell proliferation and transformation induced by growth factor stimulation or by carcinogens, viruses, or oncogenes are characterized by an associated increase in polyamine levels, which is mediated by increased polyamine biosynthesis and enhanced uptake of polyamines. Polyamines 287-296 ornithine decarboxylase, structural 1 Mus musculus 75-78 9926931-1 1999 Anti-tumor activity of antizyme which targets the ornithine decarboxylase (ODC) required for cell growth and transformation Cell proliferation and transformation induced by growth factor stimulation or by carcinogens, viruses, or oncogenes are characterized by an associated increase in polyamine levels, which is mediated by increased polyamine biosynthesis and enhanced uptake of polyamines. Polyamines 336-345 ornithine decarboxylase, structural 1 Mus musculus 75-78 9926931-1 1999 Anti-tumor activity of antizyme which targets the ornithine decarboxylase (ODC) required for cell growth and transformation Cell proliferation and transformation induced by growth factor stimulation or by carcinogens, viruses, or oncogenes are characterized by an associated increase in polyamine levels, which is mediated by increased polyamine biosynthesis and enhanced uptake of polyamines. Polyamines 382-392 ornithine decarboxylase, structural 1 Mus musculus 75-78 9926931-2 1999 Polyamine biosynthesis is catalyzed particularly, in the level of ornithine decarboxylase (ODC). Polyamines 0-9 ornithine decarboxylase, structural 1 Mus musculus 66-89 9926931-2 1999 Polyamine biosynthesis is catalyzed particularly, in the level of ornithine decarboxylase (ODC). Polyamines 0-9 ornithine decarboxylase, structural 1 Mus musculus 91-94 9926931-3 1999 The elevation of cellular polyamine levels on the other hand accelerates the induction of ornithine decarboxylase antizyme (antizyme), which is involved not only in ODC-degradation, but in the negative regulation of polyamine transport. Polyamines 26-35 ornithine decarboxylase, structural 1 Mus musculus 90-113 9926931-3 1999 The elevation of cellular polyamine levels on the other hand accelerates the induction of ornithine decarboxylase antizyme (antizyme), which is involved not only in ODC-degradation, but in the negative regulation of polyamine transport. Polyamines 26-35 ornithine decarboxylase, structural 1 Mus musculus 165-168 9926931-3 1999 The elevation of cellular polyamine levels on the other hand accelerates the induction of ornithine decarboxylase antizyme (antizyme), which is involved not only in ODC-degradation, but in the negative regulation of polyamine transport. Polyamines 216-225 ornithine decarboxylase, structural 1 Mus musculus 90-113 9926931-3 1999 The elevation of cellular polyamine levels on the other hand accelerates the induction of ornithine decarboxylase antizyme (antizyme), which is involved not only in ODC-degradation, but in the negative regulation of polyamine transport. Polyamines 216-225 ornithine decarboxylase, structural 1 Mus musculus 165-168 9884080-1 1998 We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by alpha-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 macrophages. Polyamines 43-52 ornithine decarboxylase, structural 1 Mus musculus 163-186 9884080-1 1998 We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by alpha-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 macrophages. Polyamines 43-52 ornithine decarboxylase, structural 1 Mus musculus 188-191 9563478-2 1998 We demonstrate that in transgenic mice overexpressing ornithine decarboxylase in skin, changes in tissue polyamine levels, particularly putrescine, control the development and maintenance of the neoplastic phenotype. Polyamines 105-114 ornithine decarboxylase, structural 1 Mus musculus 54-77 10564759-5 1999 Consistently, the level of antizyme, a polyamine-inducible protein, determined as the ODC-antizyme complex level, scarcely changed after feeding, and the antizyme/ODC ratio in the kidney largely decreased, resulting in the stabilization of ODC protein. Polyamines 39-48 ornithine decarboxylase, structural 1 Mus musculus 86-89 10564759-6 1999 The present results suggest that the strong excretion system of the kidney for newly synthesized polyamines enables renal ODC escape from antizyme-mediated feedback regulation. Polyamines 97-107 ornithine decarboxylase, structural 1 Mus musculus 122-125 10469614-3 1999 In order to determine how APC mutation influences intestinal tissue polyamine content, we measured steady-state RNA levels of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, antizyme (AZ), a protein which negatively regulates ODC, and the spermidine/spermine N(1)-acetyltransferase (SSAT), the first enzyme in polyamine catabolism. Polyamines 177-186 ornithine decarboxylase, structural 1 Mus musculus 126-149 10469614-3 1999 In order to determine how APC mutation influences intestinal tissue polyamine content, we measured steady-state RNA levels of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, antizyme (AZ), a protein which negatively regulates ODC, and the spermidine/spermine N(1)-acetyltransferase (SSAT), the first enzyme in polyamine catabolism. Polyamines 177-186 ornithine decarboxylase, structural 1 Mus musculus 151-154 10469614-3 1999 In order to determine how APC mutation influences intestinal tissue polyamine content, we measured steady-state RNA levels of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, antizyme (AZ), a protein which negatively regulates ODC, and the spermidine/spermine N(1)-acetyltransferase (SSAT), the first enzyme in polyamine catabolism. Polyamines 177-186 ornithine decarboxylase, structural 1 Mus musculus 126-149 10469614-3 1999 In order to determine how APC mutation influences intestinal tissue polyamine content, we measured steady-state RNA levels of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, antizyme (AZ), a protein which negatively regulates ODC, and the spermidine/spermine N(1)-acetyltransferase (SSAT), the first enzyme in polyamine catabolism. Polyamines 177-186 ornithine decarboxylase, structural 1 Mus musculus 151-154 10469614-6 1999 Treatment of Min mice with the specific ODC inhibitor difluoromethylornithine (DFMO) suppressed small intestinal, but not colonic, polyamine content and tumor number. Polyamines 131-140 ornithine decarboxylase, structural 1 Mus musculus 40-43 10469614-7 1999 These data indicate that small intestinal tissue polyamine content is elevated in Min mice by a mechanism involving APC-dependent changes in ODC and AZ RNA. Polyamines 49-58 ornithine decarboxylase, structural 1 Mus musculus 141-144 10393991-2 1999 Ornithine decarboxylase (ODC), a key enzyme in the biosynthetic pathway of polyamines, is induced in the kidney by androgens, and its activity is higher in the kidney of male mice. Polyamines 75-85 ornithine decarboxylase, structural 1 Mus musculus 0-23 10393991-2 1999 Ornithine decarboxylase (ODC), a key enzyme in the biosynthetic pathway of polyamines, is induced in the kidney by androgens, and its activity is higher in the kidney of male mice. Polyamines 75-85 ornithine decarboxylase, structural 1 Mus musculus 25-28 9769382-1 1998 The mechanism by which DL-alpha-difluoromethylornithine (DFMO) inhibits angiogenesis is generally thought to involve the inhibition of the rate-limiting enzyme, ornithine decarboxylase (ODC), leading to polyamine depletion in cells and the ultimate cytostatic effect on proliferating endothelial cells. Polyamines 203-212 ornithine decarboxylase, structural 1 Mus musculus 161-184 9769382-1 1998 The mechanism by which DL-alpha-difluoromethylornithine (DFMO) inhibits angiogenesis is generally thought to involve the inhibition of the rate-limiting enzyme, ornithine decarboxylase (ODC), leading to polyamine depletion in cells and the ultimate cytostatic effect on proliferating endothelial cells. Polyamines 203-212 ornithine decarboxylase, structural 1 Mus musculus 186-189 9744537-1 1998 Ornithine decarboxylase (ODC) is aberrantly regulated in tumor cells and results in high basal levels of ODC and polyamines in many epithelial tumors. Polyamines 113-123 ornithine decarboxylase, structural 1 Mus musculus 0-23 9744537-1 1998 Ornithine decarboxylase (ODC) is aberrantly regulated in tumor cells and results in high basal levels of ODC and polyamines in many epithelial tumors. Polyamines 113-123 ornithine decarboxylase, structural 1 Mus musculus 25-28 9744537-3 1998 A K6 keratin promoter drives the ODC transgene in K6/ ODC transgenic mice, which results in elevated ODC/ polyamine levels directed to the outer root sheath cells of hair follicles. Polyamines 106-115 ornithine decarboxylase, structural 1 Mus musculus 33-36 9744537-3 1998 A K6 keratin promoter drives the ODC transgene in K6/ ODC transgenic mice, which results in elevated ODC/ polyamine levels directed to the outer root sheath cells of hair follicles. Polyamines 106-115 ornithine decarboxylase, structural 1 Mus musculus 54-57 9744537-3 1998 A K6 keratin promoter drives the ODC transgene in K6/ ODC transgenic mice, which results in elevated ODC/ polyamine levels directed to the outer root sheath cells of hair follicles. Polyamines 106-115 ornithine decarboxylase, structural 1 Mus musculus 54-57 9563478-7 1998 The regulatory polyamine in this model appears to be putrescine, the immediate product of ornithine decarboxylase. Polyamines 15-24 ornithine decarboxylase, structural 1 Mus musculus 90-113 9609384-7 1998 Further evaluation of the effect of EGC showed that the activity of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis in cells, decreased significantly as well. Polyamines 115-124 ornithine decarboxylase, structural 1 Mus musculus 68-91 9609384-7 1998 Further evaluation of the effect of EGC showed that the activity of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis in cells, decreased significantly as well. Polyamines 115-124 ornithine decarboxylase, structural 1 Mus musculus 93-96 9517837-1 1998 The role of putrescine in synaptic neurotransmission and plasticity was studied using transgenic mice overexpressing ornithine decarboxylase (ODC), a polyamine-synthesizing enzyme. Polyamines 150-159 ornithine decarboxylase, structural 1 Mus musculus 142-145 9615732-1 1998 Polyamines and their biosynthetic enzymes, such as ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC), are crucial for normal and neoplastic cell growth and differentiation. Polyamines 0-10 ornithine decarboxylase, structural 1 Mus musculus 51-74 9615732-1 1998 Polyamines and their biosynthetic enzymes, such as ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC), are crucial for normal and neoplastic cell growth and differentiation. Polyamines 0-10 ornithine decarboxylase, structural 1 Mus musculus 76-79 9562432-1 1998 Ornithine decarboxylase (ODC) is a key enzyme in the polyamine synthesis pathway in African trypanosomes. Polyamines 53-62 ornithine decarboxylase, structural 1 Mus musculus 25-28 9428668-0 1997 Polyamines regulate both transcription and translation of the gene encoding ornithine decarboxylase antizyme in mouse. Polyamines 0-10 ornithine decarboxylase, structural 1 Mus musculus 76-99 9449846-0 1998 Metabolism of polyamines in transgenic cells of carrot expressing a mouse ornithine decarboxylase cDNA. Polyamines 14-24 ornithine decarboxylase, structural 1 Mus musculus 74-97 9428668-1 1997 The degradation of ornithine decarboxylase (ODC) is mediated by antizyme, a protein regulated by the end-products of ODC activity, the polyamines. Polyamines 135-145 ornithine decarboxylase, structural 1 Mus musculus 19-42 9428668-1 1997 The degradation of ornithine decarboxylase (ODC) is mediated by antizyme, a protein regulated by the end-products of ODC activity, the polyamines. Polyamines 135-145 ornithine decarboxylase, structural 1 Mus musculus 44-47 9428668-1 1997 The degradation of ornithine decarboxylase (ODC) is mediated by antizyme, a protein regulated by the end-products of ODC activity, the polyamines. Polyamines 135-145 ornithine decarboxylase, structural 1 Mus musculus 117-120 9428668-8 1997 These results indicate a role for polyamines in the transcriptional and translational regulation of ornithine decarboxylase antizyme. Polyamines 34-44 ornithine decarboxylase, structural 1 Mus musculus 100-123 9224728-4 1997 The effects of 1alpha,25-(OH)2D3 were preceded by the suppression of ornithine decarboxylase (ODC) activity, a rate-limiting enzyme in polyamine metabolism. Polyamines 135-144 ornithine decarboxylase, structural 1 Mus musculus 69-92 9230217-6 1997 The tumorigenicity of ODC transformants was associated with elevated polyamine levels and down-regulated growth factor receptors. Polyamines 69-78 ornithine decarboxylase, structural 1 Mus musculus 22-25 9224728-4 1997 The effects of 1alpha,25-(OH)2D3 were preceded by the suppression of ornithine decarboxylase (ODC) activity, a rate-limiting enzyme in polyamine metabolism. Polyamines 135-144 ornithine decarboxylase, structural 1 Mus musculus 94-97 9106645-1 1997 BACKGROUND: Ornithine decarboxylase (ODC) plays a pivotal role in the synthesis of polyamines, a group of chemical compounds that are essential for cell growth. Polyamines 83-93 ornithine decarboxylase, structural 1 Mus musculus 12-35 9139705-1 1997 Ornithine decarboxylase (ODC) is the key initial enzyme in the biosynthesis of polyamines. Polyamines 79-89 ornithine decarboxylase, structural 1 Mus musculus 0-23 9139705-1 1997 Ornithine decarboxylase (ODC) is the key initial enzyme in the biosynthesis of polyamines. Polyamines 79-89 ornithine decarboxylase, structural 1 Mus musculus 25-28 9139705-3 1997 Infection of Balb/MK cells with an ODC retrovirus to elevate ODC and polyamine levels increased overall protein phosphorylation as well as CK2 protein levels and enzyme activity in mimosine- or nocodazole- arrested cells. Polyamines 69-78 ornithine decarboxylase, structural 1 Mus musculus 35-38 9139705-4 1997 Immunofluorescence microscopy and enzyme analyses of subcellular fractions from ODC-overexpressing cells demonstrated translocation of CK2 from the cytoplasm to the nucleus with no apparent loss of cytoplasmic CK2 activity, suggesting polyamine activation of the remaining cytoplasmic enzyme. Polyamines 235-244 ornithine decarboxylase, structural 1 Mus musculus 80-83 9139705-8 1997 However, the addition of difluoromethylornithine, a specific ODC inhibitor, to the transgenic keratinocytes reduced both intracellular polyamine levels and CK2 enzyme activity. Polyamines 135-144 ornithine decarboxylase, structural 1 Mus musculus 61-64 9210404-1 1997 Ornithine decarboxylase antizyme is a protein that participates in the regulation of cellular polyamine levels. Polyamines 94-103 ornithine decarboxylase, structural 1 Mus musculus 0-23 9171471-3 1997 Recruitment of cells from the G0G1 state into DNA synthesis was associated with an increased mobilization of substrates for polyamine synthesis in terms of an elevated ornithine decarboxylase (ODC) activity. Polyamines 124-133 ornithine decarboxylase, structural 1 Mus musculus 168-191 9171471-3 1997 Recruitment of cells from the G0G1 state into DNA synthesis was associated with an increased mobilization of substrates for polyamine synthesis in terms of an elevated ornithine decarboxylase (ODC) activity. Polyamines 124-133 ornithine decarboxylase, structural 1 Mus musculus 193-196 9106645-1 1997 BACKGROUND: Ornithine decarboxylase (ODC) plays a pivotal role in the synthesis of polyamines, a group of chemical compounds that are essential for cell growth. Polyamines 83-93 ornithine decarboxylase, structural 1 Mus musculus 37-40 9106645-15 1997 IMPLICATIONS: Our results demonstrate a connection between the polyamine/ODC and the MAP kinase signal transduction pathways and suggest that MAP kinase may play a pivotal role in ODC-induced cell transformation and invasion. Polyamines 63-72 ornithine decarboxylase, structural 1 Mus musculus 73-76 9106645-15 1997 IMPLICATIONS: Our results demonstrate a connection between the polyamine/ODC and the MAP kinase signal transduction pathways and suggest that MAP kinase may play a pivotal role in ODC-induced cell transformation and invasion. Polyamines 63-72 ornithine decarboxylase, structural 1 Mus musculus 180-183 9191978-6 1997 We also found that the basal activity of ornithine decarboxylase (ODC), a rate-limiting enzyme of polyamine biosynthesis, was higher in Wobbler mice than in control animals. Polyamines 98-107 ornithine decarboxylase, structural 1 Mus musculus 41-64 9024798-3 1997 When C55.7 cells were transfected with either mouse ODC (M) or trypanosome ODC (Tb), intracellular putrescine content increased slightly in C55.7(Tb-ODC), compared to C55.7(M-ODC), due to the lack of response of Tb-ODC to polyamine regulation. Polyamines 222-231 ornithine decarboxylase, structural 1 Mus musculus 52-55 9024798-5 1997 When the feedback repression of polyamine uptake was blocked with cycloheximide, C55.7 cells transfected with either ODC construct accumulated very high levels of putrescine from the medium, and underwent apoptosis in a putrescine dose-dependent manner. Polyamines 32-41 ornithine decarboxylase, structural 1 Mus musculus 117-120 9027363-7 1997 The cellular uptake of polyamines in the liver from tg+ mice showed an increase and considerable changes were observed in the activity of ornithine decarboxylase (ODC) in the liver and kidney and S-adenosylmethionine decarboxylase (AdoMetDC) in the liver. Polyamines 23-33 ornithine decarboxylase, structural 1 Mus musculus 138-161 9027363-7 1997 The cellular uptake of polyamines in the liver from tg+ mice showed an increase and considerable changes were observed in the activity of ornithine decarboxylase (ODC) in the liver and kidney and S-adenosylmethionine decarboxylase (AdoMetDC) in the liver. Polyamines 23-33 ornithine decarboxylase, structural 1 Mus musculus 163-166 9020157-1 1997 When ornithine decarboxylase, the initial and highly regulated enzyme in polyamine biosynthesis, is irreversibly inactivated by alpha-difluoromethylornithine, F9 teratocarcinoma stem cells are depleted of putrescine and spermidine and as a result differentiate into a cell type which phenotypically resembles the parietal endoderm cells of the early mouse embryo. Polyamines 73-82 ornithine decarboxylase, structural 1 Mus musculus 5-28 9252204-2 1997 By treating the mice with a polyamine-deficient diet containing neomycin, metronidazole and inhibitors of ornithine decarboxylase and polyamine oxydase, tumour growth was reduced and the immune abnormalities were reversed. Polyamines 28-37 ornithine decarboxylase, structural 1 Mus musculus 106-129 9191978-6 1997 We also found that the basal activity of ornithine decarboxylase (ODC), a rate-limiting enzyme of polyamine biosynthesis, was higher in Wobbler mice than in control animals. Polyamines 98-107 ornithine decarboxylase, structural 1 Mus musculus 66-69 8912847-1 1996 pMV7-4E cells (4E-P2), which overexpress translation initiation factor eIF-4E, contain elevated levels of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in polyamine biosynthesis. Polyamines 175-184 ornithine decarboxylase, structural 1 Mus musculus 106-129 9022291-1 1996 Previous studies have shown that growth suppression and apoptosis of leukemic cells exposed to TGF-beta 1 is associated with the inhibition of ornithine decarboxylase (ODC)--the key enzyme of polyamine pathway. Polyamines 192-201 ornithine decarboxylase, structural 1 Mus musculus 143-166 9022291-1 1996 Previous studies have shown that growth suppression and apoptosis of leukemic cells exposed to TGF-beta 1 is associated with the inhibition of ornithine decarboxylase (ODC)--the key enzyme of polyamine pathway. Polyamines 192-201 ornithine decarboxylase, structural 1 Mus musculus 168-171 8912847-1 1996 pMV7-4E cells (4E-P2), which overexpress translation initiation factor eIF-4E, contain elevated levels of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in polyamine biosynthesis. Polyamines 175-184 ornithine decarboxylase, structural 1 Mus musculus 131-134 8875319-3 1996 The dramatic ODC overexpression resulted in a very high accumulation of the polyamine putrescine in the brain. Polyamines 76-85 ornithine decarboxylase, structural 1 Mus musculus 13-16 8798774-1 1996 Ornithine decarboxylase (ODC) is the initial inducible enzyme in the polyamine biosynthetic pathway. Polyamines 69-78 ornithine decarboxylase, structural 1 Mus musculus 0-23 8798774-1 1996 Ornithine decarboxylase (ODC) is the initial inducible enzyme in the polyamine biosynthetic pathway. Polyamines 69-78 ornithine decarboxylase, structural 1 Mus musculus 25-28 8764119-2 1996 Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, is induced in 4E-P2 cells, and this induction appears to be related to the transformed phenotype of these cells. Polyamines 59-68 ornithine decarboxylase, structural 1 Mus musculus 0-23 8764119-2 1996 Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, is induced in 4E-P2 cells, and this induction appears to be related to the transformed phenotype of these cells. Polyamines 59-68 ornithine decarboxylase, structural 1 Mus musculus 25-28 8764119-8 1996 To examine the differences in ODC regulation by polyamines in normal and transformed cells, the effect of N1,N12-bis(ethyl)spermine (BE-3-4-3) on the synthesis and degradation of ODC was examined. Polyamines 48-58 ornithine decarboxylase, structural 1 Mus musculus 30-33 8764119-9 1996 ODC activity in 4E-P2 cells was 10 times less sensitive to reduction by BE-3-4-3 compared to 3T3 cells, suggesting that high ODC levels in eIF-4E-overexpressing cells are the result of decreased regulation by polyamines as well as relief of translational regulation by eIF-4E. Polyamines 209-219 ornithine decarboxylase, structural 1 Mus musculus 0-3 7478599-1 1995 Ornithine decarboxylase (ODC), the first enzyme in the biosynthesis of polyamines, is essential for the process of cellular proliferation. Polyamines 71-81 ornithine decarboxylase, structural 1 Mus musculus 0-23 8721347-11 1996 In mouse mammary carcinoma FM3A cells, it was shown that the antizyme, which negatively regulates the amount of ornithine decarboxylase, also negatively regulates the activity of polyamine transport. Polyamines 179-188 ornithine decarboxylase, structural 1 Mus musculus 112-135 8707896-2 1996 The present study demonstrates a novel link between alterations in bFGF regulation during malignant conversion and the expression of ornithine decarboxylase, a key rate-limiting and regulatory activity in the biosynthesis of polyamines. Polyamines 225-235 ornithine decarboxylase, structural 1 Mus musculus 133-156 7478599-1 1995 Ornithine decarboxylase (ODC), the first enzyme in the biosynthesis of polyamines, is essential for the process of cellular proliferation. Polyamines 71-81 ornithine decarboxylase, structural 1 Mus musculus 25-28 7671221-1 1995 Ornithine decarboxylase, a critical regulatory enzyme for polyamine biosynthesis, is highly inducible by growth-promoting stimuli in mouse epidermis but the enzyme level is only transiently elevated due to rapid turnover of the protein. Polyamines 58-67 ornithine decarboxylase, structural 1 Mus musculus 0-23 7487924-0 1995 Induction of apoptosis by excessive polyamine accumulation in ornithine decarboxylase-overproducing L1210 cells. Polyamines 36-45 ornithine decarboxylase, structural 1 Mus musculus 62-85 7487924-1 1995 Deregulation of polyamine transport in L1210 cells overexpressing ornithine decarboxylase leads to a lethal accumulation of spermidine. Polyamines 16-25 ornithine decarboxylase, structural 1 Mus musculus 66-89 7865470-1 1994 We have examined the role in B cell activation of ornithine decarboxylase (ODC), the labile rate-limiting enzyme in the synthesis of polyamines thought to be required for S phase entry in all cells. Polyamines 133-143 ornithine decarboxylase, structural 1 Mus musculus 50-73 7525612-1 1994 We have tested the hypothesis that H-ras transformed cells contain alterations in signal pathways important in controlling the expression of ornithine decarboxylase (ODC), the highly regulated rate-limiting activity in the biosynthesis of polyamines. Polyamines 239-249 ornithine decarboxylase, structural 1 Mus musculus 141-164 7525612-1 1994 We have tested the hypothesis that H-ras transformed cells contain alterations in signal pathways important in controlling the expression of ornithine decarboxylase (ODC), the highly regulated rate-limiting activity in the biosynthesis of polyamines. Polyamines 239-249 ornithine decarboxylase, structural 1 Mus musculus 166-169 7712475-1 1995 Ornithine decarboxylase (ODC) plays a key role in the biosynthesis of polyamines, which are necessary for cell growth and differentiation. Polyamines 70-80 ornithine decarboxylase, structural 1 Mus musculus 0-23 7712475-1 1995 Ornithine decarboxylase (ODC) plays a key role in the biosynthesis of polyamines, which are necessary for cell growth and differentiation. Polyamines 70-80 ornithine decarboxylase, structural 1 Mus musculus 25-28 7712475-5 1995 In all infected epidermal cells with high polyamine levels, DNA synthesis is increased as measured by [3H]thymidine incorporation into DNA as well as increased bromodeoxyuridine staining in the nuclei of ODC-infected epidermal cells. Polyamines 42-51 ornithine decarboxylase, structural 1 Mus musculus 204-207 7874572-1 1995 Activity of ornithine decarboxylase (ODC), one of the rate-limiting enzymes in the pathway of polyamine biosynthesis, is regulated by various factors. Polyamines 94-103 ornithine decarboxylase, structural 1 Mus musculus 12-35 7874572-1 1995 Activity of ornithine decarboxylase (ODC), one of the rate-limiting enzymes in the pathway of polyamine biosynthesis, is regulated by various factors. Polyamines 94-103 ornithine decarboxylase, structural 1 Mus musculus 37-40 7865470-1 1994 We have examined the role in B cell activation of ornithine decarboxylase (ODC), the labile rate-limiting enzyme in the synthesis of polyamines thought to be required for S phase entry in all cells. Polyamines 133-143 ornithine decarboxylase, structural 1 Mus musculus 75-78 8033123-1 1994 Expression of ornithine decarboxylase (ODC), the initial enzyme is polyamine biosynthesis, is essential for cell growth. Polyamines 67-76 ornithine decarboxylase, structural 1 Mus musculus 14-37 8074711-6 1994 These results clearly indicate that antizyme has dual functions: one for ODC degradation and the other for negative regulation of polyamine transport. Polyamines 130-139 ornithine decarboxylase, structural 1 Mus musculus 73-76 8090747-0 1994 Antizyme protects against abnormal accumulation and toxicity of polyamines in ornithine decarboxylase-overproducing cells. Polyamines 64-74 ornithine decarboxylase, structural 1 Mus musculus 78-101 8090747-1 1994 Exposure of ornithine decarboxylase (ODC; L-ornithine carboxy-lyase, EC 4.1.1.17)-overproducing mouse FM3A cells to micromolar levels of spermine or spermidine caused abnormal accumulation and toxicity of polyamines. Polyamines 205-215 ornithine decarboxylase, structural 1 Mus musculus 12-35 8090747-2 1994 This was apparently due to the inefficiency of negative feedback control of polyamine transport by polyamines in ODC-overproducing cells. Polyamines 76-85 ornithine decarboxylase, structural 1 Mus musculus 113-116 8090747-2 1994 This was apparently due to the inefficiency of negative feedback control of polyamine transport by polyamines in ODC-overproducing cells. Polyamines 99-109 ornithine decarboxylase, structural 1 Mus musculus 113-116 8090747-3 1994 Since antizyme is the only protein thus far recognized that can interact with ODC, depletion of free antizyme was regarded as the reason for the abnormal accumulation of polyamines. Polyamines 170-180 ornithine decarboxylase, structural 1 Mus musculus 78-81 8090747-6 1994 The results indicate that antizyme can regulate not only the amount of ODC but also the activity of polyamine transport. Polyamines 100-109 ornithine decarboxylase, structural 1 Mus musculus 71-74 8033123-1 1994 Expression of ornithine decarboxylase (ODC), the initial enzyme is polyamine biosynthesis, is essential for cell growth. Polyamines 67-76 ornithine decarboxylase, structural 1 Mus musculus 39-42 8453677-5 1993 Analysis of early gene expression revealed that signaling through class II molecules led to an increase in anti-mu-induced expression of c-myc, a proto-oncogene, and of ornithine decarboxylase, a key enzyme in polyamine biosynthesis that has been shown to be intimately related to increased cell proliferation. Polyamines 210-219 ornithine decarboxylase, structural 1 Mus musculus 169-192 8026898-5 1994 Polyamines (putrescine, spermadine and spermine) were also elevated in the spleen following induction of the ODC activity. Polyamines 0-10 ornithine decarboxylase, structural 1 Mus musculus 109-112 8495425-1 1993 Ornithine decarboxylase (ODC) plays a rate-limiting role in polyamine biosynthesis and is intimately associated with cell proliferation and function. Polyamines 60-69 ornithine decarboxylase, structural 1 Mus musculus 0-23 8495425-1 1993 Ornithine decarboxylase (ODC) plays a rate-limiting role in polyamine biosynthesis and is intimately associated with cell proliferation and function. Polyamines 60-69 ornithine decarboxylase, structural 1 Mus musculus 25-28 8074989-2 1994 Ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, and thus in tissue growth and development, has been localized in mouse dental tissues, in vivo as well as in vitro by light and electron microscopic autoradiography with radiolabeled alpha-difluoromethylornithine ([3H]DFMO). Polyamines 47-56 ornithine decarboxylase, structural 1 Mus musculus 0-23 8074989-2 1994 Ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, and thus in tissue growth and development, has been localized in mouse dental tissues, in vivo as well as in vitro by light and electron microscopic autoradiography with radiolabeled alpha-difluoromethylornithine ([3H]DFMO). Polyamines 47-56 ornithine decarboxylase, structural 1 Mus musculus 25-28 7935984-1 1994 alpha-Difluoromethyl ornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), depletes cellular polyamine levels which is significantly correlated to neoplastic transformation. Polyamines 104-113 ornithine decarboxylase, structural 1 Mus musculus 55-78 7935984-1 1994 alpha-Difluoromethyl ornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), depletes cellular polyamine levels which is significantly correlated to neoplastic transformation. Polyamines 104-113 ornithine decarboxylase, structural 1 Mus musculus 80-83 8344985-3 1993 The present study demonstrates a novel link between alterations in TGF-beta regulation during malignant conversion, and the expression of ornithine decarboxylase, a key rate-limiting activity in the biosynthesis of polyamines, and an enzyme that plays an important role in cell growth and differentiation. Polyamines 215-225 ornithine decarboxylase, structural 1 Mus musculus 138-161 8499611-0 1993 Modulation of cellular polyamines in tobacco by transfer and expression of mouse ornithine decarboxylase cDNA. Polyamines 23-33 ornithine decarboxylase, structural 1 Mus musculus 81-104 1513327-2 1992 Both analogs accumulated within cells and suppressed S-adenosylmethionine decarboxylase, as well as polyamine-sensitive mouse ODC activity. Polyamines 100-109 ornithine decarboxylase, structural 1 Mus musculus 126-129 8273569-6 1993 These results suggest that post-transcriptional modification of ODC in lpr genetic background might be responsible for increased ODC activity and polyamines. Polyamines 146-156 ornithine decarboxylase, structural 1 Mus musculus 64-67 1444206-1 1992 We reported previously that polyamine deprivation by feeding a polyamine deficient diet combined with gastrointestinal tract decontamination and polyamine oxidase inhibition considerably enhanced the antitumoral effect of DFMO, a selective inhibitor of ornithine decarboxylase. Polyamines 28-37 ornithine decarboxylase, structural 1 Mus musculus 253-276 1641775-1 1992 BACKGROUND: The enzyme ornithine decarboxylase (ODC) catalyzes the rate-limiting step in polyamine biosynthesis and is important for gut mucosal repair after systemic injury (e.g., burns); however, the mechanisms responsible for the injury-mediated induction of ODC are not known. Polyamines 89-98 ornithine decarboxylase, structural 1 Mus musculus 23-46 1641775-1 1992 BACKGROUND: The enzyme ornithine decarboxylase (ODC) catalyzes the rate-limiting step in polyamine biosynthesis and is important for gut mucosal repair after systemic injury (e.g., burns); however, the mechanisms responsible for the injury-mediated induction of ODC are not known. Polyamines 89-98 ornithine decarboxylase, structural 1 Mus musculus 48-51 1641775-1 1992 BACKGROUND: The enzyme ornithine decarboxylase (ODC) catalyzes the rate-limiting step in polyamine biosynthesis and is important for gut mucosal repair after systemic injury (e.g., burns); however, the mechanisms responsible for the injury-mediated induction of ODC are not known. Polyamines 89-98 ornithine decarboxylase, structural 1 Mus musculus 262-265 8444843-12 1993 The absence of these effects in parental L1210 cells indicates that the acquisition of an ornithine decarboxylase-overproducing phenotype also involves major modifications in the expression and/or regulation of polyamine transport. Polyamines 211-220 ornithine decarboxylase, structural 1 Mus musculus 90-113 8424799-14 1993 We conclude that ODC regulation upon removal of the inhibitor is dependent on at least three steps, namely the level of mRNA, the translational efficiency of mRNA and the stability of the enzyme, the last two of which are involved in cellular polyamines. Polyamines 243-253 ornithine decarboxylase, structural 1 Mus musculus 17-20 1280331-1 1992 The enzyme ornithine decarboxylase is the key regulator of the synthesis of polyamines which are essential for cell proliferation. Polyamines 76-86 ornithine decarboxylase, structural 1 Mus musculus 11-34 1397089-1 1992 Onset of cell proliferation is associated with enhanced turnover of the polyamines putrescine, spermidine, and spermine, particularly evident in the massive increase in the activity of the rate-limiting enzyme in their production, ornithine decarboxylase (ODC). Polyamines 72-82 ornithine decarboxylase, structural 1 Mus musculus 231-254 1397089-1 1992 Onset of cell proliferation is associated with enhanced turnover of the polyamines putrescine, spermidine, and spermine, particularly evident in the massive increase in the activity of the rate-limiting enzyme in their production, ornithine decarboxylase (ODC). Polyamines 72-82 ornithine decarboxylase, structural 1 Mus musculus 256-259 1630460-0 1992 Regulated degradation of ornithine decarboxylase requires interaction with the polyamine-inducible protein antizyme. Polyamines 79-88 ornithine decarboxylase, structural 1 Mus musculus 25-48 1630460-1 1992 Intracellular degradation of vertebrate ornithine decarboxylase (ODC) is accelerated by polyamines, the products of the pathway controlled by ODC. Polyamines 88-98 ornithine decarboxylase, structural 1 Mus musculus 40-63 1630460-1 1992 Intracellular degradation of vertebrate ornithine decarboxylase (ODC) is accelerated by polyamines, the products of the pathway controlled by ODC. Polyamines 88-98 ornithine decarboxylase, structural 1 Mus musculus 65-68 1630460-1 1992 Intracellular degradation of vertebrate ornithine decarboxylase (ODC) is accelerated by polyamines, the products of the pathway controlled by ODC. Polyamines 88-98 ornithine decarboxylase, structural 1 Mus musculus 142-145 1341266-10 1992 The increase in ODC activity led to an increase in polyamine biosynthesis; putrescine, spermidine, and spermine levels in MC-26 cells were significantly elevated by 24 h after treatment with NaB. Polyamines 51-60 ornithine decarboxylase, structural 1 Mus musculus 16-19 1385320-1 1992 Histamine and putrescine (a precursor of polyamines) are formed by histidine decarboxylase (HDC) and ornithine decarboxylase (ODC), respectively. Polyamines 41-51 ornithine decarboxylase, structural 1 Mus musculus 101-124 1385320-1 1992 Histamine and putrescine (a precursor of polyamines) are formed by histidine decarboxylase (HDC) and ornithine decarboxylase (ODC), respectively. Polyamines 41-51 ornithine decarboxylase, structural 1 Mus musculus 126-129 1737994-8 1992 These ODC transgenic animals may serve as models in vivo for studies on cerebral postischemic events and on epilepsy, as polyamines are supposed to be involved in these processes. Polyamines 121-131 ornithine decarboxylase, structural 1 Mus musculus 6-9 1569947-0 1992 Structural elements of ornithine decarboxylase required for intracellular degradation and polyamine-dependent regulation. Polyamines 90-99 ornithine decarboxylase, structural 1 Mus musculus 23-46 1569947-1 1992 Mammalian ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, is rapidly degraded in cells, an attribute important to the regulation of its activity. Polyamines 57-66 ornithine decarboxylase, structural 1 Mus musculus 10-33 1569947-1 1992 Mammalian ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, is rapidly degraded in cells, an attribute important to the regulation of its activity. Polyamines 57-66 ornithine decarboxylase, structural 1 Mus musculus 35-38 1569947-5 1992 Polyamine-dependent degradation of ODC requires a distinct region outside the carboxy terminus. Polyamines 0-9 ornithine decarboxylase, structural 1 Mus musculus 35-38 1569947-7 1992 The regulatory properties of enzymatically active chimeric proteins incorporating regions of the two ODCs support the conclusion that distinct domains of mouse ODC confer constitutive degradation and polyamine-mediated regulation. Polyamines 200-209 ornithine decarboxylase, structural 1 Mus musculus 101-104 1569947-10 1992 When mouse and T. brucei ODC RNAs were translated in vitro in a reticulocyte lysate system, the effects of polyamine concentration on ODC protein production and activity were similar for the two mRNAs, which contradicts claims that this system accurately reflects the in vivo effects of polyamines on responsive ODCs. Polyamines 107-116 ornithine decarboxylase, structural 1 Mus musculus 134-137 1551114-2 1992 Ornithine decarboxylase is the first and a rate-limiting enzyme in the biosynthesis of polyamines. Polyamines 87-97 ornithine decarboxylase, structural 1 Mus musculus 0-23 1551114-3 1992 Polyamine depletion using DL-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, has been shown to suppress cell growth in a variety of settings, including those of tumor and lymphocyte proliferation. Polyamines 0-9 ornithine decarboxylase, structural 1 Mus musculus 83-106 1569411-1 1992 Ornithine decarboxylase (ODC; EC4.1.1.17), the key enzyme in polyamine biosynthesis, and intracellular polyamines increase rapidly and markedly in tissues and cells that are actively proliferating as well as differentiating and decrease as these processes cease. Polyamines 61-70 ornithine decarboxylase, structural 1 Mus musculus 0-23 1569411-1 1992 Ornithine decarboxylase (ODC; EC4.1.1.17), the key enzyme in polyamine biosynthesis, and intracellular polyamines increase rapidly and markedly in tissues and cells that are actively proliferating as well as differentiating and decrease as these processes cease. Polyamines 61-70 ornithine decarboxylase, structural 1 Mus musculus 25-28 1569411-1 1992 Ornithine decarboxylase (ODC; EC4.1.1.17), the key enzyme in polyamine biosynthesis, and intracellular polyamines increase rapidly and markedly in tissues and cells that are actively proliferating as well as differentiating and decrease as these processes cease. Polyamines 103-113 ornithine decarboxylase, structural 1 Mus musculus 25-28 1472637-3 1992 Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines. Polyamines 69-79 ornithine decarboxylase, structural 1 Mus musculus 0-23 1472637-3 1992 Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines. Polyamines 69-79 ornithine decarboxylase, structural 1 Mus musculus 25-28 1472637-4 1992 Recent studies demonstrated that down-regulation of polyamine biosynthesis by irreversible inhibition of ODC with difluoromethylornithine (DFMO0 is a novel therapeutic approach for the treatment of murine lupus in autoimmune MRL-lpr/lpr mice. Polyamines 52-61 ornithine decarboxylase, structural 1 Mus musculus 105-108 1530878-1 1992 Ornithine decarboxylase (ODC), which initiates the biosynthesis of the polyamines putrescine, spermidine, and spermine, is encoded by the spe-1 gene of the fungus Neurospora crassa. Polyamines 71-81 ornithine decarboxylase, structural 1 Mus musculus 25-28 1530878-9 1992 N. crassa ODC, which turns over rapidly in vivo in the presence of polyamines, has two PEST sequences, found in most ODCs and other proteins with rapid turnover. Polyamines 67-77 ornithine decarboxylase, structural 1 Mus musculus 10-13 1530878-10 1992 In striking contrast to other eucaryotic organisms, the variation in the rate of ODC synthesis in response to polyamines in N. crassa is largely correlated with proportional changes in the abundance of ODC mRNA. Polyamines 110-120 ornithine decarboxylase, structural 1 Mus musculus 81-84 1530878-10 1992 In striking contrast to other eucaryotic organisms, the variation in the rate of ODC synthesis in response to polyamines in N. crassa is largely correlated with proportional changes in the abundance of ODC mRNA. Polyamines 110-120 ornithine decarboxylase, structural 1 Mus musculus 202-205 1841714-7 1991 The activities of both decarboxylases were markedly decreased by administration of exogenous polyamines, ornithine decarboxylase being more sensitive than S-adenosylmethionine decarboxylase. Polyamines 93-103 ornithine decarboxylase, structural 1 Mus musculus 105-128 2049780-2 1991 Ornithine decarboxylase (ODC) is a rate-limiting enzyme that catalyzes the biosynthesis of polyamines. Polyamines 91-101 ornithine decarboxylase, structural 1 Mus musculus 0-23 2049780-2 1991 Ornithine decarboxylase (ODC) is a rate-limiting enzyme that catalyzes the biosynthesis of polyamines. Polyamines 91-101 ornithine decarboxylase, structural 1 Mus musculus 25-28 1903327-2 1991 The highly inducible enzyme ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine as the initial step in polyamine biosynthesis. Polyamines 133-142 ornithine decarboxylase, structural 1 Mus musculus 28-51 1903327-2 1991 The highly inducible enzyme ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine as the initial step in polyamine biosynthesis. Polyamines 133-142 ornithine decarboxylase, structural 1 Mus musculus 53-56 2365702-1 1990 Ornithine decarboxylase (ODC) is a key enzyme in polyamine biosynthesis. Polyamines 49-58 ornithine decarboxylase, structural 1 Mus musculus 0-23 2009332-3 1991 Furthermore, ornithine decarboxylase (ODC) is considered a key enzyme in the biosynthesis of polyamines and is regulated by PRL in certain target tissues. Polyamines 93-103 ornithine decarboxylase, structural 1 Mus musculus 13-36 2009332-3 1991 Furthermore, ornithine decarboxylase (ODC) is considered a key enzyme in the biosynthesis of polyamines and is regulated by PRL in certain target tissues. Polyamines 93-103 ornithine decarboxylase, structural 1 Mus musculus 38-41 1884248-1 1991 Polyamines are essential for cell growth of normal and neoplastic tissue, alpha-Difluoromethylornithine (DFMO) is a known irreversible inhibitor or ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Polyamines 0-10 ornithine decarboxylase, structural 1 Mus musculus 148-171 1884248-1 1991 Polyamines are essential for cell growth of normal and neoplastic tissue, alpha-Difluoromethylornithine (DFMO) is a known irreversible inhibitor or ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Polyamines 0-10 ornithine decarboxylase, structural 1 Mus musculus 173-176 1884248-1 1991 Polyamines are essential for cell growth of normal and neoplastic tissue, alpha-Difluoromethylornithine (DFMO) is a known irreversible inhibitor or ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Polyamines 207-216 ornithine decarboxylase, structural 1 Mus musculus 148-171 1884248-1 1991 Polyamines are essential for cell growth of normal and neoplastic tissue, alpha-Difluoromethylornithine (DFMO) is a known irreversible inhibitor or ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Polyamines 207-216 ornithine decarboxylase, structural 1 Mus musculus 173-176 2369749-1 1990 Ornithine decarboxylase (ODC), the initial enzyme in the polyamine biosynthetic pathway, has been used as a marker for the hyperplasia that occurs following exposure of mouse epidermis to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Polyamines 57-66 ornithine decarboxylase, structural 1 Mus musculus 0-23 2369749-1 1990 Ornithine decarboxylase (ODC), the initial enzyme in the polyamine biosynthetic pathway, has been used as a marker for the hyperplasia that occurs following exposure of mouse epidermis to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Polyamines 57-66 ornithine decarboxylase, structural 1 Mus musculus 25-28 2067204-1 1991 Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of cellular polyamines, putrescine, spermidine and spermine. Polyamines 78-88 ornithine decarboxylase, structural 1 Mus musculus 0-23 2067204-1 1991 Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of cellular polyamines, putrescine, spermidine and spermine. Polyamines 78-88 ornithine decarboxylase, structural 1 Mus musculus 25-28 1831810-1 1991 DL-alpha-Difluoromethylornithine (DFMO) is a specific inhibitor of the rate-limiting enzyme in polyamine biosynthesis, ornithine decarboxylase (ODC). Polyamines 95-104 ornithine decarboxylase, structural 1 Mus musculus 119-142 1831810-1 1991 DL-alpha-Difluoromethylornithine (DFMO) is a specific inhibitor of the rate-limiting enzyme in polyamine biosynthesis, ornithine decarboxylase (ODC). Polyamines 95-104 ornithine decarboxylase, structural 1 Mus musculus 144-147 1958536-1 1991 Ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) are two key enzymes in polyamine biosynthesis. Polyamines 103-112 ornithine decarboxylase, structural 1 Mus musculus 0-23 1958536-1 1991 Ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) are two key enzymes in polyamine biosynthesis. Polyamines 103-112 ornithine decarboxylase, structural 1 Mus musculus 25-28 2365702-1 1990 Ornithine decarboxylase (ODC) is a key enzyme in polyamine biosynthesis. Polyamines 49-58 ornithine decarboxylase, structural 1 Mus musculus 25-28 2771969-2 1989 Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis. Polyamines 61-70 ornithine decarboxylase, structural 1 Mus musculus 0-23 2234213-2 1990 Retinol, a known inhibitor of ornithine decarboxylase, was used to modulate tumor growth pattern and subsequent changes in the level of polyamines. Polyamines 136-146 ornithine decarboxylase, structural 1 Mus musculus 30-53 3125182-0 1988 Regulation of ornithine decarboxylase mRNA translation by polyamines. Polyamines 58-68 ornithine decarboxylase, structural 1 Mus musculus 14-37 3125182-2 1988 The translational control of ornithine decarboxylase (ODCase) by polyamines has been studied using a cellular as well as a cell-free system. Polyamines 65-75 ornithine decarboxylase, structural 1 Mus musculus 29-52 3125182-2 1988 The translational control of ornithine decarboxylase (ODCase) by polyamines has been studied using a cellular as well as a cell-free system. Polyamines 65-75 ornithine decarboxylase, structural 1 Mus musculus 54-60 3125182-12 1988 The present results demonstrate that at least part of the feedback regulation of ODCase exerted by the polyamines is due to direct inhibition of ODCase mRNA translation. Polyamines 103-113 ornithine decarboxylase, structural 1 Mus musculus 81-87 3125182-12 1988 The present results demonstrate that at least part of the feedback regulation of ODCase exerted by the polyamines is due to direct inhibition of ODCase mRNA translation. Polyamines 103-113 ornithine decarboxylase, structural 1 Mus musculus 145-151 2771969-2 1989 Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis. Polyamines 61-70 ornithine decarboxylase, structural 1 Mus musculus 25-28 34251640-1 2021 Arginine is a key amino acid in pregnant females as it is the precursor for nitric oxide (NO) via nitric oxide synthase and for polyamines (putrescine, spermidine, and spermine) by either arginase II and ornithine decarboxylase to putrescine or via arginine decarboxylase to agmatine and agmatine to putrescine via agmatinase. Polyamines 128-138 ornithine decarboxylase, structural 1 Mus musculus 204-227 2624872-1 1989 Ornithine decarboxylase (ODCase) is the first and rate-limiting enzyme in the polyamine biosynthetic pathway and it is androgen regulated in the mouse. Polyamines 78-87 ornithine decarboxylase, structural 1 Mus musculus 0-23 35563006-3 2022 OAZ1 inhibits polyamine uptake and targets ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis, for proteasomal degradation. Polyamines 102-111 ornithine decarboxylase, structural 1 Mus musculus 43-66 35563006-3 2022 OAZ1 inhibits polyamine uptake and targets ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis, for proteasomal degradation. Polyamines 102-111 ornithine decarboxylase, structural 1 Mus musculus 68-71 35563006-8 2022 The efficiency of polyamine-induced ribosomal +1 frameshifting of OAZ1 mRNA could also be differentially modulated by MeSpds-2-MeSpd was a poor inducer of OAZ1 biosynthesis and hence a poor downregulator of ODC activity unlike the other MeSpds. Polyamines 18-27 ornithine decarboxylase, structural 1 Mus musculus 207-210 2624872-1 1989 Ornithine decarboxylase (ODCase) is the first and rate-limiting enzyme in the polyamine biosynthetic pathway and it is androgen regulated in the mouse. Polyamines 78-87 ornithine decarboxylase, structural 1 Mus musculus 25-31 2627199-1 1989 Ornithine decarboxylase (ODC), the first enzyme in the polyamine biosynthetic pathway, is encoded by at least one member of a multi-gene family in the mouse. Polyamines 55-64 ornithine decarboxylase, structural 1 Mus musculus 0-23 2627199-1 1989 Ornithine decarboxylase (ODC), the first enzyme in the polyamine biosynthetic pathway, is encoded by at least one member of a multi-gene family in the mouse. Polyamines 55-64 ornithine decarboxylase, structural 1 Mus musculus 25-28 2525116-1 1989 Although treatment with the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) leads to depletion of intracellular polyamines and to related growth inhibition in vitro, its cytostatic effects in vivo are disappointing. Polyamines 135-145 ornithine decarboxylase, structural 1 Mus musculus 28-51 2507471-2 1989 alpha-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Polyamines 128-137 ornithine decarboxylase, structural 1 Mus musculus 69-92 2507471-2 1989 alpha-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Polyamines 128-137 ornithine decarboxylase, structural 1 Mus musculus 94-97 2511435-0 1989 Polyamine-mediated regulation of mouse ornithine decarboxylase is posttranslational. Polyamines 0-9 ornithine decarboxylase, structural 1 Mus musculus 39-62 2511435-1 1989 The activity of ornithine decarboxylase (ODC) is negatively regulated by intracellular polyamines, which thereby mediate a form of feedback inhibition of the initial enzyme in the pathway of their synthesis. Polyamines 87-97 ornithine decarboxylase, structural 1 Mus musculus 16-39 2511435-1 1989 The activity of ornithine decarboxylase (ODC) is negatively regulated by intracellular polyamines, which thereby mediate a form of feedback inhibition of the initial enzyme in the pathway of their synthesis. Polyamines 87-97 ornithine decarboxylase, structural 1 Mus musculus 41-44 2511435-7 1989 Last, we carried out experiments to measure the incorporation of [35S]methionine into ODC in polyamine-starved and polyamine-replete cells. Polyamines 93-102 ornithine decarboxylase, structural 1 Mus musculus 86-89 2511435-8 1989 Differential incorporation diminished progressively as pulse-label times were shortened; at the shortest labeling time used (4 min), the difference in favor of ODC in polyamine-starved cells was less than twofold. Polyamines 167-176 ornithine decarboxylase, structural 1 Mus musculus 160-163 2511435-9 1989 These findings suggest that it is necessary to reevaluate the question of whether polyamines cause alterations of translation of ODC mRNA. Polyamines 82-92 ornithine decarboxylase, structural 1 Mus musculus 129-132 3196761-2 1988 Ornithine decarboxylase (ODC) is subject to feedback regulation by the polyamines. Polyamines 71-81 ornithine decarboxylase, structural 1 Mus musculus 0-23 2492471-4 1989 Putrescine has rather a counter-regulatory effect as concluded from the observation that the TPA-induced TCGF production and IL-2-specific mRNA expression are augmented (superinduced) by the ODC inhibitor D,L-alpha-difluoromethylornithine (DFMO) and again suppressed after the administration of putrescine or polyamines to DFMO-treated cultures. Polyamines 309-319 ornithine decarboxylase, structural 1 Mus musculus 191-194 3196761-2 1988 Ornithine decarboxylase (ODC) is subject to feedback regulation by the polyamines. Polyamines 71-81 ornithine decarboxylase, structural 1 Mus musculus 25-28 3139441-0 1988 Plasmodium falciparum: purification, properties, and immunochemical study of ornithine decarboxylase, the key enzyme in polyamine biosynthesis. Polyamines 120-129 ornithine decarboxylase, structural 1 Mus musculus 77-100 3139441-1 1988 Ornithine decarboxylase, the rate-limiting enzyme in the polyamine biosynthetic pathway has been purified 7,600 fold from Plasmodium falciparum by affinity chromatography on a pyridoxamine phosphate column. Polyamines 57-66 ornithine decarboxylase, structural 1 Mus musculus 0-23 3134356-2 1988 Studies in which ODC protein was labeled in the D-R cells by exposure to [35S]methionine indicated that the polyamine derivatives and their physiological counterparts led to an increased rate of degradation of ODC and to a rapid reduction in ODC synthesis without affecting the content of ODC mRNA. Polyamines 108-117 ornithine decarboxylase, structural 1 Mus musculus 210-213 3134356-0 1988 Control of ornithine decarboxylase activity in alpha-difluoromethylornithine-resistant L1210 cells by polyamines and synthetic analogues. Polyamines 102-112 ornithine decarboxylase, structural 1 Mus musculus 11-34 3134356-1 1988 The regulation of ornithine decarboxylase (ODC) activity by the polyamine derivatives N1,N8-bis(ethyl)-spermidine and N1,N12-bis(ethyl)spermine was studied using a line of L1210 cells resistant to alpha-difluoromethylornithine (D-R cells), which contain very high levels of ODC, and a synthetic mRNA prepared from a plasmid containing an insert corresponding to ODC mRNA adjacent to an SP6 RNA polymerase promoter. Polyamines 64-73 ornithine decarboxylase, structural 1 Mus musculus 18-41 3134356-1 1988 The regulation of ornithine decarboxylase (ODC) activity by the polyamine derivatives N1,N8-bis(ethyl)-spermidine and N1,N12-bis(ethyl)spermine was studied using a line of L1210 cells resistant to alpha-difluoromethylornithine (D-R cells), which contain very high levels of ODC, and a synthetic mRNA prepared from a plasmid containing an insert corresponding to ODC mRNA adjacent to an SP6 RNA polymerase promoter. Polyamines 64-73 ornithine decarboxylase, structural 1 Mus musculus 43-46 3134356-2 1988 Studies in which ODC protein was labeled in the D-R cells by exposure to [35S]methionine indicated that the polyamine derivatives and their physiological counterparts led to an increased rate of degradation of ODC and to a rapid reduction in ODC synthesis without affecting the content of ODC mRNA. Polyamines 108-117 ornithine decarboxylase, structural 1 Mus musculus 17-20 3134356-2 1988 Studies in which ODC protein was labeled in the D-R cells by exposure to [35S]methionine indicated that the polyamine derivatives and their physiological counterparts led to an increased rate of degradation of ODC and to a rapid reduction in ODC synthesis without affecting the content of ODC mRNA. Polyamines 108-117 ornithine decarboxylase, structural 1 Mus musculus 210-213 3134356-2 1988 Studies in which ODC protein was labeled in the D-R cells by exposure to [35S]methionine indicated that the polyamine derivatives and their physiological counterparts led to an increased rate of degradation of ODC and to a rapid reduction in ODC synthesis without affecting the content of ODC mRNA. Polyamines 108-117 ornithine decarboxylase, structural 1 Mus musculus 210-213 3134356-3 1988 Direct evidence that the polyamine derivatives act by inhibiting the translation of the ODC mRNA was obtained by studying their effects on the translation of ODC mRNA in reticulocyte lysates. Polyamines 25-34 ornithine decarboxylase, structural 1 Mus musculus 88-91 3134356-3 1988 Direct evidence that the polyamine derivatives act by inhibiting the translation of the ODC mRNA was obtained by studying their effects on the translation of ODC mRNA in reticulocyte lysates. Polyamines 25-34 ornithine decarboxylase, structural 1 Mus musculus 158-161 3134356-6 1988 The effects of polyamine derivatives and polyamines on translation of the plasmid-derived ODC mRNA were identical with those found with the D-R L1210 cell mRNA. Polyamines 15-24 ornithine decarboxylase, structural 1 Mus musculus 90-93 3134356-6 1988 The effects of polyamine derivatives and polyamines on translation of the plasmid-derived ODC mRNA were identical with those found with the D-R L1210 cell mRNA. Polyamines 41-51 ornithine decarboxylase, structural 1 Mus musculus 90-93 3076326-0 1988 Mechanisms involved in ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate, a potent mouse skin tumor promoter and an activator of protein kinase C. ODC, the first enzyme in mammalian polyamine biosynthesis, is rapidly induced in response to a wide variety of growth stimuli. Polyamines 206-215 ornithine decarboxylase, structural 1 Mus musculus 23-46 3137232-2 1988 Ornithine decarboxylase (ODC), the rate-limiting enzyme in the polyamine biosynthetic pathway, has been shown to be causally related to an increase in glycosaminoglycan synthesis in murine embryonic palatal mesenchyme cells (MEPM). Polyamines 63-72 ornithine decarboxylase, structural 1 Mus musculus 0-23 3137232-2 1988 Ornithine decarboxylase (ODC), the rate-limiting enzyme in the polyamine biosynthetic pathway, has been shown to be causally related to an increase in glycosaminoglycan synthesis in murine embryonic palatal mesenchyme cells (MEPM). Polyamines 63-72 ornithine decarboxylase, structural 1 Mus musculus 25-28 3409547-2 1988 (2R,5R)-6-heptyne-2,5-diamine (MAP; MDL 72175), a potent irreversible inhibitor of L-ornithine decarboxylase (ODC), possesses immunosuppressive activities in vitro as the result of inhibition of lymphocyte polyamine biosynthesis. Polyamines 206-215 ornithine decarboxylase, structural 1 Mus musculus 110-113 2840461-1 1988 IL-2 regulates the expression and activation of the principal rate-limiting enzyme of polyamine synthesis, ornithine decarboxylase (ODC). Polyamines 86-95 ornithine decarboxylase, structural 1 Mus musculus 107-130 2840461-1 1988 IL-2 regulates the expression and activation of the principal rate-limiting enzyme of polyamine synthesis, ornithine decarboxylase (ODC). Polyamines 86-95 ornithine decarboxylase, structural 1 Mus musculus 132-135 3130188-6 1988 alpha-Difluoromethylornithine inhibits ornithine decarboxylase, the rate-limiting enzyme in polyamine biosynthesis. Polyamines 92-101 ornithine decarboxylase, structural 1 Mus musculus 39-62 3132336-3 1988 When DFMO is added 3 h after seeding, however, enough polyamines have already accumulated during the initial burst in ODC activity to reduce the antiproliferative effect of the drug. Polyamines 54-64 ornithine decarboxylase, structural 1 Mus musculus 118-121 3115898-6 1987 That the effects of DFMO on the macrophages probably resulted from a reduction in polyamine levels caused by inhibition of ornithine decarboxylase was indicated by the fact that these effects were not seen when the macrophages were incubated with DFMO in the presence of putrescine, the product of ornithine decarboxylation by ornithine decarboxylase. Polyamines 82-91 ornithine decarboxylase, structural 1 Mus musculus 123-146 3693414-2 1987 Cellular levels of the mRNAs coding for ornithine decarboxylase (ODC) and S-adenosyl-methionine decarboxylase (SDC), key enzymes in polyamine synthesis, increased maximally within 5 h after addition of serum to resting 3T3 cells, following a kinetic course similar to that of c-myc mRNA. Polyamines 132-141 ornithine decarboxylase, structural 1 Mus musculus 40-63 3693414-2 1987 Cellular levels of the mRNAs coding for ornithine decarboxylase (ODC) and S-adenosyl-methionine decarboxylase (SDC), key enzymes in polyamine synthesis, increased maximally within 5 h after addition of serum to resting 3T3 cells, following a kinetic course similar to that of c-myc mRNA. Polyamines 132-141 ornithine decarboxylase, structural 1 Mus musculus 65-68 3100897-2 1987 alpha-Difluoromethylornithine (DFMO), is a specific and irreversible inhibitor of ornithine decarboxylase (ODC); the rate-limiting enzyme in polyamine biosynthesis. Polyamines 141-150 ornithine decarboxylase, structural 1 Mus musculus 82-105 3566731-9 1987 These results suggest that the mechanism by which polyamines regulate ODC activity in the mouse is primarily translational. Polyamines 50-60 ornithine decarboxylase, structural 1 Mus musculus 70-73 3109985-3 1987 The interaction between EGF and PGs in regulation of murine embryonic palate mesenchymal (MEPM) cell growth and differentiation was therefore investigated by monitoring the activity of ornithine decarboxylase (ODC), the principle and rate limiting enzyme of polyamine biosynthesis. Polyamines 258-267 ornithine decarboxylase, structural 1 Mus musculus 185-208 3102048-1 1987 The antiproliferative effects of the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) are limited by the inability of the compound to deplete completely cellular polyamine pools. Polyamines 184-193 ornithine decarboxylase, structural 1 Mus musculus 37-60 3566731-0 1987 Polyamine administration reduces ornithine decarboxylase activity without affecting its mRNA content. Polyamines 0-9 ornithine decarboxylase, structural 1 Mus musculus 33-56 3566731-1 1987 Ornithine decarboxylase, the first enzyme in the polyamine biosynthetic pathway, is induced by androgens in the mouse kidney. Polyamines 49-58 ornithine decarboxylase, structural 1 Mus musculus 0-23 3036091-1 1987 Polyamine biosynthesis in intact cells can be exquisitely controlled with exogenous polyamines through the regulation of rate-limiting biosynthetic enzymes, particularly ornithine decarboxylase (ODC). Polyamines 0-9 ornithine decarboxylase, structural 1 Mus musculus 170-193 3036091-1 1987 Polyamine biosynthesis in intact cells can be exquisitely controlled with exogenous polyamines through the regulation of rate-limiting biosynthetic enzymes, particularly ornithine decarboxylase (ODC). Polyamines 0-9 ornithine decarboxylase, structural 1 Mus musculus 195-198 3036091-1 1987 Polyamine biosynthesis in intact cells can be exquisitely controlled with exogenous polyamines through the regulation of rate-limiting biosynthetic enzymes, particularly ornithine decarboxylase (ODC). Polyamines 84-94 ornithine decarboxylase, structural 1 Mus musculus 170-193 3036091-1 1987 Polyamine biosynthesis in intact cells can be exquisitely controlled with exogenous polyamines through the regulation of rate-limiting biosynthetic enzymes, particularly ornithine decarboxylase (ODC). Polyamines 84-94 ornithine decarboxylase, structural 1 Mus musculus 195-198 3099850-4 1987 Inhibition of polyamine oxidase prevents the reutilization for de novo polyamine biosynthesis of putrescine and spermidine, which are formed by oxidative splitting of N1-acetylspermine and N1-acetylspermidine, respectively, and the ornithine decarboxylase inhibitor prevents the compensatory increase of putrescine from ornithine. Polyamines 14-23 ornithine decarboxylase, structural 1 Mus musculus 232-255 3100897-2 1987 alpha-Difluoromethylornithine (DFMO), is a specific and irreversible inhibitor of ornithine decarboxylase (ODC); the rate-limiting enzyme in polyamine biosynthesis. Polyamines 141-150 ornithine decarboxylase, structural 1 Mus musculus 107-110 3550425-0 1987 Complementation of a polyamine-deficient Escherichia coli mutant by expression of mouse ornithine decarboxylase. Polyamines 21-30 ornithine decarboxylase, structural 1 Mus musculus 88-111 3027106-10 1987 Arrhenius analysis showed that polyamine mediated inactivation of ODC occurred with an activation energy of approximately 16 kcal/mol. Polyamines 31-40 ornithine decarboxylase, structural 1 Mus musculus 66-69 3096554-1 1986 Ornithine decarboxylase (ODC) catalyzes the rate-limiting step in the synthesis of polyamines, it has a short half-life, and its synthesis is under hormonal control. Polyamines 83-93 ornithine decarboxylase, structural 1 Mus musculus 0-23 3096554-1 1986 Ornithine decarboxylase (ODC) catalyzes the rate-limiting step in the synthesis of polyamines, it has a short half-life, and its synthesis is under hormonal control. Polyamines 83-93 ornithine decarboxylase, structural 1 Mus musculus 25-28 3096554-2 1986 Recently, insight into the role of ODC and thus into the physiology of polyamines has been gained by the use of an inhibitor of ODC, difluoromethylornithine (DFMO). Polyamines 71-81 ornithine decarboxylase, structural 1 Mus musculus 35-38 3096554-2 1986 Recently, insight into the role of ODC and thus into the physiology of polyamines has been gained by the use of an inhibitor of ODC, difluoromethylornithine (DFMO). Polyamines 71-81 ornithine decarboxylase, structural 1 Mus musculus 128-131 3096557-1 1986 alpha-Difluoromethylornithine (DFMO) and methyl acetylene putrescine (MAP) are inhibitors of the rate limiting enzyme in polyamine synthesis, ornithine decarboxylase. Polyamines 121-130 ornithine decarboxylase, structural 1 Mus musculus 142-165 3117720-1 1987 alpha-Difluoromethylornithine (DFMO) is a known irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Polyamines 133-142 ornithine decarboxylase, structural 1 Mus musculus 74-97 3117720-1 1987 alpha-Difluoromethylornithine (DFMO) is a known irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Polyamines 133-142 ornithine decarboxylase, structural 1 Mus musculus 99-102 3096560-3 1986 Rather the polyamine analogue is believed, from previous studies, to behave similarly to exogenous spermidine in its ability to suppress intracellular ODC activity but not in its ability to perform functions required for cell growth. Polyamines 11-20 ornithine decarboxylase, structural 1 Mus musculus 151-154 3550425-1 1987 Mouse ornithine decarboxylase (ODCase) cDNA was expressed at a high level in an Escherichia coli mutant deficient in polyamine biosynthesis. Polyamines 117-126 ornithine decarboxylase, structural 1 Mus musculus 6-29 3550425-2 1987 The expression of mouse ornithine decarboxylase relieved the dependence of the mutant on an exogenous source of polyamines, presumably by providing putrescine, the product of the enzyme. Polyamines 112-122 ornithine decarboxylase, structural 1 Mus musculus 24-47 3093066-1 1986 The objective of the present investigation was to examine the effect of in vivo polyamine depletion by DL-alpha-difluoromethylornithine (DFMO), a specific irreversible inhibitor of ornithine decarboxylase, on cell-mediated tumoricidal activity in normal and tumor-bearing (B16 melanoma) mice. Polyamines 80-89 ornithine decarboxylase, structural 1 Mus musculus 181-204 3944205-4 1986 Based on findings in other systems that IFN inhibits activity of ornithine decarboxylase (ODC), the polyamine products of which are required for myogenesis, the hypothesis that inhibition of differentiation was mediated by an effect of IFN on polyamine metabolism was tested. Polyamines 243-252 ornithine decarboxylase, structural 1 Mus musculus 90-93 3023951-13 1986 In both variant and wild-type cells, ODC activity was responsive to changes in polyamine pools; activity was reduced following augmentation of pool size. Polyamines 79-88 ornithine decarboxylase, structural 1 Mus musculus 37-40 3785214-1 1986 Ornithine decarboxylase (ODCase), the rate-limiting enzyme in polyamine biosynthesis, exhibits dramatic fluctuations in activity in response to a variety of hormones and growth factors and has been shown to be down-regulated during myogenesis. Polyamines 62-71 ornithine decarboxylase, structural 1 Mus musculus 0-23 3785214-1 1986 Ornithine decarboxylase (ODCase), the rate-limiting enzyme in polyamine biosynthesis, exhibits dramatic fluctuations in activity in response to a variety of hormones and growth factors and has been shown to be down-regulated during myogenesis. Polyamines 62-71 ornithine decarboxylase, structural 1 Mus musculus 25-31 3458709-8 1986 However, although spermidine is required for appearance of the differentiated MEL phenotype, depletion of this polyamine by ODCase inhibition had no detectable effect on the biphasic changes in c-myc RNA observed during MEL differentiation. Polyamines 111-120 ornithine decarboxylase, structural 1 Mus musculus 124-130 3093095-1 1986 The objective of this study was to evaluate induction of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, and subsequent polyamine accumulation in interleukin-2 (IL-2)- and interleukin-3 (IL-3)-dependent growth. Polyamines 116-125 ornithine decarboxylase, structural 1 Mus musculus 57-80 3093095-1 1986 The objective of this study was to evaluate induction of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, and subsequent polyamine accumulation in interleukin-2 (IL-2)- and interleukin-3 (IL-3)-dependent growth. Polyamines 116-125 ornithine decarboxylase, structural 1 Mus musculus 82-85 3953797-9 1986 Since arginase catalyzes the conversion of arginine to orthithine, thus ensuring the availability of this substrate for ornithine decarboxylase activity, these results indicate a disturbance of polyamine metabolism in mutant enterocytes with a consequent delay in postnatal differentiation and proliferation. Polyamines 194-203 ornithine decarboxylase, structural 1 Mus musculus 120-143 3944205-4 1986 Based on findings in other systems that IFN inhibits activity of ornithine decarboxylase (ODC), the polyamine products of which are required for myogenesis, the hypothesis that inhibition of differentiation was mediated by an effect of IFN on polyamine metabolism was tested. Polyamines 100-109 ornithine decarboxylase, structural 1 Mus musculus 65-88 3944205-4 1986 Based on findings in other systems that IFN inhibits activity of ornithine decarboxylase (ODC), the polyamine products of which are required for myogenesis, the hypothesis that inhibition of differentiation was mediated by an effect of IFN on polyamine metabolism was tested. Polyamines 100-109 ornithine decarboxylase, structural 1 Mus musculus 90-93 3928149-1 1985 The objective of the present study was to investigate the effect of polyamine depletion by alpha-difluoromethylornithine (DFMO), a specific irreversible inhibitor of ornithine decarboxylase, on the growth and differentiation of B16 melanoma cells grown in culture and also as solid tumors in mice. Polyamines 68-77 ornithine decarboxylase, structural 1 Mus musculus 166-189 3742607-2 1986 Lymphocyte activation was determined by the induction of polyamine synthesis (ornithine decarboxylase (ODC) induction) and DNA synthesis ([3H]thymidine([3H]Tdr) incorporation). Polyamines 57-66 ornithine decarboxylase, structural 1 Mus musculus 103-106 3934157-3 1985 Here we report that ornithine decarboxylase is regulated at the translational level by polyamines in difluoromethylornithine-resistant mouse myeloma cells that overproduce the enzyme due to amplification of an ornithine decarboxylase gene. Polyamines 87-97 ornithine decarboxylase, structural 1 Mus musculus 20-43 3934157-3 1985 Here we report that ornithine decarboxylase is regulated at the translational level by polyamines in difluoromethylornithine-resistant mouse myeloma cells that overproduce the enzyme due to amplification of an ornithine decarboxylase gene. Polyamines 87-97 ornithine decarboxylase, structural 1 Mus musculus 210-233 4053280-2 1985 Induction of ornithine decarboxylase, the rate limiting enzyme in the polyamine biosynthetic pathway, has been shown to be an essential aspect of mouse skin tumor promotion. Polyamines 70-79 ornithine decarboxylase, structural 1 Mus musculus 13-36 6743338-4 1984 In combination with inhibitors of polyamine biosynthesis, growth inhibition was greatly increased with methylglyoxal bis(guanylhydrazone), an inhibitor of AdoMet decarboxylase, but only slightly increased with alpha-difluoromethylornithine, an inhibitor of ornithine decarboxylase. Polyamines 34-43 ornithine decarboxylase, structural 1 Mus musculus 257-280 6430555-1 1984 Polyamine depletion by pretreatment with alpha-difluoromethylornithine (DFMO), a specific and irreversible inhibitor of ornithine decarboxylase, potentiates the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in L1210 leukemia cells grown in a modified soft agar system. Polyamines 0-9 ornithine decarboxylase, structural 1 Mus musculus 120-143 3926303-9 1985 These results suggest that the velocity of polyamine synthesis, or the concentration of MTA itself, may regulate ornithine decarboxylase and SAM decarboxylase activities through separate, growth-independent mechanisms. Polyamines 43-52 ornithine decarboxylase, structural 1 Mus musculus 113-136 3970689-0 1985 Hyperthermia and polyamine biosynthesis: decreased ornithine decarboxylase induction in skin and kidney after heat shock. Polyamines 17-26 ornithine decarboxylase, structural 1 Mus musculus 51-74 3917438-4 1985 Three different classes of embryonal carcinoma cell lines reflect differential changes in polyamine levels resulting from inhibition of ornithine decarboxylase enzyme activity by DFMO. Polyamines 90-99 ornithine decarboxylase, structural 1 Mus musculus 136-159 6438117-3 1984 DFMO, a specific inhibitor of ornithine decarboxylase, halts continued polyamine biosynthesis and the Spd analog serves as a functional substitute for Spd. Polyamines 71-80 ornithine decarboxylase, structural 1 Mus musculus 30-53 6378247-6 1984 The activity of the polyamine biosynthesis enzyme ornithine decarboxylase (ODC) is elevated in psoriatic skin, and it is induced in mouse epidermis by tape stripping. Polyamines 20-29 ornithine decarboxylase, structural 1 Mus musculus 50-73 6378247-6 1984 The activity of the polyamine biosynthesis enzyme ornithine decarboxylase (ODC) is elevated in psoriatic skin, and it is induced in mouse epidermis by tape stripping. Polyamines 20-29 ornithine decarboxylase, structural 1 Mus musculus 75-78 6440309-3 1984 The mice were then treated with DFMO, an irreversible inhibitor of ornithine decarboxylase, which inhibits polyamine synthesis. Polyamines 107-116 ornithine decarboxylase, structural 1 Mus musculus 67-90 6330090-1 1984 Ornithine decarboxylase, the first enzyme of the polyamine biosynthetic pathway, is induced by androgens in the mouse kidney. Polyamines 49-58 ornithine decarboxylase, structural 1 Mus musculus 0-23 6463118-0 1984 The induction of erythema, edema, and the polyamine synthesis enzymes ornithine decarboxylase and S-adenosyl-L-methionine decarboxylase in hairless mouse skin by psoralens and longwave ultraviolet light. Polyamines 42-51 ornithine decarboxylase, structural 1 Mus musculus 70-93 6240915-3 1984 To gain an insight on whether ornithine decarboxylase (ODC)--the first enzyme in polyamine biosynthesis--is the labile protein that regulates rRNA synthesis, we have investigated the correlation between liver ODC and RNA polymerase I activities under different nutritional conditions. Polyamines 81-90 ornithine decarboxylase, structural 1 Mus musculus 30-53 6240915-3 1984 To gain an insight on whether ornithine decarboxylase (ODC)--the first enzyme in polyamine biosynthesis--is the labile protein that regulates rRNA synthesis, we have investigated the correlation between liver ODC and RNA polymerase I activities under different nutritional conditions. Polyamines 81-90 ornithine decarboxylase, structural 1 Mus musculus 55-58 6423285-1 1984 Ornithine decarboxylase, a key enzyme in polyamine biosynthesis and cell growth, has been localized in mouse kidney by autoradiography after administration of radiolabeled alpha-difluoromethylornithine. Polyamines 41-50 ornithine decarboxylase, structural 1 Mus musculus 0-23 6580640-5 1983 The ornithine decarboxylase inhibitor alpha-difluoromethylornithine (5 mM) suppressed the testosterone-induced increase in polyamine levels and rates of endocytosis, hexose transport, and amino acid transport, measured by horseradish peroxidase, [14C]aminoisobutyric acid, and deoxy[3H]glucose uptake. Polyamines 123-132 ornithine decarboxylase, structural 1 Mus musculus 4-27 6580640-7 1983 These data implicate polyamine synthesis in isoproterenol stimulation of Ca2+ fluxes and membrane transport processes and support a model for signal transduction and stimulus-response coupling in which ornithine decarboxylase activation and polyamine synthesis play a pivotal role in regulating Ca2+ fluxes. Polyamines 21-30 ornithine decarboxylase, structural 1 Mus musculus 202-225 6307502-2 1983 DFMO is a specific enzyme-activated irreversible inhibitor of ornithine decarboxylase, the rate-limiting enzyme controlling polyamine biosynthesis. Polyamines 124-133 ornithine decarboxylase, structural 1 Mus musculus 62-85 6875558-4 1983 Different types of responses in the activities of the polyamine-synthesizing enzymes, ornithine decarboxylase and adenosylmethionine decarboxylase, were observed after increasing the cerebral GABA concentration of mice with varying doses of two GABA transaminase inhibitors, gabaculine and ethanolamine-O-sulphate. Polyamines 54-63 ornithine decarboxylase, structural 1 Mus musculus 86-109 6619123-0 1983 Inhibition of polyamine synthesis and proliferation in mouse L cells by DL-alpha-hydrazino-delta-aminovaleric acid, an inhibitor of ornithine decarboxylase. Polyamines 14-23 ornithine decarboxylase, structural 1 Mus musculus 132-155 6413866-3 1983 An increase in the polyamines putrescine, spermidine and spermine, and their rate-regulating, synthetic enzyme ornithine decarboxylase (ODC), is one of the earliest events that occur during cell growth, replication and differentiation. Polyamines 19-29 ornithine decarboxylase, structural 1 Mus musculus 111-134 6413866-3 1983 An increase in the polyamines putrescine, spermidine and spermine, and their rate-regulating, synthetic enzyme ornithine decarboxylase (ODC), is one of the earliest events that occur during cell growth, replication and differentiation. Polyamines 19-29 ornithine decarboxylase, structural 1 Mus musculus 136-139 6831037-3 1983 This could be abrogated by administration of putrescine, confirming the association of the stimulatory effect with polyamine biosynthesis most likely via depression of ornithine decarboxylase activity and subsequent synthesis of putrescine. Polyamines 115-124 ornithine decarboxylase, structural 1 Mus musculus 168-191 6834049-1 1983 Ornithine decarboxylase, the rate-limiting enzyme in polyamine synthesis, is known to be regulated by a macromolecular inhibitor, termed antizyme, in a number of cellular systems. Polyamines 53-62 ornithine decarboxylase, structural 1 Mus musculus 0-23 6300139-1 1983 Treatment of mouse lymphoma S49 cells with D,L-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, depleted cellular polyamine levels and stopped cell growth. Polyamines 144-153 ornithine decarboxylase, structural 1 Mus musculus 101-124 6880806-6 1983 The elevation of ornithine decarboxylase activity in the gastrocnemius by testosterone was reflected in an increased content of the polyamines in the muscle. Polyamines 132-142 ornithine decarboxylase, structural 1 Mus musculus 17-40 6300139-7 1983 The activities of the polyamine-synthesizing enzymes ornithine decarboxylase (ODC) and S-adenosyl methionine decarboxylase (SAMD) are both reduced in Bt2cAMP-treated cells to about 10% of that in control populations, as shown previously. Polyamines 22-31 ornithine decarboxylase, structural 1 Mus musculus 53-76 6300139-7 1983 The activities of the polyamine-synthesizing enzymes ornithine decarboxylase (ODC) and S-adenosyl methionine decarboxylase (SAMD) are both reduced in Bt2cAMP-treated cells to about 10% of that in control populations, as shown previously. Polyamines 22-31 ornithine decarboxylase, structural 1 Mus musculus 78-81 6821130-0 1982 alpha-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin. Polyamines 117-126 ornithine decarboxylase, structural 1 Mus musculus 60-83 6847765-1 1983 There is a correlation between the ability to induce the polyamine-biosynthetic enzyme ornithine decarboxylase (ODC) and the tumor-promoting ability of various carcinogens in mouse epidermis. Polyamines 57-66 ornithine decarboxylase, structural 1 Mus musculus 87-110 6847765-1 1983 There is a correlation between the ability to induce the polyamine-biosynthetic enzyme ornithine decarboxylase (ODC) and the tumor-promoting ability of various carcinogens in mouse epidermis. Polyamines 57-66 ornithine decarboxylase, structural 1 Mus musculus 112-115 6365767-6 1983 The polyamines and their biosynthetic enzymes, especially ornithine decarboxylase (ODC), are useful probes in the study of carcinogenesis. Polyamines 4-14 ornithine decarboxylase, structural 1 Mus musculus 58-81 6365767-6 1983 The polyamines and their biosynthetic enzymes, especially ornithine decarboxylase (ODC), are useful probes in the study of carcinogenesis. Polyamines 4-14 ornithine decarboxylase, structural 1 Mus musculus 83-86 7184470-8 1982 The validity of this ODC assay procedure using intact neonatal mouse keratinocytes was tested by use of three specific ODC inhibitors and by measuring the formation of polyamines from uniform labeled ornithine. Polyamines 168-178 ornithine decarboxylase, structural 1 Mus musculus 21-24 7057047-1 1982 Irradiation of skin with ultraviolet light of sunburn range (UVB) leads to a large and rapid induction of the polyamine biosynthetic enzyme ornithine decarboxylase in the epidermis. Polyamines 110-119 ornithine decarboxylase, structural 1 Mus musculus 140-163 6805470-6 1982 The modification of cellular polyamine pattern by mycoplasmas, especially in the presence of inhibitors of eukaryotic ornithine decarboxylase, could conceivably be used as an indicator of mycoplasma infection in cultured animal cells. Polyamines 29-38 ornithine decarboxylase, structural 1 Mus musculus 118-141 6789780-4 1981 A single topical dose of alpha-difluoromethylornithine, a selective inhibitor or ornithine decarboxylase, prevented the UV-induced increase of polyamine excretion in agreement with its effect on UV-induced epidermal polyamine turnover. Polyamines 143-152 ornithine decarboxylase, structural 1 Mus musculus 81-104 6272311-1 1981 Incubation of wild-type S49 lymphoma cells with glucocorticoids, such as dexamethasone and hydrocortisone, inhibits the activity of ornithine decarboxylase (L-ornithine carboxylyase, EC 4.1.1.17), the rate-limiting enzyme in the pathway of polyamine biosynthesis. Polyamines 240-249 ornithine decarboxylase, structural 1 Mus musculus 132-155 6789780-4 1981 A single topical dose of alpha-difluoromethylornithine, a selective inhibitor or ornithine decarboxylase, prevented the UV-induced increase of polyamine excretion in agreement with its effect on UV-induced epidermal polyamine turnover. Polyamines 216-225 ornithine decarboxylase, structural 1 Mus musculus 81-104 6775372-1 1980 alpha-Difluoromethylornithine (RMI 71,782), a specific irreversible inhibitor of the first step in polyamine biosynthesis, that is, the formation of putrescine from ornithine by ornithine decarboxylase, cures mice infected with a virulent, rodent-passaged strain of Trypanosoma brucei brucei. Polyamines 99-108 ornithine decarboxylase, structural 1 Mus musculus 178-201 6284819-1 1981 We have examined the regulation of two key enzymes that control polyamine biosynthesis-L-ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC) - by agents increasing cAMP in S49 lymphoma cells. Polyamines 64-73 ornithine decarboxylase, structural 1 Mus musculus 74-112 6284819-1 1981 We have examined the regulation of two key enzymes that control polyamine biosynthesis-L-ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC) - by agents increasing cAMP in S49 lymphoma cells. Polyamines 64-73 ornithine decarboxylase, structural 1 Mus musculus 114-117 497223-5 1979 The effectiveness of diaminopropanol in abolishing polyamine accumulation was primarily based on a rapid decay of ornithine decarboxylase activity following the exposure of the cells to the drug. Polyamines 51-60 ornithine decarboxylase, structural 1 Mus musculus 114-137 7381232-1 1980 Ornithine decarboxylase which forms putrescine by the decarboxyalation of ornithine, is the first and probably the rate-limiting enzyme in the biosynthesis of the other polyamines, spermidine and spermine. Polyamines 169-179 ornithine decarboxylase, structural 1 Mus musculus 0-23 7381752-3 1980 The effectiveness of these drugs could be related to the inhibition of ornithine decarboxylase, a rate-limiting enzyme for the synthesis of polyamines. Polyamines 140-150 ornithine decarboxylase, structural 1 Mus musculus 71-94 7426404-5 1980 Depletion of the activity of ornithine decarboxylase, the rate-limiting polyamine biosynthetic enzyme, by topical steroids was confirmed in the hairless mouse following induction of the enzyme by UV-B. Polyamines 72-81 ornithine decarboxylase, structural 1 Mus musculus 29-52 126798-3 1975 The second (and larger) of the two ornithine decarboxylase increases coincides with the surge of cells from G1-G0 into S phase, suggesting that this enzyme, or the polyamines that it synthesizes, may play a role in controlling the growth fraction of this cell population. Polyamines 164-174 ornithine decarboxylase, structural 1 Mus musculus 35-58 985447-5 1976 Examination of the enzymes involved in polyamine biosynthesis revealed that ornithine decarboxylase, the initial enzyme in the polyamine-biosynthetic pathway, was increased by 150% in the kidneys and by 100% in the liver of male PRO/Re mice. Polyamines 39-48 ornithine decarboxylase, structural 1 Mus musculus 76-99 985447-5 1976 Examination of the enzymes involved in polyamine biosynthesis revealed that ornithine decarboxylase, the initial enzyme in the polyamine-biosynthetic pathway, was increased by 150% in the kidneys and by 100% in the liver of male PRO/Re mice. Polyamines 127-136 ornithine decarboxylase, structural 1 Mus musculus 76-99 1070517-2 1976 The inhibition of ODC, the rate-limiting enzyme in polyamine synthesis, appeared to correlate with the prolonged chemotherapeutic efficacy of a single dose of the platinum complex. Polyamines 51-60 ornithine decarboxylase, structural 1 Mus musculus 18-21 486108-2 1979 The induction of ornithine decarboxylase activity in mouse 3T3 fibroblasts or an SV-40 transformed 3T3 cell line by serum was prevented by addition of the naturally occurring polyamines putrescine (butane-1,4-diamine) and spermidine. Polyamines 175-185 ornithine decarboxylase, structural 1 Mus musculus 17-40 204937-1 1978 Incubation of S49 lymphoma cells with N6,O2"-dibutyryl cyclic AMP (Bt2cAMP) decreases the activities of ornithine decarboxylase (L-ornithine carboxy-lyase; EC 4.1.1.17) and S-adenosylmethionine decarboxylase (S-adenosyl-L-methionine carboxy-lyase; EC 4.1.1.50), the two principal enzymes in the pathway of polyamine synthesis. Polyamines 306-315 ornithine decarboxylase, structural 1 Mus musculus 104-127 269443-2 1977 This response appears to be mediated through polyamine metabolism because ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17)activity is markedly increased shortly after promoter exposure and this induction varies in magnitude according to dose and promoter potency of a series of phorbol esters. Polyamines 45-54 ornithine decarboxylase, structural 1 Mus musculus 74-97 1174509-6 1975 Since ornithine decarboxylase activity decays more rapidly in the presence of each polyamine after addition of camptothecin, the major locus of amine action appears to be in the cytoplasm. Polyamines 83-92 ornithine decarboxylase, structural 1 Mus musculus 6-29 1150642-0 1975 Effect of DL-alpha-hydrazino-delta-aminovaleric acid, an inhibitor of ornithine decarboxylase, on polyamine metabolism in isoproterenol-stimulated mouse parotid glands. Polyamines 98-107 ornithine decarboxylase, structural 1 Mus musculus 70-93 4786532-2 1973 Further, there is an early prolonged increase in the activity of ornithine decarboxylase, the initial enzyme in the polyamine biosynthetic pathway. Polyamines 116-125 ornithine decarboxylase, structural 1 Mus musculus 65-88 33621898-1 2021 OBJECTIVE: Studies have confirmed that tumorigenesis is related to an imbalance of polyamine metabolism and over-expression of oncogenes resulting in the up-regulation of ornithine decarboxylase (ODC, the first rate-limiting enzyme for regulating intracellular polyamines biosynthesis), which has become a target for anti-tumor therapy. Polyamines 261-271 ornithine decarboxylase, structural 1 Mus musculus 196-199 32101568-5 2020 Polyamine depletion was induced using alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase. Polyamines 0-9 ornithine decarboxylase, structural 1 Mus musculus 105-128 33621898-1 2021 OBJECTIVE: Studies have confirmed that tumorigenesis is related to an imbalance of polyamine metabolism and over-expression of oncogenes resulting in the up-regulation of ornithine decarboxylase (ODC, the first rate-limiting enzyme for regulating intracellular polyamines biosynthesis), which has become a target for anti-tumor therapy. Polyamines 83-92 ornithine decarboxylase, structural 1 Mus musculus 171-194 33621898-1 2021 OBJECTIVE: Studies have confirmed that tumorigenesis is related to an imbalance of polyamine metabolism and over-expression of oncogenes resulting in the up-regulation of ornithine decarboxylase (ODC, the first rate-limiting enzyme for regulating intracellular polyamines biosynthesis), which has become a target for anti-tumor therapy. Polyamines 83-92 ornithine decarboxylase, structural 1 Mus musculus 196-199 33621898-1 2021 OBJECTIVE: Studies have confirmed that tumorigenesis is related to an imbalance of polyamine metabolism and over-expression of oncogenes resulting in the up-regulation of ornithine decarboxylase (ODC, the first rate-limiting enzyme for regulating intracellular polyamines biosynthesis), which has become a target for anti-tumor therapy. Polyamines 261-271 ornithine decarboxylase, structural 1 Mus musculus 171-194 32917695-6 2020 It also inhibited ODC1 expression reducing biosynthesis of polyamines, which are known to reactivate dormant embryos. Polyamines 59-69 ornithine decarboxylase, structural 1 Mus musculus 18-22 32588887-0 2020 Ornithine Decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex. Polyamines 53-62 ornithine decarboxylase, structural 1 Mus musculus 0-23