PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30700572-2	2019	Polyamines are highly regulated essential cations that are frequently elevated in cancer cells, and the rate-limiting enzyme in polyamine synthesis, ornithine decarboxylase 1 (ODC1), is a direct transcriptional target of MYCN.	Polyamines	0-10	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	221-225	
30700572-2	2019	Polyamines are highly regulated essential cations that are frequently elevated in cancer cells, and the rate-limiting enzyme in polyamine synthesis, ornithine decarboxylase 1 (ODC1), is a direct transcriptional target of MYCN.	Polyamines	128-137	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	221-225	
30700572-6	2019	In addition, MYCN directly increased polyamine synthesis and promoted neuroblastoma cell proliferation by regulating SLC3A2 and other regulatory components of the polyamine pathway.	Polyamines	37-46	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	13-17	
30700572-6	2019	In addition, MYCN directly increased polyamine synthesis and promoted neuroblastoma cell proliferation by regulating SLC3A2 and other regulatory components of the polyamine pathway.	Polyamines	163-172	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	13-17	
19047152-3	2008	We used transcriptome analyses to show that MYCN-amplified neuroblastomas have coordinately deregulated myriad polyamine enzymes (including ODC1, SRM, SMS, AMD1, OAZ2, and SMOX) to enhance polyamine biosynthesis.	Polyamines	111-120	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	44-48	
23181218-3	2012	Polyamine sufficiency may be required for MYCN oncogenicity in MYCN amplified neuroblastoma, and targeting polyamine homeostasis may therefore provide an attractive therapeutic approach.	Polyamines	0-9	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	42-46	
23181218-3	2012	Polyamine sufficiency may be required for MYCN oncogenicity in MYCN amplified neuroblastoma, and targeting polyamine homeostasis may therefore provide an attractive therapeutic approach.	Polyamines	0-9	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	63-67	
19047152-3	2008	We used transcriptome analyses to show that MYCN-amplified neuroblastomas have coordinately deregulated myriad polyamine enzymes (including ODC1, SRM, SMS, AMD1, OAZ2, and SMOX) to enhance polyamine biosynthesis.	Polyamines	189-198	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	44-48	
19047152-11	2008	This work implicates polyamine biosynthesis as an arbiter of MYCN oncogenesis and shows initial efficacy for polyamine depletion strategies in neuroblastoma, a strategy that may have utility for this and other MYC-driven embryonal tumors.	Polyamines	21-30	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	61-65