PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15384901-5 2004 Ornithine decarboxylase is a pivotal enzyme in regulating the synthesis of polyamines, cations that are important regulators of cell division, differentiation, and apoptosis. Polyamines 75-85 ornithine decarboxylase Gallus gallus 0-23 11852055-2 2002 Here we show an involvement of nuclear factor-kappaB (NF-kappaB) in the induction of nitric oxide synthase (NOS) and ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis. Polyamines 166-175 ornithine decarboxylase Gallus gallus 117-140 11852055-2 2002 Here we show an involvement of nuclear factor-kappaB (NF-kappaB) in the induction of nitric oxide synthase (NOS) and ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis. Polyamines 166-175 ornithine decarboxylase Gallus gallus 142-145 4056678-1 1985 We have measured the activities of the two rate controlling enzymes in polyamine synthesis, L-ornithine decarboxylase (ODC) and S-adenosyl-L-methionine decarboxylase (SAMDC), and the concentrations of the polyamines, putrescine, spermidine and spermine, in the developing chick embryo from laying to hatching. Polyamines 71-80 ornithine decarboxylase Gallus gallus 119-122 11164851-10 2001 Experiments with specific inhibitors of ODC and NOS, as well as with inhibitors of sGC and cGMP-dependent protein kinase (PKG), showed that polyamine-, NO- and cGMP-dependent pathways are required for the mitogenic action of TNFalpha and LPS. Polyamines 140-149 ornithine decarboxylase Gallus gallus 40-43 9075337-6 1997 IL-1, which does not act on cell proliferation, fails to activate ODC and to increase polyamine levels, thus indicating that the ODC/polyamine system is most likely to be an important link in the chain of events that leads to growth factor-induced proliferation. Polyamines 133-142 ornithine decarboxylase Gallus gallus 129-132 34613458-1 2021 Polyamines (putrescine, spermidine, and spermine) are synthesized primarily from ornithine via ornithine decarboxylase (ODC) in mammals. Polyamines 0-10 ornithine decarboxylase Gallus gallus 95-118 34613458-1 2021 Polyamines (putrescine, spermidine, and spermine) are synthesized primarily from ornithine via ornithine decarboxylase (ODC) in mammals. Polyamines 0-10 ornithine decarboxylase Gallus gallus 120-123 3119798-10 1987 This accumulation of polyamine precursors resulted in increased concentrations of putrescine despite feedback inhibition of ODC. Polyamines 21-30 ornithine decarboxylase Gallus gallus 124-127 3113732-4 1987 The cultures were treated with alpha-difluoromethylornithine (DFMO), an enzyme-activated irreversible inhibitor of ornithine decarboxylase, the first and rate-limiting enzyme in polyamine synthesis. Polyamines 178-187 ornithine decarboxylase Gallus gallus 115-138 3548994-1 1987 The localization of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis and thus in cell growth, was determined in the 4.5-day-old chick embryo, using two independent methods of analysis. Polyamines 67-76 ornithine decarboxylase Gallus gallus 20-43 3548994-1 1987 The localization of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis and thus in cell growth, was determined in the 4.5-day-old chick embryo, using two independent methods of analysis. Polyamines 67-76 ornithine decarboxylase Gallus gallus 45-48 8417156-6 1993 Postreceptor inhibition of the ornithine decarboxylase/polyamine cascade by alpha-difluoromethylornithine may provide neuroprotection against N-methyl-D-aspartate-induced excitotoxicity. Polyamines 55-64 ornithine decarboxylase Gallus gallus 31-54 4056678-1 1985 We have measured the activities of the two rate controlling enzymes in polyamine synthesis, L-ornithine decarboxylase (ODC) and S-adenosyl-L-methionine decarboxylase (SAMDC), and the concentrations of the polyamines, putrescine, spermidine and spermine, in the developing chick embryo from laying to hatching. Polyamines 205-215 ornithine decarboxylase Gallus gallus 119-122 6895593-12 1981 These results clearly indicate that the duodenal biosynthesis of polyamines is regulated by 1 alpha, 25 (OH)2D3, suggesting the possibility that duodenal ornithine decarboxylase may be involved in the calcium absorption mechanism. Polyamines 65-75 ornithine decarboxylase Gallus gallus 154-177 7310281-2 1980 A rapid increase in the activity of ornithine decarboxylase (ODC), the initial and rate-limiting enzyme in polyamine synthesis, was observed immediately after onset of incubation. Polyamines 107-116 ornithine decarboxylase Gallus gallus 36-59 7310281-2 1980 A rapid increase in the activity of ornithine decarboxylase (ODC), the initial and rate-limiting enzyme in polyamine synthesis, was observed immediately after onset of incubation. Polyamines 107-116 ornithine decarboxylase Gallus gallus 61-64