PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29180230-8 2018 GCs also affected genes involved in the synthesis of polyamines (Azin1) and taurine (Cdo1). Polyamines 53-63 antizyme inhibitor 1 Homo sapiens 65-70 30323064-4 2018 The impact of polyamines on translation is highlighted by autoregulation of the translation of mRNAs encoding key metabolic and regulatory proteins in the polyamine biosynthesis pathway, including S-adenosylmethionine decarboxylase (AdoMetDC), antizyme (OAZ), and antizyme inhibitor 1 (AZIN1). Polyamines 14-24 antizyme inhibitor 1 Homo sapiens 264-284 30323064-4 2018 The impact of polyamines on translation is highlighted by autoregulation of the translation of mRNAs encoding key metabolic and regulatory proteins in the polyamine biosynthesis pathway, including S-adenosylmethionine decarboxylase (AdoMetDC), antizyme (OAZ), and antizyme inhibitor 1 (AZIN1). Polyamines 14-24 antizyme inhibitor 1 Homo sapiens 286-291 30323064-4 2018 The impact of polyamines on translation is highlighted by autoregulation of the translation of mRNAs encoding key metabolic and regulatory proteins in the polyamine biosynthesis pathway, including S-adenosylmethionine decarboxylase (AdoMetDC), antizyme (OAZ), and antizyme inhibitor 1 (AZIN1). Polyamines 14-23 antizyme inhibitor 1 Homo sapiens 264-284 30323064-4 2018 The impact of polyamines on translation is highlighted by autoregulation of the translation of mRNAs encoding key metabolic and regulatory proteins in the polyamine biosynthesis pathway, including S-adenosylmethionine decarboxylase (AdoMetDC), antizyme (OAZ), and antizyme inhibitor 1 (AZIN1). Polyamines 14-23 antizyme inhibitor 1 Homo sapiens 286-291 29677493-3 2018 Ribosomal profiling reveals polyamine-dependent pausing of elongating ribosomes on a conserved Pro-Pro-Trp (PPW) motif in an inhibitory non-AUG-initiated upstream conserved coding region (uCC) of the antizyme inhibitor 1 (AZIN1) mRNA, encoding a regulator of cellular polyamine synthesis. Polyamines 28-37 antizyme inhibitor 1 Homo sapiens 200-220 29677493-3 2018 Ribosomal profiling reveals polyamine-dependent pausing of elongating ribosomes on a conserved Pro-Pro-Trp (PPW) motif in an inhibitory non-AUG-initiated upstream conserved coding region (uCC) of the antizyme inhibitor 1 (AZIN1) mRNA, encoding a regulator of cellular polyamine synthesis. Polyamines 28-37 antizyme inhibitor 1 Homo sapiens 222-227 29677493-3 2018 Ribosomal profiling reveals polyamine-dependent pausing of elongating ribosomes on a conserved Pro-Pro-Trp (PPW) motif in an inhibitory non-AUG-initiated upstream conserved coding region (uCC) of the antizyme inhibitor 1 (AZIN1) mRNA, encoding a regulator of cellular polyamine synthesis. Polyamines 268-277 antizyme inhibitor 1 Homo sapiens 200-220 30355739-3 2018 To a large extent, this regulation is achieved through the activity of an autoregulatory loop that involves two proteins, antizyme (Az) and antizyme inhibitor (AzI), that regulate the first enzyme in polyamine biosynthesis, ornithine decarboxylase (ODC), and polyamine uptake activity in response to intracellular polyamine levels. Polyamines 200-209 antizyme inhibitor 1 Homo sapiens 140-158 30355739-3 2018 To a large extent, this regulation is achieved through the activity of an autoregulatory loop that involves two proteins, antizyme (Az) and antizyme inhibitor (AzI), that regulate the first enzyme in polyamine biosynthesis, ornithine decarboxylase (ODC), and polyamine uptake activity in response to intracellular polyamine levels. Polyamines 200-209 antizyme inhibitor 1 Homo sapiens 160-163 30355739-3 2018 To a large extent, this regulation is achieved through the activity of an autoregulatory loop that involves two proteins, antizyme (Az) and antizyme inhibitor (AzI), that regulate the first enzyme in polyamine biosynthesis, ornithine decarboxylase (ODC), and polyamine uptake activity in response to intracellular polyamine levels. Polyamines 259-268 antizyme inhibitor 1 Homo sapiens 140-158 30355739-3 2018 To a large extent, this regulation is achieved through the activity of an autoregulatory loop that involves two proteins, antizyme (Az) and antizyme inhibitor (AzI), that regulate the first enzyme in polyamine biosynthesis, ornithine decarboxylase (ODC), and polyamine uptake activity in response to intracellular polyamine levels. Polyamines 259-268 antizyme inhibitor 1 Homo sapiens 160-163 30355739-3 2018 To a large extent, this regulation is achieved through the activity of an autoregulatory loop that involves two proteins, antizyme (Az) and antizyme inhibitor (AzI), that regulate the first enzyme in polyamine biosynthesis, ornithine decarboxylase (ODC), and polyamine uptake activity in response to intracellular polyamine levels. Polyamines 259-268 antizyme inhibitor 1 Homo sapiens 140-158 30355739-3 2018 To a large extent, this regulation is achieved through the activity of an autoregulatory loop that involves two proteins, antizyme (Az) and antizyme inhibitor (AzI), that regulate the first enzyme in polyamine biosynthesis, ornithine decarboxylase (ODC), and polyamine uptake activity in response to intracellular polyamine levels. Polyamines 259-268 antizyme inhibitor 1 Homo sapiens 160-163 30355739-4 2018 In this Minireview, I will discuss what has been learned about the mechanism of Az expression and its physical interaction with both ODC and AzI in the regulation of polyamines. Polyamines 166-176 antizyme inhibitor 1 Homo sapiens 141-144 27870265-10 2017 Encouragingly, AZIN1 has been revealed to have an additional function outside the polyamine pathway so as to bypass the deficiency of targeting the polyamine biosynthetic pathway, promising to become a critical target for cancer therapy. Polyamines 82-91 antizyme inhibitor 1 Homo sapiens 15-20 27870265-10 2017 Encouragingly, AZIN1 has been revealed to have an additional function outside the polyamine pathway so as to bypass the deficiency of targeting the polyamine biosynthetic pathway, promising to become a critical target for cancer therapy. Polyamines 148-157 antizyme inhibitor 1 Homo sapiens 15-20 27941031-11 2016 Interestingly, a protein, termed antizyme inhibitor (AzI) that is highly homologous with ODC, but retains no ornithine decarboxylating activity, seems to regulate cellular polyamines through its ability to negate Az. Polyamines 172-182 antizyme inhibitor 1 Homo sapiens 33-51 27941031-11 2016 Interestingly, a protein, termed antizyme inhibitor (AzI) that is highly homologous with ODC, but retains no ornithine decarboxylating activity, seems to regulate cellular polyamines through its ability to negate Az. Polyamines 172-182 antizyme inhibitor 1 Homo sapiens 53-56 24077669-0 2014 Multiple forms of mouse antizyme inhibitor 1 mRNA differentially regulated by polyamines. Polyamines 78-88 antizyme inhibitor 1 Homo sapiens 24-44 24077669-1 2014 Antizyme inhibitor 1 (Azin1), a positive regulator of cellular polyamines, is induced by various proliferative stimuli and repressed by polyamines. Polyamines 63-73 antizyme inhibitor 1 Homo sapiens 0-20 24077669-1 2014 Antizyme inhibitor 1 (Azin1), a positive regulator of cellular polyamines, is induced by various proliferative stimuli and repressed by polyamines. Polyamines 63-73 antizyme inhibitor 1 Homo sapiens 22-27 24077669-1 2014 Antizyme inhibitor 1 (Azin1), a positive regulator of cellular polyamines, is induced by various proliferative stimuli and repressed by polyamines. Polyamines 136-146 antizyme inhibitor 1 Homo sapiens 0-20 24077669-1 2014 Antizyme inhibitor 1 (Azin1), a positive regulator of cellular polyamines, is induced by various proliferative stimuli and repressed by polyamines. Polyamines 136-146 antizyme inhibitor 1 Homo sapiens 22-27 24077669-2 2014 It has been reported that the translational repression of Azin1 by polyamines involves an upstream open reading frame on the mRNA, but little has been known about polyamine effect on its transcription or splicing. Polyamines 67-77 antizyme inhibitor 1 Homo sapiens 58-63 24077669-2 2014 It has been reported that the translational repression of Azin1 by polyamines involves an upstream open reading frame on the mRNA, but little has been known about polyamine effect on its transcription or splicing. Polyamines 67-76 antizyme inhibitor 1 Homo sapiens 58-63 24077669-6 2014 Thus, polyamines regulate two novel steps of Azin1 expression, namely the transcription and a particular splicing pattern, both of which may affect the level of mRNA encoding the full-length active Azin1 protein. Polyamines 6-16 antizyme inhibitor 1 Homo sapiens 45-50 24077669-6 2014 Thus, polyamines regulate two novel steps of Azin1 expression, namely the transcription and a particular splicing pattern, both of which may affect the level of mRNA encoding the full-length active Azin1 protein. Polyamines 6-16 antizyme inhibitor 1 Homo sapiens 198-203 23868013-7 2013 The antizyme inhibitor Azin1, an important regulator of polyamine synthesis, was identified as a target of miR-433. Polyamines 56-65 antizyme inhibitor 1 Homo sapiens 23-28 17371267-0 2007 Antizyme inhibitor: a defective ornithine decarboxylase or a physiological regulator of polyamine biosynthesis and cellular proliferation. Polyamines 88-97 antizyme inhibitor 1 Homo sapiens 0-18 21814789-1 2012 Ornithine decarboxylase antizyme inhibitors, AZIN1 and AZIN2, are regulators and homologous proteins of ornithine decarboxylase (ODC), the rate limiting enzyme in the biosynthesis of polyamines. Polyamines 183-193 antizyme inhibitor 1 Homo sapiens 45-50 21837750-10 2011 The AZIN1-SV2 acts via a polyamine-independent pathway, as it neither interacts with antizyme nor affects the ability of AZIN1 lacking this variant to neutralize antizyme. Polyamines 25-34 antizyme inhibitor 1 Homo sapiens 4-9 19956990-4 2010 There are two antizyme inhibitors (AZIN), known as AZIN1 and AZIN2, that bind to AZs and negate their effects on polyamine metabolism. Polyamines 113-122 antizyme inhibitor 1 Homo sapiens 51-56 17371267-5 2007 Here we review the mechanism of ODC degradation with particular emphasis on AzI (antizyme inhibitor), an ODC homologous protein that appears as a central regulator of ODC stability, cellular polyamine homoeostasis and cellular proliferation. Polyamines 191-200 antizyme inhibitor 1 Homo sapiens 81-99 20095969-0 2009 Regulation of cellular polyamine levels and cellular proliferation by antizyme and antizyme inhibitor. Polyamines 23-32 antizyme inhibitor 1 Homo sapiens 83-101 19449338-1 2009 Ornithine decarboxylase (ODC) and the antizyme inhibitors (AZIN1 and AZIN2), regulatory proteins of polyamine levels, are antizyme-binding proteins. Polyamines 100-109 antizyme inhibitor 1 Homo sapiens 59-64 17371267-5 2007 Here we review the mechanism of ODC degradation with particular emphasis on AzI (antizyme inhibitor), an ODC homologous protein that appears as a central regulator of ODC stability, cellular polyamine homoeostasis and cellular proliferation. Polyamines 191-200 antizyme inhibitor 1 Homo sapiens 76-79 15670771-9 2005 Moreover, silencing AZI expression decreased intracellular polyamine levels, reduced cell proliferation, and prolonged population doubling time. Polyamines 59-68 antizyme inhibitor 1 Homo sapiens 20-23 15670771-10 2005 Our results directly demonstrate that downregulation of AZI regulates ODC activity, intracellular polyamine levels, and cell growth through regulating antizyme activity. Polyamines 98-107 antizyme inhibitor 1 Homo sapiens 56-59