PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15982768-1	2005	Endogenous polyamines like spermine are known to have four distinct effects on recombinant N-methyl-d-aspartate (NMDA) receptor channels: voltage-dependent inhibition, glycine-dependent stimulation, glycine-independent stimulation and decreased affinity to the agonist (l-glutamate).	Polyamines	11-21	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	91-127	
20523002-0	2010	Synthesis of water-soluble polyamine derivatives effective as N-methyl-D-aspartate receptor antagonists.	Polyamines	27-36	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	62-91	
7534390-4	1994	Arcaine, a putative competitive antagonist at the polyamine-binding site on the N-methyl-D-aspartate (NMDA) receptor-channel complex, reduced the spermine enhancement of ACh-induced whole-cell currents.	Polyamines	50-59	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	80-116	
8649353-13	1996	D669 in NR1A could form part of a binding site for polyamines and ifenprodil and/or part of the proton sensor of the NMDA receptor.	Polyamines	51-61	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	117-130	
8190097-0	1994	Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits.	Polyamines	52-62	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	19-48	
8058050-9	1994	Alternatively, polyamines could enhance the decay of NMDA receptor-mediated responses by increasing the rate of dissociation of glutamate from the receptor.	Polyamines	15-25	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	53-66	
8341692-0	1993	Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C. The N-methyl-D-aspartate (NMDA) receptor NR1 gene encodes RNA that is alternatively spliced to generate at least seven variants.	Polyamines	100-110	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	23-52	
8341692-0	1993	Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C. The N-methyl-D-aspartate (NMDA) receptor NR1 gene encodes RNA that is alternatively spliced to generate at least seven variants.	Polyamines	100-110	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	53-56	
8341692-0	1993	Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C. The N-methyl-D-aspartate (NMDA) receptor NR1 gene encodes RNA that is alternatively spliced to generate at least seven variants.	Polyamines	100-110	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	174-177	
7687289-9	1993	Although alpha-agatoxins can interact at the positive allosteric polyamine site on the NMDA receptor, stimulatory effects produced by this interaction may be masked in functional assays due to a separate action of the toxins as high-affinity, noncompetitive antagonists of the receptor.	Polyamines	65-74	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	87-100	
1532151-3	1992	Functional homomeric zeta 1 channels expressed in Xenopus oocytes by injection of the subunit-specific mRNA exhibit current responses characteristic for the NMDA receptor channel such as activation by glycine, Ca2+ permeability, blocking by Mg2+ and activation by polyamine.	Polyamines	264-273	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	157-170	
1838407-1	1991	The ability of polyamines to modulate N-methyl-D-aspartate (NMDA) receptor function was investigated in Xenopus oocytes injected with rat brain mRNA.	Polyamines	15-25	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	38-74	
1838407-4	1991	These findings demonstrate that polyamines exert both positive and negative modulatory control of the NMDA receptor expressed in Xenopus oocytes, and suggest that spermine and arcaine act at distinct sites in the NMDA receptor complex.	Polyamines	32-42	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	102-115	
1838407-4	1991	These findings demonstrate that polyamines exert both positive and negative modulatory control of the NMDA receptor expressed in Xenopus oocytes, and suggest that spermine and arcaine act at distinct sites in the NMDA receptor complex.	Polyamines	32-42	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	213-226