PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34206713-0	2021	Proteome Analysis in PAM Cells Reveals That African Swine Fever Virus Can Regulate the Level of Intracellular Polyamines to Facilitate Its Own Replication through ARG1.	Polyamines	110-120	arginase 1	Homo sapiens	163-167	
26475291-1	2016	Arginase 1 (Arg1) limits the availability of l-arginine for producing nitric oxide (NO) and ornithine, a substrate for polyamine synthesis.	Polyamines	119-128	arginase 1	Homo sapiens	0-10	
35159317-4	2022	One of the identified Nex-binding proteins is the nonmitochondrial, cytosolic arginase 1 (ARG1), a key enzyme of the urea cycle and involved in the de novo synthesis of polyamines, such as spermidine and spermine.	Polyamines	169-179	arginase 1	Homo sapiens	78-88	
35159317-4	2022	One of the identified Nex-binding proteins is the nonmitochondrial, cytosolic arginase 1 (ARG1), a key enzyme of the urea cycle and involved in the de novo synthesis of polyamines, such as spermidine and spermine.	Polyamines	169-179	arginase 1	Homo sapiens	90-94	
28214225-4	2017	We found that IDO1 phosphorylation and consequent activation of IDO1 signaling in DCs was strictly dependent on prior expression of Arg1 and Arg1-dependent production of polyamines.	Polyamines	170-180	arginase 1	Homo sapiens	141-145	
28214225-5	2017	Polyamines, either produced by DCs or released by bystander Arg1+ myeloid-derived suppressor cells, conditioned DCs toward an IDO1-dependent, immunosuppressive phenotype via activation of the Src kinase, which has IDO1-phosphorylating activity.	Polyamines	0-10	arginase 1	Homo sapiens	60-64	
26475291-1	2016	Arginase 1 (Arg1) limits the availability of l-arginine for producing nitric oxide (NO) and ornithine, a substrate for polyamine synthesis.	Polyamines	119-128	arginase 1	Homo sapiens	12-16	
22416259-0	2012	Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes.	Polyamines	40-49	arginase 1	Homo sapiens	17-27	
26514486-10	2015	CONCLUSIONS: These findings strongly suggest that in HNSCCs, the ARG1 pathway is stimulated leading to the formation of polyamines as indicated by higher ODC expression, which promote tumor growth.	Polyamines	120-130	arginase 1	Homo sapiens	65-69	
24133491-8	2013	Whether arginase-1, which is crucial in the synthesis of various fundamental polyamines in the body, will represent a potent therapeutic target for prevention of DM-associated CAD is still debated.	Polyamines	77-87	arginase 1	Homo sapiens	8-18	
23375628-3	2013	Arginase 1 (Arg1), a marker for the M2 anti-inflammatory subset, hydrolyzes l-arginine into urea and ornithine, a precursor to l-proline and polyamines, which are implicated in tissue repair and wound healing.	Polyamines	141-151	arginase 1	Homo sapiens	0-10	
23375628-3	2013	Arginase 1 (Arg1), a marker for the M2 anti-inflammatory subset, hydrolyzes l-arginine into urea and ornithine, a precursor to l-proline and polyamines, which are implicated in tissue repair and wound healing.	Polyamines	141-151	arginase 1	Homo sapiens	12-16	
22416259-5	2012	Remarkably, Arg1-deficient macrophages display rather enhanced IL-4-induced polyamine production, suggesting that an Arg1-independent polyamine synthesis pathway may operate in macrophages.	Polyamines	76-85	arginase 1	Homo sapiens	12-16	
22416259-5	2012	Remarkably, Arg1-deficient macrophages display rather enhanced IL-4-induced polyamine production, suggesting that an Arg1-independent polyamine synthesis pathway may operate in macrophages.	Polyamines	134-143	arginase 1	Homo sapiens	12-16	
22416259-7	2012	Overall, we propose Arg1 independently produced polyamines as novel regulators of the inflammatory status of the macrophage.	Polyamines	48-58	arginase 1	Homo sapiens	20-24	
19726720-3	2009	The IL-4-dependent, arginase-1/ornithine decarboxylase-mediated production of polyamines is important for maximal Cdh1 induction, unveiling a novel mechanism for IL-4-dependent gene transcription.	Polyamines	78-88	arginase 1	Homo sapiens	20-30	
16939563-4	2006	Arginine can also be metabolized to urea and ornithine by arginase-1, a pathway that generates L-proline, a substrate for collagen synthesis, and polyamines, which stimulate cellular proliferation.	Polyamines	146-156	arginase 1	Homo sapiens	58-68	
15811879-1	2005	Arginase 1, an enzyme induced by Th2 cytokines, is a hallmark of alternatively activated macrophages and is responsible for the hydrolysis of L-arginine into ornithine, the building block for the production of polyamines.	Polyamines	210-220	arginase 1	Homo sapiens	0-10