PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26796279-0 2016 The inhibition of PI3K and NFkappaB promoted curcumin-induced cell cycle arrest at G2/M via altering polyamine metabolism in Bcl-2 overexpressing MCF-7 breast cancer cells. Polyamines 101-110 nuclear factor kappa B subunit 1 Homo sapiens 27-35 26796279-15 2016 In conclusion, the potential role of curcumin in induction of cell cycle arrest is related with NFkappaB-regulated polyamine biosynthesis. Polyamines 115-124 nuclear factor kappa B subunit 1 Homo sapiens 96-104 12916171-0 2002 [Investigation of polyamine interactions with the nuclear transcription factor NF-kappa B by computer modelling]. Polyamines 18-27 nuclear factor kappa B subunit 1 Homo sapiens 79-89 15494691-0 2004 Role of polyamines in the function of nuclear transcription factor NF-kappaB in breast cancer cells. Polyamines 8-18 nuclear factor kappa B subunit 1 Homo sapiens 67-76 15494691-1 2004 UNLABELLED: The aim of the work was the investigation of the influence of polyamines on formation of nuclear transcription factor kappa B (NF-kappaB) complex with specific DNA-sequences nuclear response elements (NRE), and the study of content of p50 and p65 (NF-kappaB subunits) in breast tumor cells under polyamines metabolism modulation. Polyamines 74-84 nuclear factor kappa B subunit 1 Homo sapiens 101-137 15494691-1 2004 UNLABELLED: The aim of the work was the investigation of the influence of polyamines on formation of nuclear transcription factor kappa B (NF-kappaB) complex with specific DNA-sequences nuclear response elements (NRE), and the study of content of p50 and p65 (NF-kappaB subunits) in breast tumor cells under polyamines metabolism modulation. Polyamines 74-84 nuclear factor kappa B subunit 1 Homo sapiens 139-148 15494691-1 2004 UNLABELLED: The aim of the work was the investigation of the influence of polyamines on formation of nuclear transcription factor kappa B (NF-kappaB) complex with specific DNA-sequences nuclear response elements (NRE), and the study of content of p50 and p65 (NF-kappaB subunits) in breast tumor cells under polyamines metabolism modulation. Polyamines 74-84 nuclear factor kappa B subunit 1 Homo sapiens 247-250 15494691-1 2004 UNLABELLED: The aim of the work was the investigation of the influence of polyamines on formation of nuclear transcription factor kappa B (NF-kappaB) complex with specific DNA-sequences nuclear response elements (NRE), and the study of content of p50 and p65 (NF-kappaB subunits) in breast tumor cells under polyamines metabolism modulation. Polyamines 74-84 nuclear factor kappa B subunit 1 Homo sapiens 260-269 15494691-1 2004 UNLABELLED: The aim of the work was the investigation of the influence of polyamines on formation of nuclear transcription factor kappa B (NF-kappaB) complex with specific DNA-sequences nuclear response elements (NRE), and the study of content of p50 and p65 (NF-kappaB subunits) in breast tumor cells under polyamines metabolism modulation. Polyamines 308-318 nuclear factor kappa B subunit 1 Homo sapiens 139-148 15494691-3 2004 RESULTS: The data have demonstrated that polyamines falicitated p50 -- NRE binding. Polyamines 41-51 nuclear factor kappa B subunit 1 Homo sapiens 64-67 15494691-4 2004 Under conditions of polyamine depletion, an increase of content of both p50 and p65 subunits of NF-kappaB in the nucleus has been registered (especially that of p50 subunits). Polyamines 20-29 nuclear factor kappa B subunit 1 Homo sapiens 72-75 15494691-4 2004 Under conditions of polyamine depletion, an increase of content of both p50 and p65 subunits of NF-kappaB in the nucleus has been registered (especially that of p50 subunits). Polyamines 20-29 nuclear factor kappa B subunit 1 Homo sapiens 96-105 15494691-4 2004 Under conditions of polyamine depletion, an increase of content of both p50 and p65 subunits of NF-kappaB in the nucleus has been registered (especially that of p50 subunits). Polyamines 20-29 nuclear factor kappa B subunit 1 Homo sapiens 161-164 15494691-6 2004 CONCLUSION: Polyamines influence the activity of NF-kappaB transcription factor in breast tumor cells. Polyamines 12-22 nuclear factor kappa B subunit 1 Homo sapiens 49-58 24324622-10 2013 CONCLUSION: MTAP mediated regulation of MTA links polyamine metabolism with NFkappaB activation and apoptosis in HSCs. Polyamines 50-59 nuclear factor kappa B subunit 1 Homo sapiens 76-84 17825525-2 2007 We have previously shown that DFMO leads to the inhibition of de novo polyamine synthesis, which in turn rapidly activates Src, STAT3 and NF-kappaB via integrin beta3 in intestinal epithelial cells. Polyamines 70-79 nuclear factor kappa B subunit 1 Homo sapiens 138-147 15828019-0 2005 Polyamine depletion inhibits NF-kappaB binding to DNA and interleukin-8 production in human chondrocytes stimulated by tumor necrosis factor-alpha. Polyamines 0-9 nuclear factor kappa B subunit 1 Homo sapiens 29-38 15828019-2 2005 To search for new approaches to limit cartilage damage, we investigated the requirement of polyamines for NF-kappaB activation by TNFalpha in human C-28/I2 chondrocytes, using alpha-difluoromethylornithine (DFMO), a specific polyamine biosynthesis inhibitor. Polyamines 91-101 nuclear factor kappa B subunit 1 Homo sapiens 106-115 15828019-2 2005 To search for new approaches to limit cartilage damage, we investigated the requirement of polyamines for NF-kappaB activation by TNFalpha in human C-28/I2 chondrocytes, using alpha-difluoromethylornithine (DFMO), a specific polyamine biosynthesis inhibitor. Polyamines 91-100 nuclear factor kappa B subunit 1 Homo sapiens 106-115 15828019-9 2005 Our results show that the intracellular depletion of polyamines inhibits the response of chondrocytes to TNFalpha by interfering with the DNA binding activity of NF-kappaB. Polyamines 53-63 nuclear factor kappa B subunit 1 Homo sapiens 162-171 15828019-10 2005 This suggests that a pharmacological and/or genetic approach to deplete the polyamine pool in chondrocytes may represent a useful way to reduce NF-kappaB activation by inflammatory cytokines in arthritis without provoking chondrocyte apoptosis. Polyamines 76-85 nuclear factor kappa B subunit 1 Homo sapiens 144-153 16350747-1 2004 Using fluorescence resonance energy transfer technique, effects of polyamines (spermine and putrescine) on the binding of p50 subunit of the nuclear transcription factor NF-kappaB to specific DNA sequences were studied in model experiments. Polyamines 67-77 nuclear factor kappa B subunit 1 Homo sapiens 170-179 16350747-4 2004 Our results presented in this work allow us to suggest that polyamines (excessive synthesis of which proceeds in tumor growth) may participate in the regulation of transcription of several oncogenes by the factor NF-kappaB. Polyamines 60-70 nuclear factor kappa B subunit 1 Homo sapiens 213-222 12916171-1 2002 Computer modelling is used to study interactions between polyamines and nuclear transcription factor NF-kappa B and NF-kappa B. Polyamines 57-67 nuclear factor kappa B subunit 1 Homo sapiens 101-111 12916171-1 2002 Computer modelling is used to study interactions between polyamines and nuclear transcription factor NF-kappa B and NF-kappa B. Polyamines 57-67 nuclear factor kappa B subunit 1 Homo sapiens 116-126 12916171-3 2002 It is shown that polyamines can regulate interaction between NF-kappa B and the specific DNA sequence by binding to p50 subunit of NF-kappa B. Polyamines 17-27 nuclear factor kappa B subunit 1 Homo sapiens 61-71 12916171-3 2002 It is shown that polyamines can regulate interaction between NF-kappa B and the specific DNA sequence by binding to p50 subunit of NF-kappa B. Polyamines 17-27 nuclear factor kappa B subunit 1 Homo sapiens 116-119 12916171-3 2002 It is shown that polyamines can regulate interaction between NF-kappa B and the specific DNA sequence by binding to p50 subunit of NF-kappa B. Polyamines 17-27 nuclear factor kappa B subunit 1 Homo sapiens 131-141 12916171-4 2002 A possible polyamines binding site on the surface of p50 is found. Polyamines 11-21 nuclear factor kappa B subunit 1 Homo sapiens 53-56 12916171-5 2002 Dissociation of polyamines to p50.DNA complex is modelled. Polyamines 16-26 nuclear factor kappa B subunit 1 Homo sapiens 30-33 12916171-9 2002 Kd of complex p50.DNA is calculated in the presence and in the absence of polyamine in the binding site on the p50. Polyamines 74-83 nuclear factor kappa B subunit 1 Homo sapiens 14-17 12916171-9 2002 Kd of complex p50.DNA is calculated in the presence and in the absence of polyamine in the binding site on the p50. Polyamines 74-83 nuclear factor kappa B subunit 1 Homo sapiens 111-114 12916171-10 2002 It is shown that polyamines stabilizes the inter-domain interface of p50 protein due to appearance of additional electrostatic and hydrogen bonds. Polyamines 17-27 nuclear factor kappa B subunit 1 Homo sapiens 69-72 12916171-12 2002 The sequence of affinities of polyamines to NF-kappa B that we obtained corresponds well to the former sequence from the cited work. Polyamines 30-40 nuclear factor kappa B subunit 1 Homo sapiens 44-54 12916171-13 2002 Our results support the hypothesis that polyamines decreases the probability of spontaneous dissociation of DNA.p50 complex. Polyamines 40-50 nuclear factor kappa B subunit 1 Homo sapiens 112-115 11313919-8 2001 In addition, polyamine analogs inhibited the association of ER alpha and NF-kappa B with CBP/p300 and were unable to facilitate nuclear translocation of NF-kappa B. Polyamines 13-22 nuclear factor kappa B subunit 1 Homo sapiens 73-83 11390188-8 2001 Rather, the underlying mechanism of action, especially for the SS form, may be related to the close structural and functional similarities of these agents to polyamines, which have been reported to be capable of activating NFkappaB. Polyamines 158-168 nuclear factor kappa B subunit 1 Homo sapiens 223-231 11313919-3 2001 We investigated the role of polyamines in the function of NF-kappa B and estrogen receptor-alpha (ER alpha), two transcription factors implicated in breast cancer cell proliferation and cell survival, using MCF-7 breast cancer cells. Polyamines 28-38 nuclear factor kappa B subunit 1 Homo sapiens 58-68 11313919-10 2001 These data show a gene regulatory function of polyamines involving transcriptional activation of ER alpha and NF-kappa B, potentially leading to the up-regulation of genes involved in breast cancer cell proliferation. Polyamines 46-56 nuclear factor kappa B subunit 1 Homo sapiens 110-120 11313919-11 2001 Our results with BE-3-4-3 and BE-3-3-3 suggest that down-regulation of ER alpha- and NF-kappa B-regulated genes is a possible mechanism for the action of polyamine analogs in inducing apoptosis of breast cancer cells. Polyamines 154-163 nuclear factor kappa B subunit 1 Homo sapiens 85-95 10555958-4 1999 We performed electrophoretic mobility shift assays to study the role of polyamines in NF-kappaB binding to NF-kappaB response elements (NREs), the consensus sequence of which is GGGGAATTCCCC. Polyamines 72-82 nuclear factor kappa B subunit 1 Homo sapiens 86-95 10555958-4 1999 We performed electrophoretic mobility shift assays to study the role of polyamines in NF-kappaB binding to NF-kappaB response elements (NREs), the consensus sequence of which is GGGGAATTCCCC. Polyamines 72-82 nuclear factor kappa B subunit 1 Homo sapiens 107-116 10555958-8 1999 Using antibody supershift assays, we identified the p50 subunit of NF-kappaB to be a major component in NF-kappaB-NRE complex formation in the presence of polyamines. Polyamines 155-165 nuclear factor kappa B subunit 1 Homo sapiens 67-76 10555958-8 1999 Using antibody supershift assays, we identified the p50 subunit of NF-kappaB to be a major component in NF-kappaB-NRE complex formation in the presence of polyamines. Polyamines 155-165 nuclear factor kappa B subunit 1 Homo sapiens 104-113 10555958-16 1999 These data show a gene regulatory function of polyamines involving enhanced binding of NF-kappaB to NRE and a possible mechanism for the action of polyamines in breast cancer cell proliferation. Polyamines 46-56 nuclear factor kappa B subunit 1 Homo sapiens 87-96 34714483-3 2022 AIM OF THE STUDY: The study aimed to investigate the correlation between mitophagy machinery proteins, ER stress biomarkers and total polyamine and their role in disease progression via targeting NF-kappaB mechanisms. Polyamines 134-143 nuclear factor kappa B subunit 1 Homo sapiens 196-205