PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22592407-0 2012 Polyamines regulate intestinal epithelial restitution through TRPC1-mediated Ca2+ signaling by differentially modulating STIM1 and STIM2. Polyamines 0-10 transient receptor potential cation channel subfamily C member 1 Homo sapiens 62-67 33991460-10 2021 These results indicate that activation of TRPC1-mediated Ca2+ signaling enhances cell migration primarily by increasing alpha4/PP2Ac associations after wounding and this pathway is tightly regulated by cellular polyamines. Polyamines 211-221 transient receptor potential cation channel subfamily C member 1 Homo sapiens 42-47 30642111-9 2019 Moreover, DFMO abolish selectively the TRPC1-dependent component of SOCs characteristic of CRC cells and this effect is reversed by the polyamine putrescine. Polyamines 136-145 transient receptor potential cation channel subfamily C member 1 Homo sapiens 39-44 22592407-4 2012 Here, we show that polyamines regulate intestinal epithelial restitution through TRPC1-mediated Ca(2+) signaling by altering the ratio of STIM1 to STIM2. Polyamines 19-29 transient receptor potential cation channel subfamily C member 1 Homo sapiens 81-86 22592407-6 2012 Induced STIM1/TRPC1 association by increasing polyamines enhanced Ca(2+) influx and stimulated epithelial restitution, while decreased formation of the STIM1/TRPC1 complex by polyamine depletion decreased Ca(2+) influx and repressed cell migration. Polyamines 46-56 transient receptor potential cation channel subfamily C member 1 Homo sapiens 14-19 22592407-6 2012 Induced STIM1/TRPC1 association by increasing polyamines enhanced Ca(2+) influx and stimulated epithelial restitution, while decreased formation of the STIM1/TRPC1 complex by polyamine depletion decreased Ca(2+) influx and repressed cell migration. Polyamines 46-55 transient receptor potential cation channel subfamily C member 1 Homo sapiens 14-19 22592407-8 2012 These results indicate that polyamines differentially modulate cellular STIM1 and STIM2 levels in IECs, in turn controlling TRPC1-mediated Ca(2+) signaling and influencing cell migration after wounding. Polyamines 28-38 transient receptor potential cation channel subfamily C member 1 Homo sapiens 124-129