PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8632186-3 1996 The polyamine site agonist spermine showed differential modulation of glutamate- and glycine-stimulated 45Ca2+ influx for recombinant NMDA receptors, inhibiting and stimulating 45Ca2+ influx into cells expressing NR1a/NR2A receptors (IC50 = 408 microM) and NR1a/NR2B receptors (EC50 = 37.3 microM), respectively. Polyamines 4-13 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 262-266 9312102-0 1997 The NR2B-specific interactions of polyamines and protons with the N-methyl-D-aspartate receptor. Polyamines 34-44 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 4-8 9312102-2 1997 Using chimeric NR2A/NR2B subunits, we have located a region of NR2B (amino acids 138-238) which regulated glycine-independent polyamine stimulation. Polyamines 126-135 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 20-24 9312102-2 1997 Using chimeric NR2A/NR2B subunits, we have located a region of NR2B (amino acids 138-238) which regulated glycine-independent polyamine stimulation. Polyamines 126-135 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 63-67 9312102-6 1997 Polyamines and protons, therefore, share common NR2B determinants. Polyamines 0-10 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 48-52 26086092-3 2015 It was found that polyamines, especially spermidine, can permeate NMDA channels expressed from GluN1/GluN2A or GluN1/GluN2B activated by glycine and glutamate. Polyamines 18-28 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 117-123 8632355-4 1996 Histamine and the polyamine agonists spermine and spermidine enhanced glutamate toxicity in a dose-dependent manner consistent with expression of an NR1-NR2B combination of subunits. Polyamines 18-27 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 153-157 21685875-0 2011 Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines. Polyamines 78-88 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 53-59 21685875-5 2011 Here, we show that polyamines, naturally occurring polycations that selectively enhance NMDARs containing the GluN2B subunit, bind at a dimer interface between GluN1 and GluN2B subunit N-terminal domains (NTDs). Polyamines 19-29 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 110-116 21685875-5 2011 Here, we show that polyamines, naturally occurring polycations that selectively enhance NMDARs containing the GluN2B subunit, bind at a dimer interface between GluN1 and GluN2B subunit N-terminal domains (NTDs). Polyamines 19-29 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 170-176 21685875-6 2011 Polyamines act by shielding negative charges present on GluN1 and GluN2B NTD lower lobes, allowing their close apposition, an effect that in turn prevents NTD clamshell closure. Polyamines 0-10 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 66-72 22291485-5 2010 Ifenprodil and Ro25-6981, NMDAR2B antagonists at the polyamine site, also significantly (P < 0.001) inhibited the growth/survival of these cells. Polyamines 53-62 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 26-33 20451396-8 2010 Both fluorinated dioxadrol derivatives 8c and 12d showed high selectivity against sigma(1) and sigma(2) receptors as well as the polyamine binding site of NR2B receptors. Polyamines 129-138 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 155-159 18586028-3 2008 Inhibition of NR1/NR2B NMDARs by 1 muM ifenprodil severely impaired P19 neurite extension and fasciculation, and this negative effect was fully reversible by polyamine addition. Polyamines 158-167 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 18-22 16371319-10 2005 The NR2B-dependent facilitation bears close similarities with the polyamine-mediated potentiation. Polyamines 66-75 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 4-8