PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16048438-13	2005	DN-STAT3 induced the activation of caspase-3 and PARP [poly(ADP-ribose) polymerase] cleavage in polyamine-depleted cells.	Polyamines	96-105	caspase 3	Homo sapiens	35-44	
20940027-6	2011	Increase of the Bax/Bcl-2 ratio and activation of caspase-3 might be due to intracellular polyamine depletion.	Polyamines	90-99	caspase 3	Homo sapiens	50-59	
15024023-7	2004	Inactivation of Akt by either treatment with LY294002 or ectopic expression of a dominant negative Akt mutant (DNMAkt) not only enhanced the caspase-3 activation in polyamine-deficient cells but also prevented the increased resistance to tumor necrosis factor-alpha/cycloheximide-induced apoptosis.	Polyamines	165-174	caspase 3	Homo sapiens	141-150	
15941855-7	2005	The effect of polyamine depletion on caspase-3 activity was evaluated in BMSCs after treatment with 500 U/ml tumor necrosis factor-alpha (TNFalpha) and 5 microM MG132, an inhibitor of proteasome.	Polyamines	14-23	caspase 3	Homo sapiens	37-46	
15941855-9	2005	The effect of DFMO on TNFalpha/MG132-induced upregulation of caspase-3 activity was reversed by the addition of 100 microM putrescine, confirming that polyamines were really involved in the apoptotic process.	Polyamines	151-161	caspase 3	Homo sapiens	61-70	
15685629-6	2005	Real time PCR revealed that addition of polyamines to the culture media decreased the ratio of mRNA expression of Bak/Bcl-xL, Fas/Bcl-xL, and caspase 3, and enhanced mRNA expression of ornithine decarboxylase (ODC) and spermidine synthase, enzymes of polyamine biosynthesis.	Polyamines	40-50	caspase 3	Homo sapiens	142-151	
15994315-10	2005	These results indicate that polyamines regulate PP2A activity, and inhibition of PP2A in response to polyamine depletion increases steady state levels of Bad and Bcl-2 proteins and their phosphorylation and thereby prevents cytochrome c release, caspase-9, and caspase-3 activation.	Polyamines	28-38	caspase 3	Homo sapiens	261-270	
15994315-10	2005	These results indicate that polyamines regulate PP2A activity, and inhibition of PP2A in response to polyamine depletion increases steady state levels of Bad and Bcl-2 proteins and their phosphorylation and thereby prevents cytochrome c release, caspase-9, and caspase-3 activation.	Polyamines	28-37	caspase 3	Homo sapiens	261-270	
15685629-6	2005	Real time PCR revealed that addition of polyamines to the culture media decreased the ratio of mRNA expression of Bak/Bcl-xL, Fas/Bcl-xL, and caspase 3, and enhanced mRNA expression of ornithine decarboxylase (ODC) and spermidine synthase, enzymes of polyamine biosynthesis.	Polyamines	40-49	caspase 3	Homo sapiens	142-151	
15024023-0	2004	Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion.	Polyamines	100-109	caspase 3	Homo sapiens	84-93	
15024023-9	2004	These results indicate that polyamine depletion induces the Akt activation mediating suppression of apoptosis via inhibition of caspase-3 in normal intestinal epithelial cells.	Polyamines	28-37	caspase 3	Homo sapiens	128-137	
15106734-5	2004	Increase of Fas/Apo-1 expression and caspase-8 and caspase-3 activation focused two typical steps in the pathway of the pro-apoptotic mechanism exhibited by polyamines, even if to a different extent: spermine > spermidine > putrescine.	Polyamines	157-167	caspase 3	Homo sapiens	51-60	
11978014-8	2002	Depletion of polyamines induced activation of caspase-3 and disruption of the mitochondrial membrane potential (Delta psi m).	Polyamines	13-23	caspase 3	Homo sapiens	46-55	
9661878-1	1998	The polyamine analogue, N1-ethyl-N11-[(cycloheptyl)methyl]-4,8-diazaundecane (CHENSpm)-induced programmed cell death in NCI H157 cells is accompanied by cytochrome c release, the loss of mitochondrial membrane potential, activation of caspase-3, caspase-mediated poly(ADP-ribose) polymerase cleavage, G2-M arrest, and DNA and nuclear fragmentation.	Polyamines	4-13	caspase 3	Homo sapiens	235-244	
11698350-0	2001	Activation of caspase-3 activity and apoptosis in MDA-MB-468 cells by N(omega)-hydroxy-L-arginine, an inhibitor of arginase, is not solely dependent on reduction in intracellular polyamines.	Polyamines	179-189	caspase 3	Homo sapiens	14-23	
11698350-2	2001	These actions of NOHA were abolished in the presence of exogenous L-ornithine suggesting that a reduction in the intracellular polyamine content might be responsible for the activation of caspase-3 and apoptotic actions of NOHA.	Polyamines	127-136	caspase 3	Homo sapiens	188-197	
11698350-7	2001	Our results, therefore, indicate that the activation of caspase-3 and apoptosis observed with NOHA cannot be solely explained by a reduction in intracellular polyamine levels and that other mechanisms need to be also considered.	Polyamines	158-167	caspase 3	Homo sapiens	56-65